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Protein

Homeobox protein Hox-D12

Gene

Hoxd12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi200 – 25960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. embryonic digit morphogenesis Source: MGI
  2. pattern specification process Source: MGI
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. skeletal system development Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D12
Alternative name(s):
Homeobox protein Hox-4.7
Homeobox protein Hox-5.6
Gene namesi
Name:Hoxd12
Synonyms:Hox-4.7, Hoxd-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96204. Hoxd12.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Homeobox protein Hox-D12PRO_0000200239Add
BLAST

Proteomic databases

PRIDEiP23812.

PTM databases

PhosphoSiteiP23812.

Expressioni

Developmental stagei

Expressed during development of the posterior part of the body.

Gene expression databases

BgeeiP23812.
CleanExiMM_HOXD12.
GenevestigatoriP23812.

Interactioni

Protein-protein interaction databases

BioGridi200394. 9 interactions.
IntActiP23812. 1 interaction.
STRINGi10090.ENSMUSP00000001878.

Structurei

3D structure databases

ProteinModelPortaliP23812.
SMRiP23812. Positions 201-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241833.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP23812.
KOiK09297.
OMAiQAKFYAP.
OrthoDBiEOG73FQNH.
PhylomeDBiP23812.
TreeFamiTF351604.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCERSLYRAG YVGSLLNLQS PDSFYFSNLR ANGSQLAALP PISYPRSALP
60 70 80 90 100
WATTPASCTP AQPATASAFG GFSQPYLTGS GPIGLQSPGA KDGPEDQVKF
110 120 130 140 150
YTPDAPTASE ERSRTRPPFA PESSLVHSAL KGTKYDYAGV GRTAPGSATL
160 170 180 190 200
LQGAPCASSF KEDTKGPLNL NMAVQVAGVA SCLRSSLPDG LPWGAAPGRA
210 220 230 240 250
RKKRKPYTKQ QIAELENEFL VNEFINRQKR KELSNRLNLS DQQVKIWFQN
260
RRMKKKRVVQ REQALALY
Length:268
Mass (Da):29,198
Last modified:September 22, 2009 - v2
Checksum:i5EA04C2B59336AC4
GO

Sequence cautioni

The sequence CAA41654.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58849 Genomic DNA. Translation: CAA41654.1. Sequence problems.
AK031206 mRNA. Translation: BAC27299.1.
AL928644 Genomic DNA. Translation: CAM20526.1.
CH466519 Genomic DNA. Translation: EDL27169.1.
BC145656 mRNA. Translation: AAI45657.1.
CCDSiCCDS38147.1.
PIRiS16317.
RefSeqiNP_032300.2. NM_008274.3.
UniGeneiMm.57124.

Genome annotation databases

EnsembliENSMUST00000001878; ENSMUSP00000001878; ENSMUSG00000001823.
GeneIDi15432.
KEGGimmu:15432.
UCSCiuc008kdv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58849 Genomic DNA. Translation: CAA41654.1. Sequence problems.
AK031206 mRNA. Translation: BAC27299.1.
AL928644 Genomic DNA. Translation: CAM20526.1.
CH466519 Genomic DNA. Translation: EDL27169.1.
BC145656 mRNA. Translation: AAI45657.1.
CCDSiCCDS38147.1.
PIRiS16317.
RefSeqiNP_032300.2. NM_008274.3.
UniGeneiMm.57124.

3D structure databases

ProteinModelPortaliP23812.
SMRiP23812. Positions 201-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200394. 9 interactions.
IntActiP23812. 1 interaction.
STRINGi10090.ENSMUSP00000001878.

PTM databases

PhosphoSiteiP23812.

Proteomic databases

PRIDEiP23812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001878; ENSMUSP00000001878; ENSMUSG00000001823.
GeneIDi15432.
KEGGimmu:15432.
UCSCiuc008kdv.1. mouse.

Organism-specific databases

CTDi3238.
MGIiMGI:96204. Hoxd12.

Phylogenomic databases

eggNOGiNOG241833.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP23812.
KOiK09297.
OMAiQAKFYAP.
OrthoDBiEOG73FQNH.
PhylomeDBiP23812.
TreeFamiTF351604.

Miscellaneous databases

NextBioi288198.
PROiP23812.
SOURCEiSearch...

Gene expression databases

BgeeiP23812.
CleanExiMM_HOXD12.
GenevestigatoriP23812.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body."
    Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D.
    EMBO J. 10:2279-2289(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Forelimb.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHXD12_MOUSE
AccessioniPrimary (citable) accession number: P23812
Secondary accession number(s): Q8BSN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: September 22, 2009
Last modified: January 7, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.