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P23780

- BGAL_MOUSE

UniProt

P23780 - BGAL_MOUSE

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Protein

Beta-galactosidase

Gene

Glb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei189 – 1891Proton donorSequence Analysis
Active sitei269 – 2691NucleophileSequence Analysis

GO - Molecular functioni

  1. beta-galactosidase activity Source: MGI
  2. galactoside binding Source: Ensembl

GO - Biological processi

  1. galactose catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_198960. Keratan sulfate degradation.
REACT_198967. HS-GAG degradation.
REACT_199008. Glycosphingolipid metabolism.
REACT_202500. Sialic acid metabolism.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Alternative name(s):
Acid beta-galactosidase
Short name:
Lactase
Gene namesi
Name:Glb1
Synonyms:Bgl, Glb-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88151. Glb1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 295By similarityPRO_0000012190
Chaini30 – 647618Beta-galactosidasePRO_0000012191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi557 – 5571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

MaxQBiP23780.
PaxDbiP23780.
PRIDEiP23780.

PTM databases

PhosphoSiteiP23780.

Expressioni

Gene expression databases

BgeeiP23780.
CleanExiMM_GLB1.
ExpressionAtlasiP23780. baseline and differential.
GenevestigatoriP23780.

Interactioni

Protein-protein interaction databases

BioGridi198341. 1 interaction.
IntActiP23780. 1 interaction.
MINTiMINT-4089206.

Structurei

3D structure databases

ProteinModelPortaliP23780.
SMRiP23780. Positions 30-646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000221607.
HOVERGENiHBG004841.
InParanoidiP23780.
KOiK12309.
OMAiRIPRVYW.
OrthoDBiEOG7GXPCD.
PhylomeDBiP23780.
TreeFamiTF314816.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23780-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRVPLCTPL PLLALLQLLG AAHGIYNVTQ RTFKLDYSRD RFLKDGQPFR
60 70 80 90 100
YISGSIHYFR IPRFYWEDRL LKMKMAGLNA IQMYVPWNFH EPQPGQYEFS
110 120 130 140 150
GDRDVEHFIQ LAHELGLLVI LRPGPYICAE WDMGGLPAWL LEKQSIVLRS
160 170 180 190 200
SDPDYLVAVD KWLAVLLPKM KPLLYQNGGP IITVQVENEY GSYFACDYDY
210 220 230 240 250
LRFLVHRFRY HLGNDVILFT TDGASEKMLK CGTLQDLYAT VDFGTGNNIT
260 270 280 290 300
QAFLVQRKFE PKGPLINSEF YTGWLDHWGK PHSTVKTKTL ATSLYNLLAR
310 320 330 340 350
GANVNLYMFI GGTNFAYWNG ANTPYEPQPT SYDYDAPLSE AGDLTKKYFA
360 370 380 390 400
LREVIQMFKE VPEGPIPPST PKFAYGKVAL RKFKTVAEAL GILCPNGPVK
410 420 430 440 450
SLYPLTFTQV KQYFGYVLYR TTLPQDCSNP KPIFSSPFNG VRDRAYVSVD
460 470 480 490 500
GVPQGILDRN LMTALNIRGK AGATLDILVE NMGRVNYGRF INDFKGLISN
510 520 530 540 550
MTINSTVLTN WTVFPLNTEA MVRNHLWGRE ASDEGHLDGR STSNSSDLIL
560 570 580 590 600
PTFYVGNFSI PSGIPDLPQD TFIQFPGWSK GQVWINGFNL GRYWPTMGPQ
610 620 630 640
KTLFVPRNIL TTSAPNNITV LELEFAPCSE GTPELCTVEF VDTPVIS
Length:647
Mass (Da):73,121
Last modified:November 1, 1991 - v1
Checksum:i0E68EAA66A10803A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti517 – 5171N → D in AAA37292. (PubMed:1906271)Curated
Sequence conflicti539 – 5391G → R in AAA37292. (PubMed:1906271)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57734 mRNA. Translation: AAA37293.1.
M75122
, M75137, M75107, M75108, M75109, M75111, M75112, M75113, M75114, M75115, M75116, M75117, M75118, M75119, M75120, M75121 Genomic DNA. Translation: AAA37292.1.
CCDSiCCDS23593.1.
PIRiA37086.
RefSeqiNP_033882.1. NM_009752.2.
UniGeneiMm.290516.

Genome annotation databases

EnsembliENSMUST00000063042; ENSMUSP00000055803; ENSMUSG00000045594.
GeneIDi12091.
KEGGimmu:12091.
UCSCiuc009rxj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57734 mRNA. Translation: AAA37293.1 .
M75122
, M75137 , M75107 , M75108 , M75109 , M75111 , M75112 , M75113 , M75114 , M75115 , M75116 , M75117 , M75118 , M75119 , M75120 , M75121 Genomic DNA. Translation: AAA37292.1 .
CCDSi CCDS23593.1.
PIRi A37086.
RefSeqi NP_033882.1. NM_009752.2.
UniGenei Mm.290516.

3D structure databases

ProteinModelPortali P23780.
SMRi P23780. Positions 30-646.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198341. 1 interaction.
IntActi P23780. 1 interaction.
MINTi MINT-4089206.

Chemistry

BindingDBi P23780.
ChEMBLi CHEMBL1667667.

Protein family/group databases

CAZyi GH35. Glycoside Hydrolase Family 35.

PTM databases

PhosphoSitei P23780.

Proteomic databases

MaxQBi P23780.
PaxDbi P23780.
PRIDEi P23780.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063042 ; ENSMUSP00000055803 ; ENSMUSG00000045594 .
GeneIDi 12091.
KEGGi mmu:12091.
UCSCi uc009rxj.2. mouse.

Organism-specific databases

CTDi 2720.
MGIi MGI:88151. Glb1.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000221607.
HOVERGENi HBG004841.
InParanoidi P23780.
KOi K12309.
OMAi RIPRVYW.
OrthoDBi EOG7GXPCD.
PhylomeDBi P23780.
TreeFami TF314816.

Enzyme and pathway databases

Reactomei REACT_198960. Keratan sulfate degradation.
REACT_198967. HS-GAG degradation.
REACT_199008. Glycosphingolipid metabolism.
REACT_202500. Sialic acid metabolism.

Miscellaneous databases

NextBioi 280407.
PROi P23780.
SOURCEi Search...

Gene expression databases

Bgeei P23780.
CleanExi MM_GLB1.
ExpressionAtlasi P23780. baseline and differential.
Genevestigatori P23780.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PIRSFi PIRSF006336. B-gal. 1 hit.
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of mouse acid beta-galactosidase cDNA: sequence, expression of catalytic activity and comparison with the human enzyme."
    Nanba E., Suzuki K.
    Biochem. Biophys. Res. Commun. 173:141-148(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Brain.
  2. "Organization of the mouse acid beta-galactosidase gene."
    Nanba E., Suzuki K.
    Biochem. Biophys. Res. Commun. 178:158-164(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.

Entry informationi

Entry nameiBGAL_MOUSE
AccessioniPrimary (citable) accession number: P23780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3