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P23743

- DGKA_HUMAN

UniProt

P23743 - DGKA_HUMAN

Protein

Diacylglycerol kinase alpha

Gene

DGKA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 3 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Enzyme regulationi

    Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi123 – 134121CuratedAdd
    BLAST
    Calcium bindingi168 – 179122CuratedAdd
    BLAST
    Zinc fingeri205 – 25349Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri269 – 31951Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. diacylglycerol kinase activity Source: ProtInc
    4. NAD+ kinase activity Source: InterPro
    5. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. intracellular signal transduction Source: ProtInc
    3. platelet activation Source: Reactome
    4. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_2202. Effects of PIP2 hydrolysis.
    SABIO-RKP23743.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase alpha (EC:2.7.1.107)
    Short name:
    DAG kinase alpha
    Alternative name(s):
    80 kDa diacylglycerol kinase
    Diglyceride kinase alpha
    Short name:
    DGK-alpha
    Gene namesi
    Name:DGKA
    Synonyms:DAGK, DAGK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:2849. DGKA.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27310.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 735735Diacylglycerol kinase alphaPRO_0000218453Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei484 – 4841N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP23743.
    PaxDbiP23743.
    PRIDEiP23743.

    PTM databases

    PhosphoSiteiP23743.

    Expressioni

    Tissue specificityi

    Lymphocytes and oligodendroglial cells.

    Gene expression databases

    ArrayExpressiP23743.
    BgeeiP23743.
    CleanExiHS_DGKA.
    GenevestigatoriP23743.

    Organism-specific databases

    HPAiHPA041645.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi107976. 5 interactions.
    IntActiP23743. 4 interactions.
    MINTiMINT-8020268.
    STRINGi9606.ENSP00000328405.

    Structurei

    Secondary structure

    1
    735
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 2213
    Helixi27 – 359
    Helixi38 – 425
    Helixi50 – 6011
    Helixi68 – 7710
    Helixi96 – 10712

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1TUZNMR-A1-116[»]
    ProteinModelPortaliP23743.
    SMRiP23743. Positions 1-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP23743.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini110 – 14536EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini155 – 19036EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini372 – 506135DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri205 – 25349Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri269 – 31951Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG47311.
    HOVERGENiHBG051345.
    InParanoidiP23743.
    KOiK00901.
    OMAiLVGLHCV.
    OrthoDBiEOG75XGK8.
    PhylomeDBiP23743.
    TreeFamiTF313104.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.238.110. 1 hit.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR029477. DAG_kinase_typeI_N.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF14513. DAG_kinase_N. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF13405. EF-hand_6. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    PROSITEiPS50146. DAGK. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P23743-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKERGLISP SDFAQLQKYM EYSTKKVSDV LKLFEDGEMA KYVQGDAIGY    50
    EGFQQFLKIY LEVDNVPRHL SLALFQSFET GHCLNETNVT KDVVCLNDVS 100
    CYFSLLEGGR PEDKLEFTFK LYDTDRNGIL DSSEVDKIIL QMMRVAEYLD 150
    WDVSELRPIL QEMMKEIDYD GSGSVSQAEW VRAGATTVPL LVLLGLEMTL 200
    KDDGQHMWRP KRFPRPVYCN LCESSIGLGK QGLSCNLCKY TVHDQCAMKA 250
    LPCEVSTYAK SRKDIGVQSH VWVRGGCESG RCDRCQKKIR IYHSLTGLHC 300
    VWCHLEIHDD CLQAVGHECD CGLLRDHILP PSSIYPSVLA SGPDRKNSKT 350
    SQKTMDDLNL STSEALRIDP VPNTHPLLVF VNPKSGGKQG QRVLWKFQYI 400
    LNPRQVFNLL KDGPEIGLRL FKDVPDSRIL VCGGDGTVGW ILETIDKANL 450
    PVLPPVAVLP LGTGNDLARC LRWGGGYEGQ NLAKILKDLE MSKVVHMDRW 500
    SVEVIPQQTE EKSDPVPFQI INNYFSIGVD ASIAHRFHIM REKYPEKFNS 550
    RMKNKLWYFE FATSESIFST CKKLEESLTV EICGKPLDLS NLSLEGIAVL 600
    NIPSMHGGSN LWGDTRRPHG DIYGINQALG ATAKVITDPD ILKTCVPDLS 650
    DKRLEVVGLE GAIEMGQIYT KLKNAGRRLA KCSEITFHTT KTLPMQIDGE 700
    PWMQTPCTIK ITHKNQMPML MGPPPRSTNF FGFLS 735
    Length:735
    Mass (Da):82,630
    Last modified:December 15, 2009 - v3
    Checksum:iACAA0AD186EE64A0
    GO
    Isoform 2 (identifier: P23743-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         117-118: FT → WS
         119-735: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:118
    Mass (Da):13,486
    Checksum:iDC47336F5D8B584F
    GO
    Isoform 3 (identifier: P23743-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         237-247: LCKYTVHDQCA → RPITCVGARRL
         248-735: Missing.

