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Protein

Protein odd-skipped

Gene

odd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis. DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions. May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 242C2H2-type 1Add BLAST23
Zinc fingeri248 – 270C2H2-type 2Add BLAST23
Zinc fingeri276 – 298C2H2-type 3Add BLAST23
Zinc fingeri304 – 326C2H2-type 4Add BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • blastoderm segmentation Source: UniProtKB
  • imaginal disc-derived leg joint morphogenesis Source: FlyBase
  • Malpighian tubule morphogenesis Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • pattern specification process Source: CACAO
  • periodic partitioning by pair rule gene Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Pair-rule protein, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiP23803.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped
Gene namesi
Name:odd
ORF Names:CG3851
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0002985. odd.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470031 – 392Protein odd-skippedAdd BLAST392

Proteomic databases

PaxDbiP23803.
PRIDEiP23803.

Expressioni

Tissue specificityi

Has two temporally distinct modes of expression during early embryogenesis; expressed in seven stripes at the blastoderm stage, then during gastrulation the seven primary stripes are supplemented by secondary stripes which appear in alternate segments. This results in the labelling of every segment in the extended germ band. Also expressed in the embryo in distinct regions of the gut, the Garland cells associated with the proventriculus, the pericardial cells, the lymph glands associated with the heart, in a subset of cells in the central nervous system and in select apodemes. Expressed in a segmentally repeated pattern in the leg disk at the distal edge of each presumptive leg segment except in tarsal segments 1 to 4.3 Publications

Gene expression databases

BgeeiFBgn0002985.
GenevisibleiP23803. DM.

Interactioni

Protein-protein interaction databases

BioGridi59791. 20 interactors.
ELMiP23803.
IntActiP23803. 3 interactors.
MINTiMINT-759527.
STRINGi7227.FBpp0077246.

Structurei

3D structure databases

ProteinModelPortaliP23803.
SMRiP23803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 93Poly-GlnAdd BLAST12
Compositional biasi101 – 106Poly-Gln6
Compositional biasi142 – 149Poly-Gln8
Compositional biasi150 – 181His/Pro-richAdd BLAST32
Compositional biasi369 – 375Poly-Ser7

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 242C2H2-type 1Add BLAST23
Zinc fingeri248 – 270C2H2-type 2Add BLAST23
Zinc fingeri276 – 298C2H2-type 3Add BLAST23
Zinc fingeri304 – 326C2H2-type 4Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00880000137939.
InParanoidiP23803.
KOiK09215.
OMAiHLEEGPH.
OrthoDBiEOG091G0LRE.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequencei

Sequence statusi: Complete.

P23803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTSASPIS NITVDDELNL SREQDFAEED FIVIKEERET SLSPMLTPPH
60 70 80 90 100
TPTEEPLRRV HPAISEEAVA TQLHMRHMAH YQQQQQQQQQ QQQHRLWLQM
110 120 130 140 150
QQQQQQHQAP QQYPVYPTAS ADPVAVHQQL MNHWIRNAAI YQQQQQQQQH
160 170 180 190 200
PHHHHHHGHP HHPHPHPHHV RPYPAGLHSL HAAVMGRHFG AMPTLKLGGA
210 220 230 240 250
GGASGVPSGA TGSSRPKKQF ICKYCNRQFT KSYNLLIHER THTDERPYSC
260 270 280 290 300
DICGKAFRRQ DHLRDHRYIH SKDKPFKCSD CGKGFCQSRT LAVHKVTHLE
310 320 330 340 350
EGPHKCPICQ RSFNQRANLK SHLQSHSEQS TKEVVVTTSP ATSHSVPNQA
360 370 380 390
LSSPQPENLA QHLPVLDLSS SSSSSEKPKR MLGFTIDEIM SR
Length:392
Mass (Da):44,626
Last modified:July 19, 2005 - v3
Checksum:i588B55257566688A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29E → D in CAA40718 (PubMed:2120051).Curated1
Sequence conflicti185M → V in CAA40718 (PubMed:2120051).Curated1
Sequence conflicti209G → C in CAA40718 (PubMed:2120051).Curated1
Sequence conflicti360A → V in CAA40718 (PubMed:2120051).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57480 mRNA. Translation: CAA40718.1.
AE014134 Genomic DNA. Translation: AAF51085.1.
BT015214 mRNA. Translation: AAT94443.1.
PIRiS11998.
RefSeqiNP_722922.1. NM_164546.2.
UniGeneiDm.290.

Genome annotation databases

EnsemblMetazoaiFBtr0077557; FBpp0077246; FBgn0002985.
GeneIDi33583.
KEGGidme:Dmel_CG3851.

Similar proteinsi

Entry informationi

Entry nameiODD_DROME
AccessioniPrimary (citable) accession number: P23803
Secondary accession number(s): Q9VQS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: July 19, 2005
Last modified: November 22, 2017
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families