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P23623 (OXLA_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-amino-acid oxidase

Short name=LAAO
Short name=LAO
EC=1.4.3.2
Gene names
Name:lox
ORF Names:B14A6.230, NCU01066
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length696 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactor

FAD.

Induction

By addition of L-amino acids after nitrogen starvation, by starvation in phosphate buffer and by the addition of protein synthesis inhibitors, D-amino acids, or ATP.

Sequence similarities

Belongs to the flavin monoamine oxidase family.

Ontologies

Keywords
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMZymogen
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Molecular_functionL-amino-acid oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 130130
PRO_0000001708
Chain131 – 696566L-amino-acid oxidase
PRO_0000001709

Regions

Nucleotide binding236 – 2372FAD By similarity
Nucleotide binding658 – 6614FAD By similarity

Sites

Binding site2071FAD By similarity
Binding site2151FAD By similarity
Binding site2371Substrate By similarity
Binding site4401FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site5641Substrate By similarity
Binding site6491FAD By similarity

Experimental info

Sequence conflict6 – 138AAGAALLA → RGCGTAR AA sequence Ref.1
Sequence conflict531I → L AA sequence Ref.1
Sequence conflict3431F → L AA sequence Ref.1
Sequence conflict391 – 41424SASAH…STWKT → APALTRTGTRCTKGCTFPRR RGA AA sequence Ref.1
Sequence conflict4401V → L AA sequence Ref.1
Sequence conflict684 – 6852AT → GRP AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
P23623 [UniParc].

Last modified April 30, 2003. Version 2.
Checksum: 3909C59198E96008

FASTA69677,013
        10         20         30         40         50         60 
MKWSAAAGAA LLALPANSAV TASLPLKLET RSSLNSRLSN IHVERSASVE GAISYTYGSC 

        70         80         90        100        110        120 
QAKREEEAHH SISQPTDAHH DRLVWVIPEN VQSGGCISAW SRANGRLVGR SRPQSFDFKS 

       130        140        150        160        170        180 
IKMRRDLKAR ATKPSDSVAI HMTTDNGINP WGPWFDGVKL LEDKEISTVD VEKAKSKNIA 

       190        200        210        220        230        240 
IVGAGMSGLM TYLCLTQAGM TNVSIIEGGN RLGGRVHTEY LSGGPFDYSY QEMGPMRFPN 

       250        260        270        280        290        300 
TITLGNETYN VSDHQLVFQL AEEMNSLNGH SKNLSVDFIP WYQSNSNGLY YYDGIKNPET 

       310        320        330        340        350        360 
GLPPTLAELA ANSSLALTRV SNNSTKSLSQ KVDAFLPDTD KFFAEMAQNM FKAHADWLSG 

       370        380        390        400        410        420 
GLAGLPGDQW SEFGFMVNYL RGSLNDTAFL SASAHSYWDT LYEGMYFSAS TWKTIDGGLN 

       430        440        450        460        470        480 
RLPLSFHPLV DNATTLNRRV ERVAFDAETQ KVTLHSRNSY KDSFESSEHD YAVIAAPFSI 

       490        500        510        520        530        540 
VKKWRFSPAL DLTAPTLANA IQNLEYTSAC KVALEFRTRF WEHLPQPIYG SCSTTSDIPG 

       550        560        570        580        590        600 
IGSICYPSYN INGTDGPASI LASYISGADW GDRWVSTPEE EHVQYVLNAM AEIHGEELVK 

       610        620        630        640        650        660 
EQYTGQFNRR CWALDPLESA SWASPTVGQH ELYLPEYFQT RNNLVFVGEH TSYTHAWIAS 

       670        680        690 
ALESGIRGSV QLLLELGLVD EAKATVDKWM ARWIDV 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the L-amino-acid oxidase gene from Neurospora crassa."
Niedermann D.M., Lerch K.
J. Biol. Chem. 265:17246-17251(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL670007 Genomic DNA. Translation: CAD21325.1.
CM002240 Genomic DNA. Translation: EAA32442.1.
PIRA38314.
RefSeqXP_961678.1. XM_956585.1.

3D structure databases

ProteinModelPortalP23623.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU01066.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000004415; EFNCRP00000004415; EFNCRG00000004409.
GeneID3877869.
KEGGncr:NCU01066.

Phylogenomic databases

eggNOGCOG1231.
HOGENOMHOG000178764.
OMAQVNYNAY.
OrthoDBEOG7FNCH3.

Family and domain databases

InterProIPR002937. Amino_oxidase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOXLA_NEUCR
AccessionPrimary (citable) accession number: P23623
Secondary accession number(s): Q7RVE5, Q8X0D4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: April 30, 2003
Last modified: February 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families