    Show »
    Length:247
    Mass (Da):28,094
    Checksum:i8B502053A1906FB4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti339 – 3391L → P in AAC34804. 1 PublicationCurated
    Sequence conflicti379 – 3791V → L in AAC34802. 1 PublicationCurated
    Sequence conflicti385 – 3851S → W in AAC34802. 1 PublicationCurated
    Sequence conflicti684 – 6841E → G in AAC34803. 1 PublicationCurated
    Sequence conflicti699 – 6991G → V in CAA44396. (PubMed:2175712)Curated
    Sequence conflicti715 – 7151N → K in AAC34803. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti538 – 5381H → Y.1 Publication
    Corresponds to variant rs17852990 [ dbSNP | Ensembl ].
    VAR_031563

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei117 – 1182FT → WS in isoform 2. 1 PublicationVSP_032212
    Alternative sequencei119 – 735617Missing in isoform 2. 1 PublicationVSP_032213Add
    BLAST
    Alternative sequencei237 – 24711LCKYTVHDQCA → RPITCVGARRL in isoform 3. 1 PublicationVSP_047702Add
    BLAST
    Alternative sequencei248 – 735488Missing in isoform 3. 1 PublicationVSP_047703Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62535 mRNA. Translation: CAA44396.1.
    AF064767 mRNA. Translation: AAC34802.1.
    AF064768 mRNA. Translation: AAC34803.1.
    AF064769 mRNA. Translation: AAC34804.1.
    AF064771 mRNA. Translation: AAC34806.1.
    AY930112 mRNA. Translation: AAY20994.1.
    AC025162 Genomic DNA. No translation available.
    BC023523 mRNA. Translation: AAH23523.1.
    BC031870 mRNA. Translation: AAH31870.1.
    CCDSiCCDS8896.1. [P23743-1]
    PIRiS12969.
    RefSeqiNP_001336.2. NM_001345.4. [P23743-1]
    NP_958852.1. NM_201444.2. [P23743-1]
    NP_958853.1. NM_201445.1. [P23743-1]
    NP_963848.1. NM_201554.1. [P23743-1]
    UniGeneiHs.524488.

    Genome annotation databases

    EnsembliENST00000331886; ENSP00000328405; ENSG00000065357. [P23743-1]
    ENST00000394147; ENSP00000377703; ENSG00000065357. [P23743-1]
    ENST00000402956; ENSP00000385792; ENSG00000065357. [P23743-3]
    ENST00000548549; ENSP00000448565; ENSG00000065357. [P23743-2]
    ENST00000551156; ENSP00000450359; ENSG00000065357. [P23743-1]
    ENST00000553084; ENSP00000446605; ENSG00000065357. [P23743-2]
    GeneIDi1606.
    KEGGihsa:1606.
    UCSCiuc001sih.1. human. [P23743-1]

