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P23771

- GATA3_HUMAN

UniProt

P23771 - GATA3_HUMAN

Protein

Trans-acting T-cell-specific transcription factor GATA-3

Gene

GATA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri263 – 28725GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 34125GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter proximal region sequence-specific DNA binding Source: UniProtKB
    2. core promoter sequence-specific DNA binding Source: UniProtKB
    3. DNA binding Source: ProtInc
    4. E-box binding Source: BHF-UCL
    5. enhancer sequence-specific DNA binding Source: Ensembl
    6. HMG box domain binding Source: UniProtKB
    7. nucleic acid binding transcription factor activity Source: UniProtKB
    8. protein binding Source: UniProtKB
    9. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
    10. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    11. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    12. sequence-specific DNA binding transcription factor activity Source: ProtInc
    13. transcription coactivator activity Source: UniProtKB
    14. transcription factor binding Source: BHF-UCL
    15. transcription regulatory region DNA binding Source: UniProtKB
    16. transcription regulatory region sequence-specific DNA binding Source: UniProtKB
    17. zinc ion binding Source: InterPro

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: UniProtKB
    2. anatomical structure morphogenesis Source: ProtInc
    3. aortic valve morphogenesis Source: UniProtKB
    4. axon guidance Source: Ensembl
    5. blood coagulation Source: Reactome
    6. canonical Wnt signaling pathway involved in metanephric kidney development Source: UniProtKB
    7. cardiac right ventricle morphogenesis Source: UniProtKB
    8. cell fate determination Source: UniProtKB
    9. cell maturation Source: Ensembl
    10. cellular response to BMP stimulus Source: Ensembl
    11. cellular response to interferon-alpha Source: UniProtKB
    12. cellular response to interleukin-4 Source: UniProtKB
    13. cellular response to tumor necrosis factor Source: UniProtKB
    14. defense response Source: ProtInc
    15. developmental growth Source: Ensembl
    16. ear development Source: UniProtKB
    17. embryonic hemopoiesis Source: Ensembl
    18. erythrocyte differentiation Source: Ensembl
    19. humoral immune response Source: Ensembl
    20. innate immune response Source: UniProtKB-KW
    21. inner ear morphogenesis Source: Ensembl
    22. interferon-gamma secretion Source: Ensembl
    23. interleukin-4 secretion Source: Ensembl
    24. in utero embryonic development Source: Ensembl
    25. kidney development Source: UniProtKB
    26. lens development in camera-type eye Source: Ensembl
    27. lymphocyte migration Source: UniProtKB
    28. male gonad development Source: UniProtKB
    29. mast cell differentiation Source: Ensembl
    30. mesenchymal to epithelial transition Source: UniProtKB
    31. mesonephros development Source: UniProtKB
    32. negative regulation of cell cycle Source: UniProtKB
    33. negative regulation of cell motility Source: UniProtKB
    34. negative regulation of cell proliferation Source: UniProtKB
    35. negative regulation of cell proliferation involved in mesonephros development Source: UniProtKB
    36. negative regulation of endothelial cell apoptotic process Source: UniProtKB
    37. negative regulation of fat cell differentiation Source: UniProtKB
    38. negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
    39. negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
    40. negative regulation of inflammatory response Source: UniProtKB
    41. negative regulation of interferon-gamma production Source: Ensembl
    42. negative regulation of interleukin-2 production Source: Ensembl
    43. negative regulation of mammary gland epithelial cell proliferation Source: UniProtKB
    44. negative regulation of transcription, DNA-templated Source: UniProtKB
    45. nephric duct formation Source: UniProtKB
    46. nephric duct morphogenesis Source: UniProtKB
    47. neuron migration Source: Ensembl
    48. norepinephrine biosynthetic process Source: UniProtKB
    49. otic vesicle development Source: Ensembl
    50. parathyroid gland development Source: Ensembl
    51. parathyroid hormone secretion Source: Ensembl
    52. pharyngeal system development Source: UniProtKB
    53. phosphatidylinositol 3-kinase signaling Source: UniProtKB
    54. positive regulation of endothelial cell migration Source: UniProtKB
    55. positive regulation of interleukin-13 production Source: Ensembl
    56. positive regulation of interleukin-13 secretion Source: UniProtKB
    57. positive regulation of interleukin-4 production Source: UniProtKB
    58. positive regulation of interleukin-5 production Source: Ensembl
    59. positive regulation of interleukin-5 secretion Source: UniProtKB
    60. positive regulation of protein kinase B signaling Source: UniProtKB
    61. positive regulation of signal transduction Source: UniProtKB
    62. positive regulation of T cell differentiation Source: UniProtKB
    63. positive regulation of thyroid hormone generation Source: UniProtKB
    64. positive regulation of transcription, DNA-templated Source: UniProtKB
    65. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    66. positive regulation of transcription regulatory region DNA binding Source: UniProtKB
    67. positive regulation of ureteric bud formation Source: UniProtKB
    68. post-embryonic development Source: Ensembl
    69. pro-T cell differentiation Source: Ensembl
    70. regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
    71. regulation of cellular response to X-ray Source: UniProtKB
    72. regulation of cytokine biosynthetic process Source: UniProtKB
    73. regulation of establishment of cell polarity Source: Ensembl
    74. regulation of histone H3-K27 methylation Source: Ensembl
    75. regulation of histone H3-K4 methylation Source: Ensembl
    76. regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
    77. regulation of neuron apoptotic process Source: Ensembl
    78. response to drug Source: Ensembl
    79. response to estrogen Source: UniProtKB
    80. response to ethanol Source: Ensembl
    81. response to gamma radiation Source: Ensembl
    82. response to virus Source: UniProtKB
    83. signal transduction Source: UniProtKB
    84. sympathetic nervous system development Source: UniProtKB
    85. T cell receptor signaling pathway Source: UniProtKB
    86. T-helper 2 cell differentiation Source: Ensembl
    87. thymic T cell selection Source: Ensembl
    88. thymus development Source: Ensembl
    89. TOR signaling Source: UniProtKB
    90. transcription from RNA polymerase II promoter Source: ProtInc
    91. type IV hypersensitivity Source: Ensembl
    92. ureteric bud formation Source: UniProtKB
    93. ureter maturation Source: Ensembl
    94. uterus development Source: UniProtKB
    95. ventricular septum development Source: UniProtKB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Immunity, Innate immunity, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinkiP23771.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trans-acting T-cell-specific transcription factor GATA-3
    Alternative name(s):
    GATA-binding factor 3
    Gene namesi
    Name:GATA3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:4172. GATA3.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: BHF-UCL
    2. nucleolus Source: HPA
    3. nucleoplasm Source: Reactome
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) [MIM:146255]: A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti274 – 2741W → R in HDR. 1 Publication
    VAR_017818

