Trans-acting T-cell-specific transcription factor GATA-3

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P23772 (GATA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 116. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Trans-acting T-cell-specific transcription factor GATA-3

Alternative name(s):
GATA-binding factor 3

Gene names

Name:	Gata3
Synonyms:	Gata-3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.
Subcellular location	Nucleus.
Tissue specificity	T-cell specific.
Domain	Binds DNA via the 2 GATA-type zinc fingers. Ref.3
Sequence similarities	Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell receptor signaling pathway Inferred from direct assay PubMed 20696860. Source: UniProtKB T-helper 2 cell differentiation Inferred from direct assay PubMed 20706986. Source: MGI TOR signaling cascade Inferred from mutant phenotype PubMed 20696860. Source: UniProtKB aortic valve morphogenesis Inferred from mutant phenotype PubMed 18955134. Source: UniProtKB axon guidance Inferred from mutant phenotype PubMed 11135239. Source: MGI canonical Wnt receptor signaling pathway involved in metanephric kidney development Inferred from mutant phenotype PubMed 19112489. Source: UniProtKB cardiac right ventricle morphogenesis Inferred from mutant phenotype PubMed 18955134. Source: UniProtKB cell fate determination Inferred from direct assay PubMed 12923059. Source: MGI cell maturation Inferred from mutant phenotype PubMed 17082577. Source: MGI cellular response to BMP stimulus Inferred from direct assay PubMed 20501701. Source: MGI cellular response to interferon-alpha Inferred from electronic annotation. Source: Compara cellular response to interleukin-4 Inferred from expression pattern PubMed 20696860. Source: UniProtKB cellular response to tumor necrosis factor Inferred from electronic annotation. Source: Compara developmental growth Inferred from mutant phenotype PubMed 7550312. Source: MGI embryonic hemopoiesis Inferred from mutant phenotype PubMed 7550312. Source: MGI erythrocyte differentiation Inferred from direct assay PubMed 9576834. Source: MGI humoral immune response Inferred from mutant phenotype PubMed 17658279. Source: MGI in utero embryonic development Inferred from mutant phenotype PubMed 20702712. Source: MGI inner ear morphogenesis Inferred from mutant phenotype PubMed 11135239 PubMed 21553382. Source: MGI interferon-gamma secretion Inferred from mutant phenotype PubMed 17658279. Source: MGI interleukin-4 secretion Inferred from mutant phenotype PubMed 17658279. Source: MGI lens development in camera-type eye Inferred from mutant phenotype PubMed 19623612. Source: MGI lymphocyte migration Inferred from sequence or structural similarity. Source: UniProtKB male gonad development Inferred from mutant phenotype PubMed 19112489. Source: UniProtKB mast cell differentiation Inferred from direct assay PubMed 17603486. Source: MGI mesenchymal to epithelial transition Inferred from sequence or structural similarity. Source: UniProtKB mesonephros development Inferred from mutant phenotype PubMed 16319112. Source: MGI negative regulation of cell cycle Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell motility Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell proliferation involved in mesonephros development Inferred from mutant phenotype PubMed 16319112. Source: UniProtKB negative regulation of endothelial cell apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of fat cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Inferred from mutant phenotype PubMed 19112489. Source: UniProtKB negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Inferred from mutant phenotype PubMed 19112489. Source: UniProtKB negative regulation of inflammatory response Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of interferon-gamma production Inferred from direct assay PubMed 18792410. Source: MGI negative regulation of interleukin-2 production Inferred from direct assay PubMed 18792410. Source: MGI negative regulation of mammary gland epithelial cell proliferation Inferred from electronic annotation. Source: Compara nephric duct formation Inferred from mutant phenotype PubMed 16319112. Source: UniProtKB neuron migration Inferred from mutant phenotype PubMed 10556076. Source: MGI norepinephrine biosynthetic process Inferred from mutant phenotype PubMed 10835639. Source: MGI otic vesicle development Inferred from mutant phenotype PubMed 11135239. Source: MGI parathyroid gland development Inferred from mutant phenotype PubMed 20484821. Source: MGI parathyroid hormone secretion Inferred from mutant phenotype PubMed 20484821. Source: MGI pharyngeal system development Inferred from mutant phenotype PubMed 18955134. Source: UniProtKB phosphatidylinositol 3-kinase cascade Inferred from mutant phenotype PubMed 20696860. Source: UniProtKB positive regulation of T cell differentiation Inferred from direct assay PubMed 20696860. Source: UniProtKB positive regulation of endothelial cell migration Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of interleukin-13 production Inferred from mutant phenotype PubMed 10549629. Source: MGI positive regulation of interleukin-13 secretion Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of interleukin-4 production Inferred from direct assay PubMed 17658278. Source: MGI positive regulation of interleukin-5 production Inferred from mutant phenotype PubMed 10549629. Source: MGI positive regulation of interleukin-5 secretion Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein kinase B signaling cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of thyroid hormone generation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription regulatory region DNA binding Inferred from mutant phenotype PubMed 20636338. Source: UniProtKB positive regulation of ureteric bud formation Inferred from mutant phenotype PubMed 19112489. Source: UniProtKB post-embryonic development Inferred from mutant phenotype PubMed 7550312. Source: MGI pro-T cell differentiation Inferred from mutant phenotype PubMed 19934022. Source: MGI regulation of CD4-positive, alpha-beta T cell differentiation Inferred from mutant phenotype PubMed 18776904. Source: MGI regulation of cellular response to X-ray Inferred from sequence or structural similarity. Source: UniProtKB regulation of cytokine biosynthetic process Inferred from direct assay PubMed 11093124. Source: MGI regulation of establishment of cell polarity Inferred from direct assay PubMed 21613615. Source: MGI regulation of histone H3-K27 methylation Inferred from direct assay PubMed 21867929. Source: MGI regulation of histone H3-K4 methylation Inferred from direct assay PubMed 21867929. Source: MGI regulation of nephron tubule epithelial cell differentiation Inferred from mutant phenotype PubMed 19112489. Source: UniProtKB regulation of neuron apoptotic process Inferred from mutant phenotype PubMed 20702712. Source: MGI response to drug Inferred from electronic annotation. Source: Compara response to estrogen stimulus Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from electronic annotation. Source: Compara response to virus Inferred from electronic annotation. Source: Compara sympathetic nervous system development Inferred from mutant phenotype PubMed 15329349. Source: MGI thymic T cell selection Inferred from mutant phenotype PubMed 14670303. Source: MGI thymus development Inferred from mutant phenotype PubMed 14643687 PubMed 17082577. Source: MGI type IV hypersensitivity Inferred from electronic annotation. Source: Compara ureter maturation Inferred from mutant phenotype PubMed 21521737. Source: MGI ureteric bud formation Inferred from mutant phenotype PubMed 16319112. Source: UniProtKB uterus development Inferred from mutant phenotype PubMed 19112489. Source: UniProtKB ventricular septum development Inferred from mutant phenotype PubMed 18955134. Source: UniProtKB
Cellular_component	nuclear chromatin Inferred from electronic annotation. Source: Compara nucleolus Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay PubMed 20696860. Source: UniProtKB
Molecular_function	E-box binding Inferred from sequence or structural similarity. Source: UniProtKB RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Inferred from sequence or structural similarity. Source: UniProtKB RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay PubMed 7720565. Source: MGI RNA polymerase II core promoter sequence-specific DNA binding Inferred from direct assay PubMed 10549629 PubMed 20484821. Source: MGI core promoter proximal region sequence-specific DNA binding Inferred from sequence or structural similarity. Source: UniProtKB enhancer sequence-specific DNA binding Inferred from direct assay PubMed 20855530. Source: UniProtKB protein dimerization activity Inferred from direct assay Ref.3. Source: MGI transcription coactivator activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 443

