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Protein

Secretin receptor

Gene

Sctr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • peptide binding Source: RGD
  • secretin receptor activity Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • cell surface receptor signaling pathway Source: InterPro
  • positive regulation of cAMP biosynthetic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin receptor
Short name:
SCT-R
Gene namesi
Name:Sctr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621342. Sctr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 143ExtracellularSequence analysisAdd BLAST118
Transmembranei144 – 167Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini168 – 174CytoplasmicSequence analysis7
Transmembranei175 – 194Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini195 – 216ExtracellularSequence analysisAdd BLAST22
Transmembranei217 – 240Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini241 – 254CytoplasmicSequence analysisAdd BLAST14
Transmembranei255 – 276Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini277 – 294ExtracellularSequence analysisAdd BLAST18
Transmembranei295 – 317Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini318 – 343CytoplasmicSequence analysisAdd BLAST26
Transmembranei344 – 362Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini363 – 369ExtracellularSequence analysis7
Transmembranei370 – 392Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini393 – 449CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi252.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001285426 – 449Secretin receptorAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP23811.
PRIDEiP23811.

PTM databases

PhosphoSitePlusiP23811.

Interactioni

Protein-protein interaction databases

BioGridi249651. 1 interactor.
STRINGi10116.ENSRNOP00000064579.

Structurei

3D structure databases

ProteinModelPortaliP23811.
SMRiP23811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOVERGENiHBG008318.
InParanoidiP23811.
KOiK04588.
PhylomeDBiP23811.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTMRPRLS LLLLRLLLLT KAAHTVGVPP RLCDVRRVLL EERAHCLQQL
60 70 80 90 100
SKEKKGALGP ETASGCEGLW DNMSCWPSSA PARTVEVQCP KFLLMLSNKN
110 120 130 140 150
GSLFRNCTQD GWSETFPRPD LACGVNINNS FNERRHAYLL KLKVMYTVGY
160 170 180 190 200
SSSLAMLLVA LSILCSFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF
210 220 230 240 250
SSDDVTYCDA HKVGCKLVMI FFQYCIMANY AWLLVEGLYL HTLLAISFFS
260 270 280 290 300
ERKYLQAFVL LGWGSPAIFV ALWAITRHFL ENTGCWDINA NASVWWVIRG
310 320 330 340 350
PVILSILINF IFFINILRIL MRKLRTQETR GSETNHYKRL AKSTLLLIPL
360 370 380 390 400
FGIHYIVFAF SPEDAMEVQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ
410 420 430 440
KKWRQWHLQE FPLRPVAFNN SFSNATNGPT HSTKASTEQS RSIPRASII
Length:449
Mass (Da):51,234
Last modified:November 1, 1991 - v1
Checksum:iE70D05B5D061480D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59132 mRNA. Translation: CAA41849.1.
BC081781 mRNA. Translation: AAH81781.1.
PIRiS16319.
RefSeqiNP_112377.1. NM_031115.1.
UniGeneiRn.32256.

Genome annotation databases

GeneIDi81779.
KEGGirno:81779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59132 mRNA. Translation: CAA41849.1.
BC081781 mRNA. Translation: AAH81781.1.
PIRiS16319.
RefSeqiNP_112377.1. NM_031115.1.
UniGeneiRn.32256.

3D structure databases

ProteinModelPortaliP23811.
SMRiP23811.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249651. 1 interactor.
STRINGi10116.ENSRNOP00000064579.

Chemistry databases

GuidetoPHARMACOLOGYi252.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP23811.

Proteomic databases

PaxDbiP23811.
PRIDEiP23811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81779.
KEGGirno:81779.

Organism-specific databases

CTDi6344.
RGDi621342. Sctr.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOVERGENiHBG008318.
InParanoidiP23811.
KOiK04588.
PhylomeDBiP23811.

Miscellaneous databases

PROiP23811.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCTR_RAT
AccessioniPrimary (citable) accession number: P23811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.