UniProtKB - P23794 (GLNA_SULSO)
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Protein
Glutamine synthetase
Gene
glnA
Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Functioni
Catalytic activityi
ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.
Enzyme regulationi
The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- glutamate-ammonia ligase activity Source: UniProtKB-EC
GO - Biological processi
- glutamine biosynthetic process Source: InterPro
- nitrogen fixation Source: InterPro
Keywordsi
Molecular function | Ligase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamine synthetase (EC:6.3.1.2)Short name: GS Alternative name(s): Glutamate--ammonia ligase |
Gene namesi | Name:glnA Synonyms:glnA-1 Ordered Locus Names:SSO0366 |
Organismi | Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) |
Taxonomic identifieri | 273057 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153214 | 1 – 471 | Glutamine synthetaseAdd BLAST | 471 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 400 | O-AMP-tyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinStructurei
3D structure databases
ProteinModelPortali | P23794. |
SMRi | P23794. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the glutamine synthetase family.Curated
Phylogenomic databases
eggNOGi | arCOG01909. Archaea. COG0174. LUCA. |
HOGENOMi | HOG000005157. |
InParanoidi | P23794. |
KOi | K01915. |
OMAi | VFPWESK. |
OrthoDBi | POG093Z00GE. |
Family and domain databases
Gene3Di | 3.10.20.70. 1 hit. |
InterProi | View protein in InterPro IPR008147. Gln_synt_b-grasp. IPR036651. Gln_synt_N. IPR014746. Gln_synth/guanido_kin_cat_dom. IPR008146. Gln_synth_cat_dom. IPR027303. Gln_synth_gly_rich_site. IPR004809. Gln_synth_I. IPR027302. Gln_synth_N_conserv_site. |
Pfami | View protein in Pfam PF00120. Gln-synt_C. 1 hit. PF03951. Gln-synt_N. 1 hit. |
SMARTi | View protein in SMART SM01230. Gln-synt_C. 1 hit. |
SUPFAMi | SSF54368. SSF54368. 1 hit. SSF55931. SSF55931. 1 hit. |
TIGRFAMsi | TIGR00653. GlnA. 1 hit. |
PROSITEi | View protein in PROSITE PS00180. GLNA_1. 1 hit. PS00181. GLNA_ATP. 1 hit. |
i Sequence
Sequence statusi: Complete.
P23794-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSTAEDVLK FLKENNIKWV DLQFTDVPGR LHHITIPADE FDLESLKTGF
60 70 80 90 100
GKLDGSSIRG FTSIYESDMV LLPVPETMTL IPWSPGVARV LCKVFWGGGK
110 120 130 140 150
GRFERDPRFI AEEAEKYQTE QGYTSYYGPE LEFFMFDKVK LDVSAPQSGT
160 170 180 190 200
GYKIYAREAP WSDSGTFVIR FKEGYYPAPP VDQLMDVRVE IVDTLVKYFG
210 220 230 240 250
YTIEATHHEV ATAGQGEIDF RFSTLVDTAD KVQTLKYVAK NIAAKHGLVV
260 270 280 290 300
TFMPKPIYGD NGTGMHTHLS LWTKDGKKNL MYDPNDEYAE ISQFGRYVIG
310 320 330 340 350
GLLTHARALS AIVSPTVNSY RRLIPGFEAP VYIAWSKGNR SAVIRVPAYY
360 370 380 390 400
RGMEKAKRIE YRPPDPSTNP YLAFAALLMA ALDGVNKKID PGDPVDENIY
410 420 430 440 450
HLTPEKRRQL GIKELPRSLN EALDELESDK EFLKPVFNSS ILDTYIDLKR
460 470
DEARSLQGYP HPMELYYYLD S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 162 | S → T in CAA37352 (PubMed:1973523).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53263 Genomic DNA. Translation: CAA37352.1. AE006641 Genomic DNA. Translation: AAK40696.1. |
PIRi | A99180. S11899. |
RefSeqi | WP_009990668.1. NC_002754.1. |
Genome annotation databases
EnsemblBacteriai | AAK40696; AAK40696; SSO0366. |
GeneIDi | 27426661. |
KEGGi | sso:SSO0366. |
PATRICi | fig|273057.12.peg.360. |
Similar proteinsi
Entry informationi
Entry namei | GLNA_SULSO | |
Accessioni | P23794Primary (citable) accession number: P23794 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | June 20, 2001 | |
Last modified: | February 28, 2018 | |
This is version 109 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |