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P23733

- PP11_TRYBB

UniProt

P23733 - PP11_TRYBB

Protein

Serine/threonine-protein phosphatase PP1(4.8)

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi102 – 1021Manganese 1By similarity
    Metal bindingi104 – 1041Manganese 1By similarity
    Metal bindingi130 – 1301Manganese 1By similarity
    Metal bindingi130 – 1301Manganese 2By similarity
    Metal bindingi162 – 1621Manganese 2By similarity
    Active sitei163 – 1631Proton donorBy similarity
    Metal bindingi211 – 2111Manganese 2By similarity
    Metal bindingi287 – 2871Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1(4.8) (EC:3.1.3.16)
    OrganismiTrypanosoma brucei brucei
    Taxonomic identifieri5702 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Serine/threonine-protein phosphatase PP1(4.8)PRO_0000058814Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP23733.
    SMRiP23733. Positions 68-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23733-1 [UniParc]FASTAAdd to Basket

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    MNCDEIIKKL LLNPVHNTAA TRGPAGENCE SNQRTYTRIS RLAAFQSAQT    50
    QESTPKTNGT GRATTEGLTE AEVRWLVMES RALFMSQPML VEIAAPVRIC 100
    GDVHGQYTDL LRLFDLGGFP PDANYIFLGD YVDRGDQSLE RICLLLAYKL 150
    SFPETFFLLR GNHECSSINR IYGFFDECKR RYSVRLWKQF TDTFNCMPVA 200
    GLVEGRILCM HGGLSPELTD LDQIRRILRP TDVPDSGLIC DLLWSDPSTN 250
    MESNWSENDR GVSWTFSESV VKSFNKKFDL DLICRAHQVV DAGYEFFAAR 300
    QLVTVFSAPN YCDEFDNAGA FMCVDENFMC SFIRIEPTRT LLKYFF 346
    Length:346
    Mass (Da):39,373
    Last modified:February 1, 1996 - v2
    Checksum:iE4281408E35DC21D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52745 Genomic DNA. Translation: CAA36959.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52745 Genomic DNA. Translation: CAA36959.1 .

    3D structure databases

    ProteinModelPortali P23733.
    SMRi P23733. Positions 68-344.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Trypanosoma brucei protein phosphatase gene: polycistronic transcription with the RNA polymerase II largest subunit gene."
      Evers R., Cornelissen A.W.C.A.
      Nucleic Acids Res. 18:5089-5095(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPP11_TRYBB
    AccessioniPrimary (citable) accession number: P23733
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    Trypanosoma brucei contains two PP1 genes which are highly similar.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3