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P23634

- AT2B4_HUMAN

UniProt

P23634 - AT2B4_HUMAN

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Protein

Plasma membrane calcium-transporting ATPase 4

Gene
ATP2B4, ATP2B2, MXRA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 46514-aspartylphosphate intermediate By similarity
Metal bindingi785 – 7851Magnesium By similarity
Metal bindingi789 – 7891Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-transporting ATPase activity Source: ProtInc
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct
  5. scaffold protein binding Source: BHF-UCL

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. ion transmembrane transport Source: Reactome
  3. negative regulation of peptidyl-cysteine S-nitrosylation Source: BHF-UCL
  4. regulation of sodium ion transmembrane transport Source: BHF-UCL
  5. transmembrane transport Source: Reactome
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_23765. Reduction of cytosolic Ca++ levels.
REACT_25149. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.2.1. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane calcium-transporting ATPase 4 (EC:3.6.3.8)
Short name:
PMCA4
Alternative name(s):
Matrix-remodeling-associated protein 1
Plasma membrane calcium ATPase isoform 4
Plasma membrane calcium pump isoform 4
Gene namesi
Name:ATP2B4
Synonyms:ATP2B2, MXRA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:817. ATP2B4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9292Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Topological domaini114 – 15037Extracellular Reviewed predictionAdd
BLAST
Transmembranei151 – 17121Helical; Reviewed predictionAdd
BLAST
Topological domaini172 – 356185Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei357 – 37620Helical; Reviewed predictionAdd
BLAST
Topological domaini377 – 40933Extracellular Reviewed predictionAdd
BLAST
Transmembranei410 – 42718Helical; Reviewed predictionAdd
BLAST
Topological domaini428 – 840413Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei841 – 86020Helical; Reviewed predictionAdd
BLAST
Topological domaini861 – 87010Extracellular Reviewed prediction
Transmembranei871 – 89121Helical; Reviewed predictionAdd
BLAST
Topological domaini892 – 91120Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei912 – 93423Helical; Reviewed predictionAdd
BLAST
Topological domaini935 – 95218Extracellular Reviewed predictionAdd
BLAST
Transmembranei953 – 97422Helical; Reviewed predictionAdd
BLAST
Topological domaini975 – 99319Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei994 – 101522Helical; Reviewed predictionAdd
BLAST
Topological domaini1016 – 102510Extracellular Reviewed prediction
Transmembranei1026 – 104722Helical; Reviewed predictionAdd
BLAST
Topological domaini1048 – 1241194Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: HPA
  3. protein complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12411241Plasma membrane calcium-transporting ATPase 4PRO_0000046220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1102 – 11021Phosphothreonine; by PKC By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP23634.
PaxDbiP23634.
PRIDEiP23634.

PTM databases

PhosphoSiteiP23634.

Expressioni

Tissue specificityi

Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex.

Gene expression databases

ArrayExpressiP23634.
BgeeiP23634.
CleanExiHS_ATP2B2.
HS_ATP2B4.
GenevestigatoriP23634.

Organism-specific databases

HPAiCAB016118.
HPA040431.

Interactioni

Subunit structurei

Interacts with PDZD11.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCAP012582EBI-1174388,EBI-1018474
Dlg2Q636222EBI-1174437,EBI-396947From a different organism.
Dlg3Q629362EBI-1174437,EBI-349596From a different organism.

Protein-protein interaction databases

BioGridi106983. 11 interactions.
DIPiDIP-6128N.
IntActiP23634. 10 interactions.
MINTiMINT-219327.
STRINGi9606.ENSP00000350310.

Structurei

Secondary structure

1
1241
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni1087 – 10893
Turni1090 – 10923
Helixi1093 – 110210
Helixi1141 – 11477

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CFFNMR-B1086-1104[»]
2KNENMR-B1086-1149[»]
ProteinModelPortaliP23634.
SMRiP23634. Positions 47-945.

Miscellaneous databases

EvolutionaryTraceiP23634.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1086 – 110318Calmodulin-binding subdomain AAdd
BLAST
Regioni1104 – 111310Calmodulin-binding subdomain B By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi297 – 3037Poly-Lys
Compositional biasi1186 – 11905Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
HOVERGENiHBG061286.
InParanoidiP23634.
KOiK05850.
OMAiNFVIHRR.
OrthoDBiEOG7SN8BN.
PhylomeDBiP23634.
TreeFamiTF300330.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 2 hits.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site B/C (A, B, D and K). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.

