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P23660

- GUNA_RUMAL

UniProt

P23660 - GUNA_RUMAL

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Protein
Endoglucanase A
Gene
celA
Organism
Ruminococcus albus
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes both carboxymethylcellulose and xylan. Probably has a role in hydrolyzing oligosaccharides derived from cellulose, which are transported across the cell wall.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691Proton donor By similarity
Active sitei293 – 2931Nucleophile By similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
  2. xylan catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation, Xylan degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase A (EC:3.2.1.4)
Alternative name(s):
Cellulase A
Endo-1,4-beta-glucanase A
Short name:
EGA
Gene namesi
Name:celA
OrganismiRuminococcus albus
Taxonomic identifieri1264 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminococcus

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Endoglucanase A
PRO_0000184051Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23660.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23660-1 [UniParc]FASTAAdd to Basket

« Hide

MRKPDKDADR LTTLDLARSG EVRDISAMEL VGEMKTGWNL GNSLDATGAP    50
GNASEVNWGN PKTTKEMIDA VYNKGFDVIR IPVTWGGHVG DAPDYKIDDE 100
WIARVQEVVN YAYDDGAYVI INSHHEEDWR IPDNEHIDAV DEKTAAIWKQ 150
VAERFKDYGD HLIFEGLNEP RVKGSPQEWN GGTEEGRRCV DRLNKTFLDT 200
VRATGGNNEK RLLLMTTYAS SSMSNVIKDT AIPEDDHIGF SIHAYTPYAF 250
TYNANADWEL FHWDDSHDGE LVSLMTNLKE NYLDKDIPVI ITEYGAVNKD 300
NNDEDRAKWV SSYIEYAELL GGIPCVWWDN GYYSSGNELF GIFDRNTCTW 350
FTDTVTDAII ENAK 364
Length:364
Mass (Da):41,218
Last modified:November 1, 1991 - v1
Checksum:iF8DCD2E2E55781F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54931 Genomic DNA. Translation: CAA38692.1.
PIRiS12017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54931 Genomic DNA. Translation: CAA38692.1 .
PIRi S12017.

3D structure databases

ProteinModelPortali P23660.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Ruminococcus albus SY3 endoglucanase genes celA and celB."
    Poole D.M., Hazlewood G.P., Laurie J.I., Barker P.J., Gilbert H.J.
    Mol. Gen. Genet. 223:217-223(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-14.
    Strain: SY3.

Entry informationi

Entry nameiGUNA_RUMAL
AccessioniPrimary (citable) accession number: P23660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 16, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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