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P23619

- HLYX_ACTPL

UniProt

P23619 - HLYX_ACTPL

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Protein
Regulatory protein HlyX
Gene
hlyX
Organism
Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

Confers a hemolytic phenotype on E.coli. May regulate, rather than mediate, hemolytic activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi196 – 21520H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cytolysis, Hemolysis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein HlyX
Gene namesi
Name:hlyX
OrganismiActinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Taxonomic identifieri715 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Regulatory protein HlyX
PRO_0000100181Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23619.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini163 – 23674HTH crp-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 2814Essential for the oxygen-regulated activity By similarity
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23619-1 [UniParc]FASTAAdd to Basket

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MKIVSDAKHT GRTRCTIHCQ NCSISQLCLP FTLSEHELTQ LDNIIERKKP    50
VQKSQIIFQS GDELRSIYAI RSGTIKSYTI SESGEEQITA FHLPGDLVGF 100
DAIMNMKHVG FAQALETSMI CEIPFDILDD LAGKMPKIRH QIMRLMSNEI 150
KSDQEMILLL SKMSAEEKLA AFLHNLSQRY AAPGFSAREF RLTMTRGDIG 200
NYLGLTIETI SRLLGRFQKS GMITVQGKYI TINRMDELTV 240
Length:240
Mass (Da):27,107
Last modified:November 1, 1991 - v1
Checksum:iC11E5F2CFDCA58C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80712 Genomic DNA. Translation: AAA21920.1.
PIRiA37769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80712 Genomic DNA. Translation: AAA21920.1 .
PIRi A37769.

3D structure databases

ProteinModelPortali P23619.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Actinobacillus pleuropneumoniae hlyX gene homology with the fnr gene of Escherichia coli."
    Macinnes J.I., Kim J.E., Lian C.J., Soltes G.A.
    J. Bacteriol. 172:4587-4592(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHLYX_ACTPL
AccessioniPrimary (citable) accession number: P23619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron).

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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