443

Trans-acting T-cell-specific transcription factor GATA-3

PRO_0000083409

Regions

Zinc finger

263 – 287

GATA-type 1

Zinc finger

317 – 341

GATA-type 2

Compositional bias

136 – 139

Poly-Ser

Compositional bias

322 – 326

Poly-Thr

Amino acid modifications

Modified residue

114

Phosphoserine By similarity

Modified residue

161

Phosphoserine By similarity

Secondary structure

443

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P23772 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 980E58FB9872E560
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FASTA

443

47,968

        10         20         30         40         50         60 
MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LGHSYMEAQY PLTEEVDVLF NIDGQGNHVP 

        70         80         90        100        110        120 
SYYGNSVRAT VQRYPPTHHG SQVCRPPLLH GSLPWLDGGK ALSSHHTASP WNLSPFSKTS 

       130        140        150        160        170        180 
IHHGSPGPLS VYPPASSSSL AAGHSSPHLF TFPPTPPKDV SPDPSLSTPG SAGSARQDEK 

       190        200        210        220        230        240 
ECLKYQVQLP DSMKLETSHS RGSMTTLGGA SSSAHHPITT YPPYVPEYSS GLFPPSSLLG 

       250        260        270        280        290        300 
GSPTGFGCKS RPKARSSTEG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL 

       310        320        330        340        350        360 
IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG 

       370        380        390        400        410        420 
IQTRNRKMSS KSKKCKKVHD ALEDFPKSSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT 

       430        440 
PMHPPSGLSF GPHHPSSMVT AMG

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer." Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D. Mol. Cell. Biol. 11:2778-2784(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[3]	"Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA." Bates D.L., Chen Y., Kim G., Guo L., Chen L. J. Mol. Biol. 381:1292-1306(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 308-370 IN COMPLEX WITH DNA, DOMAIN.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X55123 mRNA. Translation: CAA38917.1.
BC062915 mRNA. Translation: AAH62915.1.

IPI

IPI00135883.

PIR

B39794.

RefSeq

NP_032117.1. NM_008091.3.

UniGene

Mm.313866.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DFV	X-ray	3.10	C/D	308-370	[»]
3DFX	X-ray	2.70	A/B	308-370	[»]

ProteinModelPortal

P23772.

SMR

P23772. Positions 260-365.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29712N.

PTM databases

PhosphoSite

P23772.

Proteomic databases

PRIDE

P23772.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000102976; ENSMUSP00000100041; ENSMUSG00000015619.

GeneID

14462.

KEGG

mmu:14462.

Organism-specific databases

CTD

2625.

MGI

MGI:95663. Gata3.

Phylogenomic databases

eggNOG

COG5641.

HOGENOM

HOG000047701.

HOVERGEN

HBG051705.

InParanoid

P23772.

K09182.

OMA

HHPSSMV.

OrthoDB

EOG49P9ZM.

Gene expression databases

ArrayExpress

P23772.

Bgee

P23772.

CleanEx

MM_GATA3.

Genevestigator

P23772.

GermOnline

ENSMUSG00000015619. Mus musculus.

Family and domain databases

Gene3D

3.30.50.10. 2 hits.

InterPro

IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]

Pfam

PF00320. GATA. 2 hits.
[Graphical view]

PIRSF

PIRSF003027. TF_GATA-1/2/3. 1 hit.

PRINTS

PR00619. GATAZNFINGER.

SMART

SM00401. ZnF_GATA. 2 hits.
[Graphical view]

PROSITE

PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P23772.

NextBio

286100.

SOURCE

Search...

Entry information

Entry name

GATA3_MOUSE

Accession

Primary (citable) accession number: P23772

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents