Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P23811 (SCTR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secretin receptor

Short name=SCT-R
Gene names
Name:Sctr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 449424Secretin receptor
PRO_0000012854

Regions

Topological domain26 – 143118Extracellular Potential
Transmembrane144 – 16724Helical; Name=1; Potential
Topological domain168 – 1747Cytoplasmic Potential
Transmembrane175 – 19420Helical; Name=2; Potential
Topological domain195 – 21622Extracellular Potential
Transmembrane217 – 24024Helical; Name=3; Potential
Topological domain241 – 25414Cytoplasmic Potential
Transmembrane255 – 27622Helical; Name=4; Potential
Topological domain277 – 29418Extracellular Potential
Transmembrane295 – 31723Helical; Name=5; Potential
Topological domain318 – 34326Cytoplasmic Potential
Transmembrane344 – 36219Helical; Name=6; Potential
Topological domain363 – 3697Extracellular Potential
Transmembrane370 – 39223Helical; Name=7; Potential
Topological domain393 – 44957Cytoplasmic Potential

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P23811 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: E70D05B5D061480D

FASTA44951,234
        10         20         30         40         50         60 
MLSTMRPRLS LLLLRLLLLT KAAHTVGVPP RLCDVRRVLL EERAHCLQQL SKEKKGALGP 

        70         80         90        100        110        120 
ETASGCEGLW DNMSCWPSSA PARTVEVQCP KFLLMLSNKN GSLFRNCTQD GWSETFPRPD 

       130        140        150        160        170        180 
LACGVNINNS FNERRHAYLL KLKVMYTVGY SSSLAMLLVA LSILCSFRRL HCTRNYIHMH 

       190        200        210        220        230        240 
LFVSFILRAL SNFIKDAVLF SSDDVTYCDA HKVGCKLVMI FFQYCIMANY AWLLVEGLYL 

       250        260        270        280        290        300 
HTLLAISFFS ERKYLQAFVL LGWGSPAIFV ALWAITRHFL ENTGCWDINA NASVWWVIRG 

       310        320        330        340        350        360 
PVILSILINF IFFINILRIL MRKLRTQETR GSETNHYKRL AKSTLLLIPL FGIHYIVFAF 

       370        380        390        400        410        420 
SPEDAMEVQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ KKWRQWHLQE FPLRPVAFNN 

       430        440 
SFSNATNGPT HSTKASTEQS RSIPRASII 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and expression of a cDNA encoding the secretin receptor."
Ishihara T., Nakamura S., Kaziro Y., Takahashi T., Takahashi K., Nagata S.
EMBO J. 10:1635-1641(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59132 mRNA. Translation: CAA41849.1.
BC081781 mRNA. Translation: AAH81781.1.
PIRS16319.
RefSeqNP_112377.1. NM_031115.1.
UniGeneRn.32256.

3D structure databases

ProteinModelPortalP23811.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249651. 1 interaction.

Chemistry

GuidetoPHARMACOLOGY252.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP23811.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID81779.
KEGGrno:81779.

Organism-specific databases

CTD6344.
RGD621342. Sctr.

Phylogenomic databases

HOVERGENHBG008318.
KOK04588.
PhylomeDBP23811.

Gene expression databases

GenevestigatorP23811.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615617.
PROP23811.

Entry information

Entry nameSCTR_RAT
AccessionPrimary (citable) accession number: P23811
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries