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Protein

Granulins

Gene

Grn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.

GO - Molecular functioni

GO - Biological processi

  • chondrocyte proliferation Source: RGD
  • male mating behavior Source: RGD
  • neural precursor cell proliferation Source: RGD
  • positive regulation of dendritic spine development Source: RGD
  • positive regulation of neuron projection development Source: RGD
  • response to estradiol Source: RGD
  • synaptic vesicle endocytosis Source: RGD

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Granulins
Cleaved into the following 8 chains:
Alternative name(s):
Progranulin
Alternative name(s):
Granulin G
Alternative name(s):
Granulin F
Alternative name(s):
Epithelin-2
Granulin B
Alternative name(s):
Epithelin-1
Granulin A
Alternative name(s):
Granulin C
Alternative name(s):
Granulin D
Alternative name(s):
Granulin E
Gene namesi
Name:Grn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61983 Grn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001271018 – 588AcrograninAdd BLAST571
PeptideiPRO_000001271158 – 113Granulin-1Add BLAST56
PeptideiPRO_0000012712122 – 178Granulin-2Add BLAST57
PeptideiPRO_0000012713204 – 259Granulin-3Add BLAST56
PeptideiPRO_0000012714278 – 334Granulin-4Add BLAST57
PeptideiPRO_0000012715361 – 413Granulin-5Add BLAST53
PeptideiPRO_0000012716438 – 492Granulin-6Add BLAST55
PeptideiPRO_0000012717512 – 567Granulin-7Add BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi125 ↔ 138By similarity
Disulfide bondi132 ↔ 148By similarity
Disulfide bondi294 ↔ 311By similarity
Disulfide bondi304 ↔ 318By similarity
Disulfide bondi312 ↔ 325By similarity
Disulfide bondi319 ↔ 332By similarity
Disulfide bondi363 ↔ 375By similarity
Disulfide bondi369 ↔ 385By similarity
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi394 ↔ 407By similarity
Disulfide bondi401 ↔ 413By similarity
Glycosylationi525N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Granulins are disulfide bridged.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP23785
PRIDEiP23785

Expressioni

Tissue specificityi

Ubiquitous; most abundant in the spleen and several tissues of endocrine significance.

Interactioni

Subunit structurei

Acrogranin/Progranulin is secreted as a homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247826, 2 interactors
IntActiP23785, 2 interactors
STRINGi10116.ENSRNOP00000028557

Structurei

3D structure databases

ProteinModelPortaliP23785
SMRiP23785
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the granulin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4296 Eukaryota
ENOG410XR6S LUCA
HOGENOMiHOG000067856
HOVERGENiHBG000845
InParanoidiP23785
PhylomeDBiP23785

Family and domain databases

Gene3Di3.10.20.500, 7 hits
InterProiView protein in InterPro
IPR000118 Granulin
IPR037277 Granulin_sf
PfamiView protein in Pfam
PF00396 Granulin, 7 hits
SMARTiView protein in SMART
SM00277 GRAN, 7 hits
PROSITEiView protein in PROSITE
PS00799 GRANULINS, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWILVSWLAL VARLVAGTQC PDGQFCPVAC CLDQGGANYS CCNPLLDTWP
60 70 80 90 100
IITSRRLDGS CQIRDHCPDG YSCLLTVSGT SSCCPFSEGV SCDDGQHCCP
110 120 130 140 150
RGFHCSADGK SCSQISDSLL GAVQCPGSQF ECPDSATCCI MIDGSWGCCP
160 170 180 190 200
MPQASCCEDR VHCCPHGASC DLVHTRCISP TGTHPLLKKF PAQRTNRAVA
210 220 230 240 250
SFSVVCPDAK TQCPDDSTCC ELPTGKYGCC PMPNAICCSD HLHCCPQDTV
260 270 280 290 300
CDLIQSKCIS KDYTTDLMTK LPGYPVNEVK CDLEVSCPDG YTCCRLNTGA
310 320 330 340 350
WGCCPFTKAV CCEDHIHCCP AGFQCHTETG TCELGVLQVP WMKKVTASLS
360 370 380 390 400
LPDPQILKND VPCDDFSSCP SNNTCCRLSS GDWGCCPMPE AVCCLDHQHC
410 420 430 440 450
CPQGFKCMDE GYCQKGDRMV AGLEKMPVRQ TTLLQHGDIG CDQHTSCPVG
460 470 480 490 500
QTCCPSLKGS WACCQLPHAV CCEDRQHCCP AGYTCNVKAR TCEKDAGSVQ
510 520 530 540 550
PSMDLTFGSK VGNVECGAGH FCHDNQSCCK DSQGGWACCP YVKGVCCRDG
560 570 580
RHCCPIGFHC SAKGTKCLRK KTPRWDILLR DPAPRPLL
Length:588
Mass (Da):63,370
Last modified:December 1, 1992 - v3
Checksum:i113D434F7E099B31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201S → FP in CAA44198 (PubMed:1618805).Curated1
Sequence conflicti307 – 308TK → SB AA sequence (PubMed:2268320).Curated2
Sequence conflicti324Q → T AA sequence (PubMed:2268320).Curated1
Sequence conflicti388M → I in CAA44198 (PubMed:1618805).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97750 mRNA Translation: AAA16903.1
X62322 mRNA Translation: CAA44198.1
PIRiB38128
RefSeqiNP_058809.2, NM_017113.2
UniGeneiRn.5820

Genome annotation databases

GeneIDi29143
KEGGirno:29143
UCSCiRGD:61983 rat

Similar proteinsi

Entry informationi

Entry nameiGRN_RAT
AccessioniPrimary (citable) accession number: P23785
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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