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Protein

Proteasome subunit beta type-6

Gene

PRE7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

  • proteasomal ubiquitin-independent protein catabolic process Source: SGD
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciYEAST:G3O-28942-MONOMER.
ReactomeiR-SCE-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SCE-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SCE-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-SCE-382556. ABC-family proteins mediated transport.
R-SCE-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-SCE-5668541. TNFR2 non-canonical NF-kB pathway.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-5689880. Ub-specific processing proteases.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-68949. Orc1 removal from chromatin.
R-SCE-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SCE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SCE-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SCE-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SCE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.A12.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-6 (EC:3.4.25.1)
Alternative name(s):
Multicatalytic endopeptidase complex subunit C5
Proteasome component C5
Gene namesi
Name:PRE7
Synonyms:PRS3, PTS1
Ordered Locus Names:YBL041W
ORF Names:YBL0407
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL041W.
SGDiS000000137. PRE7.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: SGD
  • nucleus Source: SGD
  • proteasome core complex, beta-subunit complex Source: SGD
  • proteasome storage granule Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003314891 – 19Add BLAST19
ChainiPRO_000014804220 – 241Proteasome subunit beta type-6Add BLAST222

Proteomic databases

MaxQBiP23724.
PRIDEiP23724.

2D gel databases

UCD-2DPAGEP23724.

PTM databases

iPTMnetiP23724.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.1 Publication

Protein-protein interaction databases

BioGridi32656. 40 interactors.
DIPiDIP-2821N.
IntActiP23724. 17 interactors.
MINTiMINT-592611.

Chemistry databases

BindingDBiP23724.

