Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P23794 (GLNA_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

Short name=GS
EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
Synonyms:glnA-1
Ordered Locus Names:SSO0366
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulation

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

nitrogen fixation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Glutamine synthetase
PRO_0000153214

Amino acid modifications

Modified residue4001O-AMP-tyrosine By similarity

Experimental info

Sequence conflict1621S → T in CAA37352. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P23794 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: 1CC4239287B6C2CD

FASTA47153,348
        10         20         30         40         50         60 
MPSTAEDVLK FLKENNIKWV DLQFTDVPGR LHHITIPADE FDLESLKTGF GKLDGSSIRG 

        70         80         90        100        110        120 
FTSIYESDMV LLPVPETMTL IPWSPGVARV LCKVFWGGGK GRFERDPRFI AEEAEKYQTE 

       130        140        150        160        170        180 
QGYTSYYGPE LEFFMFDKVK LDVSAPQSGT GYKIYAREAP WSDSGTFVIR FKEGYYPAPP 

       190        200        210        220        230        240 
VDQLMDVRVE IVDTLVKYFG YTIEATHHEV ATAGQGEIDF RFSTLVDTAD KVQTLKYVAK 

       250        260        270        280        290        300 
NIAAKHGLVV TFMPKPIYGD NGTGMHTHLS LWTKDGKKNL MYDPNDEYAE ISQFGRYVIG 

       310        320        330        340        350        360 
GLLTHARALS AIVSPTVNSY RRLIPGFEAP VYIAWSKGNR SAVIRVPAYY RGMEKAKRIE 

       370        380        390        400        410        420 
YRPPDPSTNP YLAFAALLMA ALDGVNKKID PGDPVDENIY HLTPEKRRQL GIKELPRSLN 

       430        440        450        460        470 
EALDELESDK EFLKPVFNSS ILDTYIDLKR DEARSLQGYP HPMELYYYLD S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53263 Genomic DNA. Translation: CAA37352.1.
AE006641 Genomic DNA. Translation: AAK40696.1.
PIRA99180.
S11899.
RefSeqNP_341906.1. NC_002754.1.

3D structure databases

ProteinModelPortalP23794.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0366.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40696; AAK40696; SSO0366.
GeneID1455506.
KEGGsso:SSO0366.

Phylogenomic databases

eggNOGCOG0174.
HOGENOMHOG000005157.
KOK01915.
OMAVECQHHE.
ProtClustDBCLSK883635.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-349-MONOMER.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_SULSO
AccessionPrimary (citable) accession number: P23794
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 20, 2001
Last modified: October 16, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families