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P23669

- THRC_CORGL

UniProt

P23669 - THRC_CORGL

Protein

Threonine synthase

Gene

thrC

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (11 Jul 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.1 Publication

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.1 Publication

    Cofactori

    Pyridoxal phosphate.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:thrC
    Ordered Locus Names:Cgl2220, cg2437
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481Threonine synthasePRO_0000185630Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei118 – 1181N6-(pyridoxal phosphate)lysineCurated

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    STRINGi196627.cg2437.

    Structurei

    3D structure databases

    ProteinModelPortaliP23669.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0498.
    HOGENOMiHOG000230745.
    KOiK01733.
    OMAiIANTSVK.
    OrthoDBiEOG65BDJX.

    Family and domain databases

    Gene3Di3.90.1380.10. 1 hit.
    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23669-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYISTRDAS RTPARFSDIL LGGLAPDGGL YLPATYPQLD DAQLSKWREV    50
    LANEGYAALA AEVISLFVDD IPVEDIKAIT ARAYTYPKFN SEDIVPVTEL 100
    EDNIYLGHLS EGPTAAFKDM AMQLLGELFE YELRRRNETI NILGATSGDT 150
    GSSAEYAMRG REGIRVFMLT PAGRMTPFQQ AQMFGLDDPN IFNIALDGVF 200
    DDCQDVVKAV SADAEFKKDN RIGAVNSINW ARLMAQVVYY VSSWIRTTTS 250
    NDQKVSFSVP TGNFGDICAG HIARQMGLPI DRLIVATNEN DVLDEFFRTG 300
    DYRVRSSADT HETSSPSMDI SRASNFERFI FDLLGRDATR VNDLFGTQVR 350
    QGGFSLADDA NFEKAAAEYG FASGRSTHAD RVATIADVHS RLDVLIDPHT 400
    ADGVHVARQW RDEVNTPIIV LETALPVKFA DTIVEAIGEA PQTPERFAAI 450
    MDAPFKVSDL PNDTDAVKQY IVDAIANTSV K 481
    Length:481
    Mass (Da):52,931
    Last modified:July 11, 2002 - v2
    Checksum:iBB9155C3317EE220
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611A → R in CAA39510. (PubMed:2127631)Curated
    Sequence conflicti159 – 1591R → A in CAA82670. (PubMed:8074505)Curated
    Sequence conflicti404 – 4041V → S in CAA82670. (PubMed:8074505)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56037 Genomic DNA. Translation: CAA39510.1.
    Z29563 Genomic DNA. Translation: CAA82670.1.
    BA000036 Genomic DNA. Translation: BAB99613.1.
    BX927154 Genomic DNA. Translation: CAF20560.1.
    PIRiS11979.
    RefSeqiNP_601423.1. NC_003450.3.
    YP_226461.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB99613; BAB99613; BAB99613.
    CAF20560; CAF20560; cg2437.
    GeneIDi1020172.
    KEGGicgb:cg2437.
    cgl:NCgl2139.
    PATRICi21496442. VBICorGlu203724_2157.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56037 Genomic DNA. Translation: CAA39510.1 .
    Z29563 Genomic DNA. Translation: CAA82670.1 .
    BA000036 Genomic DNA. Translation: BAB99613.1 .
    BX927154 Genomic DNA. Translation: CAF20560.1 .
    PIRi S11979.
    RefSeqi NP_601423.1. NC_003450.3.
    YP_226461.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali P23669.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg2437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB99613 ; BAB99613 ; BAB99613 .
    CAF20560 ; CAF20560 ; cg2437 .
    GeneIDi 1020172.
    KEGGi cgb:cg2437.
    cgl:NCgl2139.
    PATRICi 21496442. VBICorGlu203724_2157.

    Phylogenomic databases

    eggNOGi COG0498.
    HOGENOMi HOG000230745.
    KOi K01733.
    OMAi IANTSVK.
    OrthoDBi EOG65BDJX.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .

    Family and domain databases

    Gene3Di 3.90.1380.10. 1 hit.
    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The molecular structure of the Corynebacterium glutamicum threonine synthase gene."
      Han K.S., Archer J.A.C., Sinskey A.J.
      Mol. Microbiol. 4:1693-1702(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase."
      Malumbres M., Mateos L.M., Lumbreras M.A., Guerrero C., Martin J.F.
      Appl. Environ. Microbiol. 60:2209-2219(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
      Strain: ATCC 13869 / DSMZ 1412 / NCIMB 9567.
    3. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiTHRC_CORGL
    AccessioniPrimary (citable) accession number: P23669
    Secondary accession number(s): Q59211
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: July 11, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3