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Protein

Mitochondrial import receptor subunit TOM40

Gene

TOM40

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Channel-forming protein essential for import of protein precursors into mitochondria.1 Publication

GO - Molecular functioni

  • porin activity Source: UniProtKB-KW
  • protein channel activity Source: SGD

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • protein import into mitochondrial matrix Source: SGD
  • protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32889-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Protein family/group databases

TCDBi1.B.8.2.1. the mitochondrial and plastid porin (mpp) family.
3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40
Alternative name(s):
Mitochondrial import site protein ISP42
Translocase of outer membrane 40 kDa subunit
Gene namesi
Name:TOM40
Synonyms:ISP42, MOM38
Ordered Locus Names:YMR203W
ORF Names:YM8325.04
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR203W.
SGDiS000004816. TOM40.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Mitochondrial import receptor subunit TOM40PRO_0000051535Add
BLAST

Proteomic databases

MaxQBiP23644.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). Interacts with mitochondrial targeting sequences. Interacts with FCJ1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BAXQ078122EBI-12539,EBI-516580From a different organism.
SAM50P539694EBI-12539,EBI-28646
TOM20P351803EBI-12539,EBI-12522
TOM22P493348EBI-12539,EBI-12527

Protein-protein interaction databases

BioGridi35381. 42 interactions.
DIPiDIP-2540N.
IntActiP23644. 17 interactions.
MINTiMINT-527881.

Structurei

3D structure databases

ProteinModelPortaliP23644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

GeneTreeiENSGT00390000003308.
HOGENOMiHOG000200591.
InParanoidiP23644.
KOiK11518.
OMAiYLTRYVS.
OrthoDBiEOG7D865Z.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
IPR005686. Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00989. 3a0801s07tom40. 1 hit.

Sequencei

Sequence statusi: Complete.

P23644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPTPLAEA SQIPTIPALS PLTAKQSKGN FFSSNPISSF VVDTYKQLHS
60 70 80 90 100
HRQSLELVNP GTVENLNKEV SRDVFLSQYF FTGLRADLNK AFSMNPAFQT
110 120 130 140 150
SHTFSIGSQA LPKYAFSALF ANDNLFAQGN IDNDLSVSGR LNYGWDKKNI
160 170 180 190 200
SKVNLQISDG QPTMCQLEQD YQASDFSVNV KTLNPSFSEK GEFTGVAVAS
210 220 230 240 250
FLQSVTPQLA LGLETLYSRT DGSAPGDAGV SYLTRYVSKK QDWIFSGQLQ
260 270 280 290 300
ANGALIASLW RKVAQNVEAG IETTLQAGMV PITDPLMGTP IGIQPTVEGS
310 320 330 340 350
TTIGAKYEYR QSVYRGTLDS NGKVACFLER KVLPTLSVLF CGEIDHFKND
360 370 380
TKIGCGLQFE TAGNQELLML QQGLDADGNP LQALPQL
Length:387
Mass (Da):42,038
Last modified:November 1, 1991 - v1
Checksum:i6436FBBA4020464B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti387 – 3871L → M in AAT93040 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56885 Genomic DNA. Translation: CAA40206.1.
Z48755 Genomic DNA. Translation: CAA88644.1.
AY693021 Genomic DNA. Translation: AAT93040.1.
BK006946 Genomic DNA. Translation: DAA10102.1.
PIRiS12773.
RefSeqiNP_013930.1. NM_001182710.1.

Genome annotation databases

EnsemblFungiiYMR203W; YMR203W; YMR203W.
GeneIDi855243.
KEGGisce:YMR203W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56885 Genomic DNA. Translation: CAA40206.1.
Z48755 Genomic DNA. Translation: CAA88644.1.
AY693021 Genomic DNA. Translation: AAT93040.1.
BK006946 Genomic DNA. Translation: DAA10102.1.
PIRiS12773.
RefSeqiNP_013930.1. NM_001182710.1.

3D structure databases

ProteinModelPortaliP23644.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35381. 42 interactions.
DIPiDIP-2540N.
IntActiP23644. 17 interactions.
MINTiMINT-527881.

Protein family/group databases

TCDBi1.B.8.2.1. the mitochondrial and plastid porin (mpp) family.
3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Proteomic databases

MaxQBiP23644.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR203W; YMR203W; YMR203W.
GeneIDi855243.
KEGGisce:YMR203W.

Organism-specific databases

EuPathDBiFungiDB:YMR203W.
SGDiS000004816. TOM40.

Phylogenomic databases

GeneTreeiENSGT00390000003308.
HOGENOMiHOG000200591.
InParanoidiP23644.
KOiK11518.
OMAiYLTRYVS.
OrthoDBiEOG7D865Z.

Enzyme and pathway databases

BioCyciYEAST:G3O-32889-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Miscellaneous databases

PROiP23644.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
IPR005686. Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00989. 3a0801s07tom40. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A yeast mitochondrial outer membrane protein essential for protein import and cell viability."
    Baker K.P., Schaniel A., Vestweber D., Schatz G.
    Nature 348:605-609(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex."
    Dekker P.J.T., Ryan M.T., Brix J., Mueller H., Hoenlinger A., Pfanner N.
    Mol. Cell. Biol. 18:6515-6524(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TOM COMPLEX.
  6. "Biogenesis of Tom40, core component of the TOM complex of mitochondria."
    Rapaport D., Neupert W.
    J. Cell Biol. 146:321-331(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: INTERACTION WITH FCJ1.

Entry informationi

Entry nameiTOM40_YEAST
AccessioniPrimary (citable) accession number: P23644
Secondary accession number(s): D6W028, Q6B1Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: July 6, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.