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P23734

- PP12_TRYBB

UniProt

P23734 - PP12_TRYBB

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Protein
Serine/threonine-protein phosphatase PP1(5.9)
Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Manganese 1 By similarity
Metal bindingi104 – 1041Manganese 1 By similarity
Metal bindingi130 – 1301Manganese 1 By similarity
Metal bindingi130 – 1301Manganese 2 By similarity
Metal bindingi162 – 1621Manganese 2 By similarity
Active sitei163 – 1631Proton donor By similarity
Metal bindingi211 – 2111Manganese 2 By similarity
Metal bindingi287 – 2871Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1(5.9) (EC:3.1.3.16)
    OrganismiTrypanosoma brucei brucei
    Taxonomic identifieri5702 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Serine/threonine-protein phosphatase PP1(5.9)
    PRO_0000058815Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP23734.
    SMRiP23734. Positions 68-344.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23734-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNCREIIRKL LLNPAHNNAA TRTAQGDNGD SNQRAYTRIS RLAAFQSAQT    50
    QESTPKTNGT GRATTEGLTE AEVRWLVMES RALFMSQPML VEIAAPVRIC 100
    GDVHGQYTDL LRLFDLGGFP PDANYIFLGD YVDRGDQSLE TICLLLAYKL 150
    SFPETFFLLR GNHECSSINR IYGFFDECKR RYSVRLWKQF TDTFNCMPVA 200
    GLVEGRILCM HGGLSPELTD LDQIRRILRP TDVPDSGLIC DLLWSDPSTN 250
    MESNWSENDR GVSWTFSESV VKSFNKKFDL DLICRAHQVV DAGYEFFAAR 300
    QLVTVFSAPN YCDEFDNAGA FMCVDENLMC SFVQIEPTRT LLRYFF 346
    Length:346
    Mass (Da):39,295
    Last modified:February 1, 1996 - v2
    Checksum:i1CC8700523F0FB36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52746 Genomic DNA. Translation: CAA36960.1.
    PIRiS12599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52746 Genomic DNA. Translation: CAA36960.1 .
    PIRi S12599.

    3D structure databases

    ProteinModelPortali P23734.
    SMRi P23734. Positions 68-344.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Trypanosoma brucei protein phosphatase gene: polycistronic transcription with the RNA polymerase II largest subunit gene."
      Evers R., Cornelissen A.W.C.A.
      Nucleic Acids Res. 18:5089-5095(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPP12_TRYBB
    AccessioniPrimary (citable) accession number: P23734
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: February 1, 1996
    Last modified: June 11, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    Trypanosoma brucei contains two PP1 genes which are highly similar.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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