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Protein

Serine/threonine-protein phosphatase PP1(4.8)

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Manganese 1By similarity1
Metal bindingi104Manganese 1By similarity1
Metal bindingi130Manganese 1By similarity1
Metal bindingi130Manganese 2By similarity1
Metal bindingi162Manganese 2By similarity1
Active sitei163Proton donorBy similarity1
Metal bindingi211Manganese 2By similarity1
Metal bindingi287Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1(4.8) (EC:3.1.3.16)
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: GeneDB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588141 – 346Serine/threonine-protein phosphatase PP1(4.8)Add BLAST346

Structurei

3D structure databases

ProteinModelPortaliP23733.
SMRiP23733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P23733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCDEIIKKL LLNPVHNTAA TRGPAGENCE SNQRTYTRIS RLAAFQSAQT
60 70 80 90 100
QESTPKTNGT GRATTEGLTE AEVRWLVMES RALFMSQPML VEIAAPVRIC
110 120 130 140 150
GDVHGQYTDL LRLFDLGGFP PDANYIFLGD YVDRGDQSLE RICLLLAYKL
160 170 180 190 200
SFPETFFLLR GNHECSSINR IYGFFDECKR RYSVRLWKQF TDTFNCMPVA
210 220 230 240 250
GLVEGRILCM HGGLSPELTD LDQIRRILRP TDVPDSGLIC DLLWSDPSTN
260 270 280 290 300
MESNWSENDR GVSWTFSESV VKSFNKKFDL DLICRAHQVV DAGYEFFAAR
310 320 330 340
QLVTVFSAPN YCDEFDNAGA FMCVDENFMC SFIRIEPTRT LLKYFF
Length:346
Mass (Da):39,373
Last modified:February 1, 1996 - v2
Checksum:iE4281408E35DC21D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52745 Genomic DNA. Translation: CAA36959.1.

Genome annotation databases

GeneDBiTb927.4.5030:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52745 Genomic DNA. Translation: CAA36959.1.

3D structure databases

ProteinModelPortaliP23733.
SMRiP23733.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTb927.4.5030:pep.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPP11_TRYBB
AccessioniPrimary (citable) accession number: P23733
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: February 15, 2017
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Trypanosoma brucei contains two PP1 genes which are highly similar.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.