Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein odd-skipped

Gene

odd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis. DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions. May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 242C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • blastoderm segmentation Source: UniProtKB
  • imaginal disc-derived leg joint morphogenesis Source: FlyBase
  • Malpighian tubule morphogenesis Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • pattern specification process Source: CACAO
  • periodic partitioning by pair rule gene Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Pair-rule protein, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiP23803

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped
Gene namesi
Name:odd
ORF Names:CG3851
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0002985 odd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470031 – 392Protein odd-skippedAdd BLAST392

Proteomic databases

PaxDbiP23803
PRIDEiP23803

Expressioni

Tissue specificityi

Has two temporally distinct modes of expression during early embryogenesis; expressed in seven stripes at the blastoderm stage, then during gastrulation the seven primary stripes are supplemented by secondary stripes which appear in alternate segments. This results in the labelling of every segment in the extended germ band. Also expressed in the embryo in distinct regions of the gut, the Garland cells associated with the proventriculus, the pericardial cells, the lymph glands associated with the heart, in a subset of cells in the central nervous system and in select apodemes. Expressed in a segmentally repeated pattern in the leg disk at the distal edge of each presumptive leg segment except in tarsal segments 1 to 4.3 Publications

Gene expression databases

BgeeiFBgn0002985
GenevisibleiP23803 DM

Interactioni

Protein-protein interaction databases

BioGridi59791, 20 interactors
ELMiP23803
IntActiP23803, 3 interactors
STRINGi7227.FBpp0077246

Structurei

3D structure databases

ProteinModelPortaliP23803
SMRiP23803
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 93Poly-GlnAdd BLAST12
Compositional biasi101 – 106Poly-Gln6
Compositional biasi142 – 149Poly-Gln8
Compositional biasi150 – 181His/Pro-richAdd BLAST32
Compositional biasi369 – 375Poly-Ser7

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 242C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000137939
InParanoidiP23803
KOiK09215
OMAiHLEEGPH
OrthoDBiEOG091G0LRE

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

P23803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTSASPIS NITVDDELNL SREQDFAEED FIVIKEERET SLSPMLTPPH
60 70 80 90 100
TPTEEPLRRV HPAISEEAVA TQLHMRHMAH YQQQQQQQQQ QQQHRLWLQM
110 120 130 140 150
QQQQQQHQAP QQYPVYPTAS ADPVAVHQQL MNHWIRNAAI YQQQQQQQQH
160 170 180 190 200
PHHHHHHGHP HHPHPHPHHV RPYPAGLHSL HAAVMGRHFG AMPTLKLGGA
210 220 230 240 250
GGASGVPSGA TGSSRPKKQF ICKYCNRQFT KSYNLLIHER THTDERPYSC
260 270 280 290 300
DICGKAFRRQ DHLRDHRYIH SKDKPFKCSD CGKGFCQSRT LAVHKVTHLE
310 320 330 340 350
EGPHKCPICQ RSFNQRANLK SHLQSHSEQS TKEVVVTTSP ATSHSVPNQA
360 370 380 390
LSSPQPENLA QHLPVLDLSS SSSSSEKPKR MLGFTIDEIM SR
Length:392
Mass (Da):44,626
Last modified:July 19, 2005 - v3
Checksum:i588B55257566688A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29E → D in CAA40718 (PubMed:2120051).Curated1
Sequence conflicti185M → V in CAA40718 (PubMed:2120051).Curated1
Sequence conflicti209G → C in CAA40718 (PubMed:2120051).Curated1
Sequence conflicti360A → V in CAA40718 (PubMed:2120051).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57480 mRNA Translation: CAA40718.1
AE014134 Genomic DNA Translation: AAF51085.1
BT015214 mRNA Translation: AAT94443.1
PIRiS11998
RefSeqiNP_722922.1, NM_164546.2
UniGeneiDm.290

Genome annotation databases

EnsemblMetazoaiFBtr0077557; FBpp0077246; FBgn0002985
GeneIDi33583
KEGGidme:Dmel_CG3851

Similar proteinsi

Entry informationi

Entry nameiODD_DROME
AccessioniPrimary (citable) accession number: P23803
Secondary accession number(s): Q9VQS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health