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Protein

Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit

Gene

ppa2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor.

Miscellaneous

Retarded cell growth is produced by disruption of ppa2.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi70Manganese 1By similarity1
Metal bindingi72Manganese 1By similarity1
Metal bindingi98Manganese 1By similarity1
Metal bindingi98Manganese 2By similarity1
Metal bindingi130Manganese 2By similarity1
Active sitei131Proton donorBy similarity1
Metal bindingi180Manganese 2By similarity1
Metal bindingi254Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: PomBase

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • regulation of G2/M transition of mitotic cell cycle Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-198753. ERK/MAPK targets.
R-SPO-202670. ERKs are inactivated.

Names & Taxonomyi

Protein namesi
Recommended name:
Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:ppa2
ORF Names:SPBC16H5.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16H5.07c.
PomBaseiSPBC16H5.07c. ppa2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588721 – 322Major serine/threonine-protein phosphatase PP2A-2 catalytic subunitAdd BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei322Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP23636.
PRIDEiP23636.

Interactioni

Protein-protein interaction databases

BioGridi276610. 104 interactors.
DIPiDIP-61477N.
IntActiP23636. 1 interactor.
MINTiMINT-4687798.
STRINGi4896.SPBC16H5.07c.1.

Structurei

3D structure databases

ProteinModelPortaliP23636.
SMRiP23636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiP23636.
KOiK04382.
OMAiEGYNWGQ.
OrthoDBiEOG092C2R40.
PhylomeDBiP23636.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P23636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIDPANDSK LAPEANDATL GDVDRWIEQL KKCEPLSEAD VEMLCDKARE
60 70 80 90 100
VLCQENNVQP VRNPVTVCGD IHGQFHDLME LFKIGGDVPD MNYLFMGDYV
110 120 130 140 150
DRGYHSVETV SLLVAMKLRY PNRITILRGN HESRQITQVY GFYDECLRKY
160 170 180 190 200
GSANVWKHFT NLFDYFPLTA LIEDRIFCLH GGLSPSIDSL DHVRTLDRVQ
210 220 230 240 250
EVPHEGPMCD LLWSDPDDRC GWGISPRGAG YTFGQDISET FNHANGLSLT
260 270 280 290 300
ARAHQLVMEG FNWAHDGDVV TIFSAPNYCY RCGNQAAILE VDDTMNQVFL
310 320
QFDPAPREGE PVIARRTPDY FL
Length:322
Mass (Da):36,489
Last modified:November 1, 1991 - v1
Checksum:i8709C544FAFEDD85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58519 Genomic DNA. Translation: AAA63579.1.
CU329671 Genomic DNA. Translation: CAA17905.1.
PIRiB36076.
RefSeqiNP_595940.1. NM_001021848.2.

Genome annotation databases

EnsemblFungiiSPBC16H5.07c.1; SPBC16H5.07c.1:pep; SPBC16H5.07c.
GeneIDi2540072.
KEGGispo:SPBC16H5.07c.

Similar proteinsi

Entry informationi

Entry nameiPP2A2_SCHPO
AccessioniPrimary (citable) accession number: P23636
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 25, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families