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P23811

- SCTR_RAT

UniProt

P23811 - SCTR_RAT

Protein

Secretin receptor

Gene

Sctr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. peptide binding Source: RGD
    2. secretin receptor activity Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secretin receptor
    Short name:
    SCT-R
    Gene namesi
    Name:Sctr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621342. Sctr.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic microtubule Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 449424Secretin receptorPRO_0000012854Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP23811.

    Expressioni

    Gene expression databases

    GenevestigatoriP23811.

    Interactioni

    Protein-protein interaction databases

    BioGridi249651. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP23811.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 143118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini168 – 1747CytoplasmicSequence Analysis
    Topological domaini195 – 21622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini241 – 25414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 29418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini318 – 34326CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini363 – 3697ExtracellularSequence Analysis
    Topological domaini393 – 44957CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei144 – 16724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 19420Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 24024Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27622Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31723Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei344 – 36219Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei370 – 39223Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG008318.
    KOiK04588.
    PhylomeDBiP23811.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR002144. GPCR_2_secretin_rcpt.
    [Graphical view]
    PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR00490. SECRETINR.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23811-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSTMRPRLS LLLLRLLLLT KAAHTVGVPP RLCDVRRVLL EERAHCLQQL    50
    SKEKKGALGP ETASGCEGLW DNMSCWPSSA PARTVEVQCP KFLLMLSNKN 100
    GSLFRNCTQD GWSETFPRPD LACGVNINNS FNERRHAYLL KLKVMYTVGY 150
    SSSLAMLLVA LSILCSFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF 200
    SSDDVTYCDA HKVGCKLVMI FFQYCIMANY AWLLVEGLYL HTLLAISFFS 250
    ERKYLQAFVL LGWGSPAIFV ALWAITRHFL ENTGCWDINA NASVWWVIRG 300
    PVILSILINF IFFINILRIL MRKLRTQETR GSETNHYKRL AKSTLLLIPL 350
    FGIHYIVFAF SPEDAMEVQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ 400
    KKWRQWHLQE FPLRPVAFNN SFSNATNGPT HSTKASTEQS RSIPRASII 449
    Length:449
    Mass (Da):51,234
    Last modified:November 1, 1991 - v1
    Checksum:iE70D05B5D061480D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59132 mRNA. Translation: CAA41849.1.
    BC081781 mRNA. Translation: AAH81781.1.
    PIRiS16319.
    RefSeqiNP_112377.1. NM_031115.1.
    UniGeneiRn.32256.

    Genome annotation databases

    GeneIDi81779.
    KEGGirno:81779.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59132 mRNA. Translation: CAA41849.1 .
    BC081781 mRNA. Translation: AAH81781.1 .
    PIRi S16319.
    RefSeqi NP_112377.1. NM_031115.1.
    UniGenei Rn.32256.

    3D structure databases

    ProteinModelPortali P23811.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249651. 1 interaction.

    Chemistry

    GuidetoPHARMACOLOGYi 252.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P23811.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 81779.
    KEGGi rno:81779.

    Organism-specific databases

    CTDi 6344.
    RGDi 621342. Sctr.

    Phylogenomic databases

    HOVERGENi HBG008318.
    KOi K04588.
    PhylomeDBi P23811.

    Miscellaneous databases

    NextBioi 615617.
    PROi P23811.

    Gene expression databases

    Genevestigatori P23811.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR002144. GPCR_2_secretin_rcpt.
    [Graphical view ]
    PANTHERi PTHR12011:SF29. PTHR12011:SF29. 1 hit.
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR00490. SECRETINR.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a cDNA encoding the secretin receptor."
      Ishihara T., Nakamura S., Kaziro Y., Takahashi T., Takahashi K., Nagata S.
      EMBO J. 10:1635-1641(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiSCTR_RAT
    AccessioniPrimary (citable) accession number: P23811
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3