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Protein

Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit

Gene

ppa1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Manganese 1By similarity1
Metal bindingi59Manganese 1By similarity1
Metal bindingi85Manganese 1By similarity1
Metal bindingi85Manganese 2By similarity1
Metal bindingi117Manganese 2By similarity1
Active sitei118Proton donorBy similarity1
Metal bindingi167Manganese 2By similarity1
Metal bindingi241Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-198753. ERK/MAPK targets.
R-SPO-202670. ERKs are inactivated.

Names & Taxonomyi

Protein namesi
Recommended name:
Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:ppa1
ORF Names:SPAC823.15
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC823.15.
PomBaseiSPAC823.15. ppa1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588711 – 309Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunitAdd BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei309Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP23635.
PRIDEiP23635.

Interactioni

Protein-protein interaction databases

BioGridi278531. 14 interactors.
DIPiDIP-61476N.
MINTiMINT-4687784.

Structurei

3D structure databases

ProteinModelPortaliP23635.
SMRiP23635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiP23635.
KOiK04382.
OMAiHECRHIS.
OrthoDBiEOG092C2R40.
PhylomeDBiP23635.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P23635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSGKIGEV DRWIEQLSRC EPLSEEDVIQ MCDLAKEVLS VESNVQSVRC
60 70 80 90 100
PVTVCGDIHG QFHDLMELFN IGGPSPDTNY LFMGDYVDRG YHSVETVSLL
110 120 130 140 150
IAFKIRYPQR ITILRGNHES RQITQVYGFY DECLRKYGNA NVWQYFTDLF
160 170 180 190 200
DYLPLTALIE DRIFCLHGGL SPSIDTLDHV RILDRVQEVP HEGPICDLLW
210 220 230 240 250
SDPDDRPGWG ISPRGAGYTF GPDIAEAFNH NNGLDLIARA HQLVMEGYNW
260 270 280 290 300
TTNHNVVTIF SAPNYCYRCG NQAAIMGIDD HINYAFIQYD TAPRKEELHV

TRRTPDYFL
Length:309
Mass (Da):35,291
Last modified:November 1, 1991 - v1
Checksum:i0F47604E5F740B0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58518 Genomic DNA. Translation: AAA63578.1.
CU329670 Genomic DNA. Translation: CAB90160.1.
PIRiA36076.
RefSeqiNP_593842.1. NM_001019271.2.

Genome annotation databases

EnsemblFungiiSPAC823.15.1; SPAC823.15.1:pep; SPAC823.15.
GeneIDi2542052.
KEGGispo:SPAC823.15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58518 Genomic DNA. Translation: AAA63578.1.
CU329670 Genomic DNA. Translation: CAB90160.1.
PIRiA36076.
RefSeqiNP_593842.1. NM_001019271.2.

3D structure databases

ProteinModelPortaliP23635.
SMRiP23635.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278531. 14 interactors.
DIPiDIP-61476N.
MINTiMINT-4687784.

Proteomic databases

MaxQBiP23635.
PRIDEiP23635.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC823.15.1; SPAC823.15.1:pep; SPAC823.15.
GeneIDi2542052.
KEGGispo:SPAC823.15.

Organism-specific databases

EuPathDBiFungiDB:SPAC823.15.
PomBaseiSPAC823.15. ppa1.

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiP23635.
KOiK04382.
OMAiHECRHIS.
OrthoDBiEOG092C2R40.
PhylomeDBiP23635.

Enzyme and pathway databases

ReactomeiR-SPO-198753. ERK/MAPK targets.
R-SPO-202670. ERKs are inactivated.

Miscellaneous databases

PROiP23635.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPP2A1_SCHPO
AccessioniPrimary (citable) accession number: P23635
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: March 15, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.