Isoform XD (identifier: P23634-1) [UniParc]FASTAAdd to Basket

Also known as: AIICIV

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG     50
VQNLCSRLKT SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA 100
LQDVTLIILE IAAIISLVLS FYRPAGEENE LCGQVATTPE DENEAQAGWI 150
EGAAILFSVI IVVLVTAFND WSKEKQFRGL QCRIEQEQKF SIIRNGQLIQ 200
LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT GESDHVKKSL 250
DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK 300
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS 350
VLQGKLTRLA VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP 400
IYIQYFVKFF IIGITVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL 450
DACETMGNAT AICSDKTGTL TMNRMTVVQA YIGGIHYRQI PSPDVFLPKV 500
LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL GFVTDLKQDY 550
QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK 600
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP 650
SWDNENEILT ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI 700
NTARAIATKC GILTPGDDFL CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL 750
RVLARSSPTD KHTLVKGIID STVGEHRQVV AVTGDGTNDG PALKKADVGF 800
AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI SKFLQFQLTV 850
NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL 900
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA 950
PLHSPPSQHY TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV 1000
VLGTFICQIF IVEFGGKPFS CTSLSLSQWL WCLFIGIGEL LWGQFISAIP 1050
TRSLKFLKEA GHGTTKEEIT KDAEGLDEID HAEMELRRGQ ILWFRGLNRI 1100
QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI KVVKAFHSSL 1150
HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT 1200
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V 1241
Length:1,241
Mass (Da):137,920
Last modified:June 1, 2001 - v2
Checksum:i568544103CD5F494
GO
Isoform XA (identifier: P23634-2) [UniParc]FASTAAdd to Basket

Also known as: AIICII

The sequence of this isoform differs from the canonical sequence as follows:
     1140-1241: IKVVKAFHSS...SSLQSLETSV → VAVAPVKSSPTTSVPAVSSPPMGNQSGQSVP

Show »
Length:1,170
Mass (Da):129,403
Checksum:iC4ED2E2EFE1BB043
GO
Isoform ZA (identifier: P23634-3) [UniParc]FASTAAdd to Basket

Also known as: AICII

The sequence of this isoform differs from the canonical sequence as follows:
     301-312: Missing.
     1140-1241: IKVVKAFHSS...SSLQSLETSV → VAVAPVKSSPTTSVPAVSSPPMGNQSGQSVP

Show »
Length:1,158
Mass (Da):128,066
Checksum:iE7AA8CC9C25E0727
GO
Isoform XK (identifier: P23634-4) [UniParc]FASTAAdd to Basket

Also known as: XG

The sequence of this isoform differs from the canonical sequence as follows:
     1009-1044: Missing.
     1140-1241: IKVVKAFHSS...SSLQSLETSV → VAVAPVKSSPTTSVPAVSSPPMGNQSGQSVP

Show »
Length:1,134
Mass (Da):125,344
Checksum:i088F8CB994D46238
GO
Isoform ZK (identifier: P23634-5) [UniParc]FASTAAdd to Basket

Also known as: ZG

The sequence of this isoform differs from the canonical sequence as follows:
     301-312: Missing.
     1009-1044: Missing.
     1140-1241: IKVVKAFHSS...SSLQSLETSV → VAVAPVKSSPTTSVPAVSSPPMGNQSGQSVP

Show »
Length:1,122
Mass (Da):124,007
Checksum:i4AD4378ED226853B
GO
Isoform XB (identifier: P23634-6) [UniParc]FASTAAdd to Basket

Also known as: AIICI

The sequence of this isoform differs from the canonical sequence as follows:
     1104-1139: Missing.

Show »
Length:1,205
Mass (Da):133,931
Checksum:i76CE806974035974
GO
Isoform ZB (identifier: P23634-7) [UniParc]FASTAAdd to Basket

Also known as: AICI

The sequence of this isoform differs from the canonical sequence as follows:
     301-312: Missing.
     1104-1139: Missing.

Show »
Length:1,193
Mass (Da):132,594
Checksum:i6AA34BD1850CADB7
GO
Isoform ZD (identifier: P23634-8) [UniParc]FASTAAdd to Basket

Also known as: AICIV

The sequence of this isoform differs from the canonical sequence as follows:
     301-312: Missing.

