##gff-version 3 P23634 UniProtKB Chain 1 1241 . . . ID=PRO_0000046220;Note=Plasma membrane calcium-transporting ATPase 4 P23634 UniProtKB Topological domain 1 92 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 93 113 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 114 150 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 151 171 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 172 356 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 357 376 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 377 409 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 410 427 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 428 840 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 841 860 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 861 870 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 871 891 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 892 911 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 912 934 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 935 952 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 953 974 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 975 993 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 994 1015 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 1016 1025 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Transmembrane 1026 1047 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Topological domain 1048 1241 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23634 UniProtKB Region 294 318 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P23634 UniProtKB Region 1086 1103 . . . Note=Calmodulin-binding subdomain A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2963820;Dbxref=PMID:2963820 P23634 UniProtKB Region 1104 1113 . . . Note=Calmodulin-binding subdomain B;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P20020 P23634 UniProtKB Compositional bias 294 310 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P23634 UniProtKB Active site 465 465 . . . Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P19156 P23634 UniProtKB Binding site 785 785 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P23634 UniProtKB Binding site 789 789 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P23634 UniProtKB Modified residue 13 13 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569 P23634 UniProtKB Modified residue 328 328 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P23634 UniProtKB Modified residue 1102 1102 . . . Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000250;evidence=ECO:0000250 P23634 UniProtKB Alternative sequence 301 312 . . . ID=VSP_000402;Note=In isoform ZA%2C isoform ZK%2C isoform ZB and isoform ZD. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23634 UniProtKB Alternative sequence 1009 1044 . . . ID=VSP_000403;Note=In isoform XK and isoform ZK. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23634 UniProtKB Alternative sequence 1104 1139 . . . ID=VSP_000404;Note=In isoform XB and isoform ZB. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:2137451;Dbxref=PMID:17974005,PMID:2137451 P23634 UniProtKB Alternative sequence 1140 1241 . . . ID=VSP_000405;Note=In isoform XA%2C isoform XK%2C isoform ZA and isoform ZK. IKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV->VAVAPVKSSPTTSVPAVSSPPMGNQSGQSVP;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1531651,ECO:0000303|PubMed:15489334;Dbxref=PMID:1531651,PMID:15489334 P23634 UniProtKB Mutagenesis 672 672 . . . Note=Strongly decreased calcium transport activity. Slowed decomposition of the phosphorylated intermediate. D->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8530416;Dbxref=PMID:8530416 P23634 UniProtKB Mutagenesis 674 674 . . . Note=Decreased calcium transport activity. V->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8530416;Dbxref=PMID:8530416 P23634 UniProtKB Mutagenesis 675 675 . . . Note=Decreased calcium transport activity. R->K%2CD%2CL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8530416;Dbxref=PMID:8530416 P23634 UniProtKB Mutagenesis 686 686 . . . Note=Decreased calcium transport activity. K->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8530416;Dbxref=PMID:8530416 P23634 UniProtKB Mutagenesis 693 693 . . . Note=Mildly decreased calcium transport activity. R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8530416;Dbxref=PMID:8530416 P23634 UniProtKB Sequence conflict 492 492 . . . Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23634 UniProtKB Sequence conflict 1144 1144 . . . Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23634 UniProtKB Sequence conflict 1147 1147 . . . Note=H->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23634 UniProtKB Sequence conflict 1153 1153 . . . Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23634 UniProtKB Sequence conflict 1178 1178 . . . Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23634 UniProtKB Sequence conflict 1187 1187 . . . Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23634 UniProtKB Sequence conflict 1190 1190 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23634 UniProtKB Turn 1087 1089 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KNE P23634 UniProtKB Turn 1090 1092 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1CFF P23634 UniProtKB Helix 1093 1102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1CFF