P23740 (HBA_LATCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemoglobin subunit alpha

Alternative name(s):
Alpha-globin
Hemoglobin alpha chain

Gene names

Name:

HBA

Organism

Latimeria chalumnae (West Indian ocean coelacanth) [Reference proteome]

Taxonomic identifier

7897 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Coelacanthimorpha › Coelacanthiformes › Coelacanthidae › Latimeria

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in oxygen transport from the lung to the various peripheral tissues.
Subunit structure	Heterotetramer of two alpha chains and two beta chains (an easy dimerization is also reported).
Tissue specificity	Red blood cells.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Hemoglobin subunit alpha		PRO_0000052662
Sites
	Metal binding	59	1	Iron (heme distal ligand)
	Metal binding	88	1	Iron (heme proximal ligand)

Sequences

	Sequence		Length	Mass (Da)
	P23740 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: 86ADC5E51EAFEB4E	FASTA	142	15,867
	10 20 30 40 50 60 GLTAADKTLI KSIWGKVEKE TEAIGVEALV RLFKCFPQSK VYFDHFTDLS PSSQKLHAHA 70 80 90 100 110 120 KVVLGALTKA VNHLDNITDT LHDISLVHAK KLLVDPVNFE LLGHCLEVAL AAHFATDFTP 130 140 EVHLAIDKFL YEVEKALFET YR

References

[1]	"A 'living fossil' sequence: primary structure of the coelacanth (Latimeria chalumnae) hemoglobin -- evolutionary and functional aspects." Gorr T., Kleinschmidt T., Sgouros J.G., Kasang L. Biol. Chem. Hoppe-Seyler 372:599-612(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Close tetrapod relationships of the coelacanth Latimeria indicated by haemoglobin sequences." Gorr T., Kleinschmidt T., Fricke H. Nature 351:394-397(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PHYLOGENETIC COMPARISONS.

Cross-references

Sequence databases
PIR	S15411.
3D structure databases
ProteinModelPortal	P23740.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG009709.
OMA	HNILVVM.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin_dom. IPR002338. Haemoglobin_a. [Graphical view]
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00612. ALPHAHAEM.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HBA_LATCH

Accession

Primary (citable) accession number: P23740

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program