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P23771

- GATA3_HUMAN

UniProt

P23771 - GATA3_HUMAN

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Protein

Trans-acting T-cell-specific transcription factor GATA-3

Gene

GATA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28725GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 34125GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  2. core promoter sequence-specific DNA binding Source: UniProtKB
  3. DNA binding Source: ProtInc
  4. E-box binding Source: BHF-UCL
  5. enhancer sequence-specific DNA binding Source: Ensembl
  6. HMG box domain binding Source: UniProtKB
  7. nucleic acid binding transcription factor activity Source: UniProtKB
  8. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  9. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  10. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  11. sequence-specific DNA binding transcription factor activity Source: ProtInc
  12. transcription coactivator activity Source: UniProtKB
  13. transcription factor binding Source: BHF-UCL
  14. transcription regulatory region DNA binding Source: UniProtKB
  15. transcription regulatory region sequence-specific DNA binding Source: UniProtKB
  16. zinc ion binding Source: InterPro

GO - Biological processi

  1. anatomical structure formation involved in morphogenesis Source: UniProtKB
  2. anatomical structure morphogenesis Source: ProtInc
  3. aortic valve morphogenesis Source: UniProtKB
  4. axon guidance Source: Ensembl
  5. blood coagulation Source: Reactome
  6. canonical Wnt signaling pathway involved in metanephric kidney development Source: UniProtKB
  7. cardiac right ventricle morphogenesis Source: UniProtKB
  8. cell fate determination Source: UniProtKB
  9. cell maturation Source: Ensembl
  10. cellular response to BMP stimulus Source: Ensembl
  11. cellular response to interferon-alpha Source: UniProtKB
  12. cellular response to interleukin-4 Source: UniProtKB
  13. cellular response to tumor necrosis factor Source: UniProtKB
  14. defense response Source: ProtInc
  15. developmental growth Source: Ensembl
  16. ear development Source: UniProtKB
  17. embryonic hemopoiesis Source: Ensembl
  18. erythrocyte differentiation Source: Ensembl
  19. humoral immune response Source: Ensembl
  20. innate immune response Source: UniProtKB-KW
  21. inner ear morphogenesis Source: Ensembl
  22. interferon-gamma secretion Source: Ensembl
  23. interleukin-4 secretion Source: Ensembl
  24. in utero embryonic development Source: Ensembl
  25. kidney development Source: UniProtKB
  26. lens development in camera-type eye Source: Ensembl
  27. lymphocyte migration Source: UniProtKB
  28. male gonad development Source: UniProtKB
  29. mast cell differentiation Source: Ensembl
  30. mesenchymal to epithelial transition Source: UniProtKB
  31. mesonephros development Source: UniProtKB
  32. negative regulation of cell cycle Source: UniProtKB
  33. negative regulation of cell motility Source: UniProtKB
  34. negative regulation of cell proliferation Source: UniProtKB
  35. negative regulation of cell proliferation involved in mesonephros development Source: UniProtKB
  36. negative regulation of endothelial cell apoptotic process Source: UniProtKB
  37. negative regulation of fat cell differentiation Source: UniProtKB
  38. negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
  39. negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
  40. negative regulation of inflammatory response Source: UniProtKB
  41. negative regulation of interferon-gamma production Source: Ensembl
  42. negative regulation of interleukin-2 production Source: Ensembl
  43. negative regulation of mammary gland epithelial cell proliferation Source: UniProtKB
  44. negative regulation of transcription, DNA-templated Source: UniProtKB
  45. nephric duct formation Source: UniProtKB
  46. nephric duct morphogenesis Source: UniProtKB
  47. neuron migration Source: Ensembl
  48. norepinephrine biosynthetic process Source: UniProtKB
  49. otic vesicle development Source: Ensembl
  50. parathyroid gland development Source: Ensembl
  51. parathyroid hormone secretion Source: Ensembl
  52. pharyngeal system development Source: UniProtKB
  53. phosphatidylinositol 3-kinase signaling Source: UniProtKB
  54. positive regulation of endothelial cell migration Source: UniProtKB
  55. positive regulation of interleukin-13 production Source: Ensembl
  56. positive regulation of interleukin-13 secretion Source: UniProtKB
  57. positive regulation of interleukin-4 production Source: UniProtKB
  58. positive regulation of interleukin-5 production Source: Ensembl
  59. positive regulation of interleukin-5 secretion Source: UniProtKB
  60. positive regulation of protein kinase B signaling Source: UniProtKB
  61. positive regulation of signal transduction Source: UniProtKB
  62. positive regulation of T cell differentiation Source: UniProtKB
  63. positive regulation of thyroid hormone generation Source: UniProtKB
  64. positive regulation of transcription, DNA-templated Source: UniProtKB
  65. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  66. positive regulation of transcription regulatory region DNA binding Source: UniProtKB
  67. positive regulation of ureteric bud formation Source: UniProtKB
  68. post-embryonic development Source: Ensembl
  69. pro-T cell differentiation Source: Ensembl
  70. regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
  71. regulation of cellular response to X-ray Source: UniProtKB
  72. regulation of cytokine biosynthetic process Source: UniProtKB
  73. regulation of establishment of cell polarity Source: Ensembl
  74. regulation of histone H3-K27 methylation Source: Ensembl
  75. regulation of histone H3-K4 methylation Source: Ensembl
  76. regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  77. regulation of neuron apoptotic process Source: Ensembl
  78. regulation of neuron projection development Source: Ensembl
  79. response to drug Source: Ensembl
  80. response to estrogen Source: UniProtKB
  81. response to ethanol Source: Ensembl
  82. response to gamma radiation Source: Ensembl
  83. response to virus Source: UniProtKB
  84. signal transduction Source: UniProtKB
  85. sympathetic nervous system development Source: UniProtKB
  86. T cell receptor signaling pathway Source: UniProtKB
  87. T-helper 2 cell differentiation Source: Ensembl
  88. thymic T cell selection Source: Ensembl
  89. thymus development Source: Ensembl
  90. TOR signaling Source: UniProtKB
  91. transcription from RNA polymerase II promoter Source: ProtInc
  92. type IV hypersensitivity Source: Ensembl
  93. ureteric bud formation Source: UniProtKB
  94. ureter maturation Source: Ensembl
  95. uterus development Source: UniProtKB
  96. ventricular septum development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Immunity, Innate immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP23771.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-acting T-cell-specific transcription factor GATA-3
Alternative name(s):
GATA-binding factor 3
Gene namesi
Name:GATA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:4172. GATA3.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: BHF-UCL
  2. nucleolus Source: HPA
  3. nucleoplasm Source: Reactome
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) [MIM:146255]: A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti274 – 2741W → R in HDR. 1 Publication
VAR_017818

