ID PSA3_YEAST Reviewed; 258 AA. AC P23638; D6VUR7; DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1991, sequence version 1. DT 27-MAR-2024, entry version 229. DE RecName: Full=Proteasome subunit alpha type-3; DE AltName: Full=Macropain subunit Y13; DE AltName: Full=Multicatalytic endopeptidase complex subunit Y13; DE AltName: Full=Proteasome component Y13; DE AltName: Full=Proteinase YSCE subunit 13; GN Name=PRE9; Synonyms=PRS5; OrderedLocusNames=YGR135W; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 73-92; 120-139 RP AND 200-236. RC STRAIN=ATCC 26786 / X2180-1A; RX PubMed=1898763; DOI=10.1128/mcb.11.1.344-353.1991; RA Emori Y., Tsukahara T., Kawasaki H., Ishiura S., Sugita H., Suzuki K.; RT "Molecular cloning and functional analysis of three subunits of yeast RT proteasome."; RL Mol. Cell. Biol. 11:344-353(1991). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=9169869; RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H., RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."; RL Nature 387:81-84(1997). RN [3] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [4] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., RA O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). RN [5] RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-199, AND IDENTIFICATION BY RP MASS SPECTROMETRY. RX PubMed=14557538; DOI=10.1073/pnas.2135500100; RA Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.; RT "A subset of membrane-associated proteins is ubiquitinated in response to RT mutations in the endoplasmic reticulum degradation machinery."; RL Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003). RN [6] RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-100; LYS-199 AND LYS-231, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22106047; DOI=10.1002/pmic.201100166; RA Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.; RT "Sites of ubiquitin attachment in Saccharomyces cerevisiae."; RL Proteomics 12:236-240(2012). RN [7] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 2-245 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=9087403; DOI=10.1038/386463a0; RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D., RA Huber R.; RT "Structure of 20S proteasome from yeast at 2.4-A resolution."; RL Nature 386:463-471(1997). RN [8] RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 1-245 OF COMPLEX WITH THE 20S RP PROTEASOME AND A 11S REGULATORY COMPLEX. RX PubMed=11081519; DOI=10.1038/35040607; RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C., RA Hill C.P.; RT "Structural basis for the activation of 20S proteasomes by 11S RT regulators."; RL Nature 408:115-120(2000). RN [9] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-245 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=11062564; DOI=10.1038/80992; RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R., RA Glickman M.H., Finley D.; RT "A gated channel into the proteasome core particle."; RL Nat. Struct. Biol. 7:1062-1067(2000). RN [10] RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 2-245 OF COMPLEX WITH THE 20S RP PROTEASOME AND A TMC-95-BASED INHIBITOR. RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005; RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.; RT "TMC-95-based inhibitor design provides evidence for the catalytic RT versatility of the proteasome."; RL Chem. Biol. 13:607-614(2006). RN [11] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 2-245 OF COMPLEX WITH THE 20S RP PROTEASOME AND SALINOSPORAMIDE. RX PubMed=16608349; DOI=10.1021/ja058320b; RA Groll M., Huber R., Potts B.C.M.; RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in RT complex with the 20S proteasome reveal important consequences of beta- RT lactone ring opening and a mechanism for irreversible binding."; RL J. Am. Chem. Soc. 128:5136-5141(2006). RN [12] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 2-245 OF COMPLEX WITH THE 20S RP PROTEASOME AND