    Polymorphism databases

    DMDMi281185505.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62535 mRNA. Translation: CAA44396.1 .
    AF064767 mRNA. Translation: AAC34802.1 .
    AF064768 mRNA. Translation: AAC34803.1 .
    AF064769 mRNA. Translation: AAC34804.1 .
    AF064771 mRNA. Translation: AAC34806.1 .
    AY930112 mRNA. Translation: AAY20994.1 .
    AC025162 Genomic DNA. No translation available.
    BC023523 mRNA. Translation: AAH23523.1 .
    BC031870 mRNA. Translation: AAH31870.1 .
    CCDSi CCDS8896.1. [P23743-1 ]
    PIRi S12969.
    RefSeqi NP_001336.2. NM_001345.4. [P23743-1 ]
    NP_958852.1. NM_201444.2. [P23743-1 ]
    NP_958853.1. NM_201445.1. [P23743-1 ]
    NP_963848.1. NM_201554.1. [P23743-1 ]
    UniGenei Hs.524488.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1TUZ NMR - A 1-116 [» ]
    ProteinModelPortali P23743.
    SMRi P23743. Positions 1-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107976. 5 interactions.
    IntActi P23743. 4 interactions.
    MINTi MINT-8020268.
    STRINGi 9606.ENSP00000328405.

    Chemistry

    DrugBanki DB00163. Vitamin E.

    PTM databases

    PhosphoSitei P23743.

    Polymorphism databases

    DMDMi 281185505.

    Proteomic databases

    MaxQBi P23743.
    PaxDbi P23743.
    PRIDEi P23743.

    Protocols and materials databases

    DNASUi 1606.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331886 ; ENSP00000328405 ; ENSG00000065357 . [P23743-1 ]
    ENST00000394147 ; ENSP00000377703 ; ENSG00000065357 . [P23743-1 ]
    ENST00000402956 ; ENSP00000385792 ; ENSG00000065357 . [P23743-3 ]
    ENST00000548549 ; ENSP00000448565 ; ENSG00000065357 . [P23743-2 ]
    ENST00000551156 ; ENSP00000450359 ; ENSG00000065357 . [P23743-1 ]
    ENST00000553084 ; ENSP00000446605 ; ENSG00000065357 . [P23743-2 ]
    GeneIDi 1606.
    KEGGi hsa:1606.
    UCSCi uc001sih.1. human. [P23743-1 ]

    Organism-specific databases

    CTDi 1606.
    GeneCardsi GC12P056324.
    HGNCi HGNC:2849. DGKA.
    HPAi HPA041645.
    MIMi 125855. gene.
    neXtProti NX_P23743.
    PharmGKBi PA27310.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47311.
    HOVERGENi HBG051345.
    InParanoidi P23743.
    KOi K00901.
    OMAi LVGLHCV.
    OrthoDBi EOG75XGK8.
    PhylomeDBi P23743.
    TreeFami TF313104.

    Enzyme and pathway databases

    Reactomei REACT_2202. Effects of PIP2 hydrolysis.
    SABIO-RK P23743.

    Miscellaneous databases

    ChiTaRSi DGKA. human.
    EvolutionaryTracei P23743.
    GeneWikii DGKA.
    GenomeRNAii 1606.
    NextBioi 6590.
    PROi P23743.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23743.
    Bgeei P23743.
    CleanExi HS_DGKA.
    Genevestigatori P23743.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.238.110. 1 hit.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR029477. DAG_kinase_typeI_N.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF14513. DAG_kinase_N. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF13405. EF-hand_6. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    PROSITEi PS50146. DAGK. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lymphocyte.
    2. "Alternative splicing of diacylglycerol kinase alpha expressed in human neutrophils."
      Champagne C.M.E., Maeda H., Takashiba S., van Dyke T.E.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING.
      Tissue: Uterus.
    3. "Characterization of a novel DGK alpha transcript generated by alternative splicing."
      Batista E.L. Jr., Van Dyke T.E.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-538.
      Tissue: Brain.
    6. "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12."
      Hart T.C., Champagne C., Zhou J., van Dyke T.E.
      Mamm. Genome 5:123-124(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL LOCATION.
    7. "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis."
      Hart T.C., Zhou J., Champagne C., van Dyke T.E., Rao P.N., Pettenati M.J.
      Genomics 22:246-247(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL LOCATION.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-484, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "NMR structure of diacylglycerol kinase alpha, NESGC target HR532."
      Northeast structural genomics consortium (NESG)
      Submitted (JAN-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1-118.

    Entry informationi

    Entry nameiDGKA_HUMAN
    AccessioniPrimary (citable) accession number: P23743
    Secondary accession number(s): O75481
    , O75482, O75483, O95217, Q3ZE25, Q8IZ56, Q8N5Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 156 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3