P23749 (MRGRF_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mas-related G-protein coupled receptor member F
Short name=Mas-related gene F protein

Alternative name(s):
G-protein coupled receptor RTA

Gene names

Name:	Mrgprf
Synonyms:	Mrgf, Rta

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Gut, vas deferens, uterus and aorta; barely detectable in liver, kidney, lung, and salivary gland. In the brain, markedly abundant in the cerebellum.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Traceable author statement. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Mas-related G-protein coupled receptor member F		PRO_0000069766
Regions
	Topological domain	1 – 44	44	Extracellular Potential
	Transmembrane	45 – 66	22	Helical; Name=1; Potential
	Topological domain	67 – 82	16	Cytoplasmic Potential
	Transmembrane	83 – 104	22	Helical; Name=2; Potential
	Topological domain	105 – 123	19	Extracellular Potential
	Transmembrane	124 – 144	21	Helical; Name=3; Potential
	Topological domain	145 – 160	16	Cytoplasmic Potential
	Transmembrane	161 – 181	21	Helical; Name=4; Potential
	Topological domain	182 – 198	17	Extracellular Potential
	Transmembrane	199 – 220	22	Helical; Name=5; Potential
	Topological domain	221 – 241	21	Cytoplasmic Potential
	Transmembrane	242 – 263	22	Helical; Name=6; Potential
	Topological domain	264 – 273	10	Extracellular Potential
	Transmembrane	274 – 294	21	Helical; Name=7; Potential
	Topological domain	295 – 343	49	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P23749 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: E4630007770941F4	FASTA	343	38,364
	10 20 30 40 50 60 MAGNCSWEAH STNQNKMCPG MSEALELYSR GFLTIEQIAT LPPPAVTNYI FLLLCLCGLV 70 80 90 100 110 120 GNGLVLWFFG FSIKRTPFSI YFLHLASADG IYLFSKAVIA LLNMGTFLGS FPDYVRRVSR 130 140 150 160 170 180 IVGLCTFFAG VSLLPAISIE RCVSVIFPMW YWRRRPKRLS AGVCALLWLL SFLVTSIHNY 190 200 210 220 230 240 FCMFLGHEAS GTACLNMDIS LGILLFFLFC PLMVLPCLAL ILHVECRARR RQRSAKLNHV 250 260 270 280 290 300 VLAIVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ 310 320 330 340 RLWEPLRVVF QRALRDGAEP GDAASSTPNT VTMEMQCPSG NAS

References

[1]	"RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution." Ross P.C., Figler R.A., Corjay M.H., Barber C.M., Adam N., Harcus D.R., Lynch K.R. Proc. Natl. Acad. Sci. U.S.A. 87:3052-3056(1990) [PubMed: 2109324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: Sprague-Dawley. Tissue: Aorta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M35297 mRNA. Translation: AAA42087.1. M35298 Genomic DNA. Translation: AAA42088.1.
IPI	IPI00362222.
PIR	A35639.
RefSeq	NP_714944.1. NM_153722.2.
UniGene	Rn.9848.
3D structure databases
ProteinModelPortal	P23749.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	266762.
KEGG	rno:266762.
UCSC	NM_153722. rat.
Organism-specific databases
CTD	116535.
RGD	708478. Mrgprf.
Phylogenomic databases
eggNOG	roNOG04968.
GeneTree	ENSGT00550000074531.
HOVERGEN	HBG102190.
InParanoid	P23749.
OrthoDB	EOG43BMPC.
Gene expression databases
ArrayExpress	P23749.
Genevestigator	P23749.
GermOnline	ENSRNOG00000013426. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K08394.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	624612.

Entry information

Entry name

MRGRF_RAT

Accession

Primary (citable) accession number: P23749

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	November 16, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program