BORTEZOMIB. RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019; RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.; RT "Crystal structure of the boronic acid-based proteasome inhibitor RT bortezomib in complex with the yeast 20S proteasome."; RL Structure 14:451-456(2006). RN [13] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 14-245 IN COMPLEX WITH THE RP PROTEASOME. RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002; RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.; RT "Structure of a Blm10 complex reveals common mechanisms for proteasome RT binding and gate opening."; RL Mol. Cell 37:728-735(2010). RN [14] RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME. RX PubMed=22927375; DOI=10.1073/pnas.1213333109; RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E., RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.; RT "Near-atomic resolution structural model of the yeast 26S proteasome."; RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012). CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the CC cytoplasm and in the nucleus. It is essential for the regulated CC turnover of proteins and for the removal of misfolded proteins. The CC proteasome is a multicatalytic proteinase complex that is characterized CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu CC adjacent to the leaving group at neutral or slightly basic pH. It has CC an ATP-dependent proteolytic activity. CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two CC 19S regulatory subunits. The 20S proteasome core is composed of 28 CC subunits that are arranged in four stacked rings, resulting in a CC barrel-shaped structure. The two end rings are each formed by seven CC alpha subunits, and the two central rings are each formed by seven beta CC subunits. The catalytic chamber with the active sites is on the inside CC of the barrel. {ECO:0000269|PubMed:20227375}. CC -!- INTERACTION: CC P23638; P30656: PRE2; NbExp=2; IntAct=EBI-13967, EBI-14001; CC P23638; P23639: PRE8; NbExp=3; IntAct=EBI-13967, EBI-13959; CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. CC -!- MISCELLANEOUS: Present with 17100 molecules/cell in log phase SD CC medium. {ECO:0000269|PubMed:14562106}. CC -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE- CC ProRule:PRU00808}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M63851; AAA34907.1; -; Genomic_DNA. DR EMBL; X56730; CAA40054.1; -; Genomic_DNA. DR EMBL; Z72920; CAA97148.1; -; Genomic_DNA. DR EMBL; BK006941; DAA08228.1; -; Genomic_DNA. DR PIR; S12940; SNBYY3. DR RefSeq; NP_011651.3; NM_001181264.3. DR PDB; 1FNT; X-ray; 3.20 A; C/Q=1-245. DR PDB; 1G0U; X-ray; 2.40 A; B/P=1-245. DR PDB; 1G65; X-ray; 2.25 A; B/P=2-245. DR PDB; 1JD2; X-ray; 3.00 A; B/W=2-245. DR PDB; 1RYP; X-ray; 1.90 A; C/Q=2-245. DR PDB; 1Z7Q; X-ray; 3.22 A; C/Q=1-258. DR PDB; 2F16; X-ray; 2.80 A; B/P=2-245. DR PDB; 2FAK; X-ray; 2.80 A; B/P=2-245. DR PDB; 2GPL; X-ray; 2.81 A; B/P=2-245. DR PDB; 2ZCY; X-ray; 2.90 A; B/P=1-258. DR PDB; 3BDM; X-ray; 2.70 A; B/P=1-258. DR PDB; 3D29; X-ray; 2.60 A; B/P=2-245. DR PDB; 3DY3; X-ray; 2.81 A; B/P=2-245. DR PDB; 3DY4; X-ray; 2.80 A; B/P=2-245. DR PDB; 3E47; X-ray; 3.00 A; B/P=2-245. DR PDB; 3GPJ; X-ray; 2.70 A; B/P=2-245. DR PDB; 3GPT; X-ray; 2.41 A; B/P=2-245. DR PDB; 3GPW; X-ray; 2.50 A; B/P=2-245. DR PDB; 3HYE; X-ray; 2.50 A; B/P=2-245. DR PDB; 3JCO; EM; 4.80 A; C/c=1-258. DR PDB; 3JCP; EM; 4.60 A; C/c=1-258. DR PDB; 3MG0; X-ray; 2.68 A; B/P=2-245. DR PDB; 3MG4; X-ray; 3.11 A; B/P=2-245. DR PDB; 3MG6; X-ray; 2.60 A; B/P=1-245. DR PDB; 3MG7; X-ray; 2.78 A; B/P=1-245. DR PDB; 3MG8; X-ray; 2.59 A; B/P=1-245. DR PDB; 3NZJ; X-ray; 2.40 A; B/P=1-258. DR PDB; 3NZW; X-ray; 2.50 A; B/P=1-258. DR PDB; 3NZX; X-ray; 2.70 A; B/P=1-258. DR PDB; 3OEU; X-ray; 2.60 A; B/P=11-245. DR PDB; 3OEV; X-ray; 2.85 A; B/P=11-245. DR PDB; 3OKJ; X-ray; 2.70 A; B/P=2-245. DR PDB; 3SDI; X-ray; 2.65 A; B/P=11-245. DR PDB; 3SDK; X-ray; 2.70 A; B/P=11-245. DR PDB; 3SHJ; X-ray; 2.80 A; B/P=2-245. DR PDB; 3TDD; X-ray; 2.70 A; B/P=2-245. DR PDB; 3UN4; X-ray; 3.40 A; B/P=1-258. DR PDB; 3UN8; X-ray; 2.70 A; B/P=1-258. DR PDB; 3WXR; X-ray; 3.15 A; C/Q=1-258. DR PDB; 4CR2; EM; 7.70 A; C=1-258. DR PDB; 4CR3; EM; 9.30 A; C=1-258. DR PDB; 4CR4; EM; 8.80 A; C=1-258. DR PDB; 4EU2; X-ray; 2.51 A; C/Q=2-245. DR PDB; 4FZC; X-ray; 2.80 A; B/P=2-245. DR PDB; 4FZG; X-ray; 3.00 A; B/P=2-245. DR PDB; 4G4S; X-ray; 2.49 A; C=1-258. DR PDB; 4GK7; X-ray; 2.80 A; B/P=2-245. DR PDB; 4HNP; X-ray; 2.80 A; B/P=2-245. DR PDB; 4HRC; X-ray; 2.80 A; B/P=2-245. DR PDB; 4HRD; X-ray; 2.80 A; B/P=2-245. DR PDB; 4INR; X-ray; 2.70 A; B/P=1-258. DR PDB; 4INT; X-ray; 2.90 A; B/P=1-258. DR PDB; 4INU; X-ray; 3.10 A; B/P=1-258. DR PDB; 4J70; X-ray; 2.80 A; B/P=1-258. DR PDB; 4JSQ; X-ray; 2.80 A; B/P=1-258. DR PDB; 4JSU; X-ray; 2.90 A; B/P=1-258. DR PDB; 4JT0; X-ray; 3.10 A; B/P=1-258. DR PDB; 4LQI; X-ray; 2.70 A; B/P=2-245. DR PDB; 4LTC; X-ray; 2.50 A; B/P=1-258. DR PDB; 4NNN; X-ray; 2.50 A; B/P=1-258. DR PDB; 4NNW; X-ray; 2.60 A; B/P=1-258. DR PDB; 4NO1; X-ray; 2.50 A; B/P=1-258. DR PDB; 4NO6; X-ray; 3.00 A; B/P=1-258. DR PDB; 4NO8; X-ray; 2.70 A; B/P=1-258. DR PDB; 4NO9; X-ray; 2.90 A; B/P=1-258. DR PDB; 4Q1S; X-ray; 2.60 A; B/P=1-258. DR PDB; 4QBY; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QLQ; X-ray; 2.40 A; B/P=1-258. DR PDB; 4QLS; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QLT; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QLU; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QLV; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QUX; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QUY; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QV0; X-ray; 3.10 A; B/P=1-258. DR PDB; 4QV1; X-ray; 2.50 A; B/P=1-258. DR PDB; 4QV3; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QV4; X-ray; 2.70 A; B/P=1-258. DR PDB; 4QV5; X-ray; 2.70 A; B/P=1-258. DR PDB; 4QV6; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QV7; X-ray; 2.60 A; B/P=1-258. DR PDB; 4QV8; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QV9; X-ray; 2.60 A; B/P=1-258. DR PDB; 4QVL; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QVM; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QVN; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QVP; X-ray; 2.30 A; B/P=1-258. DR PDB; 4QVQ; X-ray; 2.60 A; B/P=1-258. DR PDB; 4QVV; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QVW; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QVY; X-ray; 2.51 A; B/P=1-258. DR PDB; 4QW0; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QW1; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QW3; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QW4; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QW5; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QW6; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QW7; X-ray; 2.70 A; B/P=1-258. DR PDB; 4QWF; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QWG; X-ray; 2.60 A; B/P=1-258. DR PDB; 4QWI; X-ray; 2.60 A; B/P=1-258. DR PDB; 4QWJ; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QWK; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QWL; X-ray; 2.60 A; B/P=1-258. DR PDB; 4QWR; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QWS; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QWU; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QWX; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QXJ; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QZ0; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QZ1; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QZ2; X-ray; 2.70 A; B/P=1-258. DR PDB; 4QZ3; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QZ4; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QZ5; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QZ6; X-ray; 2.90 A; B/P=1-258. DR PDB; 4QZ7; X-ray; 2.80 A; B/P=1-258. DR PDB; 4QZW; X-ray; 3.00 A; B/P=1-258. DR PDB; 4QZX; X-ray; 2.60 A; B/P=1-258. DR PDB; 4QZZ; X-ray; 2.90 A; B/P=1-258. DR PDB; 4R00; X-ray; 2.80 A; B/P=1-258. DR PDB; 4R02; X-ray; 2.50 A; B/P=1-258. DR PDB; 4R17; X-ray; 2.10 A; B/P=1-258. DR PDB; 4R18; X-ray; 2.40 A; B/P=1-258. DR PDB; 4RUR; X-ray; 2.50 A; B/P=1-258. DR PDB; 4V7O; X-ray; 3.00 A; AH/AT/BC/BQ=14-245. DR PDB; 4X6Z; X-ray; 2.70 A; C/Q=1-258. DR PDB; 4Y69; X-ray; 2.90 A; B/P=1-258. DR PDB; 4Y6A; X-ray; 2.60 A; B/P=1-258. DR PDB; 4Y6V; X-ray; 2.80 A; B/P=1-258. DR PDB; 4Y6Z; X-ray; 2.70 A; B/P=1-258. DR PDB; 4Y70; X-ray; 2.40 A; B/P=1-258. DR PDB; 4Y74; X-ray; 2.70 A; B/P=1-258. DR PDB; 4Y75; X-ray; 2.80 A; B/P=1-258. DR PDB; 4Y77; X-ray; 2.50 A; B/P=1-258. DR PDB; 4Y78; X-ray; 2.80 A; B/P=1-258. DR PDB; 4Y7W; X-ray; 2.50 A; B/P=1-258. DR PDB; 4Y7X; X-ray; 2.60 A; B/P=1-258. DR PDB; 4Y7Y; X-ray; 2.40 A; B/P=1-258. DR PDB; 4Y80; X-ray; 2.50 A; B/P=1-258. DR PDB; 4Y81; X-ray; 2.80 A; B/P=1-258. DR PDB; 4Y82; X-ray; 2.80 A; B/P=1-258. DR PDB; 4Y84; X-ray; 2.70 A; B/P=1-258. DR PDB; 4Y8G; X-ray; 2.60 A; B/P=1-258. DR PDB; 4Y8H; X-ray; 2.50 A; B/P=1-258. DR PDB; 4Y8I; X-ray; 2.60 A; B/P=1-258. DR PDB; 4Y8J; X-ray; 2.70 A; B/P=1-258. DR PDB; 4Y8K; X-ray; 2.60 A; B/P=1-258. DR PDB; 4Y8L; X-ray; 2.40 A; B/P=1-258. DR PDB; 4Y8M; X-ray; 2.80 A; B/P=1-258. DR PDB; 4Y8N; X-ray; 2.60 A; B/P=1-258. DR PDB; 4Y8O; X-ray; 2.70 A; B/P=1-258. DR PDB; 4Y8P; X-ray; 2.80 A; B/P=1-258. DR PDB; 4Y8Q; X-ray; 2.60 A; B/P=1-258. DR PDB; 4Y8R; X-ray; 2.70 A; B/P=1-258. DR PDB; 4Y8S; X-ray; 2.70 A; B/P=1-258. DR PDB; 4Y8T; X-ray; 2.70 A; B/P=1-258. DR PDB; 4Y8U; X-ray; 2.90 A; B/P=1-258. DR PDB; 4Y9Y; X-ray; 2.80 A; B/P=1-258. DR PDB; 4Y9Z; X-ray; 2.80 A; B/P=1-258. DR PDB; 4YA0; X-ray; 2.80 A; B/P=1-258. DR PDB; 4YA1; X-ray; 2.90 A; B/P=1-258. DR PDB; 4YA2; X-ray; 2.70 A; B/P=1-258. DR PDB; 4YA3; X-ray; 2.70 A; B/P=1-258. DR PDB; 4YA4; X-ray; 2.90 A; B/P=1-258. DR PDB; 4YA5; X-ray; 2.50 A; B/P=1-258. DR PDB; 4YA7; X-ray; 2.70 A; B/P=1-258. DR PDB; 4YA9; X-ray; 2.70 A; B/P=1-258. DR PDB; 4Z1L; X-ray; 3.00 A; B/P=1-258. DR PDB; 5A5B; EM; 9.50 A; C=1-258. DR PDB; 5AHJ; X-ray; 2.80 A; B/P=1-258. DR PDB; 5BOU; X-ray; 2.60 A; B/P=1-258. DR PDB; 5BXL; X-ray; 2.80 A; B/P=1-258. DR PDB; 5BXN; X-ray; 2.80 A; B/P=1-258. DR PDB; 5CGF; X-ray; 2.80 A; B/P=1-258. DR PDB; 5CGG; X-ray; 2.90 A; B/P=1-258. DR PDB; 5CGH; X-ray; 2.50 A; B/P=1-258. DR PDB; 5CGI; X-ray; 2.80 A; B/P=1-258. DR PDB; 5CZ4; X-ray; 2.30 A; B/P=1-258. DR PDB; 5CZ5; X-ray; 2.80 A; B/P=1-258. DR PDB; 5CZ6; X-ray; 2.70 A; B/P=1-258. DR PDB; 5CZ7; X-ray; 2.50 A; B/P=1-258. DR PDB; 5CZ8; X-ray; 2.80 A; B/P=1-258. DR PDB; 5CZ9; X-ray; 2.90 A; B/P=1-258. DR PDB; 5CZA; X-ray; 2.50 A; B/P=1-258. DR PDB; 5D0S; X-ray; 2.50 A; B/P=1-258. DR PDB; 5D0T; X-ray; 2.60 A; B/P=1-258. DR PDB; 5D0V; X-ray; 2.90 A; B/P=1-258. DR PDB; 5D0W; X-ray; 2.80 A; B/P=1-258. DR PDB; 5D0X; X-ray; 2.60 A; B/P=1-258. DR PDB; 5D0Z; X-ray; 2.90 A; B/P=1-258. DR PDB; 5DKI; X-ray; 2.80 A; B/P=1-258. DR PDB; 5DKJ; X-ray; 2.80 A; B/P=1-258. DR PDB; 5FG7; X-ray; 2.70 A; B/P=1-258. DR PDB; 5FG9; X-ray; 2.60 A; B/P=1-258. DR PDB; 5FGA; X-ray; 2.70 A; B/P=1-258. DR PDB; 5FGD; X-ray; 2.80 A; B/P=1-258. DR PDB; 5FGE; X-ray; 2.60 A; B/P=1-258. DR PDB; 5FGF; X-ray; 2.60 A; B/P=1-258. DR PDB; 5FGG; X-ray; 2.70 A; B/P=1-258. DR PDB; 5FGH; X-ray; 2.80 A; B/P=1-258. DR PDB; 5FGI; X-ray; 2.90 A; B/P=1-258. DR PDB; 5FHS; X-ray; 2.70 A; B/P=1-258. DR PDB; 5JHR; X-ray; 2.90 A; B/P=1-258. DR PDB; 5JHS; X-ray; 3.00 A; B/P=1-258. DR PDB; 5L52; X-ray; 2.70 A; B/P=1-258. DR PDB; 5L54; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L55; X-ray; 2.90 A; B/P=1-258. DR PDB; 5L5A; X-ray; 2.40 A; B/P=1-258. DR PDB; 5L5B; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L5D; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L5E; X-ray; 2.90 A; B/P=1-258. DR PDB; 5L5F; X-ray; 2.50 A; B/P=1-258. DR PDB; 5L5H; X-ray; 2.60 A; B/P=1-258. DR PDB; 5L5I; X-ray; 2.90 A; B/P=1-258. DR PDB; 5L5J; X-ray; 2.90 A; B/P=1-258. DR PDB; 5L5O; X-ray; 2.60 A; B/P=1-258. DR PDB; 5L5P; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L5Q; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L5R; X-ray; 2.90 A; B/P=1-258. DR PDB; 5L5S; X-ray; 2.60 A; B/P=1-258. DR PDB; 5L5T; X-ray; 2.90 A; B/P=1-258. DR PDB; 5L5U; X-ray; 2.60 A; B/P=1-258. DR PDB; 5L5V; X-ray; 2.70 A; B/P=1-258. DR PDB; 5L5W; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L5X; X-ray; 2.90 A; B/P=1-258. DR PDB; 5L5Y; X-ray; 2.70 A; B/P=1-258. DR PDB; 5L5Z; X-ray; 2.70 A; B/P=1-258. DR PDB; 5L60; X-ray; 2.70 A; B/P=1-258. DR PDB; 5L61; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L62; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L63; X-ray; 2.70 A; B/P=1-258. DR PDB; 5L64; X-ray; 2.70 A; B/P=1-258. DR PDB; 5L65; X-ray; 2.90 A; B/P=1-258. DR PDB; 5L66; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L67; X-ray; 2.60 A; B/P=1-258. DR PDB; 5L68; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L69; X-ray; 2.70 A; B/P=1-258. DR PDB; 5L6A; X-ray; 2.80 A; B/P=1-258. DR PDB; 5L6B; X-ray; 2.60 A; B/P=1-258. DR PDB; 5L6C; X-ray; 2.60 A; B/P=1-258. DR PDB; 5LAI; X-ray; 2.50 A; B/P=1-258. DR PDB; 5LAJ; X-ray; 2.90 A; B/P=1-258. DR PDB; 5LTT; X-ray; 2.70 A; B/P=1-258. DR PDB; 5M2B; X-ray; 2.70 A; B/P=1-258. DR PDB; 5MP9; EM; 4.10 A; C/c=1-258. DR PDB; 5MPA; EM; 4.50 A; C/c=1-258. DR PDB; 5MPB; EM; 7.80 A; C/c=1-258. DR PDB; 5MPC; EM; 7.70 A; C/c=1-258. DR PDB; 5NIF; X-ray; 3.00 A; C/Q=1-258. DR PDB; 5WVI; EM; 6.30 A; C/d=1-258. DR PDB; 5WVK; EM; 4.20 A; C/d=1-258. DR PDB; 6EF0; EM; 4.43 A; C=1-244. DR PDB; 6EF1; EM; 4.73 A; C=8-245. DR PDB; 6EF2; EM; 4.27 A; C=4-244. DR PDB; 6EF3; EM; 4.17 A; C=1-258. DR PDB; 6FVT; EM; 4.10 A; C/c=2-245. DR PDB; 6FVU; EM; 4.50 A; C/c=2-245. DR PDB; 6FVV; EM; 5.40 A; C/c=2-245. DR PDB; 6FVW; EM; 4.50 A; C/c=5-245. DR PDB; 6FVX; EM; 4.90 A; C/c=5-245. DR PDB; 6FVY; EM; 6.10 A; C/c=5-245. DR PDB; 6G7F; X-ray; 2.70 A; B/P=1-258. DR PDB; 6G8M; X-ray; 2.70 A; B/P=1-258. DR PDB; 6G8N; X-ray; 3.00 A; B/P=1-258. DR PDB; 6GOP; X-ray; 2.90 A; B/P=1-258. DR PDB; 6H39; X-ray; 2.50 A; B/P=1-258. DR PDB; 6HTB; X-ray; 2.70 A; B/P=1-258. DR PDB; 6HTC; X-ray; 2.80 A; B/P=1-258. DR PDB; 6HTD; X-ray; 3.00 A; B/P=1-258. DR PDB; 6HTP; X-ray; 3.00 A; B/P=1-258. DR PDB; 6HTR; X-ray; 2.60 A; B/P=1-258. DR PDB; 6HUB; X-ray; 2.90 A; B/P=1-258. DR PDB; 6HUC; X-ray; 3.00 A; B/P=1-258. DR PDB; 6HUQ; X-ray; 3.00 A; B/P=1-258. DR PDB; 6HUU; X-ray; 2.80 A; B/P=1-258. DR PDB; 6HUV; X-ray; 3.10 A; B/P=1-258. DR PDB; 6HV3; X-ray; 2.70 A; B/P=1-258. DR PDB; 6HV4; X-ray; 3.00 A; B/P=1-258. DR PDB; 6HV5; X-ray; 3.00 A; B/P=1-258. DR PDB; 6HV7; X-ray; 3.40 A; B/P=1-258. DR PDB; 6HVA; X-ray; 2.90 A; B/P=1-258. DR PDB; 6HVR; X-ray; 2.70 A; B/P=1-258. DR PDB; 6HVS; X-ray; 3.10 A; B/P=1-258. DR PDB; 6HVT; X-ray; 2.90 A; B/P=1-258. DR PDB; 6HVU; X-ray; 2.90 A; B/P=1-258. DR PDB; 6HVV; X-ray; 2.70 A; B/P=1-258. DR PDB; 6HVW; X-ray; 3.00 A; B/P=1-258. DR PDB; 6HVX; X-ray; 2.80 A; B/P=1-258. DR PDB; 6HVY; X-ray; 2.70 A; B/P=1-258. DR PDB; 6HW0; X-ray; 2.80 A; B/P=1-258. DR PDB; 6HW3; X-ray; 2.60 A; B/P=1-258. DR PDB; 6HW4; X-ray; 2.90 A; B/P=1-258. DR PDB; 6HW5; X-ray; 2.90 A; B/P=1-258. DR PDB; 6HW6; X-ray; 2.70 A; B/P=1-258. DR PDB; 6HW7; X-ray; 2.70 A; B/P=1-258. DR PDB; 6HW8; X-ray; 2.80 A; B/P=1-258. DR PDB; 6HW9; X-ray; 2.80 A; B/P=1-258. DR PDB; 6HWA; X-ray; 2.80 A; B/P=1-258. DR PDB; 6HWB; X-ray; 2.60 A; B/P=1-258. DR PDB; 6HWC; X-ray; 2.80 A; B/P=1-258. DR PDB; 6HWD; X-ray; 2.80 A; B/P=1-258. DR PDB; 6HWE; X-ray; 2.30 A; B/P=1-258. DR PDB; 6HWF; X-ray; 2.50 A; B/P=1-258. DR PDB; 6J2C; EM; 7.00 A; C/d=1-258. DR PDB; 6J2N; EM; 7.50 A; C/d=1-258. DR PDB; 6J2Q; EM; 3.80 A; C/d=1-258. DR PDB; 6J2X; EM; 3.80 A; C/d=1-258. DR PDB; 6J30; EM; 4.50 A; C/d=1-258. DR PDB; 6ZOU; X-ray; 2.90 A; B/P=1-258. DR PDB; 6ZP6; X-ray; 2.80 A; B/P=1-258. DR PDB; 6ZP8; X-ray; 3.00 A; B/P=1-258. DR PDB; 7LS5; EM; 2.74 A; C/Q=1-258. DR PDB; 7LS6; EM; 3.17 A; C=1-258. DR PDB; 7LSX; EM; 3.61 A; C=1-258. DR PDB; 7O2L; X-ray; 3.00 A; B/P=1-258. DR PDB; 7QO3; EM; 6.10 A; C/c=1-258. DR PDB; 7QO5; EM; 6.00 A; C/c=1-258. DR PDB; 8OLR; X-ray; 2.80 A; B/P=1-258. DR PDB; 8T08; EM; 3.00 A; C/T=1-258. DR PDB; 8T0M; EM; 2.40 A; C/Q=1-258. DR PDBsum; 1FNT; -. DR PDBsum; 1G0U; -. DR PDBsum; 1G65; -. DR PDBsum; 1JD2; -. DR PDBsum; 1RYP; -. DR PDBsum; 1Z7Q; -. DR PDBsum; 2F16; -. DR PDBsum; 2FAK; -. DR PDBsum; 2GPL; -. DR PDBsum; 2ZCY; -. DR PDBsum; 3BDM; -. DR PDBsum; 3D29; -. DR PDBsum; 3DY3; -. DR PDBsum; 3DY4; -. DR PDBsum; 3E47; -. DR PDBsum; 3GPJ; -. DR PDBsum; 3GPT; -. DR PDBsum; 3GPW; -. DR PDBsum; 3HYE; -. DR PDBsum; 3JCO; -. DR PDBsum; 3JCP; -. DR PDBsum; 3MG0; -. DR PDBsum; 3MG4; -. DR PDBsum; 3MG6; -. DR PDBsum; 3MG7; -. DR PDBsum; 3MG8; -. DR PDBsum; 3NZJ; -. DR PDBsum; 3NZW; -. DR PDBsum; 3NZX; -. DR PDBsum; 3OEU; -. DR PDBsum; 3OEV; -. DR PDBsum; 3OKJ; -. DR PDBsum; 3SDI; -. DR PDBsum; 3SDK; -. DR PDBsum; 3SHJ; -. DR PDBsum; 3TDD; -. DR PDBsum; 3UN4; -. DR PDBsum; 3UN8; -. DR PDBsum; 3WXR; -. DR PDBsum; 4CR2; -. DR PDBsum; 4CR3; -. DR PDBsum; 4CR4; -. DR PDBsum; 4EU2; -. DR PDBsum; 4FZC; -. DR PDBsum; 4FZG; -. DR PDBsum; 4G4S; -. DR PDBsum; 4GK7; -. DR PDBsum; 4HNP; -. DR PDBsum; 4HRC; -. DR PDBsum; 4HRD; -. DR PDBsum; 4INR; -. DR PDBsum; 4INT; -. DR PDBsum; 4INU; -. DR PDBsum; 4J70; -. DR PDBsum; 4JSQ; -. DR PDBsum; 4JSU; -. DR PDBsum; 4JT0; -. DR PDBsum; 4LQI; -. DR PDBsum; 4LTC; -. DR PDBsum; 4NNN; -. DR PDBsum; 4NNW; -. DR PDBsum; 4NO1; -. DR PDBsum; 4NO6; -. DR PDBsum; 4NO8; -. DR PDBsum; 4NO9; -. DR PDBsum; 4Q1S; -. DR PDBsum; 4QBY; -. DR PDBsum; 4QLQ; -. DR PDBsum; 4QLS; -. DR PDBsum; 4QLT; -. DR PDBsum; 4QLU; -. DR PDBsum; 4QLV; -. DR PDBsum; 4QUX; -. DR PDBsum; 4QUY; -. DR PDBsum; 4QV0; -. DR PDBsum; 4QV1; -. DR PDBsum; 4QV3; -. DR PDBsum; 4QV4; -. DR PDBsum; 4QV5; -. DR PDBsum; 4QV6; -. DR PDBsum; 4QV7; -. DR PDBsum; 4QV8; -. DR PDBsum; 4QV9; -. DR PDBsum; 4QVL; -. DR PDBsum; 4QVM; -. DR PDBsum; 4QVN; -. DR PDBsum; 4QVP; -. DR PDBsum; 4QVQ; -. DR PDBsum; 4QVV; -. DR PDBsum; 4QVW; -. DR PDBsum; 4QVY; -. DR PDBsum; 4QW0; -. DR PDBsum; 4QW1; -. DR PDBsum; 4QW3; -. DR PDBsum; 4QW4; -. DR PDBsum; 4QW5; -. DR PDBsum; 4QW6; -. DR PDBsum; 4QW7; -. DR PDBsum; 4QWF; -. DR PDBsum; 4QWG; -. DR PDBsum; 4QWI; -. DR PDBsum; 4QWJ; -. DR PDBsum; 4QWK; -. DR PDBsum; 4QWL; -. DR PDBsum; 4QWR; -. DR PDBsum; 4QWS; -. DR PDBsum; 4QWU; -. DR PDBsum; 4QWX; -. DR PDBsum; 4QXJ; -. DR PDBsum; 4QZ0; -. DR PDBsum; 4QZ1; -. DR PDBsum; 4QZ2; -. DR PDBsum; 4QZ3; -. DR PDBsum; 4QZ4; -. DR PDBsum; 4QZ5; -. DR PDBsum; 4QZ6; -. DR PDBsum; 4QZ7; -. DR PDBsum; 4QZW; -. DR PDBsum; 4QZX; -. DR PDBsum; 4QZZ; -. DR PDBsum; 4R00; -. DR PDBsum; 4R02; -. DR PDBsum; 4R17; -. DR PDBsum; 4R18; -. DR PDBsum; 4RUR; -. DR PDBsum; 4V7O; -. DR PDBsum; 4X6Z; -. DR PDBsum; 4Y69; -. DR PDBsum; 4Y6A; -. DR PDBsum; 4Y6V; -. DR PDBsum; 4Y6Z; -. DR PDBsum; 4Y70; -. DR PDBsum; 4Y74; -. DR PDBsum; 4Y75; -. DR PDBsum; 4Y77; -. DR PDBsum; 4Y78; -. DR PDBsum; 4Y7W; -. DR PDBsum; 4Y7X; -. DR PDBsum; 4Y7Y; -. DR PDBsum; 4Y80; -. DR PDBsum; 4Y81; -. DR PDBsum; 4Y82; -. DR PDBsum; 4Y84; -. DR PDBsum; 4Y8G; -. DR PDBsum; 4Y8H; -. DR PDBsum; 4Y8I; -. DR PDBsum; 4Y8J; -. DR PDBsum; 4Y8K; -. DR PDBsum; 4Y8L; -. DR PDBsum; 4Y8M; -. DR PDBsum; 4Y8N; -. DR PDBsum; 4Y8O; -. DR PDBsum; 4Y8P; -. DR PDBsum; 4Y8Q; -. DR PDBsum; 4Y8R; -. DR PDBsum; 4Y8S; -. DR PDBsum; 4Y8T; -. DR PDBsum; 4Y8U; -. DR PDBsum; 4Y9Y; -. DR PDBsum; 4Y9Z; -. DR PDBsum; 4YA0; -. DR PDBsum; 4YA1; -. DR PDBsum; 4YA2; -. DR PDBsum; 4YA3; -. DR PDBsum; 4YA4; -. DR PDBsum; 4YA5; -. DR PDBsum; 4YA7; -. DR PDBsum; 4YA9; -. DR PDBsum; 4Z1L; -. DR PDBsum; 5A5B; -. DR PDBsum; 5AHJ; -. DR PDBsum; 5BOU; -. DR PDBsum; 5BXL; -. DR PDBsum; 5BXN; -. DR PDBsum; 5CGF; -. DR PDBsum; 5CGG; -. DR PDBsum; 5CGH; -. DR PDBsum; 5CGI; -. DR PDBsum; 5CZ4; -. DR PDBsum; 5CZ5; -. DR PDBsum; 5CZ6; -. DR PDBsum; 5CZ7; -. DR PDBsum; 5CZ8; -. DR PDBsum; 5CZ9; -. DR