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P23669

- THRC_CORGL

UniProt

P23669 - THRC_CORGL

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Protein

Threonine synthase

Gene
thrC, Cgl2220, cg2437
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.1 Publication

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.1 Publication

Cofactori

Pyridoxal phosphate.1 Publication

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:Cgl2220, cg2437
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Threonine synthasePRO_0000185630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181N6-(pyridoxal phosphate)lysine Inferred

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi196627.cg2437.

Structurei

3D structure databases

ProteinModelPortaliP23669.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000230745.
KOiK01733.
OMAiIANTSVK.
OrthoDBiEOG65BDJX.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23669-1 [UniParc]FASTAAdd to Basket

« Hide

MDYISTRDAS RTPARFSDIL LGGLAPDGGL YLPATYPQLD DAQLSKWREV    50
LANEGYAALA AEVISLFVDD IPVEDIKAIT ARAYTYPKFN SEDIVPVTEL 100
EDNIYLGHLS EGPTAAFKDM AMQLLGELFE YELRRRNETI NILGATSGDT 150
GSSAEYAMRG REGIRVFMLT PAGRMTPFQQ AQMFGLDDPN IFNIALDGVF 200
DDCQDVVKAV SADAEFKKDN RIGAVNSINW ARLMAQVVYY VSSWIRTTTS 250
NDQKVSFSVP TGNFGDICAG HIARQMGLPI DRLIVATNEN DVLDEFFRTG 300
DYRVRSSADT HETSSPSMDI SRASNFERFI FDLLGRDATR VNDLFGTQVR 350
QGGFSLADDA NFEKAAAEYG FASGRSTHAD RVATIADVHS RLDVLIDPHT 400
ADGVHVARQW RDEVNTPIIV LETALPVKFA DTIVEAIGEA PQTPERFAAI 450
MDAPFKVSDL PNDTDAVKQY IVDAIANTSV K 481
Length:481
Mass (Da):52,931
Last modified:July 11, 2002 - v2
Checksum:iBB9155C3317EE220
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611A → R in CAA39510. 1 Publication
Sequence conflicti159 – 1591R → A in CAA82670. 1 Publication
Sequence conflicti404 – 4041V → S in CAA82670. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56037 Genomic DNA. Translation: CAA39510.1.
Z29563 Genomic DNA. Translation: CAA82670.1.
BA000036 Genomic DNA. Translation: BAB99613.1.
BX927154 Genomic DNA. Translation: CAF20560.1.
PIRiS11979.
RefSeqiNP_601423.1. NC_003450.3.
YP_226461.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99613; BAB99613; BAB99613.
CAF20560; CAF20560; cg2437.
GeneIDi1020172.
KEGGicgb:cg2437.
cgl:NCgl2139.
PATRICi21496442. VBICorGlu203724_2157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56037 Genomic DNA. Translation: CAA39510.1 .
Z29563 Genomic DNA. Translation: CAA82670.1 .
BA000036 Genomic DNA. Translation: BAB99613.1 .
BX927154 Genomic DNA. Translation: CAF20560.1 .
PIRi S11979.
RefSeqi NP_601423.1. NC_003450.3.
YP_226461.1. NC_006958.1.

3D structure databases

ProteinModelPortali P23669.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg2437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB99613 ; BAB99613 ; BAB99613 .
CAF20560 ; CAF20560 ; cg2437 .
GeneIDi 1020172.
KEGGi cgb:cg2437.
cgl:NCgl2139.
PATRICi 21496442. VBICorGlu203724_2157.

Phylogenomic databases

eggNOGi COG0498.
HOGENOMi HOG000230745.
KOi K01733.
OMAi IANTSVK.
OrthoDBi EOG65BDJX.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .

Family and domain databases

Gene3Di 3.90.1380.10. 1 hit.
InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The molecular structure of the Corynebacterium glutamicum threonine synthase gene."
    Han K.S., Archer J.A.C., Sinskey A.J.
    Mol. Microbiol. 4:1693-1702(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase."
    Malumbres M., Mateos L.M., Lumbreras M.A., Guerrero C., Martin J.F.
    Appl. Environ. Microbiol. 60:2209-2219(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
    Strain: ATCC 13869 / DSMZ 1412 / NCIMB 9567.
  3. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiTHRC_CORGL
AccessioniPrimary (citable) accession number: P23669
Secondary accession number(s): Q59211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: July 11, 2002
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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