Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-glutamine gamma-glutamyltransferase K

Gene

Tgm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity).By similarity

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei385PROSITE-ProRule annotation1
Active sitei444PROSITE-ProRule annotation1
Active sitei467PROSITE-ProRule annotation1
Metal bindingi507CalciumBy similarity1
Metal bindingi509CalciumