Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Factor VIII intron 22 protein

Gene

F8A1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Not known. Possible housekeeping role.

Names & Taxonomyi

Protein namesi
Recommended name:
Factor VIII intron 22 protein
Alternative name(s):
CpG island protein
Gene namesi
Name:F8A1
Synonyms:F8A
AND
Name:F8A2
Synonyms:F8A
AND
Name:F8A3
Synonyms:F8A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:3547. F8A1.
HGNC:31849. F8A2.
HGNC:31850. F8A3.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi474383.
474384.
8263.
OpenTargetsiENSG00000277150.
ENSG00000277203.
PharmGKBiPA27953.

Polymorphism and mutation databases

BioMutaiF8A1.
DMDMi55977780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000871592 – 371Factor VIII intron 22 proteinAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP23610.
MaxQBiP23610.
PaxDbiP23610.
PeptideAtlasiP23610.
PRIDEiP23610.

PTM databases

iPTMnetiP23610.
PhosphoSitePlusiP23610.

Expressioni

Tissue specificityi

Produced abundantly in a wide variety of cell types.

Gene expression databases

BgeeiENSG00000274791.
CleanExiHS_F8A1.
HS_F8A2.
GenevisibleiP23610. HS.

Organism-specific databases

HPAiHPA046960.

Interactioni

Protein-protein interaction databases

BioGridi113884. 4 interactors.
IntActiP23610. 2 interactors.
MINTiMINT-4720691.
STRINGi9606.ENSP00000358518.

Structurei

3D structure databases

ProteinModelPortaliP23610.
SMRiP23610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHT1. Eukaryota.
ENOG410XSGC. LUCA.
GeneTreeiENSGT00390000016992.
HOGENOMiHOG000232189.
HOVERGENiHBG005629.
InParanoidiP23610.
KOiK20135.
OMAiICESNTH.
OrthoDBiEOG091G0ERK.
PhylomeDBiP23610.
TreeFamiTF313929.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR011990. TPR-like_helical_dom.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAGLGG GGAGPGPEAG DFLARYRLVS NKLKKRFLRK PNVAEAGEQF
60 70 80 90 100
GQLGRELRAQ ECLPYAAWCQ LAVARCQQAL FHGPGEALAL TEAARLFLRQ
110 120 130 140 150
ERDARQRLVC PAAYGEPLQA AASALGAAVR LHLELGQPAA AAALCLELAA
160 170 180 190 200
ALRDLGQPAA AAGHFQRAAQ LQLPQLPLAA LQALGEAASC QLLARDYTGA
210 220 230 240 250
LAVFTRMQRL AREHGSHPVQ SLPPPPPPAP QPGPGATPAL PAALLPPNSG
260 270 280 290 300
SAAPSPAALG AFSDVLVRCE VSRVLLLLLL QPPPAKLLPE HAQTLEKYSW
310 320 330 340 350
EAFDSHGQES SGQLPEELFL LLQSLVMATH EKDTEAIKSL QVEMWPLLTA
360 370
EQNHLLHLVL QETISPSGQG V
Length:371
Mass (Da):39,103
Last modified:November 23, 2004 - v2
Checksum:i0E230A1978FAB59D
GO

Sequence cautioni

The sequence AAA35713 differs from that shown. Reason: Frameshift at positions 231, 257 and 367.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105 – 107RQR → PA in AAA35713 (PubMed:2110545).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34677 Genomic DNA. Translation: AAA35713.1. Frameshift.
AY619999 Genomic DNA. Translation: AAT44606.1.
AY620000 Genomic DNA. Translation: AAT44607.1.
AY620001 Genomic DNA. Translation: AAT44608.1.
BX276110 Genomic DNA. No translation available.
BX682237 Genomic DNA. No translation available.
BX842559 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72648.1.
BC039693 mRNA. Translation: AAH39693.1.
BC071963 mRNA. Translation: AAH71963.1.
CCDSiCCDS35459.1.
CCDS35462.1.
CCDS35463.1.
PIRiB42832.
RefSeqiNP_001007524.1. NM_001007523.1.
NP_001007525.1. NM_001007524.1.
NP_036283.2. NM_012151.3.
UniGeneiHs.533543.
Hs.731793.

Genome annotation databases

EnsembliENST00000369505; ENSP00000358518; ENSG00000274791.
ENST00000610495; ENSP00000479624; ENSG00000277203.
ENST00000622749; ENSP00000477530; ENSG00000277150.
GeneIDi474383.
474384.
8263.
KEGGihsa:474383.
hsa:474384.
hsa:8263.
UCSCiuc004fmv.4. human.

Similar proteinsi

Entry informationi

Entry nameiF8I2_HUMAN
AccessioniPrimary (citable) accession number: P23610
Secondary accession number(s): Q5HY66, Q8IXP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 23, 2004
Last modified: August 30, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot