Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P23763

- VAMP1_HUMAN

UniProt

P23763 - VAMP1_HUMAN

Protein

Vesicle-associated membrane protein 1

Gene

VAMP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the targeting and/or fusion of transport vesicles to their target membrane.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. neurotransmitter secretion Source: Reactome
    2. synaptic transmission Source: Reactome
    3. vesicle-mediated transport Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_200617. Toxicity of botulinum toxin type D (BoNT/D).
    REACT_200659. Toxicity of botulinum toxin type F (BoNT/F).
    REACT_200743. Toxicity of botulinum toxin type G (BoNT/G).

    Protein family/group databases

    TCDBi1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicle-associated membrane protein 1
    Short name:
    VAMP-1
    Alternative name(s):
    Synaptobrevin-1
    Gene namesi
    Name:VAMP1
    Synonyms:SYB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:12642. VAMP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. endocytic vesicle membrane Source: Reactome
    3. integral component of plasma membrane Source: ProtInc
    4. mitochondrial outer membrane Source: UniProtKB-SubCell
    5. neuron projection Source: UniProtKB-SubCell
    6. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Mitochondrion, Mitochondrion outer membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti251282. Autosomal dominant spastic ataxia 1.
    PharmGKBiPA37266.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 118118Vesicle-associated membrane protein 1PRO_0000206719Add
    BLAST

    Proteomic databases

    PaxDbiP23763.
    PRIDEiP23763.

    PTM databases

    PhosphoSiteiP23763.

    Miscellaneous databases

    PMAP-CutDBP23763.

    Expressioni

    Tissue specificityi

    Nervous system, skeletal muscle and adipose tissue.

    Gene expression databases

    ArrayExpressiP23763.
    BgeeiP23763.
    CleanExiHS_VAMP1.
    GenevestigatoriP23763.

    Organism-specific databases

    HPAiCAB002779.
    CAB016119.

    Interactioni

    Subunit structurei

    Interacts with VAPA and VAPB.

    Protein-protein interaction databases

    BioGridi112710. 7 interactions.
    DIPiDIP-873N.
    STRINGi9606.ENSP00000380148.

    Structurei

    3D structure databases

    ProteinModelPortaliP23763.
    SMRiP23763. Positions 30-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9696CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini117 – 1182VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei97 – 11620Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 9361v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptobrevin family.Curated
    Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5143.
    HOVERGENiHBG006675.
    InParanoidiP23763.
    KOiK08510.
    OMAiWYLMSRR.
    OrthoDBiEOG7MSMRJ.
    PhylomeDBiP23763.
    TreeFamiTF313666.

    Family and domain databases

    InterProiIPR001388. Synaptobrevin.
    IPR016444. Synaptobrevin/VAMP_met/fun.
    [Graphical view]
    PfamiPF00957. Synaptobrevin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
    PRINTSiPR00219. SYNAPTOBREVN.
    PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
    PS50892. V_SNARE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P23763-1) [UniParc]FASTAAdd to Basket

    Also known as: VAMP-1A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV    50
    NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM 100
    LGAICAIIVV VIVIYFFT 118
    Length:118
    Mass (Da):12,902
    Last modified:November 1, 1991 - v1
    Checksum:i64CE9615447B686B
    GO
    Isoform 2 (identifier: P23763-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         114-118: IYFFT → SKYR

    Show »
    Length:117
    Mass (Da):12,765
    Checksum:iF3449D319B686B1A
    GO
    Isoform 3 (identifier: P23763-2) [UniParc]FASTAAdd to Basket

    Also known as: VAMP-1B

    The sequence of this isoform differs from the canonical sequence as follows:
         114-118: IYFFT → RRD

    Show »
    Length:116
    Mass (Da):12,658
    Checksum:i957A002B686B1AE6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031A → T in CAA88760. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei114 – 1185IYFFT → SKYR in isoform 2. 2 PublicationsVSP_029185
    Alternative sequencei114 – 1185IYFFT → RRD in isoform 3. 2 PublicationsVSP_006325

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36200
    , M36196, M36197, M36198, M36199 Genomic DNA. Translation: AAA60603.1.
    AF060538 mRNA. Translation: AAC28336.1.
    Z48924 mRNA. Translation: CAA88760.1.
    CR542214 mRNA. Translation: CAG47010.1.
    CR542231 mRNA. Translation: CAG47027.1.
    CR749485 mRNA. Translation: CAH18312.1.
    AC005840 Genomic DNA. No translation available.
    CH471116 Genomic DNA. Translation: EAW88792.1.
    CH471116 Genomic DNA. Translation: EAW88795.1.
    CH471116 Genomic DNA. Translation: EAW88796.1.
    BC023286 mRNA. Translation: AAH23286.1.
    CCDSiCCDS31731.1. [P23763-3]
    CCDS41740.1. [P23763-1]
    CCDS44809.1. [P23763-2]
    PIRiA38315.
    S52747.
    RefSeqiNP_055046.1. NM_014231.3. [P23763-1]
    NP_058439.1. NM_016830.2. [P23763-2]
    NP_954740.1. NM_199245.1. [P23763-3]
    UniGeneiHs.20021.

