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P23796

- RIT1_YEAST

UniProt

P23796 - RIT1_YEAST

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Protein
tRNA A64-2'-O-ribosylphosphate transferase
Gene
RIT1, YMR283C, YM8021.09C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

tRNA backbone modifying enzyme that mediates initiator/ elongator tRNA discrimination. This enzyme modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. Recognize the stem-loop IV region that is unique in eukaryotic cytoplasmic initiator tRNAs.

GO - Molecular functioni

  1. transferase activity, transferring pentosyl groups Source: SGD

GO - Biological processi

  1. charged-tRNA amino acid modification Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32953-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA A64-2'-O-ribosylphosphate transferase (EC:2.4.2.-)
Alternative name(s):
Initiator tRNA phosphoribosyl-transferase
Gene namesi
Name:RIT1
Ordered Locus Names:YMR283C
ORF Names:YM8021.09C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR283c.
SGDiS000004896. RIT1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513tRNA A64-2'-O-ribosylphosphate transferase
PRO_0000097353Add
BLAST

Proteomic databases

MaxQBiP23796.
PaxDbiP23796.

Expressioni

Gene expression databases

GenevestigatoriP23796.

Interactioni

Protein-protein interaction databases

BioGridi35462. 51 interactions.
MINTiMINT-4498956.
STRINGi4932.YMR283C.

Structurei

3D structure databases

ProteinModelPortaliP23796.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG241557.
HOGENOMiHOG000174281.
KOiK15463.
OMAiSADDHEL.
OrthoDBiEOG7B05P8.

Family and domain databases

InterProiIPR007306. Init_tRNA_PT.
IPR016519. tRNA_ribosyl_Ptfrase_RIT1.
[Graphical view]
PfamiPF04179. Init_tRNA_PT. 1 hit.
[Graphical view]
PIRSFiPIRSF007747. Ribosyl_Ptfrase. 1 hit.

Sequencei

Sequence statusi: Complete.

P23796-1 [UniParc]FASTAAdd to Basket

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MVSRLSKRYR SRVQFSISVM DENIYLSLSQ INKDIRKENK SVRNRLQSIL    50
LDNKFLQDRV IPIFPHYPLI PNERCGLWYC NPSSFKQTSY FKSTDGHVNQ 100
WDFSTRRLNF HLLETIRDNK GIIIVDSTRR GKKIPDALSK TVPIWCAVLN 150
TLMLQETEKN VAIDKVLYLP PETVPKSEYD MIKRKIPELV AKLQKLNIID 200
SKKLNELFMG KLLRPIWVHP GSSLLDHSVD YFTGEVQEYE AWETPEDQNI 250
IPIILCTVSY QAQDGMDKRY GFTYVQGAAD DHELWSFGLD SNMFWAHIEY 300
LGDASYSDDQ LHDYIMDLAA AKLRNQCYIQ DKGSLDEVFG NIDKITNEIS 350
LGKVSSGLTI NKNLKQKLKS EYGKVIIFSN SVTVAEDTDD EEESGTDPFI 400
SIYKLQSGDK KSSKALRSTF PRIHGEIQSL FTNRDEKIKP MLICCNTGTD 450
MSIGVILSIL CTKYTEEWML TSELPDISKL IVRKHLTKLI SHLKGRNVNP 500
SRATLNSVNS FLM 513
Length:513
Mass (Da):58,882
Last modified:February 1, 1996 - v3
Checksum:i36F97B2445A4EA09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80795 Genomic DNA. Translation: CAA56770.1.
Z49704 Genomic DNA. Translation: CAA89781.1.
AY692815 Genomic DNA. Translation: AAT92834.1.
M59860 Genomic DNA. No translation available.
BK006946 Genomic DNA. Translation: DAA10184.1.
PIRiS54590.
RefSeqiNP_014010.1. NM_001182790.1.

Genome annotation databases

EnsemblFungiiYMR283C; YMR283C; YMR283C.
GeneIDi855326.
KEGGisce:YMR283C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80795 Genomic DNA. Translation: CAA56770.1 .
Z49704 Genomic DNA. Translation: CAA89781.1 .
AY692815 Genomic DNA. Translation: AAT92834.1 .
M59860 Genomic DNA. No translation available.
BK006946 Genomic DNA. Translation: DAA10184.1 .
PIRi S54590.
RefSeqi NP_014010.1. NM_001182790.1.

3D structure databases

ProteinModelPortali P23796.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35462. 51 interactions.
MINTi MINT-4498956.
STRINGi 4932.YMR283C.

Proteomic databases

MaxQBi P23796.
PaxDbi P23796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR283C ; YMR283C ; YMR283C .
GeneIDi 855326.
KEGGi sce:YMR283C.

Organism-specific databases

CYGDi YMR283c.
SGDi S000004896. RIT1.

Phylogenomic databases

eggNOGi NOG241557.
HOGENOMi HOG000174281.
KOi K15463.
OMAi SADDHEL.
OrthoDBi EOG7B05P8.

Enzyme and pathway databases

BioCyci YEAST:G3O-32953-MONOMER.

Miscellaneous databases

NextBioi 979041.

Gene expression databases

Genevestigatori P23796.

Family and domain databases

InterProi IPR007306. Init_tRNA_PT.
IPR016519. tRNA_ribosyl_Ptfrase_RIT1.
[Graphical view ]
Pfami PF04179. Init_tRNA_PT. 1 hit.
[Graphical view ]
PIRSFi PIRSF007747. Ribosyl_Ptfrase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination."
    Aastroem S.U., Bystroem A.S.
    Cell 79:535-546(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-513.
    Strain: S288c / YPH1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Characterization of a yeast nuclear gene, AEP2, required for accumulation of mitochondrial mRNA encoding subunit 9 of the ATP synthase."
    Payne M.J., Finnegan P.M., Keramidaris E., Lukins H.B.
    Curr. Genet. 20:53-61(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 418-513.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRIT1_YEAST
AccessioniPrimary (citable) accession number: P23796
Secondary accession number(s): D6W0B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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