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Protein

Trans-acting T-cell-specific transcription factor GATA-3

Gene

GATA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28725GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 34125GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  • core promoter sequence-specific DNA binding Source: UniProtKB
  • DNA binding Source: ProtInc
  • E-box binding Source: BHF-UCL
  • enhancer sequence-specific DNA binding Source: Ensembl
  • HMG box domain binding Source: UniProtKB
  • nucleic acid binding transcription factor activity Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  • RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  • sequence-specific DNA binding transcription factor activity Source: ProtInc
  • transcription coactivator activity Source: UniProtKB
  • transcription factor binding Source: BHF-UCL
  • transcription regulatory region DNA binding Source: UniProtKB
  • transcription regulatory region sequence-specific DNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Immunity, Innate immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP23771.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-acting T-cell-specific transcription factor GATA-3
Alternative name(s):
GATA-binding factor 3
Gene namesi
Name:GATA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:4172. GATA3.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: BHF-UCL
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Hypoparathyroidism, sensorineural deafness, and renal disease (HDR)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.

See also OMIM:146255
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti274 – 2741W → R in HDR. 1 Publication
VAR_017818

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

MIMi146255. phenotype.
Orphaneti2237. Hypoparathyroidism - deafness - renal disease.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBiPA28586.

Polymorphism and mutation databases

BioMutaiGATA3.
DMDMi120962.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Trans-acting T-cell-specific transcription factor GATA-3PRO_0000083408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151Phosphoserine1 Publication
Modified residuei162 – 1621Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP23771.
PaxDbiP23771.
PRIDEiP23771.

PTM databases

PhosphoSiteiP23771.

Expressioni

Tissue specificityi

T-cells and endothelial cells.

Gene expression databases

BgeeiP23771.
CleanExiHS_GATA3.
GenevestigatoriP23771.

Organism-specific databases

HPAiCAB016217.
HPA029730.
HPA029731.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA3P257883EBI-6664760,EBI-348380

Protein-protein interaction databases

BioGridi108895. 19 interactions.
DIPiDIP-61302N.
IntActiP23771. 11 interactions.
MINTiMINT-4721003.
STRINGi9606.ENSP00000368632.

Structurei

Secondary structure

1
443
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni264 – 2663Combined sources
Helixi285 – 29410Combined sources
Beta strandi307 – 3137Combined sources
Turni318 – 3203Combined sources
Helixi339 – 34810Combined sources
Helixi354 – 3563Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HC7X-ray2.65A/B260-370[»]
4HC9X-ray1.60A260-370[»]
4HCAX-ray2.80A260-370[»]
ProteinModelPortaliP23771.
SMRiP23771. Positions 261-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni288 – 31629Flexible linkerAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi344 – 35310YxKxHxxxRPBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi137 – 1426Poly-Ser
Compositional biasi322 – 3265Poly-Thr

Domaini

Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.
The YxKxHxxxRP motif is critical for DNA-binding and function.By similarity

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28725GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 34125GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiP23771.
KOiK17895.
OMAiQRYPPTH.
OrthoDBiEOG7CCBRF.
PhylomeDBiP23771.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029521. GATA-3.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P23771-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL
60 70 80 90 100
FNIDGQGNHV PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG
110 120 130 140 150
KALGSHHTAS PWNLSPFSKT SIHHGSPGPL SVYPPASSSS LSGGHASPHL
160 170 180 190 200
FTFPPTPPKD VSPDPSLSTP GSAGSARQDE KECLKYQVPL PDSMKLESSH
210 220 230 240 250
SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL GGSPTGFGCK
260 270 280 290 300
SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL
310 320 330 340 350
IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI
360 370 380 390 400
NRPLTMKKEG IQTRNRKMSS KSKKCKKVHD SLEDFPKNSS FNPAALSRHM
410 420 430 440
SSLSHISPFS HSSHMLTTPT PMHPPSSLSF GPHHPSSMVT AMG
Length:443
Mass (Da):47,916
Last modified:November 1, 1991 - v1
Checksum:iF24C58681E1D02A5
GO
Isoform 2 (identifier: P23771-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: T → TE

Show »
Length:444
Mass (Da):48,045
Checksum:i506051438132F1D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111V → L in AAA35870 (PubMed:1871134).Curated
Sequence conflicti102 – 1021A → V in CAA38877 (PubMed:1827068).Curated
Sequence conflicti173 – 1731A → G in CAA38877 (PubMed:1827068).Curated
Sequence conflicti219 – 2191I → Y in AAA35870 (PubMed:1871134).Curated
Sequence conflicti225 – 2262YV → TC in AAA35870 (PubMed:1871134).Curated
Sequence conflicti285 – 2862NA → RR in AAA35870 (PubMed:1871134).Curated
Sequence conflicti425 – 4251P → A in AAA35870 (PubMed:1871134).Curated
Sequence conflicti441 – 4411A → G in AAA35870 (PubMed:1871134).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421G → S.1 Publication
Corresponds to variant rs11567901 [ dbSNP | Ensembl ].
VAR_019202
Natural varianti274 – 2741W → R in HDR. 1 Publication
VAR_017818
Natural varianti366 – 3661R → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_033025

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei259 – 2591T → TE in isoform 2. 3 PublicationsVSP_001598

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58072 mRNA. Translation: CAA41102.1.
X55037 mRNA. Translation: CAA38877.1.
X55122 mRNA. Translation: CAA38916.1.
M69106 mRNA. Translation: AAA35870.1.
AY497006 Genomic DNA. Translation: AAR32096.1.
AL390294 Genomic DNA. Translation: CAH73143.1.
AL390294 Genomic DNA. Translation: CAH73144.1.
CH471072 Genomic DNA. Translation: EAW86367.1.
CH471072 Genomic DNA. Translation: EAW86368.1.
BC003070 mRNA. Translation: AAH03070.1.
BC006793 mRNA. Translation: AAH06793.1.
CCDSiCCDS31143.1. [P23771-2]
CCDS7083.1. [P23771-1]
PIRiA39794.
RefSeqiNP_001002295.1. NM_001002295.1. [P23771-2]
NP_002042.1. NM_002051.2. [P23771-1]
XP_005252499.1. XM_005252442.2. [P23771-2]
XP_005252500.1. XM_005252443.3. [P23771-2]
UniGeneiHs.524134.