Show »
Length:1,229
Mass (Da):136,584
Checksum:i5E9E48B86464E926
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei301 – 31212Missing in isoform ZA, isoform ZK, isoform ZB and isoform ZD. VSP_000402Add
BLAST
Alternative sequencei1009 – 104436Missing in isoform XK and isoform ZK. VSP_000403Add
BLAST
Alternative sequencei1104 – 113936Missing in isoform XB and isoform ZB. VSP_000404Add
BLAST
Alternative sequencei1140 – 1241102IKVVK…LETSV → VAVAPVKSSPTTSVPAVSSP PMGNQSGQSVP in isoform XA, isoform XK, isoform ZA and isoform ZK. VSP_000405Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti492 – 4921S → C in CAD97686. 1 Publication
Sequence conflicti1144 – 11441K → N AA sequence 1 Publication
Sequence conflicti1147 – 11471H → S AA sequence 1 Publication
Sequence conflicti1153 – 11531S → F AA sequence 1 Publication
Sequence conflicti1178 – 11781L → Q AA sequence 1 Publication
Sequence conflicti1187 – 11871E → Q AA sequence 1 Publication
Sequence conflicti1190 – 11901E → G in CAD97686. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25874 mRNA. Translation: AAA50819.1.
M83363 mRNA. Translation: AAA36455.1.
BX537444 mRNA. Translation: CAD97686.1.
U42026 mRNA. Translation: AAB17577.1.
U42061 mRNA. Translation: AAB17578.1.
U42062 mRNA. Translation: AAB17579.1.
U42378 mRNA. Translation: AAB17580.1.
AL513343, AC114402 Genomic DNA. Translation: CAI17025.1.
AL513343, AC114402 Genomic DNA. Translation: CAI17026.1.
CH471067 Genomic DNA. Translation: EAW91483.1.
CH471067 Genomic DNA. Translation: EAW91486.1.
BC140774 mRNA. Translation: AAI40775.1.
CCDSiCCDS1440.1. [P23634-6]
CCDS30977.1. [P23634-2]
PIRiA35547.
RefSeqiNP_001001396.1. NM_001001396.2. [P23634-2]
NP_001675.3. NM_001684.4. [P23634-6]
UniGeneiHs.343522.
Hs.733333.

Genome annotation databases

EnsembliENST00000341360; ENSP00000340930; ENSG00000058668. [P23634-2]
ENST00000357681; ENSP00000350310; ENSG00000058668. [P23634-6]
ENST00000367218; ENSP00000356187; ENSG00000058668. [P23634-2]
ENST00000367219; ENSP00000356188; ENSG00000058668. [P23634-3]
ENST00000391954; ENSP00000375816; ENSG00000058668. [P23634-4]
GeneIDi493.
KEGGihsa:493.
UCSCiuc001gzv.3. human. [P23634-2]
uc001gzw.3. human. [P23634-6]

Polymorphism databases

DMDMi14286105.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25874 mRNA. Translation: AAA50819.1 .
M83363 mRNA. Translation: AAA36455.1 .
BX537444 mRNA. Translation: CAD97686.1 .
U42026 mRNA. Translation: AAB17577.1 .
U42061 mRNA. Translation: AAB17578.1 .
U42062 mRNA. Translation: AAB17579.1 .
U42378 mRNA. Translation: AAB17580.1 .
AL513343 , AC114402 Genomic DNA. Translation: CAI17025.1 .
AL513343 , AC114402 Genomic DNA. Translation: CAI17026.1 .
CH471067 Genomic DNA. Translation: EAW91483.1 .
CH471067 Genomic DNA. Translation: EAW91486.1 .
BC140774 mRNA. Translation: AAI40775.1 .
CCDSi CCDS1440.1. [P23634-6 ]
CCDS30977.1. [P23634-2 ]
PIRi A35547.
RefSeqi NP_001001396.1. NM_001001396.2. [P23634-2 ]
NP_001675.3. NM_001684.4. [P23634-6 ]
UniGenei Hs.343522.
Hs.733333.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CFF NMR - B 1086-1104 [» ]
2KNE NMR - B 1086-1149 [» ]
ProteinModelPortali P23634.
SMRi P23634. Positions 47-945.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106983. 11 interactions.
DIPi DIP-6128N.
IntActi P23634. 10 interactions.
MINTi MINT-219327.
STRINGi 9606.ENSP00000350310.

Protein family/group databases

TCDBi 3.A.3.2.1. the p-type atpase (p-atpase) superfamily.

PTM databases

PhosphoSitei P23634.

Polymorphism databases

DMDMi 14286105.

Proteomic databases

MaxQBi P23634.
PaxDbi P23634.
PRIDEi P23634.

Protocols and materials databases

DNASUi 493.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341360 ; ENSP00000340930 ; ENSG00000058668 . [P23634-2 ]
ENST00000357681 ; ENSP00000350310 ; ENSG00000058668 . [P23634-6 ]
ENST00000367218 ; ENSP00000356187 ; ENSG00000058668 . [P23634-2 ]
ENST00000367219 ; ENSP00000356188 ; ENSG00000058668 . [P23634-3 ]
ENST00000391954 ; ENSP00000375816 ; ENSG00000058668 . [P23634-4 ]
GeneIDi 493.
KEGGi hsa:493.
UCSCi uc001gzv.3. human. [P23634-2 ]
uc001gzw.3. human. [P23634-6 ]

Organism-specific databases

CTDi 493.
GeneCardsi GC01P203595.
HGNCi HGNC:817. ATP2B4.
HPAi CAB016118.
HPA040431.
MIMi 108732. gene.
neXtProti NX_P23634.
PharmGKBi PA25110.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0474.
HOVERGENi HBG061286.
InParanoidi P23634.
KOi K05850.
OMAi NFVIHRR.
OrthoDBi EOG7SN8BN.
PhylomeDBi P23634.
TreeFami TF300330.

Enzyme and pathway databases

Reactomei REACT_23765. Reduction of cytosolic Ca++ levels.
REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSi ATP2B4. human.
EvolutionaryTracei P23634.
GeneWikii ATP2B4.
GenomeRNAii 493.
NextBioi 2071.
PROi P23634.
SOURCEi Search...

Gene expression databases

ArrayExpressi P23634.
Bgeei P23634.
CleanExi HS_ATP2B2.
HS_ATP2B4.
Genevestigatori P23634.

Family and domain databases

Gene3Di 1.20.1110.10. 3 hits.
InterProi IPR022141. ATP_Ca_trans_C.
IPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF12424. ATP_Ca_trans_C. 2 hits.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane."
    Strehler E.E., James P., Fischer R., Heim R., Vorherr T.E., Filoteo A.G., Penniston J.T., Carafoli E.
    J. Biol. Chem. 265:2835-2842(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM XB), PARTIAL PROTEIN SEQUENCE.
    Tissue: Erythrocyte.
  2. "Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels."
    Brandt P., Neve R.L., Kammesheidt A., Rhoads R.E., Vanaman T.C.
    J. Biol. Chem. 267:4376-4385(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM XA).
    Tissue: Fetal brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM XB).
    Tissue: Fetal kidney.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM XA).
    Tissue: Brain.
  7. "Analysis of mRNA expression and cloning of a novel plasma membrane Ca(2+)-ATPase splice variant in human heart."
    Santiago-Garcia J., Mas-Oliva J., Saavedra D., Zarain-Herzberg A.
    Mol. Cell. Biochem. 155:173-182(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS XA; XB; XK; ZA; ZB AND ZK).
    Tissue: Heart muscle.
  8. "Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes."
    James P., Maeda M., Fischer R., Verma A.K., Krebs J., Penniston J.T., Carafoli E.
    J. Biol. Chem. 263:2905-2910(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1085-1153 (ISOFORMS XB/ZB), CALMODULIN-BINDING SUBDOMAIN A.
  9. "A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase."
    Brandt P., Zurini M., Neve R.L., Rhoads R.E., Vanaman T.C.
    Proc. Natl. Acad. Sci. U.S.A. 85:2914-2918(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1177-1190.
  10. "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes."
    Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
    J. Biol. Chem. 268:25993-26003(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS X AND Z).
    Tissue: Heart.
  11. Erratum
    Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
    J. Biol. Chem. 269:32022-32022(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants."
    Goellner G.M., DeMarco S.J., Strehler E.E.
    Ann. N. Y. Acad. Sci. 986:461-471(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDZD11.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "NMR solution structure of a complex of calmodulin with a binding peptide of the Ca(2+) pump."
    Elshorst B., Hennig M., Foersterling H., Diener A., Maurer M., Schulte P., Schwalbe H., Griesinger C., Krebs J., Schmid H., Vorherr T.E., Carafoli E.
    Biochemistry 38:12320-12332(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1086-1104 IN COMPLEX WITH CALMODULIN.

Entry informationi

Entry nameiAT2B4_HUMAN
AccessioniPrimary (citable) accession number: P23634
Secondary accession number(s): B1APW5
, B1APW6, Q13450, Q13452, Q13455, Q16817, Q7Z3S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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