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Protein

Mitochondrial phosphate carrier protein

Gene

MIR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transport of phosphate groups from the cytosol to the mitochondrial matrix.

GO - Molecular functioni

  • inorganic phosphate transmembrane transporter activity Source: SGD

GO - Biological processi

  • phosphate ion transmembrane transport Source: SGD
  • protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31707-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Protein family/group databases

TCDBi2.A.29.4.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial phosphate carrier protein
Alternative name(s):
Mitochondrial import receptor
Phosphate transport protein
Short name:
PTP
mPic 1
p32
Cleaved into the following chain:
Gene namesi
Name:MIR1
Ordered Locus Names:YJR077C
ORF Names:J1837
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR077C.
SGDiS000003838. MIR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19Mitochondrial intermembraneSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 62Mitochondrial matrixSequence analysisAdd BLAST22
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 115Mitochondrial intermembraneSequence analysisAdd BLAST32
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 165Mitochondrial matrixSequence analysisAdd BLAST29
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 214Mitochondrial intermembraneSequence analysisAdd BLAST28
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini236 – 253Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 311Mitochondrial intermembraneSequence analysisAdd BLAST37

GO - Cellular componenti

  • integral component of mitochondrial inner membrane Source: SGD
  • mitochondrial inner membrane Source: Reactome
  • mitochondrial intermembrane space Source: Reactome
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906351 – 311Mitochondrial phosphate carrier proteinAdd BLAST311
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004232252 – 311Mitochondrial phosphate carrier protein, N-terminally processedAdd BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine; in Mitochondrial phosphate carrier protein, N-terminally processedCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP23641.
PRIDEiP23641.

PTM databases

iPTMnetiP23641.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TAT1P380853EBI-11178,EBI-20222

Protein-protein interaction databases

BioGridi33833. 72 interactors.
DIPiDIP-1714N.
IntActiP23641. 51 interactors.
MINTiMINT-393656.

Structurei

3D structure databases

ProteinModelPortaliP23641.
SMRiP23641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 100Solcar 1Add BLAST86
Repeati114 – 197Solcar 2Add BLAST84
Repeati212 – 297Solcar 3Add BLAST86

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00840000131664.
HOGENOMiHOG000164438.
InParanoidiP23641.
KOiK15102.
OMAiIGYENAR.
OrthoDBiEOG092C3W79.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSAAPAIP QYSVSDYMKF ALAGAIGCGS THSSMVPIDV VKTRIQLEPT
60 70 80 90 100
VYNKGMVGSF KQIIAGEGAG ALLTGFGPTL LGYSIQGAFK FGGYEVFKKF
110 120 130 140 150
FIDNLGYDTA SRYKNSVYMG SAAMAEFLAD IALCPLEATR IRLVSQPQFA
160 170 180 190 200
NGLVGGFSRI LKEEGIGSFY SGFTPILFKQ IPYNIAKFLV FERASEFYYG
210 220 230 240 250
FAGPKEKLSS TSTTLLNLLS GLTAGLAAAI VSQPADTLLS KVNKTKKAPG
260 270 280 290 300
QSTVGLLAQL AKQLGFFGSF AGLPTRLVMV GTLTSLQFGI YGSLKSTLGC
310
PPTIEIGGGG H
Length:311
Mass (Da):32,812
Last modified:November 1, 1991 - v1
Checksum:i89D1D97C49A9E8F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → Y AA sequence (PubMed:2170848).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57478 Genomic DNA. Translation: CAA40716.1.
M54879 Genomic DNA. Translation: AAA34782.1.
Z49577 Genomic DNA. Translation: CAA89605.1.
L47993 Genomic DNA. Translation: AAB39302.1.
AY557913 Genomic DNA. Translation: AAS56239.1.
BK006943 Genomic DNA. Translation: DAA08863.1.
PIRiS12318.
RefSeqiNP_012611.1. NM_001181735.1.

Genome annotation databases

EnsemblFungiiYJR077C; YJR077C; YJR077C.
GeneIDi853540.
KEGGisce:YJR077C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57478 Genomic DNA. Translation: CAA40716.1.
M54879 Genomic DNA. Translation: AAA34782.1.
Z49577 Genomic DNA. Translation: CAA89605.1.
L47993 Genomic DNA. Translation: AAB39302.1.
AY557913 Genomic DNA. Translation: AAS56239.1.
BK006943 Genomic DNA. Translation: DAA08863.1.
PIRiS12318.
RefSeqiNP_012611.1. NM_001181735.1.

3D structure databases

ProteinModelPortaliP23641.
SMRiP23641.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33833. 72 interactors.
DIPiDIP-1714N.
IntActiP23641. 51 interactors.
MINTiMINT-393656.

Protein family/group databases

TCDBi2.A.29.4.3. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiP23641.

Proteomic databases

MaxQBiP23641.
PRIDEiP23641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR077C; YJR077C; YJR077C.
GeneIDi853540.
KEGGisce:YJR077C.

Organism-specific databases

EuPathDBiFungiDB:YJR077C.
SGDiS000003838. MIR1.

Phylogenomic databases

GeneTreeiENSGT00840000131664.
HOGENOMiHOG000164438.
InParanoidiP23641.
KOiK15102.
OMAiIGYENAR.
OrthoDBiEOG092C3W79.

Enzyme and pathway databases

BioCyciYEAST:G3O-31707-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Miscellaneous databases

PROiP23641.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPCP_YEAST
AccessioniPrimary (citable) accession number: P23641
Secondary accession number(s): D6VWP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.