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Protein

Mas-related G-protein coupled receptor member F

Gene

Mrgprf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member F
Short name:
Mas-related gene F protein
Alternative name(s):
G-protein coupled receptor RTA
Gene namesi
Name:Mrgprf
Synonyms:Mrgf, Rta
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708478. Mrgprf.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence analysisAdd
BLAST
Transmembranei45 – 6622Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini67 – 8216CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 10422Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini105 – 12319ExtracellularSequence analysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini145 – 16016CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini182 – 19817ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 22022Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 24121CytoplasmicSequence analysisAdd
BLAST
Transmembranei242 – 26322Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini264 – 27310ExtracellularSequence analysis
Transmembranei274 – 29421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini295 – 34349CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Mas-related G-protein coupled receptor member FPRO_0000069766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP23749.

PTM databases

PhosphoSiteiP23749.

Expressioni

Tissue specificityi

Gut, vas deferens, uterus and aorta; barely detectable in liver, kidney, lung, and salivary gland. In the brain, markedly abundant in the cerebellum.

Structurei

3D structure databases

ProteinModelPortaliP23749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJRZ. Eukaryota.
ENOG4111BJC. LUCA.
HOGENOMiHOG000015412.
HOVERGENiHBG102190.
InParanoidiP23749.
KOiK08394.
PhylomeDBiP23749.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026228. MRGPCRF.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF3. PTHR11334:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02112. MRGPCRF.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNCSWEAH STNQNKMCPG MSEALELYSR GFLTIEQIAT LPPPAVTNYI
60 70 80 90 100
FLLLCLCGLV GNGLVLWFFG FSIKRTPFSI YFLHLASADG IYLFSKAVIA
110 120 130 140 150
LLNMGTFLGS FPDYVRRVSR IVGLCTFFAG VSLLPAISIE RCVSVIFPMW
160 170 180 190 200
YWRRRPKRLS AGVCALLWLL SFLVTSIHNY FCMFLGHEAS GTACLNMDIS
210 220 230 240 250
LGILLFFLFC PLMVLPCLAL ILHVECRARR RQRSAKLNHV VLAIVSVFLV
260 270 280 290 300
SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
310 320 330 340
RLWEPLRVVF QRALRDGAEP GDAASSTPNT VTMEMQCPSG NAS
Length:343
Mass (Da):38,364
Last modified:November 1, 1991 - v1
Checksum:iE4630007770941F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35297 mRNA. Translation: AAA42087.1.
M35298 Genomic DNA. Translation: AAA42088.1.
PIRiA35639.
RefSeqiNP_714944.1. NM_153722.2.
UniGeneiRn.9848.

Genome annotation databases

GeneIDi266762.
KEGGirno:266762.
UCSCiRGD:708478. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35297 mRNA. Translation: AAA42087.1.
M35298 Genomic DNA. Translation: AAA42088.1.
PIRiA35639.
RefSeqiNP_714944.1. NM_153722.2.
UniGeneiRn.9848.

3D structure databases

ProteinModelPortaliP23749.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP23749.

Proteomic databases

PaxDbiP23749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266762.
KEGGirno:266762.
UCSCiRGD:708478. rat.

Organism-specific databases

CTDi116535.
RGDi708478. Mrgprf.

Phylogenomic databases

eggNOGiENOG410IJRZ. Eukaryota.
ENOG4111BJC. LUCA.
HOGENOMiHOG000015412.
HOVERGENiHBG102190.
InParanoidiP23749.
KOiK08394.
PhylomeDBiP23749.

Miscellaneous databases

PROiP23749.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026228. MRGPCRF.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF3. PTHR11334:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02112. MRGPCRF.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution."
    Ross P.C., Figler R.A., Corjay M.H., Barber C.M., Adam N., Harcus D.R., Lynch K.R.
    Proc. Natl. Acad. Sci. U.S.A. 87:3052-3056(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Sprague-Dawley.
    Tissue: Aorta.

Entry informationi

Entry nameiMRGRF_RAT
AccessioniPrimary (citable) accession number: P23749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.