P23771 (GATA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trans-acting T-cell-specific transcription factor GATA-3

Alternative name(s):
GATA-binding factor 3

Gene names

Name:

GATA3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.
Subcellular location	Nucleus.
Tissue specificity	T-cells and endothelial cells.
Domain	Binds DNA via the 2 GATA-type zinc fingers By similarity.
Involvement in disease	Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) [MIM:146255]: A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.11
Sequence similarities	Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Deafness Disease mutation
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB T-helper 2 cell differentiation Inferred from electronic annotation. Source: Compara TOR signaling cascade Inferred from sequence or structural similarity. Source: UniProtKB aortic valve morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB axon guidance Inferred from electronic annotation. Source: Compara blood coagulation Traceable author statement. Source: Reactome canonical Wnt receptor signaling pathway involved in metanephric kidney development Inferred from sequence or structural similarity. Source: UniProtKB cardiac right ventricle morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB cell fate determination Inferred from sequence or structural similarity. Source: UniProtKB cell maturation Inferred from electronic annotation. Source: Compara cellular response to BMP stimulus Inferred from electronic annotation. Source: Compara cellular response to interferon-alpha Inferred from expression pattern PubMed 20554961. Source: UniProtKB cellular response to interleukin-4 Inferred from expression pattern PubMed 20554961. Source: UniProtKB cellular response to tumor necrosis factor Inferred from expression pattern PubMed 19674970. Source: UniProtKB defense response Traceable author statement PubMed 7592673. Source: ProtInc developmental growth Inferred from electronic annotation. Source: Compara ear development Inferred from mutant phenotype PubMed 19248180PubMed 19723756. Source: UniProtKB embryonic hemopoiesis Inferred from electronic annotation. Source: Compara erythrocyte differentiation Inferred from electronic annotation. Source: Compara humoral immune response Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara inner ear morphogenesis Inferred from electronic annotation. Source: Compara interferon-gamma secretion Inferred from electronic annotation. Source: Compara interleukin-4 secretion Inferred from electronic annotation. Source: Compara lens development in camera-type eye Inferred from electronic annotation. Source: Compara lymphocyte migration Inferred from direct assay PubMed 19805038. Source: UniProtKB male gonad development Inferred from sequence or structural similarity. Source: UniProtKB mast cell differentiation Inferred from electronic annotation. Source: Compara mesenchymal to epithelial transition Inferred from direct assay PubMed 20189993. Source: UniProtKB mesonephros development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell cycle Inferred from mutant phenotype PubMed 20189993. Source: UniProtKB negative regulation of cell motility Inferred from mutant phenotype PubMed 20189993. Source: UniProtKB negative regulation of cell proliferation involved in mesonephros development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of endothelial cell apoptotic process Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB negative regulation of fat cell differentiation Inferred from mutant phenotype PubMed 20705609. Source: UniProtKB negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of inflammatory response Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB negative regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-2 production Inferred from electronic annotation. Source: Compara negative regulation of mammary gland epithelial cell proliferation Inferred from direct assay PubMed 19483726. Source: UniProtKB nephric duct formation Inferred from sequence or structural similarity. Source: UniProtKB neuron migration Inferred from electronic annotation. Source: Compara norepinephrine biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB otic vesicle development Inferred from electronic annotation. Source: Compara parathyroid gland development Inferred from electronic annotation. Source: Compara parathyroid hormone secretion Inferred from electronic annotation. Source: Compara pharyngeal system development Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylinositol 3-kinase cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of T cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of endothelial cell migration Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB positive regulation of interleukin-13 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-13 secretion Inferred from direct assay PubMed 20554961. Source: UniProtKB positive regulation of interleukin-4 production Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of interleukin-5 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-5 secretion Inferred from direct assay PubMed 20554961. Source: UniProtKB positive regulation of protein kinase B signaling cascade Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB positive regulation of thyroid hormone generation Inferred from mutant phenotype PubMed 19248180PubMed 19723756. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 19232384PubMed 20189993PubMed 20484083. Source: UniProtKB positive regulation of transcription regulatory region DNA binding Inferred from mutant phenotype PubMed 20368097. Source: UniProtKB positive regulation of ureteric bud formation Inferred from sequence or structural similarity. Source: UniProtKB post-embryonic development Inferred from electronic annotation. Source: Compara pro-T cell differentiation Inferred from electronic annotation. Source: Compara regulation of CD4-positive, alpha-beta T cell differentiation Inferred from electronic annotation. Source: Compara regulation of cellular response to X-ray Inferred from mutant phenotype PubMed 19735555. Source: UniProtKB regulation of cytokine biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB regulation of establishment of cell polarity Inferred from electronic annotation. Source: Compara regulation of histone H3-K27 methylation Inferred from electronic annotation. Source: Compara regulation of histone H3-K4 methylation Inferred from electronic annotation. Source: Compara regulation of nephron tubule epithelial cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to estrogen stimulus Inferred from expression pattern PubMed 10037815. Source: UniProtKB response to ethanol Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from electronic annotation. Source: Compara response to virus Inferred from expression pattern PubMed 20583921. Source: UniProtKB sympathetic nervous system development Inferred from sequence or structural similarity. Source: UniProtKB thymic T cell selection Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara type IV hypersensitivity Inferred from electronic annotation. Source: Compara ureter maturation Inferred from electronic annotation. Source: Compara ureteric bud formation Inferred from sequence or structural similarity. Source: UniProtKB uterus development Inferred from sequence or structural similarity. Source: UniProtKB ventricular septum development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	nuclear chromatin Inferred from direct assay PubMed 20855495. Source: BHF-UCL nucleolus Inferred from direct assay. Source: HPA nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	E-box binding Inferred from direct assay PubMed 20855495. Source: BHF-UCL RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Inferred from mutant phenotype PubMed 19674970. Source: UniProtKB RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara RNA polymerase II core promoter sequence-specific DNA binding Inferred from electronic annotation. Source: Compara core promoter proximal region sequence-specific DNA binding Inferred from direct assay PubMed 19232384. Source: UniProtKB core promoter sequence-specific DNA binding Inferred from direct assay PubMed 19674970. Source: UniProtKB enhancer sequence-specific DNA binding Inferred from electronic annotation. Source: Compara transcription coactivator activity Inferred from direct assay PubMed 20484083. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P23771-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P23771-2)

