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P23673 (CTFB_CLOAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Butyrate--acetoacetate CoA-transferase subunit B

Short name=Coat B
EC=2.8.3.9
Alternative name(s):
Acetoacetyl-CoA:acetate/butyrate CoA-transferase subunit B
Gene names
Name:ctfB
Ordered Locus Names:CA_P0164
Encoded onPlasmid pSOL1
OrganismClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) [Reference proteome] [HAMAP]
Taxonomic identifier272562 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in solventogenic switch which allows C.acetobutylicum to uptake acid and produce solvents. Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation.

Catalytic activity

Butanoyl-CoA + acetoacetate = butanoate + acetoacetyl-CoA.

Subunit structure

Heterodimer.

Induction

Induced during switch to solvent production.

Sequence similarities

Belongs to the 3-oxoacid CoA-transferase subunit B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Butyrate--acetoacetate CoA-transferase subunit B
PRO_0000157926

Sites

Active site511 By similarity

Sequences

Sequence LengthMass (Da)Tools
P23673 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 9F9920709628F800

FASTA22123,624
        10         20         30         40         50         60 
MINDKNLAKE IIAKRVAREL KNGQLVNLGV GLPTMVADYI PKNFKITFQS ENGIVGMGAS 

        70         80         90        100        110        120 
PKINEADKDV VNAGGDYTTV LPDGTFFDSS VSFSLIRGGH VDVTVLGALQ VDEKGNIANW 

       130        140        150        160        170        180 
IVPGKMLSGM GGAMDLVNGA KKVIIAMRHT NKGQPKILKK CTLPLTAKSQ ANLIVTELGV 

       190        200        210        220 
IEVINDGLLL TEINKNTTID EIRSLTAADL LISNELRPMA V 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, sequencing, and molecular analysis of the acetoacetate decarboxylase gene region from Clostridium acetobutylicum."
Gerischer U., Duerre P.
J. Bacteriol. 172:6907-6918(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
[2]"Cloning, sequencing, and molecular analysis of the sol operon of Clostridium acetobutylicum, a chromosomal locus involved in solventogenesis."
Fischer R.J., Helms J., Duerre P.
J. Bacteriol. 175:6959-6969(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
[3]"Sequence and arrangement of genes encoding enzymes of the acetone-production pathway of Clostridium acetobutylicum ATCC824."
Petersen D.J., Cary J.W., Vanderleyden J., Bennett G.N.
Gene 123:93-97(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-19.
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
[4]"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum."
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.
J. Bacteriol. 183:4823-4838(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
[5]"Cloning and expression of Clostridium acetobutylicum ATCC 824 acetoacetyl-coenzyme A:acetate/butyrate:coenzyme A-transferase in Escherichia coli."
Cary J.W., Petersen D.J., Papoutsakis E.T., Bennett G.N.
Appl. Environ. Microbiol. 56:1576-1583(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-8.
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55392 Genomic DNA. Translation: AAA63762.1.
X72831 Genomic DNA. Translation: CAA51346.1.
M93363 Genomic DNA. Translation: AAB53233.1.
AE001438 Genomic DNA. Translation: AAK76909.1.
PIRJN0489.
RefSeqNP_149327.1. NC_001988.2.

3D structure databases

ProteinModelPortalP23673.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272562.CA_P0164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK76909; AAK76909; CA_P0164.
GeneID1116169.
KEGGcac:CA_P0164.
PATRIC32034214. VBICloAce74127_0165.

Phylogenomic databases

eggNOGCOG2057.
HOGENOMHOG000221245.
KOK01035.
OMATIDADMI.
OrthoDBEOG6HMXJG.

Enzyme and pathway databases

BioCycCACE272562:GJIH-4009-MONOMER.
MetaCyc:COATBCLOS-MONOMER.
SABIO-RKP23673.

Family and domain databases

InterProIPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view]
PANTHERPTHR13707. PTHR13707. 1 hit.
PfamPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEPS01274. COA_TRANSF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTFB_CLOAB
AccessionPrimary (citable) accession number: P23673
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families