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P23769 (GATA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelial transcription factor GATA-2
Alternative name(s):
GATA-binding protein 2
Gene names
Name:GATA2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Subunit structure

Interacts with BRD3 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Endothelial cells.

Involvement in disease

Dendritic cell monocyte lymphocyte B and natural killer lymphocyte deficiency (DCML) [MIM:614172]: An immunodeficiency disease characterized by profoundly decreased or absent monocytes, B lymphocytes, natural killer lymphocytes, and circulating and tissue dendritic cells, with little or no effect on T cell numbers. Clinical features of DCML include susceptibility to disseminated non-tuberculous mycobacterial infections, papillomavirus infections, opportunistic fungal infections, and pulmonary alveolar proteinosis. Bone marrow hypocellularity and dysplasia of myeloid, erythroid, and megakaryocytic lineages are present in most patients, as are karyotypic abnormalities, including monosomy 7 and trisomy 8. This syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Lymphedema, primary, with myelodysplasia (LMPM) [MIM:614038]: A chronic disabling condition characterized by swelling of the extremities due to altered lymphatic flow, associated with myelodysplasia. Patients with lymphedema suffer from recurrent local infections, and physical impairment.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9

Myelodysplastic syndrome (MDS) [MIM:614286]: A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS); chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. MDS is considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML).
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10

Sequence similarities

Contains 2 GATA-type zinc fingers.

Sequence caution

The sequence AAA35869.1 differs from that shown. Reason: Several sequencing errors.

Ontologies

Keywords
   Biological processPhagocytosis
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Traceable author statement. Source: Reactome

cell differentiation in hindbrain

Inferred from electronic annotation. Source: Ensembl

cell fate determination

Inferred from electronic annotation. Source: Ensembl

cell maturation

Inferred from electronic annotation. Source: Ensembl

central nervous system neuron development

Inferred from electronic annotation. Source: Ensembl

definitive hemopoiesis

Inferred from electronic annotation. Source: Ensembl

embryonic placenta development

Inferred from electronic annotation. Source: Ensembl

eosinophil fate commitment

Inferred from direct assay PubMed 12045236. Source: BHF-UCL

homeostasis of number of cells within a tissue

Inferred from electronic annotation. Source: Ensembl

inner ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of Notch signaling pathway

Inferred from direct assay PubMed 16672344. Source: MGI

negative regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 20705609. Source: UniProtKB

negative regulation of fat cell proliferation

Inferred from mutant phenotype PubMed 20705609. Source: UniProtKB

negative regulation of macrophage differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of neural precursor cell proliferation

Inferred from direct assay PubMed 16672344. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

neuron fate commitment

Inferred from electronic annotation. Source: Ensembl

phagocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

pituitary gland development

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from direct assay PubMed 19242469. Source: MGI

positive regulation of erythrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of megakaryocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of phagocytosis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 20206639. Source: UniProtKB

regulation of histone acetylation

Inferred from electronic annotation. Source: Ensembl

semicircular canal development

Inferred from electronic annotation. Source: Ensembl

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: GOC

urogenital system development

Inferred from electronic annotation. Source: Ensembl

ventral spinal cord interneuron differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleoplasm

Traceable author statement. Source: Reactome

protein complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

chromatin binding

Inferred from direct assay PubMed 19242469. Source: MGI

enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 19323994. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 20206639. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Lmo2P258013EBI-2806671,EBI-3903256From a different organism.
SMAD4Q134852EBI-2806671,EBI-347263

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P23769-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P23769-2)

The sequence of this isoform differs from the canonical sequence as follows:
     340-353: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Endothelial transcription factor GATA-2
PRO_0000083403

Regions

Zinc finger295 – 31925GATA-type 1
Zinc finger349 – 37325GATA-type 2

Natural variations

Alternative sequence340 – 35314Missing in isoform 2.
VSP_041126
Natural variant1641A → T. Ref.3 Ref.4 Ref.7
Corresponds to variant rs2335052 [ dbSNP | Ensembl ].
VAR_055004
Natural variant2351T → N.
Corresponds to variant rs35079193 [ dbSNP | Ensembl ].
VAR_055005
Natural variant2541P → L in DCML. Ref.8
VAR_066405
Natural variant3541T → M in DCML and MDS. Ref.8 Ref.10
VAR_066406
Natural variant3551Missing in MDS. Ref.10
VAR_066643
Natural variant3611R → P in LMPM. Ref.9
VAR_066644
Natural variant3731C → R in LMPM. Ref.9
VAR_066645
Natural variant3981R → W in DCML. Ref.8
VAR_066407

Experimental info

Sequence conflict91R → G in AAA35868. Ref.1
Sequence conflict20 – 212QH → HD in AAA35868. Ref.1
Sequence conflict38 – 392QL → HV in AAA35868. Ref.1
Sequence conflict691R → A in AAA35868. Ref.1
Sequence conflict821G → S in AAA35868. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: C879CC932C355E6A

FASTA48050,500
        10         20         30         40         50         60 
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY 

        70         80         90        100        110        120 
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHNPWTVSP 

       130        140        150        160        170        180 
FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE 

       190        200        210        220        230        240 
VSPDPSTTGA ASPASSSAGG SAARGEDKDG VKYQVSLTES MKMESGSPLR PGLATMGTQP 

       250        260        270        280        290        300 
ATHHPIPTYP SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 

       310        320        330        340        350        360 
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW 

       370        380        390        400        410        420 
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC 

       430        440        450        460        470        480 
MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG 

« Hide

Isoform 2 [UniParc].

