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Protein

Threonine synthase

Gene

thrC

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.1 Publication

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.1 Publication

Cofactori

pyridoxal 5'-phosphate1 Publication

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:Cgl2220, cg2437
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001009 Componenti: Chromosome UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Threonine synthasePRO_0000185630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181N6-(pyridoxal phosphate)lysineCurated

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi196627.cg2437.

Structurei

3D structure databases

ProteinModelPortaliP23669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000230745.
KOiK01733.
OMAiFCEILLE.
OrthoDBiEOG65BDJX.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYISTRDAS RTPARFSDIL LGGLAPDGGL YLPATYPQLD DAQLSKWREV
60 70 80 90 100
LANEGYAALA AEVISLFVDD IPVEDIKAIT ARAYTYPKFN SEDIVPVTEL
110 120 130 140 150
EDNIYLGHLS EGPTAAFKDM AMQLLGELFE YELRRRNETI NILGATSGDT
160 170 180 190 200
GSSAEYAMRG REGIRVFMLT PAGRMTPFQQ AQMFGLDDPN IFNIALDGVF
210 220 230 240 250
DDCQDVVKAV SADAEFKKDN RIGAVNSINW ARLMAQVVYY VSSWIRTTTS
260 270 280 290 300
NDQKVSFSVP TGNFGDICAG HIARQMGLPI DRLIVATNEN DVLDEFFRTG
310 320 330 340 350
DYRVRSSADT HETSSPSMDI SRASNFERFI FDLLGRDATR VNDLFGTQVR
360 370 380 390 400
QGGFSLADDA NFEKAAAEYG FASGRSTHAD RVATIADVHS RLDVLIDPHT
410 420 430 440 450
ADGVHVARQW RDEVNTPIIV LETALPVKFA DTIVEAIGEA PQTPERFAAI
460 470 480
MDAPFKVSDL PNDTDAVKQY IVDAIANTSV K
Length:481
Mass (Da):52,931
Last modified:July 10, 2002 - v2
Checksum:iBB9155C3317EE220
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611A → R in CAA39510 (PubMed:2127631).Curated
Sequence conflicti159 – 1591R → A in CAA82670 (PubMed:8074505).Curated
Sequence conflicti404 – 4041V → S in CAA82670 (PubMed:8074505).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56037 Genomic DNA. Translation: CAA39510.1.
Z29563 Genomic DNA. Translation: CAA82670.1.
BA000036 Genomic DNA. Translation: BAB99613.1.
BX927154 Genomic DNA. Translation: CAF20560.1.
PIRiS11979.
RefSeqiNP_601423.1. NC_003450.3.
YP_226461.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99613; BAB99613; BAB99613.
GeneIDi1020172.
KEGGicgb:cg2437.
cgl:NCgl2139.
PATRICi21496442. VBICorGlu203724_2157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56037 Genomic DNA. Translation: CAA39510.1.
Z29563 Genomic DNA. Translation: CAA82670.1.
BA000036 Genomic DNA. Translation: BAB99613.1.
BX927154 Genomic DNA. Translation: CAF20560.1.
PIRiS11979.
RefSeqiNP_601423.1. NC_003450.3.
YP_226461.1. NC_006958.1.

3D structure databases

ProteinModelPortaliP23669.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg2437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB99613; BAB99613; BAB99613.
GeneIDi1020172.
KEGGicgb:cg2437.
cgl:NCgl2139.
PATRICi21496442. VBICorGlu203724_2157.

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000230745.
KOiK01733.
OMAiFCEILLE.
OrthoDBiEOG65BDJX.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The molecular structure of the Corynebacterium glutamicum threonine synthase gene."
    Han K.S., Archer J.A.C., Sinskey A.J.
    Mol. Microbiol. 4:1693-1702(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase."
    Malumbres M., Mateos L.M., Lumbreras M.A., Guerrero C., Martin J.F.
    Appl. Environ. Microbiol. 60:2209-2219(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
    Strain: ATCC 13869 / DSMZ 1412 / NCIMB 9567.
  3. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiTHRC_CORGL
AccessioniPrimary (citable) accession number: P23669
Secondary accession number(s): Q59211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1991
Last sequence update: July 10, 2002
Last modified: March 31, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.