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: T → TE

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 443

443

Trans-acting T-cell-specific transcription factor GATA-3

PRO_0000083408

Regions

Zinc finger

263 – 287

25

GATA-type 1

Zinc finger

317 – 341

25

GATA-type 2

Compositional bias

137 – 142

6

Poly-Ser

Compositional bias

322 – 326

5

Poly-Thr

Amino acid modifications

Modified residue

115

1

Phosphoserine Ref.10

Modified residue

162

1

Phosphoserine Ref.10

Natural variations

Alternative sequence

259

1

T → TE in isoform 2.

VSP_001598

Natural variant

242

1

G → S. Ref.5
Corresponds to variant rs11567901 [ dbSNP | Ensembl ].

VAR_019202

Natural variant

274

1

W → R in HDR. Ref.11

VAR_017818

Natural variant

366

1

R → L in a breast cancer sample; somatic mutation. Ref.12

VAR_033025

Experimental info

Sequence conflict

11

1

V → L in AAA35870. Ref.4

Sequence conflict

102

1

A → V in CAA38877. Ref.2

Sequence conflict

173

1

A → G in CAA38877. Ref.2

Sequence conflict

219

1

I → Y in AAA35870. Ref.4

Sequence conflict

225 – 226

2

YV → TC in AAA35870. Ref.4

Sequence conflict

285 – 286

2

NA → RR in AAA35870. Ref.4

Sequence conflict

425

1

P → A in AAA35870. Ref.4

Sequence conflict

441

1

A → G in AAA35870. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

443

Helix Strand Turn

Details...

Turn

264 – 266

3

Helix

285 – 294

10

Beta strand

307 – 313

7

Turn

318 – 320

3

Helix

339 – 348

10

Helix

354 – 356

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: F24C58681E1D02A5	FASTA	443	47,916
	10 20 30 40 50 60 MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL FNIDGQGNHV 70 80 90 100 110 120 PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALGSHHTAS PWNLSPFSKT 130 140 150 160 170 180 SIHHGSPGPL SVYPPASSSS LSGGHASPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE 190 200 210 220 230 240 KECLKYQVPL PDSMKLESSH SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL 250 260 270 280 290 300 GGSPTGFGCK SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL 310 320 330 340 350 360 IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG 370 380 390 400 410 420 IQTRNRKMSS KSKKCKKVHD SLEDFPKNSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT 430 440 PMHPPSSLSF GPHHPSSMVT AMG
	Isoform 2 [UniParc]. Checksum: 506051438132F1D0	FASTA	444	48,045
	10 20 30 40 50 60 MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL FNIDGQGNHV 70 80 90 100 110 120 PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALGSHHTAS PWNLSPFSKT 130 140 150 160 170 180 SIHHGSPGPL SVYPPASSSS LSGGHASPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE 190 200 210 220 230 240 KECLKYQVPL PDSMKLESSH SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL 250 260 270 280 290 300 GGSPTGFGCK SRPKARSSTE GRECVNCGAT STPLWRRDGT GHYLCNACGL YHKMNGQNRP 310 320 330 340 350 360 LIKPKRRLSA ARRAGTSCAN CQTTTTTLWR RNANGDPVCN ACGLYYKLHN INRPLTMKKE 370 380 390 400 410 420 GIQTRNRKMS SKSKKCKKVH DSLEDFPKNS SFNPAALSRH MSSLSHISPF SHSSHMLTTP 430 440 TPMHPPSSLS FGPHHPSSMV TAMG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A T-cell specific TCR delta DNA binding protein is a member of the human GATA family." Joulin V., Bories D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei M.-G., Romeo P.-H. EMBO J. 10:1809-1816(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: T-cell.
[2]	"Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene." Ho I.-C., Vorhees P., Marin N., Oakley B.K., Tsai S.-F., Orkin S.H., Leiden J.M. EMBO J. 10:1187-1192(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: T-cell.
[3]	"Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer." Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D. Mol. Cell. Biol. 11:2778-2784(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: T-cell.
[4]	"The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements." Marine J., Winoto A. Proc. Natl. Acad. Sci. U.S.A. 88:7284-7288(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[5]	SeattleSNPs variation discovery resource Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-242.
[6]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Cervix and Placenta.
[9]	"GATA3 haplo-insufficiency causes human HDR syndrome." Van Esch H., Groenen P., Nesbit M.A., Schuffenhauer S., Lichtner P., Vanderlinden G., Harding B., Beetz R., Bilous R.W., Holdaway I., Shaw N.J., Fryns J.-P., Van de Ven W., Thakker R.V., Devriendt K. Nature 406:419-422(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN HDR.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-162, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"GATA3 abnormalities and the phenotypic spectrum of HDR syndrome." Muroya K., Hasegawa T., Ito Y., Nagai T., Isotani H., Iwata Y., Yamamoto K., Fujimoto S., Seishu S., Fukushima Y., Hasegawa Y., Ogata T. J. Med. Genet. 38:374-380(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HDR ARG-274.
[12]	"Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas." Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L. Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LEU-366.
+	Additional computationally mapped references.

