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P23734

- PP12_TRYBB

UniProt

P23734 - PP12_TRYBB

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Protein

Serine/threonine-protein phosphatase PP1(5.9)

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Manganese 1By similarity
Metal bindingi104 – 1041Manganese 1By similarity
Metal bindingi130 – 1301Manganese 1By similarity
Metal bindingi130 – 1301Manganese 2By similarity
Metal bindingi162 – 1621Manganese 2By similarity
Active sitei163 – 1631Proton donorBy similarity
Metal bindingi211 – 2111Manganese 2By similarity
Metal bindingi287 – 2871Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1(5.9) (EC:3.1.3.16)
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Serine/threonine-protein phosphatase PP1(5.9)PRO_0000058815Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23734.
SMRiP23734. Positions 68-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23734 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNCREIIRKL LLNPAHNNAA TRTAQGDNGD SNQRAYTRIS RLAAFQSAQT
60 70 80 90 100
QESTPKTNGT GRATTEGLTE AEVRWLVMES RALFMSQPML VEIAAPVRIC
110 120 130 140 150
GDVHGQYTDL LRLFDLGGFP PDANYIFLGD YVDRGDQSLE TICLLLAYKL
160 170 180 190 200
SFPETFFLLR GNHECSSINR IYGFFDECKR RYSVRLWKQF TDTFNCMPVA
210 220 230 240 250
GLVEGRILCM HGGLSPELTD LDQIRRILRP TDVPDSGLIC DLLWSDPSTN
260 270 280 290 300
MESNWSENDR GVSWTFSESV VKSFNKKFDL DLICRAHQVV DAGYEFFAAR
310 320 330 340
QLVTVFSAPN YCDEFDNAGA FMCVDENLMC SFVQIEPTRT LLRYFF
Length:346
Mass (Da):39,295
Last modified:February 1, 1996 - v2
Checksum:i1CC8700523F0FB36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52746 Genomic DNA. Translation: CAA36960.1.
PIRiS12599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52746 Genomic DNA. Translation: CAA36960.1 .
PIRi S12599.

3D structure databases

ProteinModelPortali P23734.
SMRi P23734. Positions 68-344.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Trypanosoma brucei protein phosphatase gene: polycistronic transcription with the RNA polymerase II largest subunit gene."
    Evers R., Cornelissen A.W.C.A.
    Nucleic Acids Res. 18:5089-5095(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPP12_TRYBB
AccessioniPrimary (citable) accession number: P23734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Trypanosoma brucei contains two PP1 genes which are highly similar.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3