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

MIMi146255. phenotype.
Orphaneti2237. Hypoparathyroidism - deafness - renal disease.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBiPA28586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Trans-acting T-cell-specific transcription factor GATA-3PRO_0000083408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151Phosphoserine1 Publication
Modified residuei162 – 1621Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP23771.
PaxDbiP23771.
PRIDEiP23771.

PTM databases

PhosphoSiteiP23771.

Expressioni

Tissue specificityi

T-cells and endothelial cells.

Gene expression databases

BgeeiP23771.
CleanExiHS_GATA3.
GenevestigatoriP23771.

Organism-specific databases

HPAiHPA029730.
HPA029731.

Interactioni

Protein-protein interaction databases

BioGridi108895. 18 interactions.
IntActiP23771. 3 interactions.
MINTiMINT-4721003.
STRINGi9606.ENSP00000368632.

Structurei

Secondary structure

1
443
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni264 – 2663
Helixi285 – 29410
Beta strandi307 – 3137
Turni318 – 3203
Helixi339 – 34810
Helixi354 – 3563

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HC7X-ray2.65A/B260-370[»]
4HC9X-ray1.60A260-370[»]
4HCAX-ray2.80A260-370[»]
ProteinModelPortaliP23771.
SMRiP23771. Positions 261-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni288 – 31629Flexible linkerAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi344 – 35310YxKxHxxxRPBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi137 – 1426Poly-Ser
Compositional biasi322 – 3265Poly-Thr

Domaini

Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.
The YxKxHxxxRP motif is critical for DNA-binding and function.By similarity

