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P23771 (GATA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 155. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trans-acting T-cell-specific transcription factor GATA-3
Alternative name(s):
GATA-binding factor 3
Gene names
Name:GATA3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Ref.11

Subcellular location

Nucleus.

Tissue specificity

T-cells and endothelial cells.

Domain

Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.

The YxKxHxxxRP motif is critical for DNA-binding and function By similarity.

Involvement in disease

Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) [MIM:146255]: A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.13

Sequence similarities

Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
   Biological processImmunity
Innate immunity
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDeafness
Disease mutation
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

T-helper 2 cell differentiation

Inferred from electronic annotation. Source: Ensembl

TOR signaling

Inferred from sequence or structural similarity. Source: UniProtKB

anatomical structure formation involved in morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

anatomical structure morphogenesis

Traceable author statement Ref.9. Source: ProtInc

aortic valve morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

axon guidance

Inferred from electronic annotation. Source: Ensembl

blood coagulation

Traceable author statement. Source: Reactome

canonical Wnt signaling pathway involved in metanephric kidney development

Inferred from sequence or structural similarity. Source: UniProtKB

cardiac right ventricle morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

cell fate determination

Inferred from sequence or structural similarity. Source: UniProtKB

cell maturation

Inferred from electronic annotation. Source: Ensembl

cellular response to BMP stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to interferon-alpha

Inferred from expression pattern PubMed 20554961. Source: UniProtKB

cellular response to interleukin-4

Inferred from expression pattern PubMed 20554961. Source: UniProtKB

cellular response to tumor necrosis factor

Inferred from expression pattern PubMed 19674970. Source: UniProtKB

defense response

Traceable author statement PubMed 7592673. Source: ProtInc

developmental growth

Inferred from electronic annotation. Source: Ensembl

ear development

Inferred from mutant phenotype PubMed 19248180PubMed 19723756. Source: UniProtKB

embryonic hemopoiesis

Inferred from electronic annotation. Source: Ensembl

erythrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

humoral immune response

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

inner ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

interferon-gamma secretion

Inferred from electronic annotation. Source: Ensembl

interleukin-4 secretion

Inferred from electronic annotation. Source: Ensembl

kidney development

Inferred from mutant phenotype PubMed 19248180PubMed 19723756. Source: UniProtKB

lens development in camera-type eye

Inferred from electronic annotation. Source: Ensembl

lymphocyte migration

Inferred from direct assay PubMed 19805038. Source: UniProtKB

male gonad development

Inferred from sequence or structural similarity. Source: UniProtKB

mast cell differentiation

Inferred from electronic annotation. Source: Ensembl

mesenchymal to epithelial transition

Inferred from direct assay PubMed 20189993. Source: UniProtKB

mesonephros development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell cycle

Inferred from mutant phenotype PubMed 20189993. Source: UniProtKB

negative regulation of cell motility

Inferred from mutant phenotype PubMed 20189993. Source: UniProtKB

negative regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell proliferation involved in mesonephros development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of endothelial cell apoptotic process

Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB

negative regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 20705609. Source: UniProtKB

negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of inflammatory response

Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB

negative regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-2 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of mammary gland epithelial cell proliferation

Inferred from direct assay PubMed 19483726. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB

nephric duct formation

Inferred from sequence or structural similarity. Source: UniProtKB

nephric duct morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

neuron migration

Inferred from electronic annotation. Source: Ensembl

norepinephrine biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

otic vesicle development

Inferred from electronic annotation. Source: Ensembl

parathyroid gland development

Inferred from electronic annotation. Source: Ensembl

parathyroid hormone secretion

Inferred from electronic annotation. Source: Ensembl

pharyngeal system development

Inferred from sequence or structural similarity. Source: UniProtKB

phosphatidylinositol 3-kinase signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of T cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endothelial cell migration

Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB

positive regulation of interleukin-13 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-13 secretion

Inferred from direct assay PubMed 20554961. Source: UniProtKB

positive regulation of interleukin-4 production

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of interleukin-5 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-5 secretion

Inferred from direct assay PubMed 20554961. Source: UniProtKB

positive regulation of protein kinase B signaling

Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB

positive regulation of signal transduction

Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB

positive regulation of thyroid hormone generation

Inferred from mutant phenotype PubMed 19248180PubMed 19723756. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19232384PubMed 20189993PubMed 20484083. Source: UniProtKB

positive regulation of transcription regulatory region DNA binding

Inferred from mutant phenotype PubMed 20368097. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 19723756PubMed 19805038. Source: UniProtKB

positive regulation of ureteric bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

post-embryonic development

Inferred from electronic annotation. Source: Ensembl

pro-T cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of CD4-positive, alpha-beta T cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of cellular response to X-ray

Inferred from mutant phenotype PubMed 19735555. Source: UniProtKB

regulation of cytokine biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of establishment of cell polarity

Inferred from electronic annotation. Source: Ensembl

regulation of histone H3-K27 methylation

Inferred from electronic annotation. Source: Ensembl

regulation of histone H3-K4 methylation

Inferred from electronic annotation. Source: Ensembl

regulation of nephron tubule epithelial cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from expression pattern PubMed 10037815. Source: UniProtKB