    Genome annotation databases

    EnsembliENST00000361716; ENSP00000355122; ENSG00000139190. [P23763-3]
    ENST00000396308; ENSP00000379602; ENSG00000139190. [P23763-1]
    ENST00000400911; ENSP00000383702; ENSG00000139190. [P23763-2]
    GeneIDi6843.
    KEGGihsa:6843.
    UCSCiuc001qoj.3. human. [P23763-2]
    uc001qok.3. human. [P23763-1]
    uc001qol.3. human. [P23763-3]

    Polymorphism databases

    DMDMi135093.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36200
    , M36196 , M36197 , M36198 , M36199 Genomic DNA. Translation: AAA60603.1 .
    AF060538 mRNA. Translation: AAC28336.1 .
    Z48924 mRNA. Translation: CAA88760.1 .
    CR542214 mRNA. Translation: CAG47010.1 .
    CR542231 mRNA. Translation: CAG47027.1 .
    CR749485 mRNA. Translation: CAH18312.1 .
    AC005840 Genomic DNA. No translation available.
    CH471116 Genomic DNA. Translation: EAW88792.1 .
    CH471116 Genomic DNA. Translation: EAW88795.1 .
    CH471116 Genomic DNA. Translation: EAW88796.1 .
    BC023286 mRNA. Translation: AAH23286.1 .
    CCDSi CCDS31731.1. [P23763-3 ]
    CCDS41740.1. [P23763-1 ]
    CCDS44809.1. [P23763-2 ]
    PIRi A38315.
    S52747.
    RefSeqi NP_055046.1. NM_014231.3. [P23763-1 ]
    NP_058439.1. NM_016830.2. [P23763-2 ]
    NP_954740.1. NM_199245.1. [P23763-3 ]
    UniGenei Hs.20021.

    3D structure databases

    ProteinModelPortali P23763.
    SMRi P23763. Positions 30-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112710. 7 interactions.
    DIPi DIP-873N.
    STRINGi 9606.ENSP00000380148.

    Chemistry

    DrugBanki DB00042. Botulinum Toxin Type B.

    Protein family/group databases

    TCDBi 1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

    PTM databases

    PhosphoSitei P23763.

    Polymorphism databases

    DMDMi 135093.

    Proteomic databases

    PaxDbi P23763.
    PRIDEi P23763.

    Protocols and materials databases

    DNASUi 6843.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361716 ; ENSP00000355122 ; ENSG00000139190 . [P23763-3 ]
    ENST00000396308 ; ENSP00000379602 ; ENSG00000139190 . [P23763-1 ]
    ENST00000400911 ; ENSP00000383702 ; ENSG00000139190 . [P23763-2 ]
    GeneIDi 6843.
    KEGGi hsa:6843.
    UCSCi uc001qoj.3. human. [P23763-2 ]
    uc001qok.3. human. [P23763-1 ]
    uc001qol.3. human. [P23763-3 ]

    Organism-specific databases

    CTDi 6843.
    GeneCardsi GC12M006571.
    HGNCi HGNC:12642. VAMP1.
    HPAi CAB002779.
    CAB016119.
    MIMi 185880. gene.
    neXtProti NX_P23763.
    Orphaneti 251282. Autosomal dominant spastic ataxia 1.
    PharmGKBi PA37266.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5143.
    HOVERGENi HBG006675.
    InParanoidi P23763.
    KOi K08510.
    OMAi WYLMSRR.
    OrthoDBi EOG7MSMRJ.
    PhylomeDBi P23763.
    TreeFami TF313666.

    Enzyme and pathway databases

    Reactomei REACT_200617. Toxicity of botulinum toxin type D (BoNT/D).
    REACT_200659. Toxicity of botulinum toxin type F (BoNT/F).
    REACT_200743. Toxicity of botulinum toxin type G (BoNT/G).

    Miscellaneous databases

    GeneWikii VAMP1.
    GenomeRNAii 6843.
    NextBioi 26711.
    PMAP-CutDB P23763.
    PROi P23763.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23763.
    Bgeei P23763.
    CleanExi HS_VAMP1.
    Genevestigatori P23763.

    Family and domain databases

    InterProi IPR001388. Synaptobrevin.
    IPR016444. Synaptobrevin/VAMP_met/fun.
    [Graphical view ]
    Pfami PF00957. Synaptobrevin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005409. Synaptobrevin_euk. 1 hit.
    PRINTSi PR00219. SYNAPTOBREVN.
    PROSITEi PS00417. SYNAPTOBREVIN. 1 hit.
    PS50892. V_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2."
      Archer B.T. III, Oezcelik T., Jahn R., Francke U., Suedhof T.C.
      J. Biol. Chem. 265:17267-17273(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    2. "A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal."
      Isenmann S., Khew-Goodall Y., Gamble J., Vadas M., Wattenberg B.W.
      Mol. Biol. Cell 9:1649-1660(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION.
      Tissue: Umbilical vein.
    3. Gough K.H., Verkuylen A., Cosgrove L., Frenkel M.J., Ward C.W.
      Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    6. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiVAMP1_HUMAN
    AccessioniPrimary (citable) accession number: P23763
    Secondary accession number(s): A8MVP3
    , D3DUR3, O75468, Q15857, Q6FG94, Q8IVC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3