##gff-version 3 P23763 UniProtKB Chain 1 118 . . . ID=PRO_0000206719;Note=Vesicle-associated membrane protein 1 P23763 UniProtKB Topological domain 1 96 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23763 UniProtKB Transmembrane 97 116 . . . Note=Helical%3B Anchor for type IV membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23763 UniProtKB Topological domain 117 118 . . . Note=Vesicular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23763 UniProtKB Domain 33 93 . . . Note=V-SNARE coiled-coil homology;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00290 P23763 UniProtKB Region 1 36 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P23763 UniProtKB Site 60 61 . . . Note=(Microbial infection) Cleavage%3B by C.botulinum neurotoxin type F (BoNT/F%2C botF);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22289120;Dbxref=PMID:22289120 P23763 UniProtKB Site 61 62 . . . Note=(Microbial infection) Cleavage%3B by C.botulinum neurotoxin type D (BoNT/D%2C botD);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22289120;Dbxref=PMID:22289120 P23763 UniProtKB Site 68 69 . . . Note=(Microbial infection) Cleavage%3B by C.botulinum neurotoxin type X (BoNT/X);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29540745;Dbxref=PMID:29540745 P23763 UniProtKB Site 78 79 . . . Note=(Microbial infection) Cleavage%3B by C.botulinum neurotoxin type B (BoNT/B%2C botB);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:22289120;Dbxref=PMID:22289120 P23763 UniProtKB Modified residue 63 63 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62442 P23763 UniProtKB Alternative sequence 114 118 . . . ID=VSP_029185;Note=In isoform 2. IYFFT->SKYR;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 P23763 UniProtKB Alternative sequence 114 118 . . . ID=VSP_006325;Note=In isoform 3. IYFFT->RRD;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9658161,ECO:0000303|Ref.4;Dbxref=PMID:9658161 P23763 UniProtKB Natural variant 49 49 . . . ID=VAR_082265;Note=In CMS25%3B uncertain significance. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28253535;Dbxref=dbSNP:rs754046104,PMID:28253535 P23763 UniProtKB Mutagenesis 42 42 . . . Note=No change in susceptibility to C.botulinum BoNT/B%2C BoNT/D or BoNT/F. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22289120;Dbxref=PMID:22289120 P23763 UniProtKB Mutagenesis 48 48 . . . Note=1000-fold increase in susceptibility to C.botulinum BoNT/D%2C no change in susceptibility to BoNT/B or BoNT/F. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22289120;Dbxref=PMID:22289120 P23763 UniProtKB Mutagenesis 81 81 . . . Note=No change in susceptibility to C.botulinum BoNT/B%2C BoNT/D or BoNT/F. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22289120;Dbxref=PMID:22289120 P23763 UniProtKB Sequence conflict 103 103 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305