    Keywords - Diseasei

    Deafness, Disease mutation

    Organism-specific databases

    MIMi146255. phenotype.
    Orphaneti2237. Hypoparathyroidism - deafness - renal disease.
    99860. Precursor B-cell acute lymphoblastic leukemia.
    PharmGKBiPA28586.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Trans-acting T-cell-specific transcription factor GATA-3PRO_0000083408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei115 – 1151Phosphoserine1 Publication
    Modified residuei162 – 1621Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP23771.
    PaxDbiP23771.
    PRIDEiP23771.

    PTM databases

    PhosphoSiteiP23771.

    Expressioni

    Tissue specificityi

    T-cells and endothelial cells.

    Gene expression databases

    BgeeiP23771.
    CleanExiHS_GATA3.
    GenevestigatoriP23771.

    Organism-specific databases

    HPAiHPA029730.
    HPA029731.

    Interactioni

    Protein-protein interaction databases

    BioGridi108895. 18 interactions.
    IntActiP23771. 3 interactions.
    MINTiMINT-4721003.
    STRINGi9606.ENSP00000368632.

    Structurei

    Secondary structure

    1
    443
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni264 – 2663
    Helixi285 – 29410
    Beta strandi307 – 3137
    Turni318 – 3203
    Helixi339 – 34810
    Helixi354 – 3563

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HC7X-ray2.65A/B260-370[»]
    4HC9X-ray1.60A260-370[»]
    4HCAX-ray2.80A260-370[»]
    ProteinModelPortaliP23771.
    SMRiP23771. Positions 261-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni288 – 31629Flexible linkerAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi344 – 35310YxKxHxxxRPBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi137 – 1426Poly-Ser
    Compositional biasi322 – 3265Poly-Thr

    Domaini

    Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.
    The YxKxHxxxRP motif is critical for DNA-binding and function.By similarity

    Sequence similaritiesi

    Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri263 – 28725GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 34125GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5641.
    HOGENOMiHOG000047701.
    HOVERGENiHBG051705.
    KOiK17895.
    OMAiHGSQVCR.
    OrthoDBiEOG7CCBRF.
    PhylomeDBiP23771.
    TreeFamiTF315391.

    Family and domain databases

    Gene3Di3.30.50.10. 2 hits.
    InterProiIPR029521. GATA-3.
    IPR016374. TF_GATA-1/2/3.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
    PfamiPF00320. GATA. 2 hits.
    [Graphical view]
    PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00401. ZnF_GATA. 2 hits.
    [Graphical view]
    PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P23771-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL    50
    FNIDGQGNHV PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG 100
    KALGSHHTAS PWNLSPFSKT SIHHGSPGPL SVYPPASSSS LSGGHASPHL 150
    FTFPPTPPKD VSPDPSLSTP GSAGSARQDE KECLKYQVPL PDSMKLESSH 200
    SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL GGSPTGFGCK 250
    SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL 300
    IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI 350
    NRPLTMKKEG IQTRNRKMSS KSKKCKKVHD SLEDFPKNSS FNPAALSRHM 400
    SSLSHISPFS HSSHMLTTPT PMHPPSSLSF GPHHPSSMVT AMG 443
    Length:443
    Mass (Da):47,916
    Last modified:November 1, 1991 - v1
    Checksum:iF24C58681E1D02A5
    GO
    Isoform 2 (identifier: P23771-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-259: T → TE

    Show »
    Length:444
    Mass (Da):48,045
    Checksum:i506051438132F1D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111V → L in AAA35870. (PubMed:1871134)Curated
    Sequence conflicti102 – 1021A → V in CAA38877. (PubMed:1827068)Curated
    Sequence conflicti173 – 1731A → G in CAA38877. (PubMed:1827068)Curated
    Sequence conflicti219 – 2191I → Y in AAA35870. (PubMed:1871134)Curated
    Sequence conflicti225 – 2262YV → TC in AAA35870. (PubMed:1871134)Curated
    Sequence conflicti285 – 2862NA → RR in AAA35870. (PubMed:1871134)Curated
    Sequence conflicti425 – 4251P → A in AAA35870. (PubMed:1871134)Curated
    Sequence conflicti441 – 4411A → G in AAA35870. (PubMed:1871134)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti242 – 2421G → S.1 Publication
    Corresponds to variant rs11567901 [ dbSNP | Ensembl ].
    VAR_019202
    Natural varianti274 – 2741W → R in HDR. 1 Publication
    VAR_017818
    Natural varianti366 – 3661R → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_033025

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei259 – 2591T → TE in isoform 2. 3 PublicationsVSP_001598

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58072 mRNA. Translation: CAA41102.1.
    X55037 mRNA. Translation: CAA38877.1.
    X55122 mRNA. Translation: CAA38916.1.
    M69106 mRNA. Translation: AAA35870.1.
    AY497006 Genomic DNA. Translation: AAR32096.1.
    AL390294 Genomic DNA. Translation: CAH73143.1.
    AL390294 Genomic DNA. Translation: CAH73144.1.
    CH471072 Genomic DNA. Translation: EAW86367.1.
    CH471072 Genomic DNA. Translation: EAW86368.1.
    BC003070 mRNA. Translation: AAH03070.1.
    BC006793 mRNA. Translation: AAH06793.1.
    CCDSiCCDS31143.1. [P23771-2]
    CCDS7083.1. [P23771-1]
    PIRiA39794.
    RefSeqiNP_001002295.1. NM_001002295.1. [P23771-2]
    NP_002042.1. NM_002051.2. [P23771-1]
    XP_005252499.1. XM_005252442.1. [P23771-2]
    XP_005252500.1. XM_005252443.2. [P23771-2]
    UniGeneiHs.524134.

    Genome annotation databases

    EnsembliENST00000346208; ENSP00000341619; ENSG00000107485. [P23771-1]
    ENST00000379328; ENSP00000368632; ENSG00000107485. [P23771-2]
    GeneIDi2625.
    KEGGihsa:2625.
    UCSCiuc001ijz.3. human. [P23771-2]
    uc001ika.3. human. [P23771-1]

    Polymorphism databases

    DMDMi120962.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58072 mRNA. Translation: CAA41102.1 .
    X55037 mRNA. Translation: CAA38877.1 .
    X55122 mRNA. Translation: CAA38916.1 .
    M69106 mRNA. Translation: AAA35870.1 .
    AY497006 Genomic DNA. Translation: AAR32096.1 .
    AL390294 Genomic DNA. Translation: CAH73143.1 .
    AL390294 Genomic DNA. Translation: CAH73144.1 .
    CH471072 Genomic DNA. Translation: EAW86367.1 .
    CH471072 Genomic DNA. Translation: EAW86368.1 .
    BC003070 mRNA. Translation: AAH03070.1 .
    BC006793 mRNA. Translation: AAH06793.1 .
    CCDSi CCDS31143.1. [P23771-2 ]
    CCDS7083.1. [P23771-1 ]
    PIRi A39794.
    RefSeqi NP_001002295.1. NM_001002295.1. [P23771-2 ]
    NP_002042.1. NM_002051.2. [P23771-1 ]
    XP_005252499.1. XM_005252442.1. [P23771-2 ]
    XP_005252500.1. XM_005252443.2. [P23771-2 ]
    UniGenei Hs.524134.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HC7 X-ray 2.65 A/B 260-370 [» ]
    4HC9 X-ray 1.60 A 260-370 [» ]
    4HCA X-ray 2.80 A 260-370 [» ]
    ProteinModelPortali P23771.
    SMRi P23771. Positions 261-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108895. 18 interactions.
    IntActi P23771. 3 interactions.
    MINTi MINT-4721003.
    STRINGi 9606.ENSP00000368632.

    PTM databases

    PhosphoSitei P23771.

    Polymorphism databases

    DMDMi 120962.

    Proteomic databases

    MaxQBi P23771.
    PaxDbi P23771.
    PRIDEi P23771.

    Protocols and materials databases

    DNASUi 2625.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000346208 ; ENSP00000341619 ; ENSG00000107485 . [P23771-1 ]
    ENST00000379328 ; ENSP00000368632 ; ENSG00000107485 . [P23771-2 ]
    GeneIDi 2625.
    KEGGi hsa:2625.
    UCSCi uc001ijz.3. human. [P23771-2 ]
    uc001ika.3. human. [P23771-1 ]

    Organism-specific databases

    CTDi 2625.
    GeneCardsi GC10P008095.
    HGNCi HGNC:4172. GATA3.
    HPAi HPA029730.
    HPA029731.
    MIMi 131320. gene.
    146255. phenotype.
    neXtProti NX_P23771.
    Orphaneti 2237. Hypoparathyroidism - deafness - renal disease.
    99860. Precursor B-cell acute lymphoblastic leukemia.
    PharmGKBi PA28586.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5641.
    HOGENOMi HOG000047701.
    HOVERGENi HBG051705.
    KOi K17895.
    OMAi HGSQVCR.
    OrthoDBi EOG7CCBRF.
    PhylomeDBi P23771.
    TreeFami TF315391.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinki P23771.

    Miscellaneous databases

    GeneWikii GATA3.
    GenomeRNAii 2625.
    NextBioi 10339.
    PROi P23771.
    SOURCEi Search...

    Gene expression databases

    Bgeei P23771.
    CleanExi HS_GATA3.
    Genevestigatori P23771.

    Family and domain databases

    Gene3Di 3.30.50.10. 2 hits.
    InterProi IPR029521. GATA-3.
    IPR016374. TF_GATA-1/2/3.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    PANTHERi PTHR10071:SF106. PTHR10071:SF106. 1 hit.
    Pfami PF00320. GATA. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF003027. TF_GATA-1/2/3. 1 hit.
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00401. ZnF_GATA. 2 hits.
    [Graphical view ]
    PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family."
      Joulin V., Bories D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei M.-G., Romeo P.-H.
      EMBO J. 10:1809-1816(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: T-cell.
    2. "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene."
      Ho I.-C., Vorhees P., Marin N., Oakley B.K., Tsai S.-F., Orkin S.H., Leiden J.M.
      EMBO J. 10:1187-1192(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: T-cell.
    3. "Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer."
      Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D.
      Mol. Cell. Biol. 11:2778-2784(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: T-cell.
    4. "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements."
      Marine J., Winoto A.
      Proc. Natl. Acad. Sci. U.S.A. 88:7284-7288(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    5. SeattleSNPs variation discovery resource
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-242.
    6. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cervix and Placenta.
    9. Cited for: INVOLVEMENT IN HDR.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity."
      Sasaki T., Onodera A., Hosokawa H., Watanabe Y., Horiuchi S., Yamashita J., Tanaka H., Ogawa Y., Suzuki Y., Nakayama T.
      PLoS ONE 8:E66468-E66468(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation."
      Chen Y., Bates D.L., Dey R., Chen P.H., Machado A.C., Laird-Offringa I.A., Rohs R., Chen L.
      Cell Rep. 2:1197-1206(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 260-370 IN COMPLEX WITH DNA, GATA-TYPE ZINC FINGERS.
    13. Cited for: VARIANT HDR ARG-274.
    14. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
      Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.
      Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-366.

    Entry informationi

    Entry nameiGATA3_HUMAN
    AccessioniPrimary (citable) accession number: P23771
    Secondary accession number(s): Q5VWG7, Q5VWG8, Q96J16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 157 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3