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P23619 (HLYX_ACTPL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulatory protein HlyX
Gene names
Name:hlyX
OrganismActinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Taxonomic identifier715 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Confers a hemolytic phenotype on E.coli. May regulate, rather than mediate, hemolytic activity.

Subcellular location

Cytoplasm.

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron).

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Keywords
   Biological processCytolysis
Hemolysis
Transcription
Transcription regulation
   Cellular componentCytoplasm
   LigandDNA-binding
   Molecular functionActivator
Gene Ontology (GO)
   Biological_processhemolysis in other organism

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Regulatory protein HlyX
PRO_0000100181

Regions

Domain163 – 23674HTH crp-type
DNA binding196 – 21520H-T-H motif By similarity
Region15 – 2814Essential for the oxygen-regulated activity By similarity

Sequences

Sequence LengthMass (Da)Tools
P23619 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: C11E5F2CFDCA58C8

FASTA24027,107
        10         20         30         40         50         60 
MKIVSDAKHT GRTRCTIHCQ NCSISQLCLP FTLSEHELTQ LDNIIERKKP VQKSQIIFQS 

        70         80         90        100        110        120 
GDELRSIYAI RSGTIKSYTI SESGEEQITA FHLPGDLVGF DAIMNMKHVG FAQALETSMI 

       130        140        150        160        170        180 
CEIPFDILDD LAGKMPKIRH QIMRLMSNEI KSDQEMILLL SKMSAEEKLA AFLHNLSQRY 

       190        200        210        220        230        240 
AAPGFSAREF RLTMTRGDIG NYLGLTIETI SRLLGRFQKS GMITVQGKYI TINRMDELTV 

« Hide

References

[1]"Actinobacillus pleuropneumoniae hlyX gene homology with the fnr gene of Escherichia coli."
Macinnes J.I., Kim J.E., Lian C.J., Soltes G.A.
J. Bacteriol. 172:4587-4592(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80712 Genomic DNA. Translation: AAA21920.1.
PIRA37769.

3D structure databases

ProteinModelPortalP23619.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHLYX_ACTPL
AccessionPrimary (citable) accession number: P23619
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families