PDBsum; 5CZA; -. DR PDBsum; 5D0S; -. DR PDBsum; 5D0T; -. DR PDBsum; 5D0V; -. DR PDBsum; 5D0W; -. DR PDBsum; 5D0X; -. DR PDBsum; 5D0Z; -. DR PDBsum; 5DKI; -. DR PDBsum; 5DKJ; -. DR PDBsum; 5FG7; -. DR PDBsum; 5FG9; -. DR PDBsum; 5FGA; -. DR PDBsum; 5FGD; -. DR PDBsum; 5FGE; -. DR PDBsum; 5FGF; -. DR PDBsum; 5FGG; -. DR PDBsum; 5FGH; -. DR PDBsum; 5FGI; -. DR PDBsum; 5FHS; -. DR PDBsum; 5JHR; -. DR PDBsum; 5JHS; -. DR PDBsum; 5L52; -. DR PDBsum; 5L54; -. DR PDBsum; 5L55; -. DR PDBsum; 5L5A; -. DR PDBsum; 5L5B; -. DR PDBsum; 5L5D; -. DR PDBsum; 5L5E; -. DR PDBsum; 5L5F; -. DR PDBsum; 5L5H; -. DR PDBsum; 5L5I; -. DR PDBsum; 5L5J; -. DR PDBsum; 5L5O; -. DR PDBsum; 5L5P; -. DR PDBsum; 5L5Q; -. DR PDBsum; 5L5R; -. DR PDBsum; 5L5S; -. DR PDBsum; 5L5T; -. DR PDBsum; 5L5U; -. DR PDBsum; 5L5V; -. DR PDBsum; 5L5W; -. DR PDBsum; 5L5X; -. DR PDBsum; 5L5Y; -. DR PDBsum; 5L5Z; -. DR PDBsum; 5L60; -. DR PDBsum; 5L61; -. DR PDBsum; 5L62; -. DR PDBsum; 5L63; -. DR PDBsum; 5L64; -. DR PDBsum; 5L65; -. DR PDBsum; 5L66; -. DR PDBsum; 5L67; -. DR PDBsum; 5L68; -. DR PDBsum; 5L69; -. DR PDBsum; 5L6A; -. DR PDBsum; 5L6B; -. DR PDBsum; 5L6C; -. DR PDBsum; 5LAI; -. DR PDBsum; 5LAJ; -. DR PDBsum; 5LTT; -. DR PDBsum; 5M2B; -. DR PDBsum; 5MP9; -. DR PDBsum; 5MPA; -. DR PDBsum; 5MPB; -. DR PDBsum; 5MPC; -. DR PDBsum; 5NIF; -. DR PDBsum; 5WVI; -. DR PDBsum; 5WVK; -. DR PDBsum; 6EF0; -. DR PDBsum; 6EF1; -. DR PDBsum; 6EF2; -. DR PDBsum; 6EF3; -. DR PDBsum; 6FVT; -. DR PDBsum; 6FVU; -. DR PDBsum; 6FVV; -. DR PDBsum; 6FVW; -. DR PDBsum; 6FVX; -. DR PDBsum; 6FVY; -. DR PDBsum; 6G7F; -. DR PDBsum; 6G8M; -. DR PDBsum; 6G8N; -. DR PDBsum; 6GOP; -. DR PDBsum; 6H39; -. DR PDBsum; 6HTB; -. DR PDBsum; 6HTC; -. DR PDBsum; 6HTD; -. DR PDBsum; 6HTP; -. DR PDBsum; 6HTR; -. DR PDBsum; 6HUB; -. DR PDBsum; 6HUC; -. DR PDBsum; 6HUQ; -. DR PDBsum; 6HUU; -. DR PDBsum; 6HUV; -. DR PDBsum; 6HV3; -. DR PDBsum; 6HV4; -. DR PDBsum; 6HV5; -. DR PDBsum; 6HV7; -. DR PDBsum; 6HVA; -. DR PDBsum; 6HVR; -. DR PDBsum; 6HVS; -. DR PDBsum; 6HVT; -. DR PDBsum; 6HVU; -. DR PDBsum; 6HVV; -. DR PDBsum; 6HVW; -. DR PDBsum; 6HVX; -. DR PDBsum; 6HVY; -. DR PDBsum; 6HW0; -. DR PDBsum; 6HW3; -. DR PDBsum; 6HW4; -. DR PDBsum; 6HW5; -. DR PDBsum; 6HW6; -. DR PDBsum; 6HW7; -. DR PDBsum; 6HW8; -. DR PDBsum; 6HW9; -. DR PDBsum; 6HWA; -. DR PDBsum; 6HWB; -. DR PDBsum; 6HWC; -. DR PDBsum; 6HWD; -. DR PDBsum; 6HWE; -. DR PDBsum; 6HWF; -. DR PDBsum; 6J2C; -. DR PDBsum; 6J2N; -. DR PDBsum; 6J2Q; -. DR PDBsum; 6J2X; -. DR PDBsum; 6J30; -. DR PDBsum; 6ZOU; -. DR PDBsum; 6ZP6; -. DR PDBsum; 6ZP8; -. DR PDBsum; 7LS5; -. DR PDBsum; 7LS6; -. DR PDBsum; 7LSX; -. DR PDBsum; 7O2L; -. DR PDBsum; 7QO3; -. DR PDBsum; 7QO5; -. DR PDBsum; 8OLR; -. DR PDBsum; 8T08; -. DR PDBsum; 8T0M; -. DR AlphaFoldDB; P23638; -. DR EMDB; EMD-14082; -. DR EMDB; EMD-14084; -. DR EMDB; EMD-23502; -. DR EMDB; EMD-23503; -. DR EMDB; EMD-23508; -. DR EMDB; EMD-3534; -. DR EMDB; EMD-3535; -. DR EMDB; EMD-3536; -. DR EMDB; EMD-3537; -. DR EMDB; EMD-40938; -. DR EMDB; EMD-40944; -. DR EMDB; EMD-4321; -. DR EMDB; EMD-4322; -. DR EMDB; EMD-4323; -. DR EMDB; EMD-4324; -. DR EMDB; EMD-6693; -. DR EMDB; EMD-6694; -. DR EMDB; EMD-9042; -. DR EMDB; EMD-9043; -. DR EMDB; EMD-9044; -. DR EMDB; EMD-9045; -. DR EMDB; EMD-9769; -. DR EMDB; EMD-9770; -. DR EMDB; EMD-9771; -. DR EMDB; EMD-9772; -. DR EMDB; EMD-9773; -. DR SMR; P23638; -. DR BioGRID; 33383; 548. DR ComplexPortal; CPX-2262; 26S Proteasome complex. DR DIP; DIP-2823N; -. DR IntAct; P23638; 20. DR MINT; P23638; -. DR STRING; 4932.YGR135W; -. DR MEROPS; T01.973; -. DR iPTMnet; P23638; -. DR MaxQB; P23638; -. DR PaxDb; 4932-YGR135W; -. DR PeptideAtlas; P23638; -. DR EnsemblFungi; YGR135W_mRNA; YGR135W; YGR135W. DR GeneID; 853036; -. DR KEGG; sce:YGR135W; -. DR AGR; SGD:S000003367; -. DR SGD; S000003367; PRE9. DR VEuPathDB; FungiDB:YGR135W; -. DR eggNOG; KOG0178; Eukaryota. DR GeneTree; ENSGT00550000074827; -. DR HOGENOM; CLU_035750_4_3_1; -. DR InParanoid; P23638; -. DR OMA; YVLNDNM; -. DR OrthoDB; 166567at2759; -. DR BioCyc; YEAST:G3O-30841-MONOMER; -. DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes). DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway. DR Reactome; R-SCE-5689880; Ub-specific processing proteases. DR BioGRID-ORCS; 853036; 6 hits in 10 CRISPR screens. DR EvolutionaryTrace; P23638; -. DR PRO; PR:P23638; -. DR Proteomes; UP000002311; Chromosome VII. DR RNAct; P23638; Protein. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal. DR GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD. DR GO; GO:0034515; C:proteasome storage granule; IDA:SGD. DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central. DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD. DR GO; GO:0080129; P:proteasome core complex assembly; IMP:SGD. DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD. DR CDD; cd03752; proteasome_alpha_type_4; 1. DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1. DR InterPro; IPR029055; Ntn_hydrolases_N. DR InterPro; IPR023332; Proteasome_alpha-type. DR InterPro; IPR000426; Proteasome_asu_N. DR InterPro; IPR016050; Proteasome_bsu_CS. DR InterPro; IPR001353; Proteasome_sua/b. DR PANTHER; PTHR11599:SF13; PROTEASOME SUBUNIT ALPHA TYPE-4; 1. DR PANTHER; PTHR11599; PROTEASOME SUBUNIT ALPHA/BETA; 1. DR Pfam; PF00227; Proteasome; 1. DR Pfam; PF10584; Proteasome_A_N; 1. DR SMART; SM00948; Proteasome_A_N; 1. DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1. DR PROSITE; PS00388; PROTEASOME_ALPHA_1; 1. DR PROSITE; PS51475; PROTEASOME_ALPHA_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Cytoplasm; Direct protein sequencing; Isopeptide bond; KW Nucleus; Proteasome; Reference proteome; Ubl conjugation. FT CHAIN 1..258 FT /note="Proteasome subunit alpha type-3" FT /id="PRO_0000124116" FT CROSSLNK 100 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in ubiquitin)" FT /evidence="ECO:0007744|PubMed:22106047" FT CROSSLNK 199 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in ubiquitin)" FT /evidence="ECO:0007744|PubMed:22106047" FT CROSSLNK 231 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in ubiquitin)" FT /evidence="ECO:0007744|PubMed:22106047" FT HELIX 4..6 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 20..29 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 35..40 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 43..49 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 55..57 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 59..61 FT /evidence="ECO:0007829|PDB:5CZ4" FT STRAND 64..79 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 81..102 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 108..124 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 125..127 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 133..141 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 142..144 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 145..151 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 157..166 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 169..179 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 186..200 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 202..205 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 208..210 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 211..217 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 220..224 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 226..229 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 232..241 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 242..244 FT /evidence="ECO:0007829|PDB:3BDM" SQ SEQUENCE 258 AA; 28714 MW; B43BB05233A01A9E CRC64; MGSRRYDSRT TIFSPEGRLY QVEYALESIS HAGTAIGIMA SDGIVLAAER KVTSTLLEQD TSTEKLYKLN DKIAVAVAGL TADAEILINT ARIHAQNYLK TYNEDIPVEI LVRRLSDIKQ GYTQHGGLRP FGVSFIYAGY DDRYGYQLYT SNPSGNYTGW KAISVGANTS AAQTLLQMDY KDDMKVDDAI ELALKTLSKT TDSSALTYDR LEFATIRKGA NDGEVYQKIF KPQEIKDILV KTGITKKDED EEADEDMK //