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

response to virus

Inferred from expression pattern PubMed 20583921. Source: UniProtKB

signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

sympathetic nervous system development

Inferred from sequence or structural similarity. Source: UniProtKB

thymic T cell selection

Inferred from electronic annotation. Source: Ensembl

thymus development

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Traceable author statement Ref.4. Source: ProtInc

type IV hypersensitivity

Inferred from electronic annotation. Source: Ensembl

ureter maturation

Inferred from electronic annotation. Source: Ensembl

ureteric bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

uterus development

Inferred from sequence or structural similarity. Source: UniProtKB

ventricular septum development

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentnuclear chromatin

Inferred from direct assay PubMed 20855495. Source: BHF-UCL

nucleolus

Inferred from direct assay. Source: HPA

nucleoplasm

Traceable author statement. Source: Reactome

nucleus

Inferred from direct assay PubMed 19674970PubMed 19723756PubMed 20189993. Source: UniProtKB

   Molecular_functionDNA binding

Traceable author statement Ref.4. Source: ProtInc

E-box binding

Inferred from direct assay PubMed 20855495. Source: BHF-UCL

HMG box domain binding

Inferred from physical interaction PubMed 18445004. Source: UniProtKB

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription

Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

core promoter proximal region sequence-specific DNA binding

Inferred from direct assay PubMed 19232384. Source: UniProtKB

core promoter sequence-specific DNA binding

Inferred from direct assay PubMed 19674970. Source: UniProtKB

enhancer sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

nucleic acid binding transcription factor activity

Inferred from direct assay PubMed 19232384PubMed 19805038PubMed 20189993. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 19674970PubMed 19723756PubMed 20484083. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1PubMed 8088776. Source: ProtInc

transcription coactivator activity

Inferred from direct assay PubMed 20484083. Source: UniProtKB

transcription factor binding

Inferred from physical interaction PubMed 15016828. Source: BHF-UCL

transcription regulatory region DNA binding

Inferred from direct assay PubMed 19735555PubMed 19805038PubMed 20189993PubMed 20484083. Source: UniProtKB

transcription regulatory region sequence-specific DNA binding

Inferred from direct assay PubMed 19723756. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P23771-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P23771-2)

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: T → TE

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Trans-acting T-cell-specific transcription factor GATA-3
PRO_0000083408

Regions

Zinc finger263 – 28725GATA-type 1
Zinc finger317 – 34125GATA-type 2
Region288 – 31629Flexible linker
Motif344 – 35310YxKxHxxxRP By similarity
Compositional bias137 – 1426Poly-Ser
Compositional bias322 – 3265Poly-Thr

Amino acid modifications

Modified residue1151Phosphoserine Ref.10
Modified residue1621Phosphoserine Ref.10

Natural variations

Alternative sequence2591T → TE in isoform 2.
VSP_001598
Natural variant2421G → S. Ref.5
Corresponds to variant rs11567901 [ dbSNP | Ensembl ].
VAR_019202
Natural variant2741W → R in HDR. Ref.13
VAR_017818
Natural variant3661R → L in a breast cancer sample; somatic mutation. Ref.14
VAR_033025

Experimental info

Sequence conflict111V → L in AAA35870. Ref.4
Sequence conflict1021A → V in CAA38877. Ref.2
Sequence conflict1731A → G in CAA38877. Ref.2
Sequence conflict2191I → Y in AAA35870. Ref.4
Sequence conflict225 – 2262YV → TC in AAA35870. Ref.4
Sequence conflict285 – 2862NA → RR in AAA35870. Ref.4
Sequence conflict4251P → A in AAA35870. Ref.4
Sequence conflict4411A → G in AAA35870. Ref.4

Secondary structure

............. 443
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: F24C58681E1D02A5

FASTA44347,916
        10         20         30         40         50         60 
MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL FNIDGQGNHV 

        70         80         90        100        110        120 
PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALGSHHTAS PWNLSPFSKT 

       130        140        150        160        170        180 
SIHHGSPGPL SVYPPASSSS LSGGHASPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE 

       190        200        210        220        230        240 
KECLKYQVPL PDSMKLESSH SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL 

       250        260        270        280        290        300 
GGSPTGFGCK SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL 

       310        320        330        340        350        360 
IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG 

       370        380        390        400        410        420 
IQTRNRKMSS KSKKCKKVHD SLEDFPKNSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT 

       430        440 
PMHPPSSLSF GPHHPSSMVT AMG 

« Hide

Isoform 2 [UniParc].

