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Protein

Serine/threonine-protein phosphatase PP1(4.8)

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

Trypanosoma brucei contains two PP1 genes which are highly similar.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Manganese 1By similarity1
Metal bindingi104Manganese 1By similarity1
Metal bindingi130Manganese 1By similarity1
Metal bindingi130Manganese 2By similarity1
Metal bindingi162Manganese 2By similarity1
Active sitei163Proton donorBy similarity1
Metal bindingi211Manganese 2By similarity1
Metal bindingi287Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1(4.8) (EC:3.1.3.16)
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: GeneDB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588141 – 346Serine/threonine-protein phosphatase PP1(4.8)Add BLAST346

Proteomic databases

PRIDEiP23733

Structurei

3D structure databases

ProteinModelPortaliP23733
SMRiP23733
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P23733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCDEIIKKL LLNPVHNTAA TRGPAGENCE SNQRTYTRIS RLAAFQSAQT
60 70 80 90 100
QESTPKTNGT GRATTEGLTE AEVRWLVMES RALFMSQPML VEIAAPVRIC
110 120 130 140 150
GDVHGQYTDL LRLFDLGGFP PDANYIFLGD YVDRGDQSLE RICLLLAYKL
160 170 180 190 200
SFPETFFLLR GNHECSSINR IYGFFDECKR RYSVRLWKQF TDTFNCMPVA
210 220 230 240 250
GLVEGRILCM HGGLSPELTD LDQIRRILRP TDVPDSGLIC DLLWSDPSTN
260 270 280 290 300
MESNWSENDR GVSWTFSESV VKSFNKKFDL DLICRAHQVV DAGYEFFAAR
310 320 330 340
QLVTVFSAPN YCDEFDNAGA FMCVDENFMC SFIRIEPTRT LLKYFF
Length:346
Mass (Da):39,373
Last modified:February 1, 1996 - v2
Checksum:iE4281408E35DC21D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52745 Genomic DNA Translation: CAA36959.1

Genome annotation databases

GeneDBiTb927.4.5030:pep

Similar proteinsi

Entry informationi

Entry nameiPP11_TRYBB
AccessioniPrimary (citable) accession number: P23733
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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