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28725GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 34125GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiP23771.
KOiK17895.
OMAiHGSQVCR.
OrthoDBiEOG7CCBRF.
PhylomeDBiP23771.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029521. GATA-3.
IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P23771-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL
60 70 80 90 100
FNIDGQGNHV PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG
110 120 130 140 150
KALGSHHTAS PWNLSPFSKT SIHHGSPGPL SVYPPASSSS LSGGHASPHL
160 170 180 190 200
FTFPPTPPKD VSPDPSLSTP GSAGSARQDE KECLKYQVPL PDSMKLESSH
210 220 230 240 250
SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL GGSPTGFGCK
260 270 280 290 300
SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL
310 320 330 340 350
IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI
360 370 380 390 400
NRPLTMKKEG IQTRNRKMSS KSKKCKKVHD SLEDFPKNSS FNPAALSRHM
410 420 430 440
SSLSHISPFS HSSHMLTTPT PMHPPSSLSF GPHHPSSMVT AMG
Length:443
Mass (Da):47,916
Last modified:November 1, 1991 - v1
Checksum:iF24C58681E1D02A5
GO
Isoform 2 (identifier: P23771-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: T → TE

Show »
Length:444
Mass (Da):48,045
Checksum:i506051438132F1D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111V → L in AAA35870. (PubMed:1871134)Curated
Sequence conflicti102 – 1021A → V in CAA38877. (PubMed:1827068)Curated
Sequence conflicti173 – 1731A → G in CAA38877. (PubMed:1827068)Curated
Sequence conflicti219 – 2191I → Y in AAA35870. (PubMed:1871134)Curated
Sequence conflicti225 – 2262YV → TC in AAA35870. (PubMed:1871134)Curated
Sequence conflicti285 – 2862NA → RR in AAA35870. (PubMed:1871134)Curated
Sequence conflicti425 – 4251P → A in AAA35870. (PubMed:1871134)Curated
Sequence conflicti441 – 4411A → G in AAA35870. (PubMed:1871134)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421G → S.1 Publication
Corresponds to variant rs11567901 [ dbSNP | Ensembl ].
VAR_019202
Natural varianti274 – 2741W → R in HDR. 1 Publication
VAR_017818
Natural varianti366 – 3661R → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_033025

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei259 – 2591T → TE in isoform 2. 3 PublicationsVSP_001598

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58072 mRNA. Translation: CAA41102.1.
X55037 mRNA. Translation: CAA38877.1.
X55122 mRNA. Translation: CAA38916.1.
M69106 mRNA. Translation: AAA35870.1.
AY497006 Genomic DNA. Translation: AAR32096.1.
AL390294 Genomic DNA. Translation: CAH73143.1.
AL390294 Genomic DNA. Translation: CAH73144.1.
CH471072 Genomic DNA. Translation: EAW86367.1.
CH471072 Genomic DNA. Translation: EAW86368.1.
BC003070 mRNA. Translation: AAH03070.1.
BC006793 mRNA. Translation: AAH06793.1.
CCDSiCCDS31143.1. [P23771-2]
CCDS7083.1. [P23771-1]
PIRiA39794.
RefSeqiNP_001002295.1. NM_001002295.1. [P23771-2]
NP_002042.1. NM_002051.2. [P23771-1]
XP_005252499.1. XM_005252442.1. [P23771-2]
XP_005252500.1. XM_005252443.2. [P23771-2]
UniGeneiHs.524134.

Genome annotation databases

EnsembliENST00000346208; ENSP00000341619; ENSG00000107485. [P23771-1]
ENST00000379328; ENSP00000368632; ENSG00000107485. [P23771-2]
GeneIDi2625.
KEGGihsa:2625.
UCSCiuc001ijz.3. human. [P23771-2]
uc001ika.3. human. [P23771-1]

Polymorphism databases

DMDMi120962.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58072 mRNA. Translation: CAA41102.1 .
X55037 mRNA. Translation: CAA38877.1 .
X55122 mRNA. Translation: CAA38916.1 .
M69106 mRNA. Translation: AAA35870.1 .
AY497006 Genomic DNA. Translation: AAR32096.1 .
AL390294 Genomic DNA. Translation: CAH73143.1 .
AL390294 Genomic DNA. Translation: CAH73144.1 .
CH471072 Genomic DNA. Translation: EAW86367.1 .
CH471072 Genomic DNA. Translation: EAW86368.1 .
BC003070 mRNA. Translation: AAH03070.1 .
BC006793 mRNA. Translation: AAH06793.1 .
CCDSi CCDS31143.1. [P23771-2 ]
CCDS7083.1. [P23771-1 ]
PIRi A39794.
RefSeqi NP_001002295.1. NM_001002295.1. [P23771-2 ]
NP_002042.1. NM_002051.2. [P23771-1 ]
XP_005252499.1. XM_005252442.1. [P23771-2 ]
XP_005252500.1. XM_005252443.2. [P23771-2 ]
UniGenei Hs.524134.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HC7 X-ray 2.65 A/B 260-370 [» ]
4HC9 X-ray 1.60 A 260-370 [» ]
4HCA X-ray 2.80 A 260-370 [» ]
ProteinModelPortali P23771.
SMRi P23771. Positions 261-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108895. 18 interactions.
IntActi P23771. 3 interactions.
MINTi MINT-4721003.
STRINGi 9606.ENSP00000368632.

