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Protein

Serum amyloid P-component

Gene

Apcs

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Calcium 1By similarity
Metal bindingi79 – 791Calcium 1By similarity
Metal bindingi156 – 1561Calcium 1By similarity
Metal bindingi156 – 1561Calcium 2By similarity
Metal bindingi157 – 1571Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi158 – 1581Calcium 1By similarity
Metal bindingi158 – 1581Calcium 2By similarity
Metal bindingi168 – 1681Calcium 2By similarity

GO - Molecular functioni

GO - Biological processi

  • protein complex assembly Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid P-component
Short name:
SAP
Gene namesi
Name:Apcs
Synonyms:Ptx2, Sap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68322. Apcs.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Secreted

Pathology & Biotechi

Involvement in diseasei

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 228208Serum amyloid P-componentPRO_0000023544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Curated
Disulfide bondi56 ↔ 115By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP23680.
PRIDEiP23680.

Expressioni

Gene expression databases

GenevisibleiP23680. RN.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012092.

Structurei

3D structure databases

ProteinModelPortaliP23680.
SMRiP23680. Positions 21-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 228208PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1FD. Eukaryota.
ENOG410YN8S. LUCA.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP23680.
OMAiDNTNKEM.
OrthoDBiEOG71RXMB.
PhylomeDBiP23680.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLLLWMSV FTSLLSEAFA QTDLNQKVFV FPRESETDYV KLIPWLEKPL
60 70 80 90 100
QNFTLCFRAY SDLSRSQSLF SYSVNSRDNE LLIYKDKVGQ YSLYIGNSKV
110 120 130 140 150
TVRGLEEFPS PIHFCTSWES SSGIAEFWVN GKPWVKKGLQ KGYTVKSSPS
160 170 180 190 200
IVLGQEQDTY GGGFDKTQSF VGEIADLYMW DSVLTPENIH SVDRGFPPNP
210 220
NILDWRALNY EINGYVVIKP RMWDNKSS
Length:228
Mass (Da):26,176
Last modified:July 15, 1998 - v2
Checksum:iE2314CBDA1103996
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861D → A (PubMed:2400402).Curated
Sequence conflicti88 – 892VG → LE (PubMed:2400402).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55761 mRNA. Translation: CAA39287.1.
M83177 mRNA. Translation: AAB59696.1.
PIRiS11473.
RefSeqiNP_058866.2. NM_017170.2.
UniGeneiRn.109007.

Genome annotation databases

GeneIDi29339.
KEGGirno:29339.
UCSCiRGD:68322. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55761 mRNA. Translation: CAA39287.1.
M83177 mRNA. Translation: AAB59696.1.
PIRiS11473.
RefSeqiNP_058866.2. NM_017170.2.
UniGeneiRn.109007.

3D structure databases

ProteinModelPortaliP23680.
SMRiP23680. Positions 21-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012092.

Proteomic databases

PaxDbiP23680.
PRIDEiP23680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29339.
KEGGirno:29339.
UCSCiRGD:68322. rat.

Organism-specific databases

CTDi325.
RGDi68322. Apcs.

Phylogenomic databases

eggNOGiENOG410J1FD. Eukaryota.
ENOG410YN8S. LUCA.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP23680.
OMAiDNTNKEM.
OrthoDBiEOG71RXMB.
PhylomeDBiP23680.
TreeFamiTF330208.

Miscellaneous databases

NextBioi608828.
PROiP23680.

Gene expression databases

GenevisibleiP23680. RN.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat serum amyloid P component. Analysis of cDNA sequence and gene expression."
    Dowton S.B., McGrew S.D.
    Biochem. J. 270:553-556(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Rassouli M., Murray R.K.
    Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiSAMP_RAT
AccessioniPrimary (citable) accession number: P23680
Secondary accession number(s): Q63539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: July 15, 1998
Last modified: February 17, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.