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Protein

Homeobox protein Hox-D12

Gene

Hoxd12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi200 – 259HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • embryonic digit morphogenesis Source: MGI
  • pattern specification process Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • skeletal system development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D12
Alternative name(s):
Homeobox protein Hox-4.7
Homeobox protein Hox-5.6
Gene namesi
Name:Hoxd12
Synonyms:Hox-4.7, Hoxd-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96204. Hoxd12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002391 – 268Homeobox protein Hox-D12Add BLAST268

Proteomic databases

MaxQBiP23812.
PaxDbiP23812.
PRIDEiP23812.

PTM databases

iPTMnetiP23812.
PhosphoSitePlusiP23812.

Expressioni

Developmental stagei

Expressed during development of the posterior part of the body.

Gene expression databases

BgeeiENSMUSG00000001823.
CleanExiMM_HOXD12.
GenevisibleiP23812. MM.

Interactioni

Protein-protein interaction databases

BioGridi200394. 9 interactors.
IntActiP23812. 1 interactor.
STRINGi10090.ENSMUSP00000001878.

Structurei

3D structure databases

ProteinModelPortaliP23812.
SMRiP23812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP23812.
KOiK09297.
OMAiKFYAPEA.
OrthoDBiEOG091G0P35.
PhylomeDBiP23812.
TreeFamiTF351604.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P23812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCERSLYRAG YVGSLLNLQS PDSFYFSNLR ANGSQLAALP PISYPRSALP
60 70 80 90 100
WATTPASCTP AQPATASAFG GFSQPYLTGS GPIGLQSPGA KDGPEDQVKF
110 120 130 140 150
YTPDAPTASE ERSRTRPPFA PESSLVHSAL KGTKYDYAGV GRTAPGSATL
160 170 180 190 200
LQGAPCASSF KEDTKGPLNL NMAVQVAGVA SCLRSSLPDG LPWGAAPGRA
210 220 230 240 250
RKKRKPYTKQ QIAELENEFL VNEFINRQKR KELSNRLNLS DQQVKIWFQN
260
RRMKKKRVVQ REQALALY
Length:268
Mass (Da):29,198
Last modified:September 22, 2009 - v2
Checksum:i5EA04C2B59336AC4
GO

Sequence cautioni

The sequence CAA41654 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58849 Genomic DNA. Translation: CAA41654.1. Sequence problems.
AK031206 mRNA. Translation: BAC27299.1.
AL928644 Genomic DNA. Translation: CAM20526.1.
CH466519 Genomic DNA. Translation: EDL27169.1.
BC145656 mRNA. Translation: AAI45657.1.
CCDSiCCDS38147.1.
PIRiS16317.
RefSeqiNP_032300.2. NM_008274.3.
UniGeneiMm.57124.

Genome annotation databases

EnsembliENSMUST00000001878; ENSMUSP00000001878; ENSMUSG00000001823.
GeneIDi15432.
KEGGimmu:15432.
UCSCiuc008kdv.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiHXD12_MOUSE
AccessioniPrimary (citable) accession number: P23812
Secondary accession number(s): Q8BSN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: September 22, 2009
Last modified: September 27, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families