Genome annotation databases

EnsembliENST00000346208; ENSP00000341619; ENSG00000107485. [P23771-1]
ENST00000379328; ENSP00000368632; ENSG00000107485. [P23771-2]
GeneIDi2625.
KEGGihsa:2625.
UCSCiuc001ijz.3. human. [P23771-2]
uc001ika.3. human. [P23771-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58072 mRNA. Translation: CAA41102.1.
X55037 mRNA. Translation: CAA38877.1.
X55122 mRNA. Translation: CAA38916.1.
M69106 mRNA. Translation: AAA35870.1.
AY497006 Genomic DNA. Translation: AAR32096.1.
AL390294 Genomic DNA. Translation: CAH73143.1.
AL390294 Genomic DNA. Translation: CAH73144.1.
CH471072 Genomic DNA. Translation: EAW86367.1.
CH471072 Genomic DNA. Translation: EAW86368.1.
BC003070 mRNA. Translation: AAH03070.1.
BC006793 mRNA. Translation: AAH06793.1.
CCDSiCCDS31143.1. [P23771-2]
CCDS7083.1. [P23771-1]
PIRiA39794.
RefSeqiNP_001002295.1. NM_001002295.1. [P23771-2]
NP_002042.1. NM_002051.2. [P23771-1]
XP_005252499.1. XM_005252442.2. [P23771-2]
XP_005252500.1. XM_005252443.3. [P23771-2]
UniGeneiHs.524134.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HC7X-ray2.65A/B260-370[»]
4HC9X-ray1.60A260-370[»]
4HCAX-ray2.80A260-370[»]
ProteinModelPortaliP23771.
SMRiP23771. Positions 261-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108895. 19 interactions.
DIPiDIP-61302N.
IntActiP23771. 11 interactions.
MINTiMINT-4721003.
STRINGi9606.ENSP00000368632.

PTM databases

PhosphoSiteiP23771.

Polymorphism and mutation databases

BioMutaiGATA3.
DMDMi120962.

Proteomic databases

MaxQBiP23771.
PaxDbiP23771.
PRIDEiP23771.

Protocols and materials databases

DNASUi2625.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346208; ENSP00000341619; ENSG00000107485. [P23771-1]
ENST00000379328; ENSP00000368632; ENSG00000107485. [P23771-2]
GeneIDi2625.
KEGGihsa:2625.
UCSCiuc001ijz.3. human. [P23771-2]
uc001ika.3. human. [P23771-1]

Organism-specific databases

CTDi2625.
GeneCardsiGC10P008095.
HGNCiHGNC:4172. GATA3.
HPAiCAB016217.
HPA029730.
HPA029731.
MIMi131320. gene.
146255. phenotype.
neXtProtiNX_P23771.
Orphaneti2237. Hypoparathyroidism - deafness - renal disease.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBiPA28586.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiP23771.
KOiK17895.
OMAiQRYPPTH.
OrthoDBiEOG7CCBRF.
PhylomeDBiP23771.
TreeFamiTF315391.

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP23771.

Miscellaneous databases

GeneWikiiGATA3.
GenomeRNAii2625.
NextBioi10339.
PROiP23771.
SOURCEiSearch...

Gene expression databases

BgeeiP23771.
CleanExiHS_GATA3.
GenevestigatoriP23771.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029521. GATA-3.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family."
    Joulin V., Bories D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei M.-G., Romeo P.-H.
    EMBO J. 10:1809-1816(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: T-cell.
  2. "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene."
    Ho I.-C., Vorhees P., Marin N., Oakley B.K., Tsai S.-F., Orkin S.H., Leiden J.M.
    EMBO J. 10:1187-1192(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: T-cell.
  3. "Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer."
    Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D.
    Mol. Cell. Biol. 11:2778-2784(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: T-cell.
  4. "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements."
    Marine J., Winoto A.
    Proc. Natl. Acad. Sci. U.S.A. 88:7284-7288(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. SeattleSNPs variation discovery resource
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-242.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cervix and Placenta.
  9. Cited for: INVOLVEMENT IN HDR.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity."
    Sasaki T., Onodera A., Hosokawa H., Watanabe Y., Horiuchi S., Yamashita J., Tanaka H., Ogawa Y., Suzuki Y., Nakayama T.
    PLoS ONE 8:E66468-E66468(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation."
    Chen Y., Bates D.L., Dey R., Chen P.H., Machado A.C., Laird-Offringa I.A., Rohs R., Chen L.
    Cell Rep. 2:1197-1206(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 260-370 IN COMPLEX WITH DNA, GATA-TYPE ZINC FINGERS.
  13. Cited for: VARIANT HDR ARG-274.
  14. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
    Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.
    Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-366.

Entry informationi

Entry nameiGATA3_HUMAN
AccessioniPrimary (citable) accession number: P23771
Secondary accession number(s): Q5VWG7, Q5VWG8, Q96J16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 29, 2015
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.