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Reviewed, UniProtKB/Swiss-Prot P23677 (IP3KA_HUMAN)

Last modified June 16, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Inositol-trisphosphate 3-kinase A
    EC=2.7.1.127
Alternative name(s):
    Inositol 1,4,5-trisphosphate 3-kinase A
    IP3 3-kinase A
      Short name=IP3K A
Gene names
Name: ITPKA
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulation

IP3K is activated by calmodulin.

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

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Ontologies

Keywords
   LigandATP-binding
Calmodulin-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical term3D-structure
Gene Ontology (GO)
   Biological processsignal transduction Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

calmodulin binding

Inferred from electronic annotation. Source: UniProtKB-KW

inositol trisphosphate 3-kinase activity

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Inositol-trisphosphate 3-kinase A
PRO_0000066865

Regions

Nucleotide binding249 – 2513ATP
Region287 – 2959Calmodulin-binding By similarity
Region312 – 3198Substrate binding

Sites

Binding site1971ATP
Binding site2091ATP
Binding site2621ATP
Binding site2641Substrate
Binding site2851Substrate
Binding site3361ATP
Binding site4161ATP
Binding site4191Substrate

Experimental info

Sequence conflict711P → Q in AAH26331. Ref.3

Secondary structure

1 ................................................ 461
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P23677-1 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 18CA214A091F5B19

FASTA46151,009
        10         20         30         40         50         60 
MTLPGGPTGM ARPGGARPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA AGEPRARGAK 

        70         80         90        100        110        120 
RRGGQVPNGL PRAPPAPVIP QLTVTAEEPD VPPTSPGPPE RERDCLPAAG SSHLQQPRRL 

       130        140        150        160        170        180 
STSSVSSTGS SSLLEDSEDD LLSDSESRSR GNVQLEAGED VGQKNHWQKI RTMVNLPVIS 

       190        200        210        220        230        240 
PFKKRYAWVQ LAGHTGSFKA AGTSGLILKR CSEPERYCLA RLMADALRGC VPAFHGVVER 

       250        260        270        280        290        300 
DGESYLQLQD LLDGFDGPCV LDCKMGVRTY LEEELTKARE RPKLRKDMYK KMLAVDPEAP 

       310        320        330        340        350        360 
TEEEHAQRAV TKPRYMQWRE GISSSTTLGF RIEGIKKADG SCSTDFKTTR SREQVLRVFE 

       370        380        390        400        410        420 
EFVQGDEEVL RRYLNRLQQI RDTLEVSEFF RRHEVIGSSL LFVHDHCHRA GVWLIDFGKT 

       430        440        450        460 
TPLPDGQILD HRRPWEEGNR EDGYLLGLDN LIGILASLAE R

« Hide

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References

« Hide 'large scale' references
[1]"Molecular cloning and expression of a human brain inositol 1,4,5-trisphosphate 3-kinase."
Takazawa K., Perret J., Dumont J.E., Erneux C.
Biochem. Biophys. Res. Commun. 174:529-535(1991) [PubMed: 1847047] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence."
Takazawa K., Perret J., Dumont J.E., Erneux C.
Nucleic Acids Res. 18:7141-7141(1990) [PubMed: 2175886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase."
Gonzalez B., Schell M.J., Letcher A.J., Veprintsev D.B., Irvine R.F., Williams R.L.
Mol. Cell 15:689-701(2004) [PubMed: 15350214] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 197-461 IN COMPLEX WITH SUBSTRATE AND ADP.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X54938 mRNA. Translation: CAA38700.1.
BC026331 mRNA. Translation: AAH26331.1.
IPIIPI00012538.
PIRJN0129.
RefSeqNP_002211.1.
UniGeneHs.2722

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1W2CX-ray1.95A/B197-461[»]
1W2DX-ray1.94A/B197-461[»]
1W2FX-ray1.80A/B188-461[»]
ModBaseSearch...

PTM databases

PhosphoSiteP23677.

Proteomic databases

PRIDEP23677.

Genome annotation databases

EnsemblENSG00000137825. Homo sapiens. [Contig view]
GeneID3706.
KEGGhsa:3706.

Organism-specific databases

GeneCardsGC15P039573.
H-InvDBHIX0012154.
HGNCHGNC:6178. ITPKA.
MIM147521. gene.
PharmGKBPA29975.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP23677.
HOVERGENP23677.
OMAP23677. YSWVQLA.

Enzyme and pathway databases

BRENDA2.7.1.127. 247.

Gene expression databases

BgeeP23677.
CleanExHS_ITPKA.
GermOnlineENSG00000137825. Homo sapiens.

Family and domain databases

InterProIPR005522. IPK.
[Graphical view]
PANTHERPTHR12400. IPK. 1 hit.
PfamPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio14525.
SOURCESearch...

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Entry information

Entry nameIP3KA_HUMAN
AccessionPrimary (citable) accession number: P23677
Secondary accession number(s): Q8TAN3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents