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P23695

- IGF2_PIG

UniProt

P23695 - IGF2_PIG

Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
    Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.By similarity

    GO - Biological processi

    1. glucose metabolic process Source: UniProtKB-KW
    2. ossification Source: UniProtKB-KW
    3. positive regulation of cell division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Growth factor, Hormone, Mitogen

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor II
    Short name:
    IGF-II
    Cleaved into the following 2 chains:
    Gene namesi
    Name:IGF2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 9167Insulin-like growth factor IIPRO_0000015727Add
    BLAST
    Propeptidei92 – 18190E peptidePRO_0000015728Add
    BLAST
    Peptidei93 – 12634PreptinPRO_0000370379Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 71By similarity
    Disulfide bondi45 ↔ 84By similarity
    Disulfide bondi70 ↔ 75By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP23695.

    Structurei

    3D structure databases

    ProteinModelPortaliP23695.
    SMRiP23695. Positions 25-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 5228BAdd
    BLAST
    Regioni53 – 6412CAdd
    BLAST
    Regioni65 – 8521AAdd
    BLAST
    Regioni86 – 916D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006137.
    KOiK13769.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomiPD005188. IGF2_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23695-1 [UniParc]FASTAAdd to Basket

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    MGIPMRKPLL VLLVFLALAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF    50
    YFSRPASRVN RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV 100
    LPDNFPRYPV GKFFRYDTWK QSAQRLRRGL PALLRARRGR TLAKELEAVR 150
    EAKRHRPLTA RPTRDPAAHG GASPEASGHR K 181
    Length:181
    Mass (Da):20,313
    Last modified:February 1, 1996 - v2
    Checksum:i1816B935299B44E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56094 mRNA. Translation: CAA39574.1.
    AY044828 Genomic DNA. Translation: AAL69551.1.
    AY242098 Genomic DNA. Translation: AAQ00953.1.
    AY242099 Genomic DNA. Translation: AAQ00955.1.
    AY242100 Genomic DNA. Translation: AAQ00958.1.
    AY242101 Genomic DNA. Translation: AAQ00961.1.
    AY242102 Genomic DNA. Translation: AAQ00964.1.
    AY242103 Genomic DNA. Translation: AAQ00967.1.
    AY242104 Genomic DNA. Translation: AAQ00970.1.
    AY242105 Genomic DNA. Translation: AAQ00973.1.
    AY242106 Genomic DNA. Translation: AAQ00976.1.
    AY242107 Genomic DNA. Translation: AAQ00979.1.
    AY242108 Genomic DNA. Translation: AAQ00982.1.
    AY242109 Genomic DNA. Translation: AAQ00984.1.
    AY242110 Genomic DNA. Translation: AAQ00986.1.
    AY242111 Genomic DNA. Translation: AAQ00988.1.
    AY242112 Genomic DNA. Translation: AAQ00991.1.
    PIRiS12614. B60738.
    RefSeqiNP_999048.1. NM_213883.2.
    UniGeneiSsc.9365.

    Genome annotation databases

    GeneIDi396916.
    KEGGissc:396916.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56094 mRNA. Translation: CAA39574.1 .
    AY044828 Genomic DNA. Translation: AAL69551.1 .
    AY242098 Genomic DNA. Translation: AAQ00953.1 .
    AY242099 Genomic DNA. Translation: AAQ00955.1 .
    AY242100 Genomic DNA. Translation: AAQ00958.1 .
    AY242101 Genomic DNA. Translation: AAQ00961.1 .
    AY242102 Genomic DNA. Translation: AAQ00964.1 .
    AY242103 Genomic DNA. Translation: AAQ00967.1 .
    AY242104 Genomic DNA. Translation: AAQ00970.1 .
    AY242105 Genomic DNA. Translation: AAQ00973.1 .
    AY242106 Genomic DNA. Translation: AAQ00976.1 .
    AY242107 Genomic DNA. Translation: AAQ00979.1 .
    AY242108 Genomic DNA. Translation: AAQ00982.1 .
    AY242109 Genomic DNA. Translation: AAQ00984.1 .
    AY242110 Genomic DNA. Translation: AAQ00986.1 .
    AY242111 Genomic DNA. Translation: AAQ00988.1 .
    AY242112 Genomic DNA. Translation: AAQ00991.1 .
    PIRi S12614. B60738.
    RefSeqi NP_999048.1. NM_213883.2.
    UniGenei Ssc.9365.

    3D structure databases

    ProteinModelPortali P23695.
    SMRi P23695. Positions 25-91.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P23695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396916.
    KEGGi ssc:396916.

    Organism-specific databases

    CTDi 3481.

    Phylogenomic databases

    HOVERGENi HBG006137.
    KOi K13769.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomi PD005188. IGF2_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a porcine insulin-like growth factor II cDNA."
      Catchpole I.R., Engstroem W.
      Nucleic Acids Res. 18:6430-6430(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs."
      Amarger V., Nguyen M., Van Laere A.-S., Braunschweig M., Nezer C., Georges M., Andersson L.
      Mamm. Genome 13:388-398(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Large white.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: European wild boar, Hampshire, Japanese wild boar, Landrace, Large white, Meishan and Pietrain.
    4. "Purification, amino acid sequences and assay cross-reactivities of porcine insulin-like growth factor-I and -II."
      Francis G.L., Owens P.C., McNeil K.A., Wallace J.C., Ballard F.J.
      J. Endocrinol. 122:681-687(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-91.

    Entry informationi

    Entry nameiIGF2_PIG
    AccessioniPrimary (citable) accession number: P23695
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3