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P23734 (PP12_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP1(5.9)

EC=3.1.3.16
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Miscellaneous

Trypanosoma brucei contains two PP1 genes which are highly similar.

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Serine/threonine-protein phosphatase PP1(5.9)
PRO_0000058815

Sites

Active site1631Proton donor By similarity
Metal binding1021Iron By similarity
Metal binding1041Iron By similarity
Metal binding1301Iron By similarity
Metal binding1301Manganese By similarity
Metal binding1621Manganese By similarity
Metal binding2111Manganese By similarity
Metal binding2871Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
P23734 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 1CC8700523F0FB36

FASTA34639,295
        10         20         30         40         50         60 
MNCREIIRKL LLNPAHNNAA TRTAQGDNGD SNQRAYTRIS RLAAFQSAQT QESTPKTNGT 

        70         80         90        100        110        120 
GRATTEGLTE AEVRWLVMES RALFMSQPML VEIAAPVRIC GDVHGQYTDL LRLFDLGGFP 

       130        140        150        160        170        180 
PDANYIFLGD YVDRGDQSLE TICLLLAYKL SFPETFFLLR GNHECSSINR IYGFFDECKR 

       190        200        210        220        230        240 
RYSVRLWKQF TDTFNCMPVA GLVEGRILCM HGGLSPELTD LDQIRRILRP TDVPDSGLIC 

       250        260        270        280        290        300 
DLLWSDPSTN MESNWSENDR GVSWTFSESV VKSFNKKFDL DLICRAHQVV DAGYEFFAAR 

       310        320        330        340 
QLVTVFSAPN YCDEFDNAGA FMCVDENLMC SFVQIEPTRT LLRYFF 

« Hide

References

[1]"The Trypanosoma brucei protein phosphatase gene: polycistronic transcription with the RNA polymerase II largest subunit gene."
Evers R., Cornelissen A.W.C.A.
Nucleic Acids Res. 18:5089-5095(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52746 Genomic DNA. Translation: CAA36960.1.
PIRS12599.

3D structure databases

ProteinModelPortalP23734.
SMRP23734. Positions 68-344.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP12_TRYBB
AccessionPrimary (citable) accession number: P23734
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families