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi40 – 45Combined sources6
Beta strandi48 – 50Combined sources3
Beta strandi53 – 57Combined sources5
Beta strandi62 – 64Combined sources3
Beta strandi70 – 76Combined sources7
Helixi77 – 97Combined sources21
Turni98 – 100Combined sources3
Helixi105 – 117Combined sources13
Turni118 – 121Combined sources4
Beta strandi126 – 133Combined sources8
Beta strandi139 – 144Combined sources6
Beta strandi146 – 148Combined sources3
Beta strandi150 – 159Combined sources10
Helixi162 – 172Combined sources11
Turni181 – 183Combined sources3
Beta strandi186 – 188Combined sources3
Helixi196 – 213Combined sources18
Beta strandi214 – 217Combined sources4
Beta strandi219 – 227Combined sources9
Beta strandi230 – 237Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FNTX-ray3.20M/a20-240[»]
1G0UX-ray2.40L/Z1-241[»]
1G65X-ray2.25L/Z20-241[»]
1JD2X-ray3.00L/S20-241[»]
1RYPX-ray1.901/M20-241[»]
1Z7QX-ray3.22M/a20-241[»]
2F16X-ray2.80L/Z20-241[»]
2FAKX-ray2.80L/Z20-241[»]
2GPLX-ray2.81L/Z20-241[»]
2ZCYX-ray2.90L/Z1-241[»]
3BDMX-ray2.70L/Z1-241[»]
3D29X-ray2.60L/Z20-241[»]
3DY3X-ray2.81L/Z20-241[»]
3DY4X-ray2.80L/Z20-241[»]
3E47X-ray3.00L/Z20-241[»]
3GPJX-ray2.70L/Z20-241[»]
3GPTX-ray2.41L/Z20-241[»]
3GPWX-ray2.50L/Z20-241[»]
3HYEX-ray2.50L/Z20-241[»]
3JCOelectron microscopy4.801/81-241[»]
3JCPelectron microscopy4.601/81-241[»]
3MG0X-ray2.68L/Z20-241[»]
3MG4X-ray3.11L/Z20-241[»]
3MG6X-ray2.60L/Z1-241[»]
3MG7X-ray2.78L/Z1-241[»]
3MG8X-ray2.59L/Z1-241[»]
3NZJX-ray2.40L/Z1-241[»]
3NZWX-ray2.50L/Z1-241[»]
3NZXX-ray2.70L/Z1-241[»]
3OEUX-ray2.60L/Z20-241[»]
3OEVX-ray2.85L/Z20-241[»]
3OKJX-ray2.70L/Z20-241[»]
3SDIX-ray2.65L/Z20-241[»]
3SDKX-ray2.70L/Z20-241[»]
3SHJX-ray2.80L/Z20-241[»]
3TDDX-ray2.70L/Z20-241[»]
3UN4X-ray3.40L/Z20-241[»]
3UN8X-ray2.70L/Z20-241[»]
3WXRX-ray3.151/M1-241[»]
4CR2electron microscopy7.7061-241[»]
4CR3electron microscopy9.3061-241[»]
4CR4electron microscopy8.8061-241[»]
4EU2X-ray2.511/M20-241[»]
4FZCX-ray2.80L/Z20-241[»]
4FZGX-ray3.00L/Z20-241[»]
4G4SX-ray2.49M20-241[»]
4GK7X-ray2.80L/Z20-241[»]
4HNPX-ray2.80L/Z20-241[»]
4HRCX-ray2.80L/Z20-241[»]
4HRDX-ray2.80L/Z20-241[»]
4INRX-ray2.70L/Z20-241[»]
4INTX-ray2.90L/Z20-241[»]
4INUX-ray3.10L/Z20-241[»]
4J70X-ray2.80L/Z20-241[»]
4JSQX-ray2.80L/Z20-241[»]
4JSUX-ray2.90L/Z20-241[»]
4JT0X-ray3.10L/Z20-241[»]
4LQIX-ray2.70L/Z20-241[»]
4LTCX-ray2.50L/Z20-241[»]
4NNNX-ray2.50L/Z20-241[»]
4NNWX-ray2.60L/Z20-241[»]
4NO1X-ray2.50L/Z20-241[»]
4NO6X-ray3.00L/Z20-241[»]
4NO8X-ray2.70L/Z20-241[»]
4NO9X-ray2.90L/Z20-241[»]
4Q1SX-ray2.60L/Z20-241[»]
4QBYX-ray3.00L/Z20-241[»]
4QLQX-ray2.40L/Z20-241[»]
4QLSX-ray2.80L/Z20-241[»]
4QLTX-ray2.80L/Z20-241[»]
4QLUX-ray2.80L/Z20-241[»]
4QLVX-ray2.90L/Z20-241[»]
4QUXX-ray3.00L/Z20-241[»]
4QUYX-ray2.80L/Z20-241[»]
4QV0X-ray3.10L/Z20-241[»]
4QV1X-ray2.50L/Z20-241[»]
4QV3X-ray3.00L/Z20-241[»]
4QV4X-ray2.70L/Z20-241[»]
4QV5X-ray2.70L/Z20-241[»]
4QV6X-ray2.80L/Z20-241[»]
4QV7X-ray2.60L/Z20-241[»]
4QV8X-ray2.90L/Z20-241[»]
4QV9X-ray2.60L/Z20-241[»]
4QVLX-ray2.80L/Z20-241[»]
4QVMX-ray2.80L/Z20-241[»]
4QVNX-ray2.90L/Z20-241[»]
4QVPX-ray2.30L/Z20-241[»]
4QVQX-ray2.60L/Z20-241[»]
4QVVX-ray2.80L/Z20-241[»]
4QVWX-ray3.00L/Z20-241[»]
4QVYX-ray2.51L/Z20-241[»]
4QW0X-ray2.90L/Z20-241[»]
4QW1X-ray2.90L/Z20-241[»]
4QW3X-ray2.90L/Z20-241[»]
4QW4X-ray2.80L/Z20-241[»]
4QW5X-ray3.00L/Z20-241[»]
4QW6X-ray2.90L/Z20-241[»]
4QW7X-ray2.70L/Z20-241[»]
4QWFX-ray3.00L/Z20-241[»]
4QWGX-ray2.60L/Z20-241[»]
4QWIX-ray2.60L/Z20-241[»]
4QWJX-ray2.90L/Z20-241[»]
4QWKX-ray2.80L/Z20-241[»]
4QWLX-ray2.60L/Z20-241[»]
4QWRX-ray2.90L/Z20-241[»]
4QWSX-ray3.00L/Z20-241[»]
4QWUX-ray3.00L/Z20-241[»]
4QWXX-ray2.90L/Z20-241[»]
4QXJX-ray2.80L/Z20-241[»]
4QZ0X-ray3.00L/Z20-241[»]
4QZ1X-ray3.00L/Z20-241[»]
4QZ2X-ray2.70L/Z20-241[»]
4QZ3X-ray2.80L/Z20-241[»]
4QZ4X-ray3.00L/Z20-241[»]
4QZ5X-ray2.80L/Z20-241[»]
4QZ6X-ray2.90L/Z20-241[»]
4QZ7X-ray2.80L/Z20-241[»]
4QZWX-ray3.00L/Z20-241[»]
4QZXX-ray2.60L/Z20-241[»]
4QZZX-ray2.90L/Z20-241[»]
4R00X-ray2.80L/Z20-241[»]
4R02X-ray2.50L/Z20-241[»]
4R17X-ray2.10L/Z20-241[»]
4R18X-ray2.40L/Z20-241[»]
4RURX-ray2.50L/Z20-241[»]
4V7OX-ray3.00A3/AQ/B1/BM20-241[»]
4X6ZX-ray2.701/M1-241[»]
4Y69X-ray2.90L/Z20-241[»]
4Y6AX-ray2.60L/Z20-241[»]
4Y6VX-ray2.80L/Z20-241[»]
4Y6ZX-ray2.70L/Z20-241[»]
4Y70X-ray2.40L/Z20-241[»]
4Y74X-ray2.70L/Z20-241[»]
4Y75X-ray2.80L/Z20-241[»]
4Y77X-ray2.50L/Z20-241[»]
4Y78X-ray2.80L/Z20-241[»]
4Y7WX-ray2.50L/Z20-241[»]
4Y7XX-ray2.60L/Z20-241[»]
4Y7YX-ray2.40L/Z20-241[»]
4Y80X-ray2.50L/Z20-241[»]
4Y81X-ray2.80L/Z20-241[»]
4Y82X-ray2.80L/Z20-241[»]
4Y84X-ray2.70L/Z20-241[»]
4Y8GX-ray2.60L/Z20-241[»]
4Y8HX-ray2.50L/Z20-241[»]
4Y8IX-ray2.60L/Z20-241[»]
4Y8JX-ray2.70L/Z20-241[»]
4Y8KX-ray2.60L/Z20-241[»]
4Y8LX-ray2.40L/Z20-241[»]
4Y8MX-ray2.80L/Z20-241[»]
4Y8NX-ray2.60L/Z20-241[»]
4Y8OX-ray2.70L/Z20-241[»]
4Y8PX-ray2.80L/Z20-241[»]
4Y8QX-ray2.60L/Z20-241[»]
4Y8RX-ray2.70L/Z20-241[»]
4Y8SX-ray2.70L/Z20-241[»]
4Y8TX-ray2.70L/Z20-241[»]
4Y8UX-ray2.90L/Z20-241[»]
4Y9YX-ray2.80L/Z20-241[»]
4Y9ZX-ray2.80L/Z20-241[»]
4YA0X-ray2.80L/Z20-241[»]
4YA1X-ray2.90L/Z20-241[»]
4YA2X-ray2.70L/Z20-241[»]
4YA3X-ray2.70L/Z20-241[»]
4YA4X-ray2.90L/Z20-241[»]
4YA5X-ray2.50L/Z20-241[»]
4YA7X-ray2.70L/Z20-241[»]
4YA9X-ray2.70L/Z20-241[»]
4Z1LX-ray3.00L/Z20-241[»]
4ZZGX-ray3.001/M1-241[»]
5A5Belectron microscopy9.5061-241[»]
5AHJX-ray2.80L/Z20-241[»]
5BOUX-ray2.60L/Z20-241[»]
5BXLX-ray2.80L/Z20-241[»]
5BXNX-ray2.80L/Z20-241[»]
5CGFX-ray2.80L/Z20-241[»]
5CGGX-ray2.90L/Z20-241[»]
5CGHX-ray2.50L/Z20-241[»]
5CGIX-ray2.80L/Z20-241[»]
5CZ4X-ray2.30L/Z20-241[»]
5CZ5X-ray2.80L/Z20-241[»]
5CZ6X-ray2.70L/Z20-241[»]
5CZ7X-ray2.50L/Z20-241[»]
5CZ8X-ray2.80L/Z20-241[»]
5CZ9X-ray2.90L/Z20-241[»]
5CZAX-ray2.50L/Z20-241[»]
5D0SX-ray2.50L/Z20-241[»]
5D0TX-ray2.60L/Z20-241[»]
5D0VX-ray2.90L/Z20-241[»]
5D0WX-ray2.80L/Z20-241[»]
5D0XX-ray2.60L/Z20-241[»]
5D0ZX-ray2.90L/Z20-241[»]
5DKIX-ray2.80L/Z20-241[»]
5DKJX-ray2.80L/Z20-241[»]
5FG7X-ray2.70L/Z20-241[»]
5FG9X-ray2.60L/Z20-241[»]
5FGAX-ray2.70L/Z20-241[»]
5FGDX-ray2.80L/Z20-241[»]
5FGEX-ray2.60L/Z20-241[»]
5FGFX-ray2.60L/Z20-241[»]
5FGGX-ray2.70L/Z20-241[»]
5FGHX-ray2.80L/Z20-241[»]
5FGIX-ray2.90L/Z20-241[»]
5FHSX-ray2.70L/Z20-241[»]
5JHRX-ray2.90L/Z20-241[»]
5JHSX-ray3.00L/Z20-241[»]
ProteinModelPortaliP23724.
SMRiP23724.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23724.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075035.
HOGENOMiHOG000091081.
InParanoidiP23724.
KOiK02732.
OMAiCKICRET.
OrthoDBiEOG092C4IM8.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIASEYSS EASNTPIEHQ FNPYGDNGGT ILGIAGEDFA VLAGDTRNIT
60 70 80 90 100
DYSINSRYEP KVFDCGDNIV MSANGFAADG DALVKRFKNS VKWYHFDHND
110 120 130 140 150
KKLSINSAAR NIQHLLYGKR FFPYYVHTII AGLDEDGKGA VYSFDPVGSY
160 170 180 190 200
EREQCRAGGA AASLIMPFLD NQVNFKNQYE PGTNGKVKKP LKYLSVEEVI
210 220 230 240
KLVRDSFTSA TERHIQVGDG LEILIVTKDG VRKEFYELKR D
Length:241
Mass (Da):26,871
Last modified:November 1, 1991 - v1
Checksum:i770A4DF1DF0A0F0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34777 Genomic DNA. Translation: AAA68908.1.
D00845 Genomic DNA. Translation: BAA00725.1.
X78214 Genomic DNA. Translation: CAA55053.1.
Z35802 Genomic DNA. Translation: CAA84861.1.
AY558462 Genomic DNA. Translation: AAS56788.1.
BK006936 Genomic DNA. Translation: DAA07077.1.
PIRiS42436.
RefSeqiNP_009512.1. NM_001178281.1.

Genome annotation databases

EnsemblFungiiYBL041W; YBL041W; YBL041W.
GeneIDi852239.
KEGGisce:YBL041W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34777 Genomic DNA. Translation: AAA68908.1.
D00845 Genomic DNA. Translation: BAA00725.1.
X78214 Genomic DNA. Translation: CAA55053.1.
Z35802 Genomic DNA. Translation: CAA84861.1.
AY558462 Genomic DNA. Translation: AAS56788.1.
BK006936 Genomic DNA. Translation: DAA07077.1.
PIRiS42436.
RefSeqiNP_009512.1. NM_001178281.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FNTX-ray3.20M/a20-240[»]
1G0UX-ray2.40L/Z1-241[»]
1G65X-ray2.25L/Z20-241[»]
1JD2X-ray3.00L/S20-241[»]
1RYPX-ray1.901/M20-241[»]
1Z7QX-ray3.22M/a20-241[»]
2F16X-ray2.80L/Z20-241[»]
2FAKX-ray2.80L/Z20-241[»]
2GPLX-ray2.81L/Z20-241[»]
2ZCYX-ray2.90L/Z1-241[»]
3BDMX-ray2.70L/Z1-241[»]
3D29X-ray2.60L/Z20-241[»]
3DY3X-ray2.81L/Z20-241[»]
3DY4X-ray2.80L/Z20-241[»]
3E47X-ray3.00L/Z20-241[»]
3GPJX-ray2.70L/Z20-241[»]
3GPTX-ray2.41L/Z20-241[»]
3GPWX-ray2.50L/Z20-241[»]
3HYEX-ray2.50L/Z20-241[»]
3JCOelectron microscopy4.801/81-241[»]
3JCPelectron microscopy4.601/81-241[»]
3MG0X-ray2.68L/Z20-241[»]
3MG4X-ray3.11L/Z20-241[»]
3MG6X-ray2.60L/Z1-241[»]
3MG7X-ray2.78L/Z1-241[»]
3MG8X-ray2.59L/Z1-241[»]
3NZJX-ray2.40L/Z1-241[»]
3NZWX-ray2.50L/Z1-241[»]
3NZXX-ray2.70L/Z1-241[»]
3OEUX-ray2.60L/Z20-241[»]
3OEVX-ray2.85L/Z20-241[»]
3OKJX-ray2.70L/Z20-241[»]
3SDIX-ray2.65L/Z20-241[»]
3SDKX-ray2.70L/Z20-241[»]
3SHJX-ray2.80L/Z20-241[»]
3TDDX-ray2.70L/Z20-241[»]
3UN4X-ray3.40L/Z20-241[»]
3UN8X-ray2.70L/Z20-241[»]
3WXRX-ray3.151/M1-241[»]
4CR2electron microscopy7.7061-241[»]
4CR3electron microscopy9.3061-241[»]
4CR4electron microscopy8.8061-241[»]
4EU2X-ray2.511/M20-241[»]
4FZCX-ray2.80L/Z20-241[»]
4FZGX-ray3.00L/Z20-241[»]
4G4SX-ray2.49M20-241[»]
4GK7X-ray2.80L/Z20-241[»]
4HNPX-ray2.80L/Z20-241[»]
4HRCX-ray2.80L/Z20-241[»]
4HRDX-ray2.80L/Z20-241[»]
4INRX-ray2.70L/Z20-241[»]
4INTX-ray2.90L/Z20-241[»]
4INUX-ray3.10L/Z20-241[»]
4J70X-ray2.80L/Z20-241[»]
4JSQX-ray2.80L/Z20-241[»]
4JSUX-ray2.90L/Z20-241[»]
4JT0X-ray3.10L/Z20-241[»]
4LQIX-ray2.70L/Z20-241[»]
4LTCX-ray2.50L/Z20-241[»]
4NNNX-ray2.50L/Z20-241[»]
4NNWX-ray2.60L/Z20-241[»]
4NO1X-ray2.50L/Z20-241[»]
4NO6X-ray3.00L/Z20-241[»]
4NO8X-ray2.70L/Z20-241[»]
4NO9X-ray2.90L/Z20-241[»]
4Q1SX-ray2.60L/Z20-241[»]
4QBYX-ray3.00L/Z20-241[»]
4QLQX-ray2.40L/Z20-241[»]
4QLSX-ray2.80L/Z20-241[»]
4QLTX-ray2.80L/Z20-241[»]
4QLUX-ray2.80L/Z20-241[»]
4QLVX-ray2.90L/Z20-241[»]
4QUXX-ray3.00L/Z20-241[»]
4QUYX-ray2.80L/Z20-241[»]
4QV0X-ray3.10L/Z20-241[»]
4QV1X-ray2.50L/Z20-241[»]
4QV3X-ray3.00L/Z20-241[»]
4QV4X-ray2.70L/Z20-241[»]
4QV5X-ray2.70L/Z20-241[»]
4QV6X-ray2.80L/Z20-241[»]
4QV7X-ray2.60L/Z20-241[»]
4QV8X-ray2.90L/Z20-241[»]
4QV9X-ray2.60L/Z20-241[»]
4QVLX-ray2.80L/Z20-241[»]
4QVMX-ray2.80L/Z20-241[»]
4QVNX-ray2.90L/Z20-241[»]
4QVPX-ray2.30L/Z20-241[»]
4QVQX-ray2.60L/Z20-241[»]
4QVVX-ray2.80L/Z20-241[»]
4QVWX-ray3.00L/Z20-241[»]
4QVYX-ray2.51L/Z20-241[»]
4QW0X-ray2.90L/Z20-241[»]
4QW1X-ray2.90L/Z20-241[»]
4QW3X-ray2.90L/Z20-241[»]
4QW4X-ray2.80L/Z20-241[»]
4QW5X-ray3.00L/Z20-241[»]
