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P23623

- OXLA_NEUCR

UniProt

P23623 - OXLA_NEUCR

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Protein

L-amino-acid oxidase

Gene

lox

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei207 – 2071FADBy similarity
Binding sitei215 – 2151FADBy similarity
Binding sitei237 – 2371SubstrateBy similarity
Binding sitei440 – 4401FAD; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei564 – 5641SubstrateBy similarity
Binding sitei649 – 6491FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi236 – 2372FADBy similarity
Nucleotide bindingi658 – 6614FADBy similarity

GO - Molecular functioni

  1. L-amino-acid oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
L-amino-acid oxidase (EC:1.4.3.2)
Short name:
LAAO
Short name:
LAO
Gene namesi
Name:lox
ORF Names:B14A6.230, NCU01066
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 2, Linkage Group V

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 130130PRO_0000001708Add
BLAST
Chaini131 – 696566L-amino-acid oxidasePRO_0000001709Add
BLAST

Keywords - PTMi

Zymogen

Expressioni

Inductioni

By addition of L-amino acids after nitrogen starvation, by starvation in phosphate buffer and by the addition of protein synthesis inhibitors, D-amino acids, or ATP.

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU01066.1.

Structurei

3D structure databases

ProteinModelPortaliP23623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1231.
HOGENOMiHOG000178764.
InParanoidiP23623.
OMAiHCQFDEG.
OrthoDBiEOG7FNCH3.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23623-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKWSAAAGAA LLALPANSAV TASLPLKLET RSSLNSRLSN IHVERSASVE
60 70 80 90 100
GAISYTYGSC QAKREEEAHH SISQPTDAHH DRLVWVIPEN VQSGGCISAW
110 120 130 140 150
SRANGRLVGR SRPQSFDFKS IKMRRDLKAR ATKPSDSVAI HMTTDNGINP
160 170 180 190 200
WGPWFDGVKL LEDKEISTVD VEKAKSKNIA IVGAGMSGLM TYLCLTQAGM
210 220 230 240 250
TNVSIIEGGN RLGGRVHTEY LSGGPFDYSY QEMGPMRFPN TITLGNETYN
260 270 280 290 300
VSDHQLVFQL AEEMNSLNGH SKNLSVDFIP WYQSNSNGLY YYDGIKNPET
310 320 330 340 350
GLPPTLAELA ANSSLALTRV SNNSTKSLSQ KVDAFLPDTD KFFAEMAQNM
360 370 380 390 400
FKAHADWLSG GLAGLPGDQW SEFGFMVNYL RGSLNDTAFL SASAHSYWDT
410 420 430 440 450
LYEGMYFSAS TWKTIDGGLN RLPLSFHPLV DNATTLNRRV ERVAFDAETQ
460 470 480 490 500
KVTLHSRNSY KDSFESSEHD YAVIAAPFSI VKKWRFSPAL DLTAPTLANA
510 520 530 540 550
IQNLEYTSAC KVALEFRTRF WEHLPQPIYG SCSTTSDIPG IGSICYPSYN
560 570 580 590 600
INGTDGPASI LASYISGADW GDRWVSTPEE EHVQYVLNAM AEIHGEELVK
610 620 630 640 650
EQYTGQFNRR CWALDPLESA SWASPTVGQH ELYLPEYFQT RNNLVFVGEH
660 670 680 690
TSYTHAWIAS ALESGIRGSV QLLLELGLVD EAKATVDKWM ARWIDV
Length:696
Mass (Da):77,013
Last modified:April 30, 2003 - v2
Checksum:i3909C59198E96008
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 138AAGAALLA → RGCGTAR AA sequence (PubMed:2145270)Curated
Sequence conflicti53 – 531I → L AA sequence (PubMed:2145270)Curated
Sequence conflicti343 – 3431F → L AA sequence (PubMed:2145270)Curated
Sequence conflicti391 – 41424SASAH…STWKT → APALTRTGTRCTKGCTFPRR RGA AA sequence (PubMed:2145270)CuratedAdd
BLAST
Sequence conflicti440 – 4401V → L AA sequence (PubMed:2145270)Curated
Sequence conflicti684 – 6852AT → GRP AA sequence (PubMed:2145270)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670007 Genomic DNA. Translation: CAD21325.1.
CM002240 Genomic DNA. Translation: EAA32442.1.
PIRiA38314.
RefSeqiXP_961678.1. XM_956585.1.

Genome annotation databases

EnsemblFungiiEFNCRT00000004415; EFNCRP00000004415; EFNCRG00000004409.
GeneIDi3877869.
KEGGincr:NCU01066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670007 Genomic DNA. Translation: CAD21325.1 .
CM002240 Genomic DNA. Translation: EAA32442.1 .
PIRi A38314.
RefSeqi XP_961678.1. XM_956585.1.

3D structure databases

ProteinModelPortali P23623.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU01066.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000004415 ; EFNCRP00000004415 ; EFNCRG00000004409 .
GeneIDi 3877869.
KEGGi ncr:NCU01066.

Phylogenomic databases

eggNOGi COG1231.
HOGENOMi HOG000178764.
InParanoidi P23623.
OMAi HCQFDEG.
OrthoDBi EOG7FNCH3.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the L-amino-acid oxidase gene from Neurospora crassa."
    Niedermann D.M., Lerch K.
    J. Biol. Chem. 265:17246-17251(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiOXLA_NEUCR
AccessioniPrimary (citable) accession number: P23623
Secondary accession number(s): Q7RVE5, Q8X0D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: April 30, 2003
Last modified: November 26, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3