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P23710

- NDUS3_NEUCR

UniProt

P23710 - NDUS3_NEUCR

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Protein
NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial
Gene
nuo-31, NCU04074
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation
NADH + acceptor = NAD+ + reduced acceptor.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Protein family/group databases

    TCDBi3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    CI-31kD
    Complex I-30kD
    Gene namesi
    Name:nuo-31
    ORF Names:NCU04074
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 5, Linkage Group VI

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1717Mitochondrion Reviewed prediction
    Add
    BLAST
    Chaini18 – 283266NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrialUniRule annotation
    PRO_0000020000Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of about 40 different subunits. This is a component of the iron-sulfur protein fraction.

    Protein-protein interaction databases

    STRINGi5141.NCU04074.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP23710.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0852.
    HOGENOMiHOG000009797.
    KOiK03936.
    OMAiLRDHSQC.
    OrthoDBiEOG7ZGXDG.

    Family and domain databases

    HAMAPiMF_01357. NDH1_NuoC.
    InterProiIPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view]
    PfamiPF00329. Complex1_30kDa. 1 hit.
    [Graphical view]
    ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
    PROSITEiPS00542. COMPLEX1_30K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23710-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKLCRSRA LASALRSAKP SPAIRCLATT SRNLINMPEG PNPRQFPREP    50
    LPGALNAAVV NPADKYQSKA DNLHKYGSWL MGCLPKYIQQ FSVWKDELTI 100
    YISPAGVIPV FSFLKYNTAA EYTQVSDITA VDFPTKDQRF EVVYNLLSVR 150
    HNSRIRVKTY ADEVSPVPSI TPLYDGANWY EREVYDLFGV FFTGHPDLRR 200
    IMTDYGFDGH PLRKDFPMTG YTEIRYDEEK KRIVTEPLEM TQAFRNFEGG 250
    SSAWEQVGAG IDRKPESFKL PTPKPETKPE EKK 283
    Length:283
    Mass (Da):32,185
    Last modified:June 7, 2005 - v2
    Checksum:i3A2DCD3489F32C6F
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401G → R1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002241 Genomic DNA. Translation: EAA28453.1.
    PIRiA35935.
    RefSeqiXP_957689.1. XM_952596.2.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000003652; EFNCRP00000003652; EFNCRG00000003648.
    GeneIDi3873779.
    KEGGincr:NCU04074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002241 Genomic DNA. Translation: EAA28453.1 .
    PIRi A35935.
    RefSeqi XP_957689.1. XM_952596.2.

    3D structure databases

    ProteinModelPortali P23710.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU04074.1.

    Protein family/group databases

    TCDBi 3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000003652 ; EFNCRP00000003652 ; EFNCRG00000003648 .
    GeneIDi 3873779.
    KEGGi ncr:NCU04074.

    Phylogenomic databases

    eggNOGi COG0852.
    HOGENOMi HOG000009797.
    KOi K03936.
    OMAi LRDHSQC.
    OrthoDBi EOG7ZGXDG.

    Family and domain databases

    HAMAPi MF_01357. NDH1_NuoC.
    InterProi IPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view ]
    Pfami PF00329. Complex1_30kDa. 1 hit.
    [Graphical view ]
    ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
    PROSITEi PS00542. COMPLEX1_30K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Primary structure and expression of a nuclear-coded subunit of complex I homologous to proteins specified by the chloroplast genome."
      Videira A., Tropschug M., Werner S.
      Biochem. Biophys. Res. Commun. 171:1168-1174(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiNDUS3_NEUCR
    AccessioniPrimary (citable) accession number: P23710
    Secondary accession number(s): Q7RV79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: June 7, 2005
    Last modified: February 19, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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