ID   MRGRF_RAT               Reviewed;         343 AA.
AC   P23749;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   16-NOV-2011, entry version 86.
DE   RecName: Full=Mas-related G-protein coupled receptor member F;
DE            Short=Mas-related gene F protein;
DE   AltName: Full=G-protein coupled receptor RTA;
GN   Name=Mrgprf; Synonyms=Mrgf, Rta;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Aorta;
RX   MEDLINE=90222168; PubMed=2109324; DOI=10.1073/pnas.87.8.3052;
RA   Ross P.C., Figler R.A., Corjay M.H., Barber C.M., Adam N.,
RA   Harcus D.R., Lynch K.R.;
RT   "RTA, a candidate G protein-coupled receptor: cloning, sequencing, and
RT   tissue distribution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:3052-3056(1990).
CC   -!- FUNCTION: Orphan receptor. May bind to a neuropeptide and may
CC       regulate nociceptor function and/or development, including the
CC       sensation or modulation of pain (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Gut, vas deferens, uterus and aorta; barely
CC       detectable in liver, kidney, lung, and salivary gland. In the
CC       brain, markedly abundant in the cerebellum.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; M35297; AAA42087.1; -; mRNA.
DR   EMBL; M35298; AAA42088.1; -; Genomic_DNA.
DR   IPI; IPI00362222; -.
DR   PIR; A35639; A35639.
DR   RefSeq; NP_714944.1; NM_153722.2.
DR   UniGene; Rn.9848; -.
DR   ProteinModelPortal; P23749; -.
DR   GeneID; 266762; -.
DR   KEGG; rno:266762; -.
DR   UCSC; NM_153722; rat.
DR   CTD; 116535; -.
DR   RGD; 708478; Mrgprf.
DR   eggNOG; roNOG04968; -.
DR   GeneTree; ENSGT00550000074531; -.
DR   HOVERGEN; HBG102190; -.
DR   InParanoid; P23749; -.
DR   OrthoDB; EOG43BMPC; -.
DR   NextBio; 624612; -.
DR   ArrayExpress; P23749; -.
DR   Genevestigator; P23749; -.
DR   GermOnline; ENSRNOG00000013426; Rattus norvegicus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; TAS:RGD.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   KO; K08394; -.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    343       Mas-related G-protein coupled receptor
FT                                member F.
FT                                /FTId=PRO_0000069766.
FT   TOPO_DOM      1     44       Extracellular (Potential).
FT   TRANSMEM     45     66       Helical; Name=1; (Potential).
FT   TOPO_DOM     67     82       Cytoplasmic (Potential).
FT   TRANSMEM     83    104       Helical; Name=2; (Potential).
FT   TOPO_DOM    105    123       Extracellular (Potential).
FT   TRANSMEM    124    144       Helical; Name=3; (Potential).
FT   TOPO_DOM    145    160       Cytoplasmic (Potential).
FT   TRANSMEM    161    181       Helical; Name=4; (Potential).
FT   TOPO_DOM    182    198       Extracellular (Potential).
FT   TRANSMEM    199    220       Helical; Name=5; (Potential).
FT   TOPO_DOM    221    241       Cytoplasmic (Potential).
FT   TRANSMEM    242    263       Helical; Name=6; (Potential).
FT   TOPO_DOM    264    273       Extracellular (Potential).
FT   TRANSMEM    274    294       Helical; Name=7; (Potential).
FT   TOPO_DOM    295    343       Cytoplasmic (Potential).
FT   CARBOHYD      4      4       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   343 AA;  38364 MW;  E4630007770941F4 CRC64;
     MAGNCSWEAH STNQNKMCPG MSEALELYSR GFLTIEQIAT LPPPAVTNYI FLLLCLCGLV
     GNGLVLWFFG FSIKRTPFSI YFLHLASADG IYLFSKAVIA LLNMGTFLGS FPDYVRRVSR
     IVGLCTFFAG VSLLPAISIE RCVSVIFPMW YWRRRPKRLS AGVCALLWLL SFLVTSIHNY
     FCMFLGHEAS GTACLNMDIS LGILLFFLFC PLMVLPCLAL ILHVECRARR RQRSAKLNHV
     VLAIVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
     RLWEPLRVVF QRALRDGAEP GDAASSTPNT VTMEMQCPSG NAS
//