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Protein

Carnitine O-palmitoyltransferase 2, mitochondrial

Gene

CPT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei372Proton acceptorBy similarity1
Binding sitei486CarnitineBy similarity1
Binding sitei488CarnitineBy similarity1
Binding sitei499CarnitineBy similarity1

GO - Molecular functioni

  • carnitine O-palmitoyltransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS08187-MONOMER.
BRENDAi2.3.1.21. 2681.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-200425. Import of palmitoyl-CoA into the mitochondrial matrix.
UniPathwayiUPA00659.

Chemistry databases

SwissLipidsiSLP:000001044.

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-palmitoyltransferase 2, mitochondrial (EC:2.3.1.21)
Alternative name(s):
Carnitine palmitoyltransferase II
Short name:
CPT II
Gene namesi
Name:CPT2
Synonyms:CPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2330. CPT2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 178Mitochondrial matrixBy similarityAdd BLAST153
Intramembranei179 – 208Note=Mitochondrial inner membraneBy similarityAdd BLAST30
Topological domaini209 – 658Mitochondrial matrixBy similarityAdd BLAST450

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrion Source: HPA
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Carnitine palmitoyltransferase 2 deficiency, myopathic, stress-induced (CPT2D)14 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of mitochondrial long-chain fatty acid oxidation, characterized by recurrent myoglobinuria, episodes of muscle pain, stiffness, and rhabdomyolysis. These symptoms are exacerbated by prolonged exercise, fasting, cold, or viral infection. CPT2DM affects most frequently children or young adults, and severity of attacks is highly variable. Myoglobinuria can cause kidney failure and death.
See also OMIM:255110
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00139150P → H in CPT2D; muscular type. 2 PublicationsCorresponds to variant dbSNP:rs28936674Ensembl.1
Natural variantiVAR_001392113S → L in CPT2D; muscular form; frequent mutation. 4 PublicationsCorresponds to variant dbSNP:rs74315294Ensembl.1
Natural variantiVAR_020540151R → Q in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs515726177Ensembl.1
Natural variantiVAR_001393174E → K in CPT2D; muscular type. 1 PublicationCorresponds to variant dbSNP:rs28936674Ensembl.1
Natural variantiVAR_020541210Y → D in CPT2D. 1 Publication1
Natural variantiVAR_037976213D → G in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315300Ensembl.1
Natural variantiVAR_007966214M → T in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs515726174Ensembl.1
Natural variantiVAR_007967227P → L in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs74315298Ensembl.1
Natural variantiVAR_020542296R → Q in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs764849762Ensembl.1
Natural variantiVAR_001396383F → Y in CPT2D; hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs28936673Ensembl.1
Natural variantiVAR_007968448F → L in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315297Ensembl.1
Natural variantiVAR_007969479Y → F in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs749895856Ensembl.1
Natural variantiVAR_007970503R → C in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315296Ensembl.1
Natural variantiVAR_007971549G → D in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs186044004Ensembl.1
Natural variantiVAR_020543550Q → R in CPT2D. 1 Publication1
Natural variantiVAR_001397553D → N in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs28936376Ensembl.1
Natural variantiVAR_020544600G → R in CPT2D. 1 Publication1
Natural variantiVAR_020545604P → S in CPT2D. 1 Publication1
Natural variantiVAR_001398628Y → S in CPT2DI; hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs28936673Ensembl.1
Natural variantiVAR_001399631R → C in CPT2DI; early-onset hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs74315293Ensembl.1
Carnitine palmitoyltransferase 2 deficiency, infantile (CPT2DI)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of mitochondrial long-chain fatty acid oxidation, characterized by hepatic or hepato-cardio-muscular manifestations with onset in infancy. Clinical features include hypoketotic hypoglycemia, lethargy, seizures, hepatomegaly, liver dysfunction, cardiomegaly and dilated cardiomyopathy.
See also OMIM:600649
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_001398628Y → S in CPT2DI; hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs28936673Ensembl.1
Natural variantiVAR_001399631R → C in CPT2DI; early-onset hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs74315293Ensembl.1
Carnitine palmitoyltransferase 2 deficiency, lethal neonatal (CPT2DLN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of mitochondrial long-chain fatty acid oxidation with fatal outcome, presenting shortly after birth. It is characterized by respiratory distress, seizures, altered mental status, hepatomegaly, cardiomegaly, cardiac arrhythmia, and, in many cases, dysmorphic features, renal dysgenesis, and migration defects. recessive.
See also OMIM:608836
Encephalopathy, acute, infection-induced, 4 (IIAE4)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. CPT2 polymorphic variants do not cause classical carnitine palmitoyltransferase 2 deficiency, and patients harboring any of them are asymptomatic most of the time. However, they are prone to viral infection (high fever)-related encephalopathy (PubMed:21697855).1 Publication
Disease descriptionA severe neurologic complication of an infection. It manifests within days in otherwise healthy children after common viral infections, without evidence of viral infection of the brain or inflammatory cell infiltration. In affected children, high-grade fever is accompanied within 12 to 48 hours by febrile convulsions, often leading to coma, multiple-organ failure, brain edema, and high morbidity and mortality. The infections are usually viral, particularly influenza, although other viruses and even mycoplasma have been found to cause the disorder.
See also OMIM:614212
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_001394352F → C Polymorphism associated with susceptibility to IIAE4; 3-fold decrease of affinity for L-carnitine; lower thermal stability compared to wild-type. 4 PublicationsCorresponds to variant dbSNP:rs2229291Ensembl.1
Natural variantiVAR_001395368V → I Common polymorphism associated with susceptibility to IIAE4; no effect on activity; does not affect affinity for L-carnitine; lower thermal stability compared to wild-type. 6 PublicationsCorresponds to variant dbSNP:rs1799821Ensembl.1
Natural variantiVAR_066567504P → L in a patient with IIAE4. 1 PublicationCorresponds to variant dbSNP:rs368311455Ensembl.1
Natural variantiVAR_066568605V → L in a patient with IIAE4. 1 PublicationCorresponds to variant dbSNP:rs751557097Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1376.
MalaCardsiCPT2.
MIMi255110. phenotype.
600649. phenotype.
608836. phenotype.
614212. phenotype.
OpenTargetsiENSG00000157184.
Orphaneti263524. Acute necrotizing encephalopathy of childhood.
228302. Carnitine palmitoyl transferase II deficiency, myopathic form.
228308. Carnitine palmitoyl transferase II deficiency, neonatal form.
228305. Carnitine palmitoyl transferase II deficiency, severe infantile form.
PharmGKBiPA26849.

