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P23811

- SCTR_RAT

UniProt

P23811 - SCTR_RAT

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Protein

Secretin receptor

Gene
Sctr
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. peptide binding Source: RGD
  2. secretin receptor activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin receptor
Short name:
SCT-R
Gene namesi
Name:Sctr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621342. Sctr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 143118Extracellular Reviewed predictionAdd
BLAST
Transmembranei144 – 16724Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini168 – 1747Cytoplasmic Reviewed prediction
Transmembranei175 – 19420Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini195 – 21622Extracellular Reviewed predictionAdd
BLAST
Transmembranei217 – 24024Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini241 – 25414Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei255 – 27622Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini277 – 29418Extracellular Reviewed predictionAdd
BLAST
Transmembranei295 – 31723Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini318 – 34326Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei344 – 36219Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini363 – 3697Extracellular Reviewed prediction
Transmembranei370 – 39223Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini393 – 44957Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic microtubule Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 449424Secretin receptorPRO_0000012854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi291 – 2911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP23811.

Expressioni

Gene expression databases

GenevestigatoriP23811.

Interactioni

Protein-protein interaction databases

BioGridi249651. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP23811.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG008318.
KOiK04588.
PhylomeDBiP23811.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23811-1 [UniParc]FASTAAdd to Basket

« Hide

MLSTMRPRLS LLLLRLLLLT KAAHTVGVPP RLCDVRRVLL EERAHCLQQL    50
SKEKKGALGP ETASGCEGLW DNMSCWPSSA PARTVEVQCP KFLLMLSNKN 100
GSLFRNCTQD GWSETFPRPD LACGVNINNS FNERRHAYLL KLKVMYTVGY 150
SSSLAMLLVA LSILCSFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF 200
SSDDVTYCDA HKVGCKLVMI FFQYCIMANY AWLLVEGLYL HTLLAISFFS 250
ERKYLQAFVL LGWGSPAIFV ALWAITRHFL ENTGCWDINA NASVWWVIRG 300
PVILSILINF IFFINILRIL MRKLRTQETR GSETNHYKRL AKSTLLLIPL 350
FGIHYIVFAF SPEDAMEVQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ 400
KKWRQWHLQE FPLRPVAFNN SFSNATNGPT HSTKASTEQS RSIPRASII 449
Length:449
Mass (Da):51,234
Last modified:November 1, 1991 - v1
Checksum:iE70D05B5D061480D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59132 mRNA. Translation: CAA41849.1.
BC081781 mRNA. Translation: AAH81781.1.
PIRiS16319.
RefSeqiNP_112377.1. NM_031115.1.
UniGeneiRn.32256.

Genome annotation databases

GeneIDi81779.
KEGGirno:81779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59132 mRNA. Translation: CAA41849.1 .
BC081781 mRNA. Translation: AAH81781.1 .
PIRi S16319.
RefSeqi NP_112377.1. NM_031115.1.
UniGenei Rn.32256.

3D structure databases

ProteinModelPortali P23811.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249651. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi 252.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P23811.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81779.
KEGGi rno:81779.

Organism-specific databases

CTDi 6344.
RGDi 621342. Sctr.

Phylogenomic databases

HOVERGENi HBG008318.
KOi K04588.
PhylomeDBi P23811.

Miscellaneous databases

NextBioi 615617.
PROi P23811.

Gene expression databases

Genevestigatori P23811.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view ]
PANTHERi PTHR12011:SF29. PTHR12011:SF29. 1 hit.
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of a cDNA encoding the secretin receptor."
    Ishihara T., Nakamura S., Kaziro Y., Takahashi T., Takahashi K., Nagata S.
    EMBO J. 10:1635-1641(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiSCTR_RAT
AccessioniPrimary (citable) accession number: P23811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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