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Protein

Butyrate--acetoacetate CoA-transferase subunit B

Gene

ctfB

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in solventogenic switch which allows C.acetobutylicum to uptake acid and produce solvents. Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation.

Catalytic activityi

Butanoyl-CoA + acetoacetate = butanoate + acetoacetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciMetaCyc:COATBCLOS-MONOMER.
SABIO-RKiP23673.

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrate--acetoacetate CoA-transferase subunit B (EC:2.8.3.9)
Short name:
Coat B
Alternative name(s):
Acetoacetyl-CoA:acetate/butyrate CoA-transferase subunit B
Gene namesi
Name:ctfB
Ordered Locus Names:CA_P0164
Encoded oniPlasmid pSOL10 Publication
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Plasmid pSOL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001579261 – 221Butyrate--acetoacetate CoA-transferase subunit BAdd BLAST221

Expressioni

Inductioni

Induced during switch to solvent production.

Interactioni

Subunit structurei

Heterodimer.

Structurei

3D structure databases

ProteinModelPortaliP23673.
SMRiP23673.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000221245.
KOiK01035.
OMAiVAMMHTN.

Family and domain databases

InterProiView protein in InterPro
IPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
IPR037171. NagB/RpiA_transferase-like.
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiView protein in Pfam
PF01144. CoA_trans. 1 hit.
SMARTiView protein in SMART
SM00882. CoA_trans. 1 hit.
SUPFAMiSSF100950. SSF100950. 1 hit.
TIGRFAMsiTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEiView protein in PROSITE
PS01274. COA_TRANSF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P23673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINDKNLAKE IIAKRVAREL KNGQLVNLGV GLPTMVADYI PKNFKITFQS
60 70 80 90 100
ENGIVGMGAS PKINEADKDV VNAGGDYTTV LPDGTFFDSS VSFSLIRGGH
110 120 130 140 150
VDVTVLGALQ VDEKGNIANW IVPGKMLSGM GGAMDLVNGA KKVIIAMRHT
160 170 180 190 200
NKGQPKILKK CTLPLTAKSQ ANLIVTELGV IEVINDGLLL TEINKNTTID
210 220
EIRSLTAADL LISNELRPMA V
Length:221
Mass (Da):23,624
Last modified:November 1, 1991 - v1
Checksum:i9F9920709628F800
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55392 Genomic DNA. Translation: AAA63762.1.
X72831 Genomic DNA. Translation: CAA51346.1.
M93363 Genomic DNA. Translation: AAB53233.1.
AE001438 Genomic DNA. Translation: AAK76909.1.
PIRiJN0489.
RefSeqiNP_149327.1. NC_001988.2.
WP_010890848.1. NC_001988.2.

Genome annotation databases

EnsemblBacteriaiAAK76909; AAK76909; CA_P0164.
GeneIDi1116169.
KEGGicac:CA_P0164.
PATRICifig|272562.8.peg.165.

Similar proteinsi

Entry informationi

Entry nameiCTFB_CLOAB
AccessioniPrimary (citable) accession number: P23673
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 22, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families