Chemistry databases

ChEMBLiCHEMBL3238.
DrugBankiDB00583. L-Carnitine.
DB01074. Perhexiline.

Polymorphism and mutation databases

BioMutaiCPT2.
DMDMi416836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionAdd BLAST25
ChainiPRO_000000442426 – 658Carnitine O-palmitoyltransferase 2, mitochondrialAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-succinyllysineBy similarity1
Modified residuei79N6-acetyllysineBy similarity1
Modified residuei85N6-succinyllysineBy similarity1
Modified residuei239N6-acetyllysine; alternateBy similarity1
Modified residuei239N6-succinyllysine; alternateBy similarity1
Modified residuei305N6-acetyllysineBy similarity1
Modified residuei424N6-succinyllysineBy similarity1
Modified residuei439N6-succinyllysineBy similarity1
Modified residuei510N6-acetyllysine; alternateBy similarity1
Modified residuei510N6-succinyllysine; alternateBy similarity1
Modified residuei544N6-acetyllysine; alternateBy similarity1
Modified residuei544N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP23786.
MaxQBiP23786.
PaxDbiP23786.
PeptideAtlasiP23786.
PRIDEiP23786.

2D gel databases

REPRODUCTION-2DPAGEiIPI00012912.

PTM databases

iPTMnetiP23786.
PhosphoSitePlusiP23786.
SwissPalmiP23786.

Expressioni

Gene expression databases

BgeeiENSG00000157184.
CleanExiHS_CPT2.
ExpressionAtlasiP23786. baseline and differential.
GenevisibleiP23786. HS.

Organism-specific databases

HPAiHPA028201.
HPA028202.
HPA028214.

Interactioni

Protein-protein interaction databases

BioGridi107767. 34 interactors.
IntActiP23786. 2 interactors.
MINTiMINT-3010089.
STRINGi9606.ENSP00000360541.

Chemistry databases

BindingDBiP23786.

