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P23636

- PP2A2_SCHPO

UniProt

P23636 - PP2A2_SCHPO

Protein

Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit

Gene

ppa2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi70 – 701Manganese 1By similarity
    Metal bindingi72 – 721Manganese 1By similarity
    Metal bindingi98 – 981Manganese 1By similarity
    Metal bindingi98 – 981Manganese 2By similarity
    Metal bindingi130 – 1301Manganese 2By similarity
    Active sitei131 – 1311Proton donorBy similarity
    Metal bindingi180 – 1801Manganese 2By similarity
    Metal bindingi254 – 2541Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: PomBase

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
    3. negative regulation of mitotic cell cycle Source: PomBase
    4. protein dephosphorylation Source: PomBase
    5. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC:3.1.3.16)
    Gene namesi
    Name:ppa2
    ORF Names:SPBC16H5.07c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC16H5.07c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Major serine/threonine-protein phosphatase PP2A-2 catalytic subunitPRO_0000058872Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei322 – 3221Leucine methyl esterBy similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    MaxQBiP23636.
    PaxDbiP23636.

    Interactioni

    Protein-protein interaction databases

    BioGridi276610. 103 interactions.
    MINTiMINT-4687798.
    STRINGi4896.SPBC16H5.07c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP23636.
    SMRiP23636. Positions 22-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172696.
    KOiK04382.
    OMAiDPANDSK.
    OrthoDBiEOG7FFN29.
    PhylomeDBiP23636.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23636-1 [UniParc]FASTAAdd to Basket

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    MSIDPANDSK LAPEANDATL GDVDRWIEQL KKCEPLSEAD VEMLCDKARE    50
    VLCQENNVQP VRNPVTVCGD IHGQFHDLME LFKIGGDVPD MNYLFMGDYV 100
    DRGYHSVETV SLLVAMKLRY PNRITILRGN HESRQITQVY GFYDECLRKY 150
    GSANVWKHFT NLFDYFPLTA LIEDRIFCLH GGLSPSIDSL DHVRTLDRVQ 200
    EVPHEGPMCD LLWSDPDDRC GWGISPRGAG YTFGQDISET FNHANGLSLT 250
    ARAHQLVMEG FNWAHDGDVV TIFSAPNYCY RCGNQAAILE VDDTMNQVFL 300
    QFDPAPREGE PVIARRTPDY FL 322
    Length:322
    Mass (Da):36,489
    Last modified:November 1, 1991 - v1
    Checksum:i8709C544FAFEDD85
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58519 Genomic DNA. Translation: AAA63579.1.
    CU329671 Genomic DNA. Translation: CAA17905.1.
    PIRiB36076.
    RefSeqiNP_595940.1. NM_001021848.2.

    Genome annotation databases

    EnsemblFungiiSPBC16H5.07c.1; SPBC16H5.07c.1:pep; SPBC16H5.07c.
    GeneIDi2540072.
    KEGGispo:SPBC16H5.07c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58519 Genomic DNA. Translation: AAA63579.1 .
    CU329671 Genomic DNA. Translation: CAA17905.1 .
    PIRi B36076.
    RefSeqi NP_595940.1. NM_001021848.2.

    3D structure databases

    ProteinModelPortali P23636.
    SMRi P23636. Positions 22-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276610. 103 interactions.
    MINTi MINT-4687798.
    STRINGi 4896.SPBC16H5.07c-1.

    Proteomic databases

    MaxQBi P23636.
    PaxDbi P23636.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC16H5.07c.1 ; SPBC16H5.07c.1:pep ; SPBC16H5.07c .
    GeneIDi 2540072.
    KEGGi spo:SPBC16H5.07c.

    Organism-specific databases

    PomBasei SPBC16H5.07c.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172696.
    KOi K04382.
    OMAi DPANDSK.
    OrthoDBi EOG7FFN29.
    PhylomeDBi P23636.

    Miscellaneous databases

    NextBioi 20801209.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle."
      Kinoshita N., Ohkura H., Yanagida M.
      Cell 63:405-415(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / HM123.
    2. "DNA sequencing and analysis of a 67.4 kb region from the right arm of Schizosaccharomyces pombe chromosome II reveals 28 open reading frames including the genes his5, pol5, ppa2, rip1, rpb8 and skb1."
      Xiang Z., Lyne M.H., Wood V., Rajandream M.A., Barrell B.G., Aves S.J.
      Yeast 15:893-901(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPP2A2_SCHPO
    AccessioniPrimary (citable) accession number: P23636
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Retarded cell growth is produced by disruption of ppa2.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3