4QW6X-ray2.90L/Z20-241[»]
4QW7X-ray2.70L/Z20-241[»]
4QWFX-ray3.00L/Z20-241[»]
4QWGX-ray2.60L/Z20-241[»]
4QWIX-ray2.60L/Z20-241[»]
4QWJX-ray2.90L/Z20-241[»]
4QWKX-ray2.80L/Z20-241[»]
4QWLX-ray2.60L/Z20-241[»]
4QWRX-ray2.90L/Z20-241[»]
4QWSX-ray3.00L/Z20-241[»]
4QWUX-ray3.00L/Z20-241[»]
4QWXX-ray2.90L/Z20-241[»]
4QXJX-ray2.80L/Z20-241[»]
4QZ0X-ray3.00L/Z20-241[»]
4QZ1X-ray3.00L/Z20-241[»]
4QZ2X-ray2.70L/Z20-241[»]
4QZ3X-ray2.80L/Z20-241[»]
4QZ4X-ray3.00L/Z20-241[»]
4QZ5X-ray2.80L/Z20-241[»]
4QZ6X-ray2.90L/Z20-241[»]
4QZ7X-ray2.80L/Z20-241[»]
4QZWX-ray3.00L/Z20-241[»]
4QZXX-ray2.60L/Z20-241[»]
4QZZX-ray2.90L/Z20-241[»]
4R00X-ray2.80L/Z20-241[»]
4R02X-ray2.50L/Z20-241[»]
4R17X-ray2.10L/Z20-241[»]
4R18X-ray2.40L/Z20-241[»]
4RURX-ray2.50L/Z20-241[»]
4V7OX-ray3.00A3/AQ/B1/BM20-241[»]
4X6ZX-ray2.701/M1-241[»]
4Y69X-ray2.90L/Z20-241[»]
4Y6AX-ray2.60L/Z20-241[»]
4Y6VX-ray2.80L/Z20-241[»]
4Y6ZX-ray2.70L/Z20-241[»]
4Y70X-ray2.40L/Z20-241[»]
4Y74X-ray2.70L/Z20-241[»]
4Y75X-ray2.80L/Z20-241[»]
4Y77X-ray2.50L/Z20-241[»]
4Y78X-ray2.80L/Z20-241[»]
4Y7WX-ray2.50L/Z20-241[»]
4Y7XX-ray2.60L/Z20-241[»]
4Y7YX-ray2.40L/Z20-241[»]
4Y80X-ray2.50L/Z20-241[»]
4Y81X-ray2.80L/Z20-241[»]
4Y82X-ray2.80L/Z20-241[»]
4Y84X-ray2.70L/Z20-241[»]
4Y8GX-ray2.60L/Z20-241[»]
4Y8HX-ray2.50L/Z20-241[»]
4Y8IX-ray2.60L/Z20-241[»]
4Y8JX-ray2.70L/Z20-241[»]
4Y8KX-ray2.60L/Z20-241[»]
4Y8LX-ray2.40L/Z20-241[»]
4Y8MX-ray2.80L/Z20-241[»]
4Y8NX-ray2.60L/Z20-241[»]
4Y8OX-ray2.70L/Z20-241[»]
4Y8PX-ray2.80L/Z20-241[»]
4Y8QX-ray2.60L/Z20-241[»]
4Y8RX-ray2.70L/Z20-241[»]
4Y8SX-ray2.70L/Z20-241[»]
4Y8TX-ray2.70L/Z20-241[»]
4Y8UX-ray2.90L/Z20-241[»]
4Y9YX-ray2.80L/Z20-241[»]
4Y9ZX-ray2.80L/Z20-241[»]
4YA0X-ray2.80L/Z20-241[»]
4YA1X-ray2.90L/Z20-241[»]
4YA2X-ray2.70L/Z20-241[»]
4YA3X-ray2.70L/Z20-241[»]
4YA4X-ray2.90L/Z20-241[»]
4YA5X-ray2.50L/Z20-241[»]
4YA7X-ray2.70L/Z20-241[»]
4YA9X-ray2.70L/Z20-241[»]
4Z1LX-ray3.00L/Z20-241[»]
4ZZGX-ray3.001/M1-241[»]
5A5Belectron microscopy9.5061-241[»]
5AHJX-ray2.80L/Z20-241[»]
5BOUX-ray2.60L/Z20-241[»]
5BXLX-ray2.80L/Z20-241[»]
5BXNX-ray2.80L/Z20-241[»]
5CGFX-ray2.80L/Z20-241[»]
5CGGX-ray2.90L/Z20-241[»]
5CGHX-ray2.50L/Z20-241[»]
5CGIX-ray2.80L/Z20-241[»]
5CZ4X-ray2.30L/Z20-241[»]
5CZ5X-ray2.80L/Z20-241[»]
5CZ6X-ray2.70L/Z20-241[»]
5CZ7X-ray2.50L/Z20-241[»]
5CZ8X-ray2.80L/Z20-241[»]
5CZ9X-ray2.90L/Z20-241[»]
5CZAX-ray2.50L/Z20-241[»]
5D0SX-ray2.50L/Z20-241[»]
5D0TX-ray2.60L/Z20-241[»]
5D0VX-ray2.90L/Z20-241[»]
5D0WX-ray2.80L/Z20-241[»]
5D0XX-ray2.60L/Z20-241[»]
5D0ZX-ray2.90L/Z20-241[»]
5DKIX-ray2.80L/Z20-241[»]
5DKJX-ray2.80L/Z20-241[»]
5FG7X-ray2.70L/Z20-241[»]
5FG9X-ray2.60L/Z20-241[»]
5FGAX-ray2.70L/Z20-241[»]
5FGDX-ray2.80L/Z20-241[»]
5FGEX-ray2.60L/Z20-241[»]
5FGFX-ray2.60L/Z20-241[»]
5FGGX-ray2.70L/Z20-241[»]
5FGHX-ray2.80L/Z20-241[»]
5FGIX-ray2.90L/Z20-241[»]
5FHSX-ray2.70L/Z20-241[»]
5JHRX-ray2.90L/Z20-241[»]
5JHSX-ray3.00L/Z20-241[»]
ProteinModelPortaliP23724.
SMRiP23724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32656. 40 interactors.
DIPiDIP-2821N.
IntActiP23724. 17 interactors.
MINTiMINT-592611.