Structurei

3D structure databases

ProteinModelPortaliP23786.
SMRiP23786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni452 – 464Coenzyme A bindingBy similarityAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3719. Eukaryota.
ENOG410XNZ9. LUCA.
GeneTreeiENSGT00550000074786.
HOGENOMiHOG000007446.
HOVERGENiHBG098001.
InParanoidiP23786.
KOiK08766.
OMAiFNPFMAF.
OrthoDBiEOG091G0697.
PhylomeDBiP23786.
TreeFamiTF315202.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
InterProiView protein in InterPro
IPR000542. Carn_acyl_trans.
IPR023213. CAT-like_dom.
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiView protein in Pfam
PF00755. Carn_acyltransf. 1 hit.
PROSITEiView protein in PROSITE
PS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRLLLRAW PRGPAVGPGA PSRPLSAGSG PGQYLQRSIV PTMHYQDSLP
60 70 80 90 100
RLPIPKLEDT IRRYLSAQKP LLNDGQFRKT EQFCKSFENG IGKELHEQLV
110 120 130 140 150
ALDKQNKHTS YISGPWFDMY LSARDSVVLN FNPFMAFNPD PKSEYNDQLT
160 170 180 190 200
RATNMTVSAI RFLKTLRAGL LEPEVFHLNP AKSDTITFKR LIRFVPSSLS
210 220 230 240 250
WYGAYLVNAY PLDMSQYFRL FNSTRLPKPS RDELFTDDKA RHLLVLRKGN
260 270 280 290 300
FYIFDVLDQD GNIVSPSEIQ AHLKYILSDS SPAPEFPLAY LTSENRDIWA
310 320 330 340 350
ELRQKLMSSG NEESLRKVDS AVFCLCLDDF PIKDLVHLSH NMLHGDGTNR
360 370 380 390 400
WFDKSFNLII AKDGSTAVHF EHSWGDGVAV LRFFNEVFKD STQTPAVTPQ
410 420 430 440 450
SQPATTDSTV TVQKLNFELT DALKTGITAA KEKFDATMKT LTIDCVQFQR
460 470 480 490 500
GGKEFLKKQK LSPDAVAQLA FQMAFLRQYG QTVATYESCS TAAFKHGRTE
510 520 530 540 550
TIRPASVYTK RCSEAFVREP SRHSAGELQQ MMVECSKYHG QLTKEAAMGQ
560 570 580 590 600
GFDRHLFALR HLAAAKGIIL PELYLDPAYG QINHNVLSTS TLSSPAVNLG
610 620 630 640 650
GFAPVVSDGF GVGYAVHDNW IGCNVSSYPG RNAREFLQCV EKALEDMFDA

LEGKSIKS
Length:658
Mass (Da):73,777
Last modified:October 1, 1993 - v2
Checksum:i6444B75ACD57140F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00139150P → H in CPT2D; muscular type. 2 PublicationsCorresponds to variant dbSNP:rs28936674Ensembl.1
Natural variantiVAR_001392113S → L in CPT2D; muscular form; frequent mutation. 4 PublicationsCorresponds to variant dbSNP:rs74315294Ensembl.1
Natural variantiVAR_020540151R → Q in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs515726177Ensembl.1
Natural variantiVAR_001393174E → K in CPT2D; muscular type. 1 PublicationCorresponds to variant dbSNP:rs28936674Ensembl.1
Natural variantiVAR_020541210Y → D in CPT2D. 1 Publication1
Natural variantiVAR_037976213D → G in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315300Ensembl.1
Natural variantiVAR_007966214M → T in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs515726174Ensembl.1
Natural variantiVAR_007967227P → L in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs74315298Ensembl.1
Natural variantiVAR_020542296R → Q in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs764849762Ensembl.1
Natural variantiVAR_001394352F → C Polymorphism associated with susceptibility to IIAE4; 3-fold decrease of affinity for L-carnitine; lower thermal stability compared to wild-type. 4 PublicationsCorresponds to variant dbSNP:rs2229291Ensembl.1
Natural variantiVAR_001395368V → I Common polymorphism associated with susceptibility to IIAE4; no effect on activity; does not affect affinity for L-carnitine; lower thermal stability compared to wild-type. 6 PublicationsCorresponds to variant dbSNP:rs1799821Ensembl.1
Natural variantiVAR_001396383F → Y in CPT2D; hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs28936673Ensembl.1
Natural variantiVAR_007968448F → L in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315297Ensembl.1
Natural variantiVAR_007969479Y → F in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs749895856Ensembl.1
Natural variantiVAR_007970503R → C in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315296Ensembl.1
Natural variantiVAR_066567504P → L in a patient with IIAE4. 1 PublicationCorresponds to variant dbSNP:rs368311455Ensembl.1
Natural variantiVAR_007971549G → D in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs186044004Ensembl.1
Natural variantiVAR_020543550Q → R in CPT2D. 1 Publication1
Natural variantiVAR_001397553D → N in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs28936376Ensembl.1
Natural variantiVAR_011741588S → C. Corresponds to variant dbSNP:rs1871748Ensembl.1
Natural variantiVAR_020544600G → R in CPT2D. 1 Publication1
Natural variantiVAR_020545604P → S in CPT2D. 1 Publication1
Natural variantiVAR_066568605V → L in a patient with IIAE4. 1 PublicationCorresponds to variant dbSNP:rs751557097Ensembl.1
Natural variantiVAR_001398628Y → S in CPT2DI; hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs28936673Ensembl.1
Natural variantiVAR_001399631R → C in CPT2DI; early-onset hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs74315293Ensembl.1
Natural variantiVAR_001400647M → V Common polymorphism; confirmed at protein level. 7 PublicationsCorresponds to variant dbSNP:rs1799822Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09648 mRNA. Translation: AAB60383.1.
M58581 mRNA. Translation: AAB59462.1.
U09646
, U09642, U09643, U09644, U09645 Genomic DNA. Translation: AAB60382.1.
AK312687 mRNA. Translation: BAG35567.1.
AL606760 Genomic DNA. Translation: CAI18907.1.
CH471059 Genomic DNA. Translation: EAX06753.1.
BC002445 mRNA. Translation: AAH02445.1.
BC005172 mRNA. Translation: AAH05172.1.
CCDSiCCDS575.1.
PIRiA39018.
RefSeqiNP_000089.1. NM_000098.2.
UniGeneiHs.713535.