Checksum: 506051438132F1D0
Show »

FASTA44448,045

References

« Hide 'large scale' references
[1]"A T-cell specific TCR delta DNA binding protein is a member of the human GATA family."
Joulin V., Bories D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei M.-G., Romeo P.-H.
EMBO J. 10:1809-1816(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: T-cell.
[2]"Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene."
Ho I.-C., Vorhees P., Marin N., Oakley B.K., Tsai S.-F., Orkin S.H., Leiden J.M.
EMBO J. 10:1187-1192(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: T-cell.
[3]"Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer."
Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D.
Mol. Cell. Biol. 11:2778-2784(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: T-cell.
[4]"The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements."
Marine J., Winoto A.
Proc. Natl. Acad. Sci. U.S.A. 88:7284-7288(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[5]SeattleSNPs variation discovery resource
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-242.
[6]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Cervix and Placenta.
[9]"GATA3 haplo-insufficiency causes human HDR syndrome."
Van Esch H., Groenen P., Nesbit M.A., Schuffenhauer S., Lichtner P., Vanderlinden G., Harding B., Beetz R., Bilous R.W., Holdaway I., Shaw N.J., Fryns J.-P., Van de Ven W., Thakker R.V., Devriendt K.
Nature 406:419-422(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN HDR.
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity."
Sasaki T., Onodera A., Hosokawa H., Watanabe Y., Horiuchi S., Yamashita J., Tanaka H., Ogawa Y., Suzuki Y., Nakayama T.
PLoS ONE 8:E66468-E66468(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation."
Chen Y., Bates D.L., Dey R., Chen P.H., Machado A.C., Laird-Offringa I.A., Rohs R., Chen L.
Cell Rep. 2:1197-1206(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 260-370 IN COMPLEX WITH DNA, GATA-TYPE ZINC FINGERS.
[13]"GATA3 abnormalities and the phenotypic spectrum of HDR syndrome."
Muroya K., Hasegawa T., Ito Y., Nagai T., Isotani H., Iwata Y., Yamamoto K., Fujimoto S., Seishu S., Fukushima Y., Hasegawa Y., Ogata T.
J. Med. Genet. 38:374-380(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HDR ARG-274.
[14]"Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.
Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LEU-366.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58072 mRNA. Translation: CAA41102.1.
X55037 mRNA. Translation: CAA38877.1.
X55122 mRNA. Translation: CAA38916.1.
M69106 mRNA. Translation: AAA35870.1.
AY497006 Genomic DNA. Translation: AAR32096.1.
AL390294 Genomic DNA. Translation: CAH73143.1.
AL390294 Genomic DNA. Translation: CAH73144.1.
CH471072 Genomic DNA. Translation: EAW86367.1.
CH471072 Genomic DNA. Translation: EAW86368.1.
BC003070 mRNA. Translation: AAH03070.1.
BC006793 mRNA. Translation: AAH06793.1.
CCDSCCDS31143.1. [P23771-2]
CCDS7083.1. [P23771-1]
PIRA39794.
RefSeqNP_001002295.1. NM_001002295.1. [P23771-2]
NP_002042.1. NM_002051.2. [P23771-1]
XP_005252499.1. XM_005252442.1. [P23771-2]
XP_005252500.1. XM_005252443.2. [P23771-2]
UniGeneHs.524134.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HC7X-ray2.65A/B260-370[»]
4HC9X-ray1.60A260-370[»]
4HCAX-ray2.80A260-370[»]
ProteinModelPortalP23771.
SMRP23771. Positions 261-365.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108895. 18 interactions.
IntActP23771. 3 interactions.
MINTMINT-4721003.
STRING9606.ENSP00000368632.

PTM databases

PhosphoSiteP23771.

Polymorphism databases

DMDM120962.

Proteomic databases

MaxQBP23771.
PaxDbP23771.
PRIDEP23771.

Protocols and materials databases

DNASU2625.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000346208; ENSP00000341619; ENSG00000107485. [P23771-1]
ENST00000379328; ENSP00000368632; ENSG00000107485. [P23771-2]
GeneID2625.
KEGGhsa:2625.
UCSCuc001ijz.3. human. [P23771-2]
uc001ika.3. human. [P23771-1]

Organism-specific databases

CTD2625.
GeneCardsGC10P008095.
HGNCHGNC:4172. GATA3.
HPAHPA029730.
HPA029731.
MIM131320. gene.
146255. phenotype.
neXtProtNX_P23771.
Orphanet2237. Hypoparathyroidism - deafness - renal disease.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBPA28586.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5641.
HOGENOMHOG000047701.
HOVERGENHBG051705.
KOK17895.
OMAHGSQVCR.
OrthoDBEOG7CCBRF.
PhylomeDBP23771.
TreeFamTF315391.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
SignaLinkP23771.

Gene expression databases

BgeeP23771.
CleanExHS_GATA3.
GenevestigatorP23771.

Family and domain databases

Gene3D3.30.50.10. 2 hits.
InterProIPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00320. GATA. 2 hits.
[Graphical view]
PIRSFPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSPR00619. GATAZNFINGER.
SMARTSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGATA3.
GenomeRNAi2625.
NextBio10339.
PROP23771.
SOURCESearch...

Entry information

Entry nameGATA3_HUMAN
AccessionPrimary (citable) accession number: P23771
Secondary accession number(s): Q5VWG7, Q5VWG8, Q96J16
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: July 9, 2014
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM