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Protein

Inositol-trisphosphate 3-kinase A

Gene

ITPKA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulationi

IP3K is activated by calmodulin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197ATPCombined sources1 Publication1
Binding sitei209ATPCombined sources1 Publication1
Binding sitei262ATPCombined sources1 Publication1
Binding sitei264SubstrateCombined sources1 Publication1
Binding sitei285SubstrateCombined sources1 Publication1
Binding sitei336ATPCombined sources1 Publication1
Binding sitei416ATPCombined sources1 Publication1
Binding sitei419SubstrateCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi249 – 251ATPCombined sources1 Publication3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06405-MONOMER.
ZFISH:HS06405-MONOMER.
BRENDAi2.7.1.127. 2681.
ReactomeiR-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
SIGNORiP23677.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-trisphosphate 3-kinase A (EC:2.7.1.127)
Alternative name(s):
Inositol 1,4,5-trisphosphate 3-kinase A
Short name:
IP3 3-kinase A
Short name:
IP3K A
Short name:
InsP 3-kinase A
Gene namesi
Name:ITPKA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:6178. ITPKA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi3706.
OpenTargetsiENSG00000137825.
PharmGKBiPA29975.

Polymorphism and mutation databases

BioMutaiITPKA.
DMDMi124807.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668651 – 461Inositol-trisphosphate 3-kinase AAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35Omega-N-methylarginineBy similarity1
Modified residuei55Omega-N-methylarginineBy similarity1
Modified residuei62Omega-N-methylarginineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei197PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP23677.
MaxQBiP23677.
PaxDbiP23677.
PeptideAtlasiP23677.
PRIDEiP23677.

PTM databases

iPTMnetiP23677.
PhosphoSitePlusiP23677.

Expressioni

Gene expression databases

BgeeiENSG00000137825.
CleanExiHS_ITPKA.
ExpressionAtlasiP23677. baseline and differential.
GenevisibleiP23677. HS.

Organism-specific databases

HPAiHPA040454.

Interactioni

Protein-protein interaction databases

BioGridi109911. 2 interactors.
IntActiP23677. 1 interactor.
STRINGi9606.ENSP00000260386.

Chemistry databases

BindingDBiP23677.

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi166 – 174Combined sources9
Turni177 – 179Combined sources3
Helixi188 – 191Combined sources4
Beta strandi198 – 200Combined sources3
Beta strandi206 – 210Combined sources5
Helixi213 – 223Combined sources11
Helixi226 – 230Combined sources5
Beta strandi234 – 240Combined sources7
Beta strandi243 – 249Combined sources7
Turni251 – 254Combined sources4
Beta strandi259 – 267Combined sources9
Helixi272 – 280Combined sources9
Helixi286 – 295Combined sources10
Helixi302 – 307Combined sources6
Helixi312 – 322Combined sources11
Helixi325 – 328Combined sources4
Beta strandi329 – 336Combined sources8
Beta strandi338 – 340Combined sources3
Helixi352 – 363Combined sources12
Helixi367 – 384Combined sources18
Helixi388 – 391Combined sources4
Beta strandi393 – 397Combined sources5
Beta strandi399 – 404Combined sources6
Beta strandi410 – 415Combined sources6
Beta strandi419 – 422Combined sources4
Beta strandi431 – 433Combined sources3
Helixi444 – 459Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W2CX-ray1.95A/B197-461[»]
1W2DX-ray1.94A/B197-461[»]
1W2FX-ray1.80A/B188-461[»]
4UPUX-ray2.34B158-183[»]
ProteinModelPortaliP23677.
SMRiP23677.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23677.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni287 – 295Calmodulin-bindingBy similarity9
Regioni312 – 319Substrate binding1 Publication8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1621. Eukaryota.
ENOG410Y8AC. LUCA.
GeneTreeiENSGT00390000017438.
HOGENOMiHOG000231765.
HOVERGENiHBG052138.
InParanoidiP23677.
KOiK00911.
OMAiWLPAVGS.
OrthoDBiEOG091G03J3.
PhylomeDBiP23677.
TreeFamiTF318394.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPGGPTGM ARPGGARPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA
60 70 80 90 100
AGEPRARGAK RRGGQVPNGL PRAPPAPVIP QLTVTAEEPD VPPTSPGPPE
110 120 130 140 150
RERDCLPAAG SSHLQQPRRL STSSVSSTGS SSLLEDSEDD LLSDSESRSR
160 170 180 190 200
GNVQLEAGED VGQKNHWQKI RTMVNLPVIS PFKKRYAWVQ LAGHTGSFKA
210 220 230 240 250
AGTSGLILKR CSEPERYCLA RLMADALRGC VPAFHGVVER DGESYLQLQD
260 270 280 290 300
LLDGFDGPCV LDCKMGVRTY LEEELTKARE RPKLRKDMYK KMLAVDPEAP
310 320 330 340 350
TEEEHAQRAV TKPRYMQWRE GISSSTTLGF RIEGIKKADG SCSTDFKTTR
360 370 380 390 400
SREQVLRVFE EFVQGDEEVL RRYLNRLQQI RDTLEVSEFF RRHEVIGSSL
410 420 430 440 450
LFVHDHCHRA GVWLIDFGKT TPLPDGQILD HRRPWEEGNR EDGYLLGLDN
460
LIGILASLAE R
Length:461
Mass (Da):51,009
Last modified:November 1, 1991 - v1
Checksum:i18CA214A091F5B19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71P → Q in AAH26331 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54938 mRNA. Translation: CAA38700.1.
BC026331 mRNA. Translation: AAH26331.1.
CCDSiCCDS10076.1.
PIRiJN0129.
RefSeqiNP_002211.1. NM_002220.2.
UniGeneiHs.2722.

Genome annotation databases

EnsembliENST00000260386; ENSP00000260386; ENSG00000137825.
GeneIDi3706.
KEGGihsa:3706.
UCSCiuc001znz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54938 mRNA. Translation: CAA38700.1.
BC026331 mRNA. Translation: AAH26331.1.
CCDSiCCDS10076.1.
PIRiJN0129.
RefSeqiNP_002211.1. NM_002220.2.
UniGeneiHs.2722.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W2CX-ray1.95A/B197-461[»]
1W2DX-ray1.94A/B197-461[»]
1W2FX-ray1.80A/B188-461[»]
4UPUX-ray2.34B158-183[»]
ProteinModelPortaliP23677.
SMRiP23677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109911. 2 interactors.
IntActiP23677. 1 interactor.
STRINGi9606.ENSP00000260386.

Chemistry databases

BindingDBiP23677.

PTM databases

iPTMnetiP23677.
PhosphoSitePlusiP23677.

Polymorphism and mutation databases

BioMutaiITPKA.
DMDMi124807.

Proteomic databases

EPDiP23677.
MaxQBiP23677.
PaxDbiP23677.
PeptideAtlasiP23677.
PRIDEiP23677.

Protocols and materials databases

DNASUi3706.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260386; ENSP00000260386; ENSG00000137825.
GeneIDi3706.
KEGGihsa:3706.
UCSCiuc001znz.4. human.

Organism-specific databases

CTDi3706.
DisGeNETi3706.
GeneCardsiITPKA.
HGNCiHGNC:6178. ITPKA.
HPAiHPA040454.
MIMi147521. gene.
neXtProtiNX_P23677.
OpenTargetsiENSG00000137825.
PharmGKBiPA29975.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1621. Eukaryota.
ENOG410Y8AC. LUCA.
GeneTreeiENSGT00390000017438.
HOGENOMiHOG000231765.
HOVERGENiHBG052138.
InParanoidiP23677.
KOiK00911.
OMAiWLPAVGS.
OrthoDBiEOG091G03J3.
PhylomeDBiP23677.
TreeFamiTF318394.

Enzyme and pathway databases

BioCyciMetaCyc:HS06405-MONOMER.
ZFISH:HS06405-MONOMER.
BRENDAi2.7.1.127. 2681.
ReactomeiR-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
SIGNORiP23677.

Miscellaneous databases

ChiTaRSiITPKA. human.
EvolutionaryTraceiP23677.
GeneWikiiITPKA.
GenomeRNAii3706.
PROiP23677.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137825.
CleanExiHS_ITPKA.
ExpressionAtlasiP23677. baseline and differential.
GenevisibleiP23677. HS.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIP3KA_HUMAN
AccessioniPrimary (citable) accession number: P23677
Secondary accession number(s): Q8TAN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.