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P23695

- IGF2_PIG

UniProt

P23695 - IGF2_PIG

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Protein
Insulin-like growth factor II
Gene
IGF2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
  2. ossification Source: UniProtKB-KW
  3. positive regulation of cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone, Mitogen

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Cleaved into the following 2 chains:
Gene namesi
Name:IGF2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 By similarity
Add
BLAST
Chaini25 – 9167Insulin-like growth factor II
PRO_0000015727Add
BLAST
Propeptidei92 – 18190E peptide
PRO_0000015728Add
BLAST
Peptidei93 – 12634Preptin
PRO_0000370379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 71 By similarity
Disulfide bondi45 ↔ 84 By similarity
Disulfide bondi70 ↔ 75 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP23695.

Structurei

3D structure databases

ProteinModelPortaliP23695.
SMRiP23695. Positions 25-91.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 5228B
Add
BLAST
Regioni53 – 6412C
Add
BLAST
Regioni65 – 8521A
Add
BLAST
Regioni86 – 916D

Sequence similaritiesi

Belongs to the insulin family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
KOiK13769.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23695-1 [UniParc]FASTAAdd to Basket

« Hide

MGIPMRKPLL VLLVFLALAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF    50
YFSRPASRVN RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV 100
LPDNFPRYPV GKFFRYDTWK QSAQRLRRGL PALLRARRGR TLAKELEAVR 150
EAKRHRPLTA RPTRDPAAHG GASPEASGHR K 181
Length:181
Mass (Da):20,313
Last modified:February 1, 1996 - v2
Checksum:i1816B935299B44E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56094 mRNA. Translation: CAA39574.1.
AY044828 Genomic DNA. Translation: AAL69551.1.
AY242098 Genomic DNA. Translation: AAQ00953.1.
AY242099 Genomic DNA. Translation: AAQ00955.1.
AY242100 Genomic DNA. Translation: AAQ00958.1.
AY242101 Genomic DNA. Translation: AAQ00961.1.
AY242102 Genomic DNA. Translation: AAQ00964.1.
AY242103 Genomic DNA. Translation: AAQ00967.1.
AY242104 Genomic DNA. Translation: AAQ00970.1.
AY242105 Genomic DNA. Translation: AAQ00973.1.
AY242106 Genomic DNA. Translation: AAQ00976.1.
AY242107 Genomic DNA. Translation: AAQ00979.1.
AY242108 Genomic DNA. Translation: AAQ00982.1.
AY242109 Genomic DNA. Translation: AAQ00984.1.
AY242110 Genomic DNA. Translation: AAQ00986.1.
AY242111 Genomic DNA. Translation: AAQ00988.1.
AY242112 Genomic DNA. Translation: AAQ00991.1.
PIRiS12614. B60738.
RefSeqiNP_999048.1. NM_213883.2.
UniGeneiSsc.9365.

Genome annotation databases

GeneIDi396916.
KEGGissc:396916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56094 mRNA. Translation: CAA39574.1 .
AY044828 Genomic DNA. Translation: AAL69551.1 .
AY242098 Genomic DNA. Translation: AAQ00953.1 .
AY242099 Genomic DNA. Translation: AAQ00955.1 .
AY242100 Genomic DNA. Translation: AAQ00958.1 .
AY242101 Genomic DNA. Translation: AAQ00961.1 .
AY242102 Genomic DNA. Translation: AAQ00964.1 .
AY242103 Genomic DNA. Translation: AAQ00967.1 .
AY242104 Genomic DNA. Translation: AAQ00970.1 .
AY242105 Genomic DNA. Translation: AAQ00973.1 .
AY242106 Genomic DNA. Translation: AAQ00976.1 .
AY242107 Genomic DNA. Translation: AAQ00979.1 .
AY242108 Genomic DNA. Translation: AAQ00982.1 .
AY242109 Genomic DNA. Translation: AAQ00984.1 .
AY242110 Genomic DNA. Translation: AAQ00986.1 .
AY242111 Genomic DNA. Translation: AAQ00988.1 .
AY242112 Genomic DNA. Translation: AAQ00991.1 .
PIRi S12614. B60738.
RefSeqi NP_999048.1. NM_213883.2.
UniGenei Ssc.9365.

3D structure databases

ProteinModelPortali P23695.
SMRi P23695. Positions 25-91.
ModBasei Search...

Proteomic databases

PRIDEi P23695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396916.
KEGGi ssc:396916.

Organism-specific databases

CTDi 3481.

Phylogenomic databases

HOVERGENi HBG006137.
KOi K13769.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomi PD005188. IGF2_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a porcine insulin-like growth factor II cDNA."
    Catchpole I.R., Engstroem W.
    Nucleic Acids Res. 18:6430-6430(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs."
    Amarger V., Nguyen M., Van Laere A.-S., Braunschweig M., Nezer C., Georges M., Andersson L.
    Mamm. Genome 13:388-398(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Large white.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: European wild boar, Hampshire, Japanese wild boar, Landrace, Large white, Meishan and Pietrain.
  4. "Purification, amino acid sequences and assay cross-reactivities of porcine insulin-like growth factor-I and -II."
    Francis G.L., Owens P.C., McNeil K.A., Wallace J.C., Ballard F.J.
    J. Endocrinol. 122:681-687(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-91.

Entry informationi

Entry nameiIGF2_PIG
AccessioniPrimary (citable) accession number: P23695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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