Web resources

GeneReviews

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X58072 mRNA. Translation: CAA41102.1.
X55037 mRNA. Translation: CAA38877.1.
X55122 mRNA. Translation: CAA38916.1.
M69106 mRNA. Translation: AAA35870.1.
AY497006 Genomic DNA. Translation: AAR32096.1.
AL390294 Genomic DNA. Translation: CAH73143.1.
AL390294 Genomic DNA. Translation: CAH73144.1.
CH471072 Genomic DNA. Translation: EAW86367.1.
CH471072 Genomic DNA. Translation: EAW86368.1.
BC003070 mRNA. Translation: AAH03070.1.
BC006793 mRNA. Translation: AAH06793.1.

IPI

IPI00012901.
IPI00216199.

PIR

A39794.

RefSeq

NP_001002295.1. NM_001002295.1.
NP_002042.1. NM_002051.2.

UniGene

Hs.524134.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4HC7	X-ray	2.65	A/B	260-370	[»]
4HC9	X-ray	1.60	A	260-370	[»]
4HCA	X-ray	2.80	A	260-370	[»]

ProteinModelPortal

P23771.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000368632.

PTM databases

PhosphoSite

P23771.

Polymorphism databases

DMDM

120962.

Proteomic databases

PaxDb

P23771.

PRIDE

P23771.

Protocols and materials databases

DNASU

2625.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000346208; ENSP00000341619; ENSG00000107485.
ENST00000379328; ENSP00000368632; ENSG00000107485.

GeneID

2625.

KEGG

hsa:2625.

UCSC

uc001ijz.3. human.
uc001ika.3. human.

Organism-specific databases

CTD

2625.

GeneCards

GC10P008095.

HGNC

HGNC:4172. GATA3.

HPA

HPA029730.
HPA029731.

MIM

131320. gene.
146255. phenotype.

neXtProt

NX_P23771.

Orphanet

2237. Hypoparathyroidism - deafness - renal disease.

PharmGKB

PA28586.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5641.

HOGENOM

HOG000047701.

HOVERGEN

HBG051705.

KO

K09182.

OMA

HHPSSMV.

Enzyme and pathway databases

Pathway_Interaction_DB

nfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes.
il27pathway. IL27-mediated signaling events.
smad2_3nuclearpathway. Regulation of nuclear SMAD2/3 signaling.

Reactome

REACT_604. Hemostasis.

Gene expression databases

Bgee

P23771.

CleanEx

HS_GATA3.

Genevestigator

P23771.

GermOnline

ENSG00000107485. Homo sapiens.

Family and domain databases

Gene3D

3.30.50.10. 2 hits.

InterPro

IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]

Pfam

PF00320. GATA. 2 hits.
[Graphical view]

PIRSF

PIRSF003027. TF_GATA-1/2/3. 1 hit.

PRINTS

PR00619. GATAZNFINGER.

SMART

SM00401. ZnF_GATA. 2 hits.
[Graphical view]

PROSITE

PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

2625.

NextBio

10339.

SOURCE

Search...

Entry information

Entry name

GATA3_HUMAN

Accession

Primary (citable) accession number: P23771
Secondary accession number(s): Q5VWG7, Q5VWG8, Q96J16

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	May 1, 2013
This is version 143 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.