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Protein

Arginine deiminase

Gene

arcA

Organism
Mycoplasma arginini
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-citrulline + NH3.

Pathwayi: L-arginine degradation via ADI pathway

This protein is involved in step 1 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA), Arginine deiminase (arcA), Arginine deiminase (arcA)
  2. no protein annotated in this organism
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei398Amidino-cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Enzyme and pathway databases

BRENDAi3.5.3.6. 3521.
SABIO-RKP23793.
UniPathwayiUPA00254; UER00364.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine deiminase (EC:3.5.3.6)
Short name:
ADI
Alternative name(s):
Arginine dihydrolase
Short name:
AD
Gene namesi
Name:arcA
OrganismiMycoplasma arginini
Taxonomic identifieri2094 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001822192 – 410Arginine deiminaseAdd BLAST409

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi16 – 18Combined sources3
Beta strandi20 – 25Combined sources6
Helixi30 – 34Combined sources5
Helixi37 – 39Combined sources3
Helixi40 – 43Combined sources4
Helixi51 – 66Combined sources16
Turni67 – 69Combined sources3
Beta strandi71 – 74Combined sources4
Helixi75 – 85Combined sources11
Helixi88 – 100Combined sources13
Helixi108 – 119Combined sources12
Helixi124 – 133Combined sources10
Helixi137 – 140Combined sources4
Beta strandi145 – 150Combined sources6
Helixi154 – 157Combined sources4
Beta strandi161 – 167Combined sources7
Beta strandi169 – 172Combined sources4
Helixi178 – 181Combined sources4
Helixi184 – 193Combined sources10
Turni195 – 199Combined sources5
Beta strandi202 – 204Combined sources3
Helixi206 – 208Combined sources3
Helixi214 – 216Combined sources3
Beta strandi217 – 219Combined sources3
Beta strandi221 – 232Combined sources12
Helixi235 – 247Combined sources13
Beta strandi255 – 260Combined sources6
Helixi270 – 272Combined sources3
Beta strandi274 – 276Combined sources3
Beta strandi278 – 284Combined sources7
Helixi286 – 288Combined sources3
Turni289 – 291Combined sources3
Beta strandi293 – 298Combined sources6
Turni299 – 301Combined sources3
Beta strandi309 – 311Combined sources3
Helixi315 – 323Combined sources9
Beta strandi328 – 331Combined sources4
Helixi339 – 347Combined sources9
Turni348 – 351Combined sources4
Beta strandi354 – 357Combined sources4
Beta strandi360 – 364Combined sources5
Helixi368 – 376Combined sources9
Beta strandi380 – 384Combined sources5
Helixi387 – 390Combined sources4
Turni396 – 399Combined sources4
Beta strandi401 – 405Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LXYX-ray2.00A/B2-410[»]
1S9RX-ray1.60A/B1-410[»]
ProteinModelPortaliP23793.
SMRiP23793.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23793.

Family & Domainsi

Sequence similaritiesi

Belongs to the arginine deiminase family.Curated

Family and domain databases

HAMAPiMF_00242. Arg_deiminase. 1 hit.
InterProiIPR003876. Arg_deiminase.
IPR033199. DDAH/AD.
[Graphical view]
PANTHERiPTHR12737. PTHR12737. 3 hits.
PIRSFiPIRSF006356. Arg_deiminase. 1 hit.
PRINTSiPR01466. ARGDEIMINASE.
TIGRFAMsiTIGR01078. arcA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVFDSKFKG IHVYSEIGEL ESVLVHEPGR EIDYITPARL DELLFSAILE
60 70 80 90 100
SHDARKEHKQ FVAELKANDI NVVELIDLVA ETYDLASQEA KDKLIEEFLE
110 120 130 140 150
DSEPVLSEEH KVVVRNFLKA KKTSRELVEI MMAGITKYDL GIEADHELIV
160 170 180 190 200
DPMPNLYFTR DPFASVGNGV TIHYMRYKVR QRETLFSRFV FSNHPKLINT
210 220 230 240 250
PWYYDPSLKL SIEGGDVFIY NNDTLVVGVS ERTDLQTVTL LAKNIVANKE
260 270 280 290 300
CEFKRIVAIN VPKWTNLMHL DTWLTMLDKD KFLYSPIAND VFKFWDYDLV
310 320 330 340 350
NGGAEPQPVE NGLPLEGLLQ SIINKKPVLI PIAGEGASQM EIERETHFDG
360 370 380 390 400
TNYLAIRPGV VIGYSRNEKT NAALEAAGIK VLPFHGNQLS LGMGNARCMS
410
MPLSRKDVKW
Length:410
Mass (Da):46,507
Last modified:January 23, 2007 - v4
Checksum:iE15C9A8AC90176FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76I → T in CAA36693 (PubMed:2325633).Curated1
Sequence conflicti120A → S in CAA36693 (PubMed:2325633).Curated1
Sequence conflicti126E → K in CAA38210 (PubMed:2228248).Curated1
Sequence conflicti375 – 410EAAGI…KDVKW → DKKDYLRPISI in CAA36693 (PubMed:2325633).CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54141 Genomic DNA. Translation: CAA38080.1.
X54312 Genomic DNA. Translation: CAA38210.1.
X52459 Genomic DNA. Translation: CAA36693.2.
PIRiA41465.
RefSeqiWP_004416214.1. NZ_AP014657.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54141 Genomic DNA. Translation: CAA38080.1.
X54312 Genomic DNA. Translation: CAA38210.1.
X52459 Genomic DNA. Translation: CAA36693.2.
PIRiA41465.
RefSeqiWP_004416214.1. NZ_AP014657.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LXYX-ray2.00A/B2-410[»]
1S9RX-ray1.60A/B1-410[»]
ProteinModelPortaliP23793.
SMRiP23793.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00254; UER00364.
BRENDAi3.5.3.6. 3521.
SABIO-RKP23793.

Miscellaneous databases

EvolutionaryTraceiP23793.

Family and domain databases

HAMAPiMF_00242. Arg_deiminase. 1 hit.
InterProiIPR003876. Arg_deiminase.
IPR033199. DDAH/AD.
[Graphical view]
PANTHERiPTHR12737. PTHR12737. 3 hits.
PIRSFiPIRSF006356. Arg_deiminase. 1 hit.
PRINTSiPR01466. ARGDEIMINASE.
TIGRFAMsiTIGR01078. arcA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARCA_MYCAR
AccessioniPrimary (citable) accession number: P23793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.