Checksum: B074D2E927CE263B
Show »

FASTA46649,106

References

« Hide 'large scale' references
[1]"Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells."
Lee M.-E., Temizer D.T., Clifford J.A., Quertermous T.
J. Biol. Chem. 266:16188-16192(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells."
Dorfman D.M., Wilson D.B., Bruns G.A.P., Orkin S.H.
J. Biol. Chem. 267:1279-1285(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Endothelial cell.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-164.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-164.
Tissue: Placenta.
[5]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-164.
Tissue: Brain and Placenta.
[8]"Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome."
Hsu A.P., Sampaio E.P., Khan J., Calvo K.R., Lemieux J.E., Patel S.Y., Frucht D.M., Vinh D.C., Auth R.D., Freeman A.F., Olivier K.N., Uzel G., Zerbe C.S., Spalding C., Pittaluga S., Raffeld M., Kuhns D.B., Ding L. expand/collapse author list , Paulson M.L., Marciano B.E., Gea-Banacloche J.C., Orange J.S., Cuellar-Rodriguez J., Hickstein D.D., Holland S.M.
Blood 118:2653-2655(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS DCML LEU-254; MET-354 AND TRP-398.
[9]"Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)."
Ostergaard P., Simpson M.A., Connell F.C., Steward C.G., Brice G., Woollard W.J., Dafou D., Kilo T., Smithson S., Lunt P., Murday V.A., Hodgson S., Keenan R., Pilz D.T., Martinez-Corral I., Makinen T., Mortimer P.S., Jeffery S., Trembath R.C., Mansour S.
Nat. Genet. 43:929-931(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LMPM PRO-361 AND ARG-373.
[10]"Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia."
Hahn C.N., Chong C.E., Carmichael C.L., Wilkins E.J., Brautigan P.J., Li X.C., Babic M., Lin M., Carmagnac A., Lee Y.K., Kok C.H., Gagliardi L., Friend K.L., Ekert P.G., Butcher C.M., Brown A.L., Lewis I.D., To L.B. expand/collapse author list , Timms A.E., Storek J., Moore S., Altree M., Escher R., Bardy P.G., Suthers G.K., D'Andrea R.J., Horwitz M.S., Scott H.S.
Nat. Genet. 43:1012-1017(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS MDS MET-354 AND THR-355 DEL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M68891 mRNA. Translation: AAA35868.1.
M77810 mRNA. Translation: AAA35869.1. Sequence problems.
BT006671 mRNA. Translation: AAP35317.1.
AK314826 mRNA. Translation: BAG37347.1.
AC080005 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79313.1.
CH471052 Genomic DNA. Translation: EAW79314.1.
CH471052 Genomic DNA. Translation: EAW79315.1.
CH471052 Genomic DNA. Translation: EAW79316.1.
CH471052 Genomic DNA. Translation: EAW79317.1.
BC002557 mRNA. Translation: AAH02557.1.
BC015613 mRNA. Translation: AAH15613.1.
BC015577 mRNA. Translation: AAH15577.1.
BC018988 mRNA. Translation: AAH18988.1.
BC051272 mRNA. Translation: AAH51272.1.
BC051342 mRNA. Translation: AAH51342.1.
PIRA40815.
A41782.
RefSeqNP_001139133.1. NM_001145661.1.
NP_001139134.1. NM_001145662.1.
NP_116027.2. NM_032638.4.
XP_005247401.1. XM_005247344.1.
UniGeneHs.367725.

3D structure databases

ProteinModelPortalP23769.
SMRP23769. Positions 261-397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108894. 17 interactions.
DIPDIP-29711N.
IntActP23769. 5 interactions.
STRING9606.ENSP00000345681.

PTM databases

PhosphoSiteP23769.

Polymorphism databases

DMDM229462971.

Proteomic databases

PaxDbP23769.
PRIDEP23769.

Protocols and materials databases

DNASU2624.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341105; ENSP00000345681; ENSG00000179348. [P23769-1]
ENST00000430265; ENSP00000400259; ENSG00000179348. [P23769-2]
ENST00000487848; ENSP00000417074; ENSG00000179348. [P23769-1]
GeneID2624.
KEGGhsa:2624.
UCSCuc003ekm.3. human. [P23769-1]
uc003ekn.3. human. [P23769-2]

Organism-specific databases

CTD2624.
GeneCardsGC03M128198.
HGNCHGNC:4171. GATA2.
HPACAB024847.
HPA005633.
MIM137295. gene.
614038. phenotype.
614172. phenotype.
614286. phenotype.
neXtProtNX_P23769.
Orphanet519. Acute myeloid leukemia.
3226. Deafness - lymphedema - leukemia.
228423. Monocytopenia with susceptibility to infections.
52688. Myelodysplastic syndromes.
PharmGKBPA28585.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5641.
HOGENOMHOG000047701.
HOVERGENHBG051705.
InParanoidP23769.
KOK17894.
OMALAAMGTQ.
OrthoDBEOG7CCBRF.
TreeFamTF315391.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
SignaLinkP23769.

Gene expression databases

ArrayExpressP23769.
BgeeP23769.
CleanExHS_GATA2.
GenevestigatorP23769.

Family and domain databases

Gene3D3.30.50.10. 2 hits.
InterProIPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00320. GATA. 2 hits.
[Graphical view]
PIRSFPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSPR00619. GATAZNFINGER.
SMARTSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGATA2. human.
GeneWikiGATA2.
GenomeRNAi2624.
NextBio10335.
PROP23769.
SOURCESearch...

Entry information

Entry nameGATA2_HUMAN
AccessionPrimary (citable) accession number: P23769
Secondary accession number(s): D3DNB3 expand/collapse secondary AC list , Q53YE0, Q96BH0, Q96BH8, Q9BUJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 5, 2009
Last modified: March 19, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM