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P23712 (GLNA_LACSA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

EC=6.3.1.2
Alternative name(s):
GS(1)
Glutamate--ammonia ligase
OrganismLactuca sativa (Garden lettuce)
Taxonomic identifier4236 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeCichorioideaeCichorieaeLactucinaeLactuca

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Subunit structure

Homooctamer.

Subcellular location

Cytoplasm.

Miscellaneous

Irreversibly inhibited by the herbicide L-phosphinothricin (PPT).

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Glutamine synthetase
PRO_0000153174

Sequences

Sequence LengthMass (Da)Tools
P23712 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 789A4E731DDDFBEB

FASTA35839,470
        10         20         30         40         50         60 
MALLSDLVNL DLSSITDKII AEYIWIGGSG MDLRSKARTL SGPVSDPSEL PKWNYDGSST 

        70         80         90        100        110        120 
GQAPGEDSEV IIYPQAIFKD PFRRGNHILV MCDAYTPAGE PIPTNKRAAA AKIFSNPEVE 

       130        140        150        160        170        180 
KEVTWYGIEQ EYTLLQKDTN WPLGWPLGGF PGPQGPYYCG IGADKAFGRD IVDAHYKACL 

       190        200        210        220        230        240 
YAGVNISGIN GEVMPGQWEF QVGPSVGIAA ADQIWVARYI LERITEIYGV VVSFDPKPIP 

       250        260        270        280        290        300 
GDWNGAGAHT NYSTKTMREE GGYEVIKKAI EKLGLRHKEH IAAYGEGNER RLTGRHETAD 

       310        320        330        340        350 
INTFLWGVAN RGASIRVGRD TEKEGKGYFE DRRPASNMDP YVVTSMIAET TILWDNKS 

« Hide

References

[1]"Phytochrome-mediated activation of the gene for cytosolic glutamine-synthetase (GS1) during imbibition of photosensitive lettuce seeds."
Sakamoto A., Takeba G., Shibata D., Tanaka K.
Plant Mol. Biol. 15:317-323(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. New York 515 improved.
Tissue: Seed.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60092 mRNA. Translation: CAA42689.1.
PIRAJLCQB. S11965.

3D structure databases

ProteinModelPortalP23712.
SMRP23712. Positions 4-354.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_LACSA
AccessionPrimary (citable) accession number: P23712
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families