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P23780

- BGAL_MOUSE

UniProt

P23780 - BGAL_MOUSE

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Protein
Beta-galactosidase
Gene
Glb1, Bgl, Glb-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei189 – 1891Proton donor Reviewed prediction
Active sitei269 – 2691Nucleophile Reviewed prediction

GO - Molecular functioni

  1. beta-galactosidase activity Source: MGI
  2. galactoside binding Source: Ensembl

GO - Biological processi

  1. galactose catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_198960. Keratan sulfate degradation.
REACT_198967. HS-GAG degradation.
REACT_199008. Glycosphingolipid metabolism.
REACT_202500. Sialic acid metabolism.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Alternative name(s):
Acid beta-galactosidase
Short name:
Lactase
Gene namesi
Name:Glb1
Synonyms:Bgl, Glb-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88151. Glb1.

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Propeptidei25 – 295 By similarity
PRO_0000012190
Chaini30 – 647618Beta-galactosidase
PRO_0000012191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi504 – 5041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi510 – 5101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi544 – 5441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi557 – 5571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi617 – 6171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

MaxQBiP23780.
PaxDbiP23780.
PRIDEiP23780.

PTM databases

PhosphoSiteiP23780.

Expressioni

Gene expression databases

ArrayExpressiP23780.
BgeeiP23780.
CleanExiMM_GLB1.
GenevestigatoriP23780.

Interactioni

Protein-protein interaction databases

BioGridi198341. 1 interaction.
IntActiP23780. 1 interaction.
MINTiMINT-4089206.

Structurei

3D structure databases

ProteinModelPortaliP23780.
SMRiP23780. Positions 30-646.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000221607.
HOVERGENiHBG004841.
InParanoidiP23780.
KOiK12309.
OMAiRIPRVYW.
OrthoDBiEOG7GXPCD.
PhylomeDBiP23780.
TreeFamiTF314816.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23780-1 [UniParc]FASTAAdd to Basket

« Hide

MLRVPLCTPL PLLALLQLLG AAHGIYNVTQ RTFKLDYSRD RFLKDGQPFR    50
YISGSIHYFR IPRFYWEDRL LKMKMAGLNA IQMYVPWNFH EPQPGQYEFS 100
GDRDVEHFIQ LAHELGLLVI LRPGPYICAE WDMGGLPAWL LEKQSIVLRS 150
SDPDYLVAVD KWLAVLLPKM KPLLYQNGGP IITVQVENEY GSYFACDYDY 200
LRFLVHRFRY HLGNDVILFT TDGASEKMLK CGTLQDLYAT VDFGTGNNIT 250
QAFLVQRKFE PKGPLINSEF YTGWLDHWGK PHSTVKTKTL ATSLYNLLAR 300
GANVNLYMFI GGTNFAYWNG ANTPYEPQPT SYDYDAPLSE AGDLTKKYFA 350
LREVIQMFKE VPEGPIPPST PKFAYGKVAL RKFKTVAEAL GILCPNGPVK 400
SLYPLTFTQV KQYFGYVLYR TTLPQDCSNP KPIFSSPFNG VRDRAYVSVD 450
GVPQGILDRN LMTALNIRGK AGATLDILVE NMGRVNYGRF INDFKGLISN 500
MTINSTVLTN WTVFPLNTEA MVRNHLWGRE ASDEGHLDGR STSNSSDLIL 550
PTFYVGNFSI PSGIPDLPQD TFIQFPGWSK GQVWINGFNL GRYWPTMGPQ 600
KTLFVPRNIL TTSAPNNITV LELEFAPCSE GTPELCTVEF VDTPVIS 647
Length:647
Mass (Da):73,121
Last modified:November 1, 1991 - v1
Checksum:i0E68EAA66A10803A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti517 – 5171N → D in AAA37292. 1 Publication
Sequence conflicti539 – 5391G → R in AAA37292. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57734 mRNA. Translation: AAA37293.1.
M75122
, M75137, M75107, M75108, M75109, M75111, M75112, M75113, M75114, M75115, M75116, M75117, M75118, M75119, M75120, M75121 Genomic DNA. Translation: AAA37292.1.
CCDSiCCDS23593.1.
PIRiA37086.
RefSeqiNP_033882.1. NM_009752.2.
UniGeneiMm.290516.

Genome annotation databases

EnsembliENSMUST00000063042; ENSMUSP00000055803; ENSMUSG00000045594.
GeneIDi12091.
KEGGimmu:12091.
UCSCiuc009rxj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57734 mRNA. Translation: AAA37293.1 .
M75122
, M75137 , M75107 , M75108 , M75109 , M75111 , M75112 , M75113 , M75114 , M75115 , M75116 , M75117 , M75118 , M75119 , M75120 , M75121 Genomic DNA. Translation: AAA37292.1 .
CCDSi CCDS23593.1.
PIRi A37086.
RefSeqi NP_033882.1. NM_009752.2.
UniGenei Mm.290516.

3D structure databases

ProteinModelPortali P23780.
SMRi P23780. Positions 30-646.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198341. 1 interaction.
IntActi P23780. 1 interaction.
MINTi MINT-4089206.

Chemistry

BindingDBi P23780.
ChEMBLi CHEMBL1667667.

Protein family/group databases

CAZyi GH35. Glycoside Hydrolase Family 35.

PTM databases

PhosphoSitei P23780.

Proteomic databases

MaxQBi P23780.
PaxDbi P23780.
PRIDEi P23780.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063042 ; ENSMUSP00000055803 ; ENSMUSG00000045594 .
GeneIDi 12091.
KEGGi mmu:12091.
UCSCi uc009rxj.2. mouse.

Organism-specific databases

CTDi 2720.
MGIi MGI:88151. Glb1.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000221607.
HOVERGENi HBG004841.
InParanoidi P23780.
KOi K12309.
OMAi RIPRVYW.
OrthoDBi EOG7GXPCD.
PhylomeDBi P23780.
TreeFami TF314816.

Enzyme and pathway databases

Reactomei REACT_198960. Keratan sulfate degradation.
REACT_198967. HS-GAG degradation.
REACT_199008. Glycosphingolipid metabolism.
REACT_202500. Sialic acid metabolism.

Miscellaneous databases

NextBioi 280407.
PROi P23780.
SOURCEi Search...

Gene expression databases

ArrayExpressi P23780.
Bgeei P23780.
CleanExi MM_GLB1.
Genevestigatori P23780.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PIRSFi PIRSF006336. B-gal. 1 hit.
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of mouse acid beta-galactosidase cDNA: sequence, expression of catalytic activity and comparison with the human enzyme."
    Nanba E., Suzuki K.
    Biochem. Biophys. Res. Commun. 173:141-148(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Brain.
  2. "Organization of the mouse acid beta-galactosidase gene."
    Nanba E., Suzuki K.
    Biochem. Biophys. Res. Commun. 178:158-164(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.

Entry informationi

Entry nameiBGAL_MOUSE
AccessioniPrimary (citable) accession number: P23780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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