Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P23709

- NDUS3_BOVIN

UniProt

P23709 - NDUS3_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Gene

NDUFS3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  2. NADH dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of cell growth Source: UniProtKB
  2. negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
  3. reactive oxygen species metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-30kD
Short name:
CI-30kD
NADH-ubiquinone oxidoreductase 30 kDa subunit
Gene namesi
Name:NDUFS3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB
  2. mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3838MitochondrionAdd
BLAST
Chaini39 – 266228NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialPRO_0000019997Add
BLAST

Proteomic databases

PaxDbiP23709.
PRIDEiP23709.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. Interacts with NDUFAF3 By similarity.By similarity

Protein-protein interaction databases

IntActiP23709. 3 interactions.
STRINGi9913.ENSBTAP00000024600.

Structurei

3D structure databases

ProteinModelPortaliP23709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 30 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0852.
HOGENOMiHOG000009797.
HOVERGENiHBG000450.
InParanoidiP23709.
KOiK03936.

Family and domain databases

HAMAPiMF_01357. NDH1_NuoC.
InterProiIPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR020396. NADH_UbQ_OxRdtase_CS.
[Graphical view]
PfamiPF00329. Complex1_30kDa. 1 hit.
[Graphical view]
ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
PROSITEiPS00542. COMPLEX1_30K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23709-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAVAAAAR GCWQRLVGSA APARVAGRPS VLLLPVRRES SAADTRPTVR
60 70 80 90 100
PRNDVAHKQL SAFGEYVAEI LPKYVQQVQV SCFNELEICI HPDGVIPVLT
110 120 130 140 150
FLRDHSNAQF KSLADLTAVD IPTRQNRFEI VYNLLSLRFN SRIRVKTYTD
160 170 180 190 200
ELTPIESSVP VYKAANWYER EIWDMFGVFF ANHPDLRRIL TDYGFEGHPF
210 220 230 240 250
RKDFPLSGYV ELRYDDEVKR VVAEPVELAQ EFRKFDLNSP WEAFPAYRQP
260
PESLKLEAGD TKPEAK
Length:266
Mass (Da):30,284
Last modified:November 1, 1991 - v1
Checksum:i43494B3359D2FEB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541L → E AA sequence (PubMed:1907966)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58469 mRNA. Translation: AAA30663.1. Sequence problems.
PIRiA37957.
RefSeqiNP_777244.1. NM_174819.3.
UniGeneiBt.1153.

Genome annotation databases

GeneIDi287327.
KEGGibta:287327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58469 mRNA. Translation: AAA30663.1 . Sequence problems.
PIRi A37957.
RefSeqi NP_777244.1. NM_174819.3.
UniGenei Bt.1153.

3D structure databases

ProteinModelPortali P23709.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P23709. 3 interactions.
STRINGi 9913.ENSBTAP00000024600.

Protein family/group databases

TCDBi 3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbi P23709.
PRIDEi P23709.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 287327.
KEGGi bta:287327.

Organism-specific databases

CTDi 4722.

Phylogenomic databases

eggNOGi COG0852.
HOGENOMi HOG000009797.
HOVERGENi HBG000450.
InParanoidi P23709.
KOi K03936.

Miscellaneous databases

NextBioi 20806550.

Family and domain databases

HAMAPi MF_01357. NDH1_NuoC.
InterProi IPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR020396. NADH_UbQ_OxRdtase_CS.
[Graphical view ]
Pfami PF00329. Complex1_30kDa. 1 hit.
[Graphical view ]
ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
PROSITEi PS00542. COMPLEX1_30K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The 30-kilodalton subunit of bovine mitochondrial complex I is homologous to a protein coded in chloroplast DNA."
    Pilkington S.J., Skehel J.M., Walker J.E.
    Biochemistry 30:1901-1908(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "The amino acid sequences of two 13 kDa polypeptides and partial amino acid sequence of 30 kDa polypeptide of complex I from bovine heart mitochondria: possible location of iron-sulfur clusters."
    Masui R., Wakabayashi S., Matsubara H., Hatefi Y.
    J. Biochem. 109:534-543(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 59-99 AND 197-266.
    Tissue: Heart.

Entry informationi

Entry nameiNDUS3_BOVIN
AccessioniPrimary (citable) accession number: P23709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 1, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3