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P23711

- HMOX2_RAT

UniProt

P23711 - HMOX2_RAT

Protein

Heme oxygenase 2

Gene

Hmox2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi44 – 441Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme oxygenase (decyclizing) activity Source: RGD
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. heme oxidation Source: RGD
    2. response to hypoxia Source: Ensembl
    3. response to oxidative stress Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKP23711.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme oxygenase 2 (EC:1.14.99.3)
    Short name:
    HO-2
    Gene namesi
    Name:Hmox2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi67402. Hmox2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 315314Heme oxygenase 2PRO_0000209694Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP23711.
    PRIDEiP23711.

    Expressioni

    Tissue specificityi

    Widely distributed in body with a high concentration in the brain.

    Inductioni

    Heme oxygenase 2 activity is non-inducible.

    Gene expression databases

    GenevestigatoriP23711.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CALMP621573EBI-2910092,EBI-397403From a different organism.
    Calm3P621612EBI-2910092,EBI-397530

    Protein-protein interaction databases

    IntActiP23711. 2 interactions.
    MINTiMINT-4565100.
    STRINGi10116.ENSRNOP00000005031.

    Structurei

    3D structure databases

    ProteinModelPortaliP23711.
    SMRiP23711. Positions 29-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati263 – 2686HRM 1
    Repeati280 – 2856HRM 2

    Sequence similaritiesi

    Belongs to the heme oxygenase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5398.
    GeneTreeiENSGT00390000017673.
    HOGENOMiHOG000233221.
    HOVERGENiHBG005982.
    InParanoidiP23711.
    KOiK00510.
    OMAiMDRNKDH.
    OrthoDBiEOG7JQBNR.
    PhylomeDBiP23711.
    TreeFamiTF314786.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    InterProiIPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view]
    PANTHERiPTHR10720. PTHR10720. 1 hit.
    PfamiPF01126. Heme_oxygenase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000343. Haem_Oase. 1 hit.
    PRINTSiPR00088. HAEMOXYGNASE.
    SUPFAMiSSF48613. SSF48613. 1 hit.
    PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23711-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEVETSEG VDESENNSTA PEKENHTKMA DLSELLKEGT KEAHDRAENT    50
    QFVKDFLKGN IKKELFKLAT TALYFTYSAL EEEMDRNKDH PAFAPLYFPT 100
    ELHRKEALIK DMEYFFGENW EEQVKCSEAA QKYVDRIHYV GQNEPELLVA 150
    HAYTRYMGDL SGGQVLKKVA QRALKLPSTG EGTQFYLFEH VDNAQQFKQF 200
    YRARMNALDL SMKTKERIVE EANKAFEYNM QIFSELDQAG SMLTKETLED 250
    GLPVHDGKGD VRKCPFYAAQ PDKGTLGGSN CPFRTAMAVL RKPSLQLILA 300
    ASVALVAGLL AWYYM 315
    Length:315
    Mass (Da):35,762
    Last modified:November 1, 1991 - v1
    Checksum:i981AADE01DE1AFCF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1465QNEPE → EFRNK in AAA41347. (PubMed:3343248)Curated
    Sequence conflicti230 – 2323MQI → TEF in AAA41347. (PubMed:3343248)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05405 mRNA. Translation: AAA41340.1.
    U05013 Genomic DNA. Translation: AAA19130.1.
    BC062061 mRNA. Translation: AAH62061.1.
    M18918 mRNA. Translation: AAA41347.1.
    PIRiA35199.
    RefSeqiNP_001264002.1. NM_001277073.1.
    NP_077363.1. NM_024387.2.
    XP_006245889.1. XM_006245827.1.
    UniGeneiRn.10241.

    Genome annotation databases

    EnsembliENSRNOT00000005031; ENSRNOP00000005031; ENSRNOG00000003773.
    GeneIDi79239.
    KEGGirno:79239.
    UCSCiRGD:67402. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05405 mRNA. Translation: AAA41340.1 .
    U05013 Genomic DNA. Translation: AAA19130.1 .
    BC062061 mRNA. Translation: AAH62061.1 .
    M18918 mRNA. Translation: AAA41347.1 .
    PIRi A35199.
    RefSeqi NP_001264002.1. NM_001277073.1.
    NP_077363.1. NM_024387.2.
    XP_006245889.1. XM_006245827.1.
    UniGenei Rn.10241.

    3D structure databases

    ProteinModelPortali P23711.
    SMRi P23711. Positions 29-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P23711. 2 interactions.
    MINTi MINT-4565100.
    STRINGi 10116.ENSRNOP00000005031.

    Chemistry

    BindingDBi P23711.
    ChEMBLi CHEMBL3348.

    Proteomic databases

    PaxDbi P23711.
    PRIDEi P23711.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005031 ; ENSRNOP00000005031 ; ENSRNOG00000003773 .
    GeneIDi 79239.
    KEGGi rno:79239.
    UCSCi RGD:67402. rat.

    Organism-specific databases

    CTDi 3163.
    RGDi 67402. Hmox2.

    Phylogenomic databases

    eggNOGi COG5398.
    GeneTreei ENSGT00390000017673.
    HOGENOMi HOG000233221.
    HOVERGENi HBG005982.
    InParanoidi P23711.
    KOi K00510.
    OMAi MDRNKDH.
    OrthoDBi EOG7JQBNR.
    PhylomeDBi P23711.
    TreeFami TF314786.

    Enzyme and pathway databases

    SABIO-RK P23711.

    Miscellaneous databases

    NextBioi 614672.
    PROi P23711.

    Gene expression databases

    Genevestigatori P23711.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    InterProi IPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view ]
    PANTHERi PTHR10720. PTHR10720. 1 hit.
    Pfami PF01126. Heme_oxygenase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000343. Haem_Oase. 1 hit.
    PRINTSi PR00088. HAEMOXYGNASE.
    SUPFAMi SSF48613. SSF48613. 1 hit.
    PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2."
      Rotenberg M.O., Maines M.D.
      J. Biol. Chem. 265:7501-7506(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The structure, organization and differential expression of the gene encoding rat heme oxygenase-2."
      McCoubrey W.K. Jr., Maines M.D.
      Gene 139:155-161(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    4. "Evidence suggesting that the two forms of heme oxygenase are products of different genes."
      Cruse I., Maines M.D.
      J. Biol. Chem. 263:3348-3353(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 142-232, PARTIAL PROTEIN SEQUENCE.
      Tissue: Liver and Testis.

    Entry informationi

    Entry nameiHMOX2_RAT
    AccessioniPrimary (citable) accession number: P23711
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3