P23741 (HBB_LATCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemoglobin subunit beta

Alternative name(s):
Beta-globin
Hemoglobin beta chain

Gene names

Name:

HBB

Organism

Latimeria chalumnae (West Indian ocean coelacanth) [Reference proteome]

Taxonomic identifier

7897 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Coelacanthimorpha › Coelacanthiformes › Coelacanthidae › Latimeria

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in oxygen transport from the lung to the various peripheral tissues.
Subunit structure	Heterotetramer of two alpha chains and two beta chains (an easy dimerization is also reported).
Tissue specificity	Red blood cells.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Hemoglobin subunit beta		PRO_0000052985
Sites
	Metal binding	63	1	Iron (heme distal ligand) By similarity
	Metal binding	92	1	Iron (heme proximal ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23741 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: E61EA7DBB67EFC52	FASTA	146	16,872
	10 20 30 40 50 60 VHWTETERAT IETVYQKLHL DEVGREALTR LFIVYPWTTR YFKSFGDLSS SKAIASNPKV 70 80 90 100 110 120 TEHGLKVMNK LTEAIHNLDH IKDLFHKLSE KHFHELHVDP QNFKLLSKCL IIVLATKLGK 130 140 QLTPDVQATW EKLLSVVVAA LSREYH

References

[1]	"A 'living fossil' sequence: primary structure of the coelacanth (Latimeria chalumnae) hemoglobin -- evolutionary and functional aspects." Gorr T., Kleinschmidt T., Sgouros J.G., Kasang L. Biol. Chem. Hoppe-Seyler 372:599-612(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Close tetrapod relationships of the coelacanth Latimeria indicated by haemoglobin sequences." Gorr T., Kleinschmidt T., Fricke H. Nature 351:394-397(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PHYLOGENETIC COMPARISONS.

Cross-references

Sequence databases
PIR	S15449.
3D structure databases
ProteinModelPortal	P23741.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG009709.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin_dom. IPR002337. Haemoglobin_b. [Graphical view]
PANTHER	PTHR11442:SF7. PTHR11442:SF7. 1 hit.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00814. BETAHAEM.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HBB_LATCH

Accession

Primary (citable) accession number: P23741

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program