Genome annotation databases

EnsembliENST00000371486; ENSP00000360541; ENSG00000157184.
GeneIDi1376.
KEGGihsa:1376.
UCSCiuc001cvb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09648 mRNA. Translation: AAB60383.1.
M58581 mRNA. Translation: AAB59462.1.
U09646
, U09642, U09643, U09644, U09645 Genomic DNA. Translation: AAB60382.1.
AK312687 mRNA. Translation: BAG35567.1.
AL606760 Genomic DNA. Translation: CAI18907.1.
CH471059 Genomic DNA. Translation: EAX06753.1.
BC002445 mRNA. Translation: AAH02445.1.
BC005172 mRNA. Translation: AAH05172.1.
CCDSiCCDS575.1.
PIRiA39018.
RefSeqiNP_000089.1. NM_000098.2.
UniGeneiHs.713535.

3D structure databases

ProteinModelPortaliP23786.
SMRiP23786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107767. 34 interactors.
IntActiP23786. 2 interactors.
MINTiMINT-3010089.
STRINGi9606.ENSP00000360541.

Chemistry databases

BindingDBiP23786.
ChEMBLiCHEMBL3238.
DrugBankiDB00583. L-Carnitine.
DB01074. Perhexiline.
SwissLipidsiSLP:000001044.

PTM databases

iPTMnetiP23786.
PhosphoSitePlusiP23786.
SwissPalmiP23786.

Polymorphism and mutation databases

BioMutaiCPT2.
DMDMi416836.

2D gel databases

REPRODUCTION-2DPAGEiIPI00012912.

Proteomic databases

EPDiP23786.
MaxQBiP23786.
PaxDbiP23786.
PeptideAtlasiP23786.
PRIDEiP23786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371486; ENSP00000360541; ENSG00000157184.
GeneIDi1376.
KEGGihsa:1376.
UCSCiuc001cvb.4. human.

Organism-specific databases

CTDi1376.
DisGeNETi1376.
GeneCardsiCPT2.
GeneReviewsiCPT2.
HGNCiHGNC:2330. CPT2.
HPAiHPA028201.
HPA028202.
HPA028214.
MalaCardsiCPT2.
MIMi255110. phenotype.
600649. phenotype.
600650. gene.
608836. phenotype.
614212. phenotype.
neXtProtiNX_P23786.
OpenTargetsiENSG00000157184.
Orphaneti263524. Acute necrotizing encephalopathy of childhood.
228302. Carnitine palmitoyl transferase II deficiency, myopathic form.
228308. Carnitine palmitoyl transferase II deficiency, neonatal form.
228305. Carnitine palmitoyl transferase II deficiency, severe infantile form.
PharmGKBiPA26849.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3719. Eukaryota.
ENOG410XNZ9. LUCA.
GeneTreeiENSGT00550000074786.
HOGENOMiHOG000007446.
HOVERGENiHBG098001.
InParanoidiP23786.
KOiK08766.
OMAiFNPFMAF.
OrthoDBiEOG091G0697.
PhylomeDBiP23786.
TreeFamiTF315202.

Enzyme and pathway databases

UniPathwayiUPA00659.
BioCyciMetaCyc:HS08187-MONOMER.
BRENDAi2.3.1.21. 2681.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Miscellaneous databases

ChiTaRSiCPT2. human.
GeneWikiiCarnitine_palmitoyltransferase_II.
GenomeRNAii1376.
PROiPR:P23786.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157184.
CleanExiHS_CPT2.
ExpressionAtlasiP23786. baseline and differential.
GenevisibleiP23786. HS.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
InterProiView protein in InterPro
IPR000542. Carn_acyl_trans.
IPR023213. CAT-like_dom.
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiView protein in Pfam
PF00755. Carn_acyltransf. 1 hit.
PROSITEiView protein in PROSITE
PS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPT2_HUMAN
AccessioniPrimary (citable) accession number: P23786
Secondary accession number(s): B2R6S0, Q5SW68, Q9BQ26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1993
Last modified: April 12, 2017
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.