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P23743

- DGKA_HUMAN

UniProt

P23743 - DGKA_HUMAN

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Protein

Diacylglycerol kinase alpha

Gene

DGKA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Enzyme regulationi

Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi123 – 134121CuratedAdd
BLAST
Calcium bindingi168 – 179122CuratedAdd
BLAST
Zinc fingeri205 – 25349Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 31951Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. diacylglycerol kinase activity Source: ProtInc
  4. NAD+ kinase activity Source: InterPro
  5. phospholipid binding Source: Ensembl

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. intracellular signal transduction Source: ProtInc
  3. platelet activation Source: Reactome
  4. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_2202. Effects of PIP2 hydrolysis.
SABIO-RKP23743.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase alpha (EC:2.7.1.107)
Short name:
DAG kinase alpha
Alternative name(s):
80 kDa diacylglycerol kinase
Diglyceride kinase alpha
Short name:
DGK-alpha
Gene namesi
Name:DGKA
Synonyms:DAGK, DAGK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:2849. DGKA.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Diacylglycerol kinase alphaPRO_0000218453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei484 – 4841N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP23743.
PaxDbiP23743.
PRIDEiP23743.

PTM databases

PhosphoSiteiP23743.

Expressioni

Tissue specificityi

Lymphocytes and oligodendroglial cells.

Gene expression databases

BgeeiP23743.
CleanExiHS_DGKA.
ExpressionAtlasiP23743. baseline and differential.
GenevestigatoriP23743.

Organism-specific databases

HPAiHPA041645.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi107976. 5 interactions.
IntActiP23743. 4 interactions.
MINTiMINT-8020268.
STRINGi9606.ENSP00000328405.

Structurei

Secondary structure

1
735
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2213Combined sources
Helixi27 – 359Combined sources
Helixi38 – 425Combined sources
Helixi50 – 6011Combined sources
Helixi68 – 7710Combined sources
Helixi96 – 10712Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TUZNMR-A1-116[»]
ProteinModelPortaliP23743.
SMRiP23743. Positions 1-198.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23743.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 14536EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini155 – 19036EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini372 – 506135DAGKcPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri205 – 25349Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 31951Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00760000119050.
HOVERGENiHBG051345.
InParanoidiP23743.
KOiK00901.
OMAiLVGLHCV.
OrthoDBiEOG75XGK8.
PhylomeDBiP23743.
TreeFamiTF313104.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.238.110. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF14513. DAG_kinase_N. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P23743-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKERGLISP SDFAQLQKYM EYSTKKVSDV LKLFEDGEMA KYVQGDAIGY
60 70 80 90 100
EGFQQFLKIY LEVDNVPRHL SLALFQSFET GHCLNETNVT KDVVCLNDVS
110 120 130 140 150
CYFSLLEGGR PEDKLEFTFK LYDTDRNGIL DSSEVDKIIL QMMRVAEYLD
160 170 180 190 200
WDVSELRPIL QEMMKEIDYD GSGSVSQAEW VRAGATTVPL LVLLGLEMTL
210 220 230 240 250
KDDGQHMWRP KRFPRPVYCN LCESSIGLGK QGLSCNLCKY TVHDQCAMKA
260 270 280 290 300
LPCEVSTYAK SRKDIGVQSH VWVRGGCESG RCDRCQKKIR IYHSLTGLHC
310 320 330 340 350
VWCHLEIHDD CLQAVGHECD CGLLRDHILP PSSIYPSVLA SGPDRKNSKT
360 370 380 390 400
SQKTMDDLNL STSEALRIDP VPNTHPLLVF VNPKSGGKQG QRVLWKFQYI
410 420 430 440 450
LNPRQVFNLL KDGPEIGLRL FKDVPDSRIL VCGGDGTVGW ILETIDKANL
460 470 480 490 500
PVLPPVAVLP LGTGNDLARC LRWGGGYEGQ NLAKILKDLE MSKVVHMDRW
510 520 530 540 550
SVEVIPQQTE EKSDPVPFQI INNYFSIGVD ASIAHRFHIM REKYPEKFNS
560 570 580 590 600
RMKNKLWYFE FATSESIFST CKKLEESLTV EICGKPLDLS NLSLEGIAVL
610 620 630 640 650
NIPSMHGGSN LWGDTRRPHG DIYGINQALG ATAKVITDPD ILKTCVPDLS
660 670 680 690 700
DKRLEVVGLE GAIEMGQIYT KLKNAGRRLA KCSEITFHTT KTLPMQIDGE
710 720 730
PWMQTPCTIK ITHKNQMPML MGPPPRSTNF FGFLS
Length:735
Mass (Da):82,630
Last modified:December 15, 2009 - v3
Checksum:iACAA0AD186EE64A0
GO
Isoform 2 (identifier: P23743-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-118: FT → WS
     119-735: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:118
Mass (Da):13,486
Checksum:iDC47336F5D8B584F
GO
Isoform 3 (identifier: P23743-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-247: LCKYTVHDQCA → RPITCVGARRL
     248-735: Missing.

