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Protein

Regulatory protein HlyX

Gene

hlyX

Organism
Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Confers a hemolytic phenotype on E.coli. May regulate, rather than mediate, hemolytic activity.

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi196 – 215H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCytolysis, Hemolysis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein HlyX
Gene namesi
Name:hlyX
OrganismiActinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Taxonomic identifieri715 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001811 – 240Regulatory protein HlyXAdd BLAST240

Interactioni

Protein-protein interaction databases

STRINGi228399.Aple02000311.

Structurei

3D structure databases

ProteinModelPortaliP23619.
SMRiP23619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 236HTH crp-typePROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 28Essential for the oxygen-regulated activityBy similarityAdd BLAST14

Phylogenomic databases

eggNOGiENOG4105DS0. Bacteria.
COG0664. LUCA.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
PRINTSiPR00034. HTHCRP.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P23619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVSDAKHT GRTRCTIHCQ NCSISQLCLP FTLSEHELTQ LDNIIERKKP
60 70 80 90 100
VQKSQIIFQS GDELRSIYAI RSGTIKSYTI SESGEEQITA FHLPGDLVGF
110 120 130 140 150
DAIMNMKHVG FAQALETSMI CEIPFDILDD LAGKMPKIRH QIMRLMSNEI
160 170 180 190 200
KSDQEMILLL SKMSAEEKLA AFLHNLSQRY AAPGFSAREF RLTMTRGDIG
210 220 230 240
NYLGLTIETI SRLLGRFQKS GMITVQGKYI TINRMDELTV
Length:240
Mass (Da):27,107
Last modified:November 1, 1991 - v1
Checksum:iC11E5F2CFDCA58C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80712 Genomic DNA. Translation: AAA21920.1.
PIRiA37769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80712 Genomic DNA. Translation: AAA21920.1.
PIRiA37769.

3D structure databases

ProteinModelPortaliP23619.
SMRiP23619.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228399.Aple02000311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DS0. Bacteria.
COG0664. LUCA.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
PRINTSiPR00034. HTHCRP.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHLYX_ACTPL
AccessioniPrimary (citable) accession number: P23619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: March 15, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.