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P23695

- IGF2_PIG

UniProt

P23695 - IGF2_PIG

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Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.By similarity

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
  2. ossification Source: UniProtKB-KW
  3. positive regulation of cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone, Mitogen

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Cleaved into the following 2 chains:
Gene namesi
Name:IGF2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 9167Insulin-like growth factor IIPRO_0000015727Add
BLAST
Propeptidei92 – 18190E peptidePRO_0000015728Add
BLAST
Peptidei93 – 12634PreptinPRO_0000370379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 71By similarity
Disulfide bondi45 ↔ 84By similarity
Disulfide bondi70 ↔ 75By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP23695.

Structurei

3D structure databases

ProteinModelPortaliP23695.
SMRiP23695. Positions 25-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 5228BAdd
BLAST
Regioni53 – 6412CAdd
BLAST
Regioni65 – 8521AAdd
BLAST
Regioni86 – 916D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
InParanoidiP23695.
KOiK13769.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23695-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGIPMRKPLL VLLVFLALAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF
60 70 80 90 100
YFSRPASRVN RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV
110 120 130 140 150
LPDNFPRYPV GKFFRYDTWK QSAQRLRRGL PALLRARRGR TLAKELEAVR
160 170 180
EAKRHRPLTA RPTRDPAAHG GASPEASGHR K
Length:181
Mass (Da):20,313
Last modified:February 1, 1996 - v2
Checksum:i1816B935299B44E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56094 mRNA. Translation: CAA39574.1.
AY044828 Genomic DNA. Translation: AAL69551.1.
AY242098 Genomic DNA. Translation: AAQ00953.1.
AY242099 Genomic DNA. Translation: AAQ00955.1.
AY242100 Genomic DNA. Translation: AAQ00958.1.
AY242101 Genomic DNA. Translation: AAQ00961.1.
AY242102 Genomic DNA. Translation: AAQ00964.1.
AY242103 Genomic DNA. Translation: AAQ00967.1.
AY242104 Genomic DNA. Translation: AAQ00970.1.
AY242105 Genomic DNA. Translation: AAQ00973.1.
AY242106 Genomic DNA. Translation: AAQ00976.1.
AY242107 Genomic DNA. Translation: AAQ00979.1.
AY242108 Genomic DNA. Translation: AAQ00982.1.
AY242109 Genomic DNA. Translation: AAQ00984.1.
AY242110 Genomic DNA. Translation: AAQ00986.1.
AY242111 Genomic DNA. Translation: AAQ00988.1.
AY242112 Genomic DNA. Translation: AAQ00991.1.
PIRiS12614. B60738.
RefSeqiNP_999048.1. NM_213883.2.
UniGeneiSsc.9365.

Genome annotation databases

GeneIDi396916.
KEGGissc:396916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56094 mRNA. Translation: CAA39574.1 .
AY044828 Genomic DNA. Translation: AAL69551.1 .
AY242098 Genomic DNA. Translation: AAQ00953.1 .
AY242099 Genomic DNA. Translation: AAQ00955.1 .
AY242100 Genomic DNA. Translation: AAQ00958.1 .
AY242101 Genomic DNA. Translation: AAQ00961.1 .
AY242102 Genomic DNA. Translation: AAQ00964.1 .
AY242103 Genomic DNA. Translation: AAQ00967.1 .
AY242104 Genomic DNA. Translation: AAQ00970.1 .
AY242105 Genomic DNA. Translation: AAQ00973.1 .
AY242106 Genomic DNA. Translation: AAQ00976.1 .
AY242107 Genomic DNA. Translation: AAQ00979.1 .
AY242108 Genomic DNA. Translation: AAQ00982.1 .
AY242109 Genomic DNA. Translation: AAQ00984.1 .
AY242110 Genomic DNA. Translation: AAQ00986.1 .
AY242111 Genomic DNA. Translation: AAQ00988.1 .
AY242112 Genomic DNA. Translation: AAQ00991.1 .
PIRi S12614. B60738.
RefSeqi NP_999048.1. NM_213883.2.
UniGenei Ssc.9365.

3D structure databases

ProteinModelPortali P23695.
SMRi P23695. Positions 25-91.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P23695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396916.
KEGGi ssc:396916.

Organism-specific databases

CTDi 3481.

Phylogenomic databases

HOVERGENi HBG006137.
InParanoidi P23695.
KOi K13769.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomi PD005188. IGF2_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a porcine insulin-like growth factor II cDNA."
    Catchpole I.R., Engstroem W.
    Nucleic Acids Res. 18:6430-6430(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs."
    Amarger V., Nguyen M., Van Laere A.-S., Braunschweig M., Nezer C., Georges M., Andersson L.
    Mamm. Genome 13:388-398(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Large white.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: European wild boar, Hampshire, Japanese wild boar, Landrace, Large white, Meishan and Pietrain.
  4. "Purification, amino acid sequences and assay cross-reactivities of porcine insulin-like growth factor-I and -II."
    Francis G.L., Owens P.C., McNeil K.A., Wallace J.C., Ballard F.J.
    J. Endocrinol. 122:681-687(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-91.

Entry informationi

Entry nameiIGF2_PIG
AccessioniPrimary (citable) accession number: P23695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3