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P23812

- HXD12_MOUSE

UniProt

P23812 - HXD12_MOUSE

Protein

Homeobox protein Hox-D12

Gene

Hoxd12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi200 – 25960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. embryonic digit morphogenesis Source: MGI
    2. pattern specification process Source: MGI
    3. skeletal system development Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D12
    Alternative name(s):
    Homeobox protein Hox-4.7
    Homeobox protein Hox-5.6
    Gene namesi
    Name:Hoxd12
    Synonyms:Hox-4.7, Hoxd-12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96204. Hoxd12.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Homeobox protein Hox-D12PRO_0000200239Add
    BLAST

    Proteomic databases

    PRIDEiP23812.

    PTM databases

    PhosphoSiteiP23812.

    Expressioni

    Developmental stagei

    Expressed during development of the posterior part of the body.

    Gene expression databases

    BgeeiP23812.
    CleanExiMM_HOXD12.
    GenevestigatoriP23812.

    Interactioni

    Protein-protein interaction databases

    BioGridi200394. 9 interactions.
    IntActiP23812. 1 interaction.
    STRINGi10090.ENSMUSP00000001878.

    Structurei

    3D structure databases

    ProteinModelPortaliP23812.
    SMRiP23812. Positions 201-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241833.
    GeneTreeiENSGT00750000117432.
    HOGENOMiHOG000231177.
    HOVERGENiHBG052050.
    InParanoidiQ8BSN0.
    KOiK09297.
    OMAiQAKFYAP.
    OrthoDBiEOG73FQNH.
    PhylomeDBiP23812.
    TreeFamiTF351604.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23812-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCERSLYRAG YVGSLLNLQS PDSFYFSNLR ANGSQLAALP PISYPRSALP    50
    WATTPASCTP AQPATASAFG GFSQPYLTGS GPIGLQSPGA KDGPEDQVKF 100
    YTPDAPTASE ERSRTRPPFA PESSLVHSAL KGTKYDYAGV GRTAPGSATL 150
    LQGAPCASSF KEDTKGPLNL NMAVQVAGVA SCLRSSLPDG LPWGAAPGRA 200
    RKKRKPYTKQ QIAELENEFL VNEFINRQKR KELSNRLNLS DQQVKIWFQN 250
    RRMKKKRVVQ REQALALY 268
    Length:268
    Mass (Da):29,198
    Last modified:September 22, 2009 - v2
    Checksum:i5EA04C2B59336AC4
    GO

    Sequence cautioni

    The sequence CAA41654.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58849 Genomic DNA. Translation: CAA41654.1. Sequence problems.
    AK031206 mRNA. Translation: BAC27299.1.
    AL928644 Genomic DNA. Translation: CAM20526.1.
    CH466519 Genomic DNA. Translation: EDL27169.1.
    BC145656 mRNA. Translation: AAI45657.1.
    CCDSiCCDS38147.1.
    PIRiS16317.
    RefSeqiNP_032300.2. NM_008274.3.
    UniGeneiMm.57124.

    Genome annotation databases

    EnsembliENSMUST00000001878; ENSMUSP00000001878; ENSMUSG00000001823.
    GeneIDi15432.
    KEGGimmu:15432.
    UCSCiuc008kdv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58849 Genomic DNA. Translation: CAA41654.1 . Sequence problems.
    AK031206 mRNA. Translation: BAC27299.1 .
    AL928644 Genomic DNA. Translation: CAM20526.1 .
    CH466519 Genomic DNA. Translation: EDL27169.1 .
    BC145656 mRNA. Translation: AAI45657.1 .
    CCDSi CCDS38147.1.
    PIRi S16317.
    RefSeqi NP_032300.2. NM_008274.3.
    UniGenei Mm.57124.

    3D structure databases

    ProteinModelPortali P23812.
    SMRi P23812. Positions 201-258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200394. 9 interactions.
    IntActi P23812. 1 interaction.
    STRINGi 10090.ENSMUSP00000001878.

    PTM databases

    PhosphoSitei P23812.

    Proteomic databases

    PRIDEi P23812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001878 ; ENSMUSP00000001878 ; ENSMUSG00000001823 .
    GeneIDi 15432.
    KEGGi mmu:15432.
    UCSCi uc008kdv.1. mouse.

    Organism-specific databases

    CTDi 3238.
    MGIi MGI:96204. Hoxd12.

    Phylogenomic databases

    eggNOGi NOG241833.
    GeneTreei ENSGT00750000117432.
    HOGENOMi HOG000231177.
    HOVERGENi HBG052050.
    InParanoidi Q8BSN0.
    KOi K09297.
    OMAi QAKFYAP.
    OrthoDBi EOG73FQNH.
    PhylomeDBi P23812.
    TreeFami TF351604.

    Miscellaneous databases

    NextBioi 288198.
    PROi P23812.
    SOURCEi Search...

    Gene expression databases

    Bgeei P23812.
    CleanExi MM_HOXD12.
    Genevestigatori P23812.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body."
      Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D.
      EMBO J. 10:2279-2289(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Forelimb.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiHXD12_MOUSE
    AccessioniPrimary (citable) accession number: P23812
    Secondary accession number(s): Q8BSN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3