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Reviewed, UniProtKB/Swiss-Prot P23715 (ARGC_BACSU)

Last modified November 3, 2009. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase
Gene names
Name: argC
Ordered Locus Names: BSU11190
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

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Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionN-acetyl-gamma-glutamyl-phosphate reductase activity

Inferred from electronic annotation. Source: HAMAP

NAD or NADH binding

Inferred from electronic annotation. Source: InterPro

protein dimerization activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150
PRO_0000112385

Sites

Active site1491 By similarity

Experimental info

Sequence conflict2351V → F in CAA37016. Ref.1
Sequence conflict2351V → F in CAA81543. Ref.2
Sequence conflict3401I → II in CAA81543. Ref.2
Sequence conflict3401I → II in CAB01842. Ref.3
Sequence conflict3401I → II in CAA70638. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P23715-1 [UniParc].

Last modified June 16, 2009. Version 3.
Checksum: 35B40ADC17633EA4

FASTA34537,960
        10         20         30         40         50         60 
MKIGIVGATG YGGTELVRIL SHHPHAEECI LYSSSGEGNV YSEGYPHLTG LADQQLKPID 

        70         80         90        100        110        120 
MNTIKHEIDI MFLAAPPGVS SELTPKLADA GITVIDLSGD LRIKEPAEYE KWYKRTAAPK 

       130        140        150        160        170        180 
AVIQEAVYGL AELNQLQIQQ AKLIANPGCF PTAVLLGLAP LAQKKLLDES FVIVDAKTGV 

       190        200        210        220        230        240 
SGAGRKASMG THFSELNDNF KIYKVNEHQH TPEIEQALNE WQPGLGPITF SAHLVPMTRG 

       250        260        270        280        290        300 
IMATMYTRLT CDLTADDLHD LYSEFYQDSY FVRVRPKGQY PQTKEVYGSN FCDIAVTLDE 

       310        320        330        340 
RTNRVTIVSV IDNLMKGAAG QAVQNFNLMN GWNEETGLTI TPIYP

« Hide

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References

« Hide 'large scale' references
[1]"Nucleotide sequence of the Bacillus subtilis argC gene encoding N-acetylglutamate-gamma-semialdehyde dehydrogenase."
Smith M.C.M., Mountain A., Baumberg S.
Nucleic Acids Res. 18:4595-4595(1990) [PubMed: 2117746] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / EMG50.
[2]"Sequence and analysis of the citrulline biosynthetic operon argC-F from Bacillus subtilis."
O'Reilly M., Devine K.M.
Microbiology 140:1023-1025(1994) [PubMed: 8025667] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"A 10.3 kbp segment from nprB to argJ at the 102 degrees region of the Bacillus subtilis chromosome."
Levine A., Vannier F., Roche B., Autret S., Mavel D., Seror S.J.
Microbiology 143:175-177(1997) [PubMed: 9025291] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[4]"Sequencing of regions downstream of addA (98 degrees) and citG (289 degrees) in Bacillus subtilis."
Medina N., Vannier F., Roche B., Autret S., Levine A., Seror S.J.
Microbiology 143:3305-3308(1997) [PubMed: 9353931] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[5]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[6]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract]
Cited for: SEQUENCE REVISION TO 235 AND 340.
[7]"Sequence analysis of the Bacillus subtilis argC promoter region."
Smith M.C.M., Mountain A., Baumberg S.
Gene 49:53-60(1986) [PubMed: 3106155] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.

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Cross-references

Sequence databases

X52834 Genomic DNA. Translation: CAA37016.1.
Z26919 Genomic DNA. Translation: CAA81543.1.
Z79580 Genomic DNA. Translation: CAB01842.1.
Y09476 Genomic DNA. Translation: CAA70638.1.
AL009126 Genomic DNA. Translation: CAB12960.2.
M15420 Genomic DNA. Translation: AAA22248.1.
PIRI40372.
RefSeqNP_389001.2.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID936389.
GenomeReviewsGene locus BSU11190 in contig AL009126_GR.
KEGGbsu:BSU11190.

Organism-specific databases

SubtiListBG10191. argC. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMP23715.

Enzyme and pathway databases

BioCycBSUB224308:BSU1120-MON.
BRENDA1.2.1.38. 150.

Family and domain databases

HAMAPMF_00150.
[Tree]
InterProIPR000706. AGPR_act_site.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_C.
[Graphical view]
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
ProDomPD003765. AGPR_act_site. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameARGC_BACSU
AccessionPrimary (citable) accession number: P23715
Secondary accession number(s): O08146, P70953
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 16, 2009
Last modified: November 3, 2009
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents