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P23794

- GLNA_SULSO

UniProt

P23794 - GLNA_SULSO

Protein

Glutamine synthetase

Gene

glnA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-349-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Synonyms:glnA-1
    Ordered Locus Names:SSO0366
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Glutamine synthetasePRO_0000153214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei400 – 4001O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi273057.SSO0366.

    Structurei

    3D structure databases

    ProteinModelPortaliP23794.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    HOGENOMiHOG000005157.
    KOiK01915.
    OMAiVHAWEIE.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23794-1 [UniParc]FASTAAdd to Basket

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    MPSTAEDVLK FLKENNIKWV DLQFTDVPGR LHHITIPADE FDLESLKTGF    50
    GKLDGSSIRG FTSIYESDMV LLPVPETMTL IPWSPGVARV LCKVFWGGGK 100
    GRFERDPRFI AEEAEKYQTE QGYTSYYGPE LEFFMFDKVK LDVSAPQSGT 150
    GYKIYAREAP WSDSGTFVIR FKEGYYPAPP VDQLMDVRVE IVDTLVKYFG 200
    YTIEATHHEV ATAGQGEIDF RFSTLVDTAD KVQTLKYVAK NIAAKHGLVV 250
    TFMPKPIYGD NGTGMHTHLS LWTKDGKKNL MYDPNDEYAE ISQFGRYVIG 300
    GLLTHARALS AIVSPTVNSY RRLIPGFEAP VYIAWSKGNR SAVIRVPAYY 350
    RGMEKAKRIE YRPPDPSTNP YLAFAALLMA ALDGVNKKID PGDPVDENIY 400
    HLTPEKRRQL GIKELPRSLN EALDELESDK EFLKPVFNSS ILDTYIDLKR 450
    DEARSLQGYP HPMELYYYLD S 471
    Length:471
    Mass (Da):53,348
    Last modified:June 20, 2001 - v2
    Checksum:i1CC4239287B6C2CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti162 – 1621S → T in CAA37352. (PubMed:1973523)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53263 Genomic DNA. Translation: CAA37352.1.
    AE006641 Genomic DNA. Translation: AAK40696.1.
    PIRiA99180.
    S11899.
    RefSeqiNP_341906.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK40696; AAK40696; SSO0366.
    GeneIDi1455506.
    KEGGisso:SSO0366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53263 Genomic DNA. Translation: CAA37352.1 .
    AE006641 Genomic DNA. Translation: AAK40696.1 .
    PIRi A99180.
    S11899.
    RefSeqi NP_341906.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali P23794.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO0366.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK40696 ; AAK40696 ; SSO0366 .
    GeneIDi 1455506.
    KEGGi sso:SSO0366.

    Phylogenomic databases

    eggNOGi COG0174.
    HOGENOMi HOG000005157.
    KOi K01915.
    OMAi VHAWEIE.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-349-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and nucleotide sequence of an archaebacterial glutamine synthetase gene: phylogenetic implications."
      Sanangelantoni A.M., Barbarini D., di Pasquale G., Cammarano P., Tiboni O.
      Mol. Gen. Genet. 221:187-194(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiGLNA_SULSO
    AccessioniPrimary (citable) accession number: P23794
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3