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P23673

- CTFB_CLOAB

UniProt

P23673 - CTFB_CLOAB

Protein

Butyrate--acetoacetate CoA-transferase subunit B

Gene

ctfB

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Involved in solventogenic switch which allows C.acetobutylicum to uptake acid and produce solvents. Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation.

    Catalytic activityi

    Butanoyl-CoA + acetoacetate = butanoate + acetoacetyl-CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei51 – 511PROSITE-ProRule annotation

    GO - Molecular functioni

    1. butyrate-acetoacetate CoA-transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    BioCyciCACE272562:GJIH-4009-MONOMER.
    MetaCyc:COATBCLOS-MONOMER.
    SABIO-RKP23673.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Butyrate--acetoacetate CoA-transferase subunit B (EC:2.8.3.9)
    Short name:
    Coat B
    Alternative name(s):
    Acetoacetyl-CoA:acetate/butyrate CoA-transferase subunit B
    Gene namesi
    Name:ctfB
    Ordered Locus Names:CA_P0164
    Encoded oniPlasmid pSOL10 Publication
    OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
    Taxonomic identifieri272562 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000814: Plasmid pSOL1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Butyrate--acetoacetate CoA-transferase subunit BPRO_0000157926Add
    BLAST

    Expressioni

    Inductioni

    Induced during switch to solvent production.

    Interactioni

    Subunit structurei

    Heterodimer.

    Protein-protein interaction databases

    STRINGi272562.CA_P0164.

    Structurei

    3D structure databases

    ProteinModelPortaliP23673.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2057.
    HOGENOMiHOG000221245.
    KOiK01035.
    OMAiWTRQEMA.
    OrthoDBiEOG6HMXJG.

    Family and domain databases

    InterProiIPR012791. 3-oxoacid_CoA-transf_B.
    IPR004165. CoA_trans_fam_I.
    IPR004164. CoA_transf_AS.
    [Graphical view]
    PANTHERiPTHR13707. PTHR13707. 1 hit.
    PfamiPF01144. CoA_trans. 1 hit.
    [Graphical view]
    SMARTiSM00882. CoA_trans. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02428. pcaJ_scoB_fam. 1 hit.
    PROSITEiPS01274. COA_TRANSF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23673-1 [UniParc]FASTAAdd to Basket

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    MINDKNLAKE IIAKRVAREL KNGQLVNLGV GLPTMVADYI PKNFKITFQS    50
    ENGIVGMGAS PKINEADKDV VNAGGDYTTV LPDGTFFDSS VSFSLIRGGH 100
    VDVTVLGALQ VDEKGNIANW IVPGKMLSGM GGAMDLVNGA KKVIIAMRHT 150
    NKGQPKILKK CTLPLTAKSQ ANLIVTELGV IEVINDGLLL TEINKNTTID 200
    EIRSLTAADL LISNELRPMA V 221
    Length:221
    Mass (Da):23,624
    Last modified:November 1, 1991 - v1
    Checksum:i9F9920709628F800
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55392 Genomic DNA. Translation: AAA63762.1.
    X72831 Genomic DNA. Translation: CAA51346.1.
    M93363 Genomic DNA. Translation: AAB53233.1.
    AE001438 Genomic DNA. Translation: AAK76909.1.
    PIRiJN0489.
    RefSeqiNP_149327.1. NC_001988.2.
    WP_010890848.1. NC_001988.2.

    Genome annotation databases

    EnsemblBacteriaiAAK76909; AAK76909; CA_P0164.
    GeneIDi1116169.
    KEGGicac:CA_P0164.
    PATRICi32034214. VBICloAce74127_0165.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55392 Genomic DNA. Translation: AAA63762.1 .
    X72831 Genomic DNA. Translation: CAA51346.1 .
    M93363 Genomic DNA. Translation: AAB53233.1 .
    AE001438 Genomic DNA. Translation: AAK76909.1 .
    PIRi JN0489.
    RefSeqi NP_149327.1. NC_001988.2.
    WP_010890848.1. NC_001988.2.

    3D structure databases

    ProteinModelPortali P23673.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272562.CA_P0164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK76909 ; AAK76909 ; CA_P0164 .
    GeneIDi 1116169.
    KEGGi cac:CA_P0164.
    PATRICi 32034214. VBICloAce74127_0165.

    Phylogenomic databases

    eggNOGi COG2057.
    HOGENOMi HOG000221245.
    KOi K01035.
    OMAi WTRQEMA.
    OrthoDBi EOG6HMXJG.

    Enzyme and pathway databases

    BioCyci CACE272562:GJIH-4009-MONOMER.
    MetaCyc:COATBCLOS-MONOMER.
    SABIO-RK P23673.

    Family and domain databases

    InterProi IPR012791. 3-oxoacid_CoA-transf_B.
    IPR004165. CoA_trans_fam_I.
    IPR004164. CoA_transf_AS.
    [Graphical view ]
    PANTHERi PTHR13707. PTHR13707. 1 hit.
    Pfami PF01144. CoA_trans. 1 hit.
    [Graphical view ]
    SMARTi SM00882. CoA_trans. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02428. pcaJ_scoB_fam. 1 hit.
    PROSITEi PS01274. COA_TRANSF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing, and molecular analysis of the acetoacetate decarboxylase gene region from Clostridium acetobutylicum."
      Gerischer U., Duerre P.
      J. Bacteriol. 172:6907-6918(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
    2. "Cloning, sequencing, and molecular analysis of the sol operon of Clostridium acetobutylicum, a chromosomal locus involved in solventogenesis."
      Fischer R.J., Helms J., Duerre P.
      J. Bacteriol. 175:6959-6969(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
    3. "Sequence and arrangement of genes encoding enzymes of the acetone-production pathway of Clostridium acetobutylicum ATCC824."
      Petersen D.J., Cary J.W., Vanderleyden J., Bennett G.N.
      Gene 123:93-97(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-19.
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
    5. "Cloning and expression of Clostridium acetobutylicum ATCC 824 acetoacetyl-coenzyme A:acetate/butyrate:coenzyme A-transferase in Escherichia coli."
      Cary J.W., Petersen D.J., Papoutsakis E.T., Bennett G.N.
      Appl. Environ. Microbiol. 56:1576-1583(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-8.
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

    Entry informationi

    Entry nameiCTFB_CLOAB
    AccessioniPrimary (citable) accession number: P23673
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Plasmid, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3