Show »
Length:247
Mass (Da):28,094
Checksum:i8B502053A1906FB4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti339 – 3391L → P in AAC34804. 1 PublicationCurated
Sequence conflicti379 – 3791V → L in AAC34802. 1 PublicationCurated
Sequence conflicti385 – 3851S → W in AAC34802. 1 PublicationCurated
Sequence conflicti684 – 6841E → G in AAC34803. 1 PublicationCurated
Sequence conflicti699 – 6991G → V in CAA44396. (PubMed:2175712)Curated
Sequence conflicti715 – 7151N → K in AAC34803. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti538 – 5381H → Y.1 Publication
Corresponds to variant rs17852990 [ dbSNP | Ensembl ].
VAR_031563

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 1182FT → WS in isoform 2. 1 PublicationVSP_032212
Alternative sequencei119 – 735617Missing in isoform 2. 1 PublicationVSP_032213Add
BLAST
Alternative sequencei237 – 24711LCKYTVHDQCA → RPITCVGARRL in isoform 3. 1 PublicationVSP_047702Add
BLAST
Alternative sequencei248 – 735488Missing in isoform 3. 1 PublicationVSP_047703Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62535 mRNA. Translation: CAA44396.1.
AF064767 mRNA. Translation: AAC34802.1.
AF064768 mRNA. Translation: AAC34803.1.
AF064769 mRNA. Translation: AAC34804.1.
AF064771 mRNA. Translation: AAC34806.1.
AY930112 mRNA. Translation: AAY20994.1.
AC025162 Genomic DNA. No translation available.
BC023523 mRNA. Translation: AAH23523.1.
BC031870 mRNA. Translation: AAH31870.1.
CCDSiCCDS8896.1. [P23743-1]
PIRiS12969.
RefSeqiNP_001336.2. NM_001345.4. [P23743-1]
NP_958852.1. NM_201444.2. [P23743-1]
NP_958853.1. NM_201445.1. [P23743-1]
NP_963848.1. NM_201554.1. [P23743-1]
UniGeneiHs.524488.

Genome annotation databases

EnsembliENST00000331886; ENSP00000328405; ENSG00000065357. [P23743-1]
ENST00000394147; ENSP00000377703; ENSG00000065357. [P23743-1]
ENST00000402956; ENSP00000385792; ENSG00000065357. [P23743-3]
ENST00000548549; ENSP00000448565; ENSG00000065357. [P23743-2]
ENST00000551156; ENSP00000450359; ENSG00000065357. [P23743-1]
ENST00000553084; ENSP00000446605; ENSG00000065357. [P23743-2]
GeneIDi1606.
KEGGihsa:1606.
UCSCiuc001sih.1. human. [P23743-1]
uc009zoe.1. human.

Polymorphism databases

DMDMi281185505.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62535 mRNA. Translation: CAA44396.1 .
AF064767 mRNA. Translation: AAC34802.1 .
AF064768 mRNA. Translation: AAC34803.1 .
AF064769 mRNA. Translation: AAC34804.1 .
AF064771 mRNA. Translation: AAC34806.1 .
AY930112 mRNA. Translation: AAY20994.1 .
AC025162 Genomic DNA. No translation available.
BC023523 mRNA. Translation: AAH23523.1 .
BC031870 mRNA. Translation: AAH31870.1 .
CCDSi CCDS8896.1. [P23743-1 ]
PIRi S12969.
RefSeqi NP_001336.2. NM_001345.4. [P23743-1 ]
NP_958852.1. NM_201444.2. [P23743-1 ]
NP_958853.1. NM_201445.1. [P23743-1 ]
NP_963848.1. NM_201554.1. [P23743-1 ]
UniGenei Hs.524488.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1TUZ NMR - A 1-116 [» ]
ProteinModelPortali P23743.
SMRi P23743. Positions 1-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107976. 5 interactions.
IntActi P23743. 4 interactions.
MINTi MINT-8020268.
STRINGi 9606.ENSP00000328405.

Chemistry

DrugBanki DB00163. Vitamin E.

PTM databases

PhosphoSitei P23743.

Polymorphism databases

DMDMi 281185505.

Proteomic databases

MaxQBi P23743.
PaxDbi P23743.
PRIDEi P23743.

Protocols and materials databases

DNASUi 1606.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331886 ; ENSP00000328405 ; ENSG00000065357 . [P23743-1 ]
ENST00000394147 ; ENSP00000377703 ; ENSG00000065357 . [P23743-1 ]
ENST00000402956 ; ENSP00000385792 ; ENSG00000065357 . [P23743-3 ]
ENST00000548549 ; ENSP00000448565 ; ENSG00000065357 . [P23743-2 ]
ENST00000551156 ; ENSP00000450359 ; ENSG00000065357 . [P23743-1 ]
ENST00000553084 ; ENSP00000446605 ; ENSG00000065357 . [P23743-2 ]
GeneIDi 1606.
KEGGi hsa:1606.
UCSCi uc001sih.1. human. [P23743-1 ]
uc009zoe.1. human.

Organism-specific databases

CTDi 1606.
GeneCardsi GC12P056324.
HGNCi HGNC:2849. DGKA.
HPAi HPA041645.
MIMi 125855. gene.
neXtProti NX_P23743.
PharmGKBi PA27310.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47311.
GeneTreei ENSGT00760000119050.
HOVERGENi HBG051345.
InParanoidi P23743.
KOi K00901.
OMAi LVGLHCV.
OrthoDBi EOG75XGK8.
PhylomeDBi P23743.
TreeFami TF313104.

Enzyme and pathway databases

Reactomei REACT_2202. Effects of PIP2 hydrolysis.
SABIO-RK P23743.

Miscellaneous databases

ChiTaRSi DGKA. human.
EvolutionaryTracei P23743.
GeneWikii DGKA.
GenomeRNAii 1606.
NextBioi 6590.
PROi P23743.
SOURCEi Search...

Gene expression databases

Bgeei P23743.
CleanExi HS_DGKA.
ExpressionAtlasi P23743. baseline and differential.
Genevestigatori P23743.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.238.110. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF14513. DAG_kinase_N. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13405. EF-hand_6. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
PROSITEi PS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphocyte.
  2. "Alternative splicing of diacylglycerol kinase alpha expressed in human neutrophils."
    Champagne C.M.E., Maeda H., Takashiba S., van Dyke T.E.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING.
    Tissue: Uterus.
  3. "Characterization of a novel DGK alpha transcript generated by alternative splicing."
    Batista E.L. Jr., Van Dyke T.E.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-538.
    Tissue: Brain.
  6. "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12."
    Hart T.C., Champagne C., Zhou J., van Dyke T.E.
    Mamm. Genome 5:123-124(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL LOCATION.
  7. "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis."
    Hart T.C., Zhou J., Champagne C., van Dyke T.E., Rao P.N., Pettenati M.J.
    Genomics 22:246-247(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL LOCATION.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-484, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "NMR structure of diacylglycerol kinase alpha, NESGC target HR532."
    Northeast structural genomics consortium (NESG)
    Submitted (JAN-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-118.

Entry informationi

Entry nameiDGKA_HUMAN
AccessioniPrimary (citable) accession number: P23743
Secondary accession number(s): O75481
, O75482, O75483, O95217, Q3ZE25, Q8IZ56, Q8N5Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: December 15, 2009
Last modified: November 26, 2014
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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