Chemistry databases

BindingDBiP23724.
ChEMBLiCHEMBL4904.

Protein family/group databases

MEROPSiT01.A12.

PTM databases

iPTMnetiP23724.

2D gel databases

UCD-2DPAGEP23724.

Proteomic databases

MaxQBiP23724.
PRIDEiP23724.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL041W; YBL041W; YBL041W.
GeneIDi852239.
KEGGisce:YBL041W.

Organism-specific databases

EuPathDBiFungiDB:YBL041W.
SGDiS000000137. PRE7.

Phylogenomic databases

GeneTreeiENSGT00550000075035.
HOGENOMiHOG000091081.
InParanoidiP23724.
KOiK02732.
OMAiCKICRET.
OrthoDBiEOG092C4IM8.

Enzyme and pathway databases

BioCyciYEAST:G3O-28942-MONOMER.
ReactomeiR-SCE-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SCE-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SCE-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-SCE-382556. ABC-family proteins mediated transport.
R-SCE-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-SCE-5668541. TNFR2 non-canonical NF-kB pathway.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-5689880. Ub-specific processing proteases.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-68949. Orc1 removal from chromatin.
R-SCE-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SCE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SCE-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SCE-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SCE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

EvolutionaryTraceiP23724.
PROiP23724.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSB6_YEAST
AccessioniPrimary (citable) accession number: P23724
Secondary accession number(s): D6VPV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 184 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.