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P23695 (IGF2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor II

Short name=IGF-II

Cleaved into the following 2 chains:

  1. Insulin-like growth factor II
  2. Preptin
Gene names
Name:IGF2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.

Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the insulin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 9167Insulin-like growth factor II
PRO_0000015727
Propeptide92 – 18190E peptide
PRO_0000015728
Peptide93 – 12634Preptin
PRO_0000370379

Regions

Region25 – 5228B
Region53 – 6412C
Region65 – 8521A
Region86 – 916D

Amino acid modifications

Disulfide bond33 ↔ 71 By similarity
Disulfide bond45 ↔ 84 By similarity
Disulfide bond70 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
P23695 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 1816B935299B44E1

FASTA18120,313
        10         20         30         40         50         60 
MGIPMRKPLL VLLVFLALAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVN 

        70         80         90        100        110        120 
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFRYDTWK 

       130        140        150        160        170        180 
QSAQRLRRGL PALLRARRGR TLAKELEAVR EAKRHRPLTA RPTRDPAAHG GASPEASGHR 


K 

« Hide

References

[1]"Nucleotide sequence of a porcine insulin-like growth factor II cDNA."
Catchpole I.R., Engstroem W.
Nucleic Acids Res. 18:6430-6430(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs."
Amarger V., Nguyen M., Van Laere A.-S., Braunschweig M., Nezer C., Georges M., Andersson L.
Mamm. Genome 13:388-398(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Large white.
[3]"A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig."
Van Laere A.-S., Nguyen M., Braunschweig M., Nezer C., Collette C., Moreau L., Archibald A.L., Haley C., Buys N., Tally M., Andersson G., Georges M., Andersson L.
Nature 425:832-836(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: European wild boar, Hampshire, Japanese wild boar, Landrace, Large white, Meishan and Pietrain.
[4]"Purification, amino acid sequences and assay cross-reactivities of porcine insulin-like growth factor-I and -II."
Francis G.L., Owens P.C., McNeil K.A., Wallace J.C., Ballard F.J.
J. Endocrinol. 122:681-687(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-91.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56094 mRNA. Translation: CAA39574.1.
AY044828 Genomic DNA. Translation: AAL69551.1.
AY242098 Genomic DNA. Translation: AAQ00953.1.
AY242099 Genomic DNA. Translation: AAQ00955.1.
AY242100 Genomic DNA. Translation: AAQ00958.1.
AY242101 Genomic DNA. Translation: AAQ00961.1.
AY242102 Genomic DNA. Translation: AAQ00964.1.
AY242103 Genomic DNA. Translation: AAQ00967.1.
AY242104 Genomic DNA. Translation: AAQ00970.1.
AY242105 Genomic DNA. Translation: AAQ00973.1.
AY242106 Genomic DNA. Translation: AAQ00976.1.
AY242107 Genomic DNA. Translation: AAQ00979.1.
AY242108 Genomic DNA. Translation: AAQ00982.1.
AY242109 Genomic DNA. Translation: AAQ00984.1.
AY242110 Genomic DNA. Translation: AAQ00986.1.
AY242111 Genomic DNA. Translation: AAQ00988.1.
AY242112 Genomic DNA. Translation: AAQ00991.1.
PIRB60738. S12614.
RefSeqNP_999048.1. NM_213883.2.
UniGeneSsc.9365.

3D structure databases

ProteinModelPortalP23695.
SMRP23695. Positions 25-91.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP23695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396916.
KEGGssc:396916.

Organism-specific databases

CTD3481.

Phylogenomic databases

HOVERGENHBG006137.
KOK13769.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIGF2_PIG
AccessionPrimary (citable) accession number: P23695
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families