Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Secretin receptor

Gene

Sctr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. peptide binding Source: RGD
  2. secretin receptor activity Source: RGD

GO - Biological processi

  1. brain development Source: RGD
  2. positive regulation of cAMP biosynthetic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin receptor
Short name:
SCT-R
Gene namesi
Name:Sctr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621342. Sctr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 143118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei144 – 16724Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini168 – 1747CytoplasmicSequence Analysis
Transmembranei175 – 19420Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini195 – 21622ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 24024Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini241 – 25414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei255 – 27622Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini277 – 29418ExtracellularSequence AnalysisAdd
BLAST
Transmembranei295 – 31723Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini318 – 34326CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei344 – 36219Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini363 – 3697ExtracellularSequence Analysis
Transmembranei370 – 39223Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini393 – 44957CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic microtubule Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 449424Secretin receptorPRO_0000012854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP23811.

Expressioni

Gene expression databases

GenevestigatoriP23811.

Interactioni

Protein-protein interaction databases

BioGridi249651. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP23811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG008318.
InParanoidiP23811.
KOiK04588.
PhylomeDBiP23811.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTMRPRLS LLLLRLLLLT KAAHTVGVPP RLCDVRRVLL EERAHCLQQL
60 70 80 90 100
SKEKKGALGP ETASGCEGLW DNMSCWPSSA PARTVEVQCP KFLLMLSNKN
110 120 130 140 150
GSLFRNCTQD GWSETFPRPD LACGVNINNS FNERRHAYLL KLKVMYTVGY
160 170 180 190 200
SSSLAMLLVA LSILCSFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF
210 220 230 240 250
SSDDVTYCDA HKVGCKLVMI FFQYCIMANY AWLLVEGLYL HTLLAISFFS
260 270 280 290 300
ERKYLQAFVL LGWGSPAIFV ALWAITRHFL ENTGCWDINA NASVWWVIRG
310 320 330 340 350
PVILSILINF IFFINILRIL MRKLRTQETR GSETNHYKRL AKSTLLLIPL
360 370 380 390 400
FGIHYIVFAF SPEDAMEVQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ
410 420 430 440
KKWRQWHLQE FPLRPVAFNN SFSNATNGPT HSTKASTEQS RSIPRASII
Length:449
Mass (Da):51,234
Last modified:October 31, 1991 - v1
Checksum:iE70D05B5D061480D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59132 mRNA. Translation: CAA41849.1.
BC081781 mRNA. Translation: AAH81781.1.
PIRiS16319.
RefSeqiNP_112377.1. NM_031115.1.
UniGeneiRn.32256.

Genome annotation databases

GeneIDi81779.
KEGGirno:81779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59132 mRNA. Translation: CAA41849.1.
BC081781 mRNA. Translation: AAH81781.1.
PIRiS16319.
RefSeqiNP_112377.1. NM_031115.1.
UniGeneiRn.32256.

3D structure databases

ProteinModelPortaliP23811.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249651. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi252.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP23811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81779.
KEGGirno:81779.

Organism-specific databases

CTDi6344.
RGDi621342. Sctr.

Phylogenomic databases

HOVERGENiHBG008318.
InParanoidiP23811.
KOiK04588.
PhylomeDBiP23811.

Miscellaneous databases

NextBioi615617.
PROiP23811.

Gene expression databases

GenevestigatoriP23811.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of a cDNA encoding the secretin receptor."
    Ishihara T., Nakamura S., Kaziro Y., Takahashi T., Takahashi K., Nagata S.
    EMBO J. 10:1635-1641(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiSCTR_RAT
AccessioniPrimary (citable) accession number: P23811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1991
Last sequence update: October 31, 1991
Last modified: February 3, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.