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P23673

- CTFB_CLOAB

UniProt

P23673 - CTFB_CLOAB

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Protein

Butyrate--acetoacetate CoA-transferase subunit B

Gene
ctfB, CA_P0164
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in solventogenic switch which allows C.acetobutylicum to uptake acid and produce solvents. Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation.

Catalytic activityi

Butanoyl-CoA + acetoacetate = butanoate + acetoacetyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511 By similarity

GO - Molecular functioni

  1. butyrate-acetoacetate CoA-transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciCACE272562:GJIH-4009-MONOMER.
MetaCyc:COATBCLOS-MONOMER.
SABIO-RKP23673.

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrate--acetoacetate CoA-transferase subunit B (EC:2.8.3.9)
Short name:
Coat B
Alternative name(s):
Acetoacetyl-CoA:acetate/butyrate CoA-transferase subunit B
Gene namesi
Name:ctfB
Ordered Locus Names:CA_P0164
Encoded oniPlasmid pSOL10 Publication
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814: Plasmid pSOL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Butyrate--acetoacetate CoA-transferase subunit BPRO_0000157926Add
BLAST

Expressioni

Inductioni

Induced during switch to solvent production.

Interactioni

Subunit structurei

Heterodimer.

Protein-protein interaction databases

STRINGi272562.CA_P0164.

Structurei

3D structure databases

ProteinModelPortaliP23673.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2057.
HOGENOMiHOG000221245.
KOiK01035.
OMAiWTRQEMA.
OrthoDBiEOG6HMXJG.

Family and domain databases

InterProiIPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEiPS01274. COA_TRANSF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23673-1 [UniParc]FASTAAdd to Basket

« Hide

MINDKNLAKE IIAKRVAREL KNGQLVNLGV GLPTMVADYI PKNFKITFQS    50
ENGIVGMGAS PKINEADKDV VNAGGDYTTV LPDGTFFDSS VSFSLIRGGH 100
VDVTVLGALQ VDEKGNIANW IVPGKMLSGM GGAMDLVNGA KKVIIAMRHT 150
NKGQPKILKK CTLPLTAKSQ ANLIVTELGV IEVINDGLLL TEINKNTTID 200
EIRSLTAADL LISNELRPMA V 221
Length:221
Mass (Da):23,624
Last modified:November 1, 1991 - v1
Checksum:i9F9920709628F800
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55392 Genomic DNA. Translation: AAA63762.1.
X72831 Genomic DNA. Translation: CAA51346.1.
M93363 Genomic DNA. Translation: AAB53233.1.
AE001438 Genomic DNA. Translation: AAK76909.1.
PIRiJN0489.
RefSeqiNP_149327.1. NC_001988.2.
WP_010890848.1. NC_001988.2.

Genome annotation databases

EnsemblBacteriaiAAK76909; AAK76909; CA_P0164.
GeneIDi1116169.
KEGGicac:CA_P0164.
PATRICi32034214. VBICloAce74127_0165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55392 Genomic DNA. Translation: AAA63762.1 .
X72831 Genomic DNA. Translation: CAA51346.1 .
M93363 Genomic DNA. Translation: AAB53233.1 .
AE001438 Genomic DNA. Translation: AAK76909.1 .
PIRi JN0489.
RefSeqi NP_149327.1. NC_001988.2.
WP_010890848.1. NC_001988.2.

3D structure databases

ProteinModelPortali P23673.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272562.CA_P0164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK76909 ; AAK76909 ; CA_P0164 .
GeneIDi 1116169.
KEGGi cac:CA_P0164.
PATRICi 32034214. VBICloAce74127_0165.

Phylogenomic databases

eggNOGi COG2057.
HOGENOMi HOG000221245.
KOi K01035.
OMAi WTRQEMA.
OrthoDBi EOG6HMXJG.

Enzyme and pathway databases

BioCyci CACE272562:GJIH-4009-MONOMER.
MetaCyc:COATBCLOS-MONOMER.
SABIO-RK P23673.

Family and domain databases

InterProi IPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view ]
PANTHERi PTHR13707. PTHR13707. 1 hit.
Pfami PF01144. CoA_trans. 1 hit.
[Graphical view ]
SMARTi SM00882. CoA_trans. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEi PS01274. COA_TRANSF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing, and molecular analysis of the acetoacetate decarboxylase gene region from Clostridium acetobutylicum."
    Gerischer U., Duerre P.
    J. Bacteriol. 172:6907-6918(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  2. "Cloning, sequencing, and molecular analysis of the sol operon of Clostridium acetobutylicum, a chromosomal locus involved in solventogenesis."
    Fischer R.J., Helms J., Duerre P.
    J. Bacteriol. 175:6959-6969(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  3. "Sequence and arrangement of genes encoding enzymes of the acetone-production pathway of Clostridium acetobutylicum ATCC824."
    Petersen D.J., Cary J.W., Vanderleyden J., Bennett G.N.
    Gene 123:93-97(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-19.
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  5. "Cloning and expression of Clostridium acetobutylicum ATCC 824 acetoacetyl-coenzyme A:acetate/butyrate:coenzyme A-transferase in Escherichia coli."
    Cary J.W., Petersen D.J., Papoutsakis E.T., Bennett G.N.
    Appl. Environ. Microbiol. 56:1576-1583(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-8.
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiCTFB_CLOAB
AccessioniPrimary (citable) accession number: P23673
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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