Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit

Gene

ppa1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Manganese 1By similarity1
Metal bindingi59Manganese 1By similarity1
Metal bindingi85Manganese 1By similarity1
Metal bindingi85Manganese 2By similarity1
Metal bindingi117Manganese 2By similarity1
Active sitei118Proton donorBy similarity1
Metal bindingi167Manganese 2By similarity1
Metal bindingi241Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-198753 ERK/MAPK targets
R-SPO-202670 ERKs are inactivated

Names & Taxonomyi

Protein namesi
Recommended name:
Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:ppa1
ORF Names:SPAC823.15
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC823.15
PomBaseiSPAC823.15 ppa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588711 – 309Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunitAdd BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei309Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP23635
PaxDbiP23635
PRIDEiP23635

Interactioni

Protein-protein interaction databases

BioGridi278531, 14 interactors
DIPiDIP-61476N
IntActiP23635, 1 interactor
STRINGi4896.SPAC823.15.1

Structurei

3D structure databases

ProteinModelPortaliP23635
SMRiP23635
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172696
InParanoidiP23635
KOiK04382
OMAiNWGHDKN
OrthoDBiEOG092C2R40
PhylomeDBiP23635

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P23635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSGKIGEV DRWIEQLSRC EPLSEEDVIQ MCDLAKEVLS VESNVQSVRC
60 70 80 90 100
PVTVCGDIHG QFHDLMELFN IGGPSPDTNY LFMGDYVDRG YHSVETVSLL
110 120 130 140 150
IAFKIRYPQR ITILRGNHES RQITQVYGFY DECLRKYGNA NVWQYFTDLF
160 170 180 190 200
DYLPLTALIE DRIFCLHGGL SPSIDTLDHV RILDRVQEVP HEGPICDLLW
210 220 230 240 250
SDPDDRPGWG ISPRGAGYTF GPDIAEAFNH NNGLDLIARA HQLVMEGYNW
260 270 280 290 300
TTNHNVVTIF SAPNYCYRCG NQAAIMGIDD HINYAFIQYD TAPRKEELHV

TRRTPDYFL
Length:309
Mass (Da):35,291
Last modified:November 1, 1991 - v1
Checksum:i0F47604E5F740B0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58518 Genomic DNA Translation: AAA63578.1
CU329670 Genomic DNA Translation: CAB90160.1
PIRiA36076
RefSeqiNP_593842.1, NM_001019271.2

Genome annotation databases

EnsemblFungiiSPAC823.15.1; SPAC823.15.1:pep; SPAC823.15
KEGGispo:SPAC823.15

Similar proteinsi

Entry informationi

Entry nameiPP2A1_SCHPO
AccessioniPrimary (citable) accession number: P23635
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health