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P23778 (PP2A_BRANA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit

EC=3.1.3.16
OrganismBrassica napus (Rape)
Taxonomic identifier3708 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

Protein attributes

Sequence length309 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 309›309Serine/threonine-protein phosphatase PP2A catalytic subunit
PRO_0000058857

Sites

Active site1181Proton donor By similarity
Metal binding571Iron By similarity
Metal binding591Iron By similarity
Metal binding851Iron By similarity
Metal binding851Manganese By similarity
Metal binding1171Manganese By similarity
Metal binding1671Manganese By similarity
Metal binding2411Manganese By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P23778 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 50701E2E6768F581

FASTA30935,176
        10         20         30         40         50         60 
SIPTDATLDL DEQISQLMQC KPLSEQQVRA LCEKAKEILM DESNVQPVKS PVTICGDIHG 

        70         80         90        100        110        120 
QFHDLAELFR IGGMCPDTNY LFMGDYVDRG YYSVETVTLL VGLKVRYPQR ITILRGNHES 

       130        140        150        160        170        180 
RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVE SEIFCLHGGL SPSIETLDNI 

       190        200        210        220        230        240 
RNFDRVQEVP HGGPMCDLLW SDPDDRCGWG ISPRGAGYTF GQDISNQFNH SNSLKLISRA 

       250        260        270        280        290        300 
HQLVMDGYNW AHEAKGGTIF SAPNYCYRCG NMASILEVDD CRNHTFIQFE PAPRRGEPDV 


TRRTPDYFL 

« Hide

References

[1]"Identification by molecular cloning of two cDNA sequences from the plant Brassica napus which are very similar to mammalian protein phosphatases-1 and -2A."
Mackintosh R.W., Haycox G., Hardie D.G., Cohen P.T.W.
FEBS Lett. 276:156-160(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57439 mRNA. Translation: CAA40687.1.
PIRS12986.

3D structure databases

ProteinModelPortalP23778.
SMRP23778. Positions 7-309.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A_BRANA
AccessionPrimary (citable) accession number: P23778
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families