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P23794

- GLNA_SULSO

UniProt

P23794 - GLNA_SULSO

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Protein

Glutamine synthetase

Gene

glnA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-349-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Synonyms:glnA-1
Ordered Locus Names:SSO0366
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Glutamine synthetasePRO_0000153214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei400 – 4001O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0366.

Structurei

3D structure databases

ProteinModelPortaliP23794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
InParanoidiP23794.
KOiK01915.
OMAiVHAWEIE.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23794-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSTAEDVLK FLKENNIKWV DLQFTDVPGR LHHITIPADE FDLESLKTGF
60 70 80 90 100
GKLDGSSIRG FTSIYESDMV LLPVPETMTL IPWSPGVARV LCKVFWGGGK
110 120 130 140 150
GRFERDPRFI AEEAEKYQTE QGYTSYYGPE LEFFMFDKVK LDVSAPQSGT
160 170 180 190 200
GYKIYAREAP WSDSGTFVIR FKEGYYPAPP VDQLMDVRVE IVDTLVKYFG
210 220 230 240 250
YTIEATHHEV ATAGQGEIDF RFSTLVDTAD KVQTLKYVAK NIAAKHGLVV
260 270 280 290 300
TFMPKPIYGD NGTGMHTHLS LWTKDGKKNL MYDPNDEYAE ISQFGRYVIG
310 320 330 340 350
GLLTHARALS AIVSPTVNSY RRLIPGFEAP VYIAWSKGNR SAVIRVPAYY
360 370 380 390 400
RGMEKAKRIE YRPPDPSTNP YLAFAALLMA ALDGVNKKID PGDPVDENIY
410 420 430 440 450
HLTPEKRRQL GIKELPRSLN EALDELESDK EFLKPVFNSS ILDTYIDLKR
460 470
DEARSLQGYP HPMELYYYLD S
Length:471
Mass (Da):53,348
Last modified:June 20, 2001 - v2
Checksum:i1CC4239287B6C2CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621S → T in CAA37352. (PubMed:1973523)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53263 Genomic DNA. Translation: CAA37352.1.
AE006641 Genomic DNA. Translation: AAK40696.1.
PIRiA99180.
S11899.
RefSeqiNP_341906.1. NC_002754.1.
WP_009990668.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40696; AAK40696; SSO0366.
GeneIDi1455506.
KEGGisso:SSO0366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53263 Genomic DNA. Translation: CAA37352.1 .
AE006641 Genomic DNA. Translation: AAK40696.1 .
PIRi A99180.
S11899.
RefSeqi NP_341906.1. NC_002754.1.
WP_009990668.1. NC_002754.1.

3D structure databases

ProteinModelPortali P23794.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO0366.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40696 ; AAK40696 ; SSO0366 .
GeneIDi 1455506.
KEGGi sso:SSO0366.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005157.
InParanoidi P23794.
KOi K01915.
OMAi VHAWEIE.

Enzyme and pathway databases

BioCyci SSOL273057:GCH2-349-MONOMER.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and nucleotide sequence of an archaebacterial glutamine synthetase gene: phylogenetic implications."
    Sanangelantoni A.M., Barbarini D., di Pasquale G., Cammarano P., Tiboni O.
    Mol. Gen. Genet. 221:187-194(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiGLNA_SULSO
AccessioniPrimary (citable) accession number: P23794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 20, 2001
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3