PTM databases

PhosphoSitei P23771.

Polymorphism databases

DMDMi 120962.

Proteomic databases

MaxQBi P23771.
PaxDbi P23771.
PRIDEi P23771.

Protocols and materials databases

DNASUi 2625.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000346208 ; ENSP00000341619 ; ENSG00000107485 . [P23771-1 ]
ENST00000379328 ; ENSP00000368632 ; ENSG00000107485 . [P23771-2 ]
GeneIDi 2625.
KEGGi hsa:2625.
UCSCi uc001ijz.3. human. [P23771-2 ]
uc001ika.3. human. [P23771-1 ]

Organism-specific databases

CTDi 2625.
GeneCardsi GC10P008095.
HGNCi HGNC:4172. GATA3.
HPAi HPA029730.
HPA029731.
MIMi 131320. gene.
146255. phenotype.
neXtProti NX_P23771.
Orphaneti 2237. Hypoparathyroidism - deafness - renal disease.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBi PA28586.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5641.
GeneTreei ENSGT00760000119221.
HOGENOMi HOG000047701.
HOVERGENi HBG051705.
InParanoidi P23771.
KOi K17895.
OMAi HGSQVCR.
OrthoDBi EOG7CCBRF.
PhylomeDBi P23771.
TreeFami TF315391.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.
SignaLinki P23771.

Miscellaneous databases

GeneWikii GATA3.
GenomeRNAii 2625.
NextBioi 10339.
PROi P23771.
SOURCEi Search...

Gene expression databases

Bgeei P23771.
CleanExi HS_GATA3.
Genevestigatori P23771.

Family and domain databases

Gene3Di 3.30.50.10. 2 hits.
InterProi IPR029521. GATA-3.
IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
PANTHERi PTHR10071:SF106. PTHR10071:SF106. 1 hit.
Pfami PF00320. GATA. 2 hits.
[Graphical view ]
PIRSFi PIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSi PR00619. GATAZNFINGER.
SMARTi SM00401. ZnF_GATA. 2 hits.
[Graphical view ]
PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family."
    Joulin V., Bories D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei M.-G., Romeo P.-H.
    EMBO J. 10:1809-1816(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: T-cell.
  2. "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene."
    Ho I.-C., Vorhees P., Marin N., Oakley B.K., Tsai S.-F., Orkin S.H., Leiden J.M.
    EMBO J. 10:1187-1192(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: T-cell.
  3. "Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer."
    Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D.
    Mol. Cell. Biol. 11:2778-2784(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: T-cell.
  4. "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements."
    Marine J., Winoto A.
    Proc. Natl. Acad. Sci. U.S.A. 88:7284-7288(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. SeattleSNPs variation discovery resource
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-242.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cervix and Placenta.
  9. Cited for: INVOLVEMENT IN HDR.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity."
    Sasaki T., Onodera A., Hosokawa H., Watanabe Y., Horiuchi S., Yamashita J., Tanaka H., Ogawa Y., Suzuki Y., Nakayama T.
    PLoS ONE 8:E66468-E66468(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation."
    Chen Y., Bates D.L., Dey R., Chen P.H., Machado A.C., Laird-Offringa I.A., Rohs R., Chen L.
    Cell Rep. 2:1197-1206(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 260-370 IN COMPLEX WITH DNA, GATA-TYPE ZINC FINGERS.
  13. Cited for: VARIANT HDR ARG-274.
  14. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
    Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.
    Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-366.

Entry informationi

Entry nameiGATA3_HUMAN
AccessioniPrimary (citable) accession number: P23771
Secondary accession number(s): Q5VWG7, Q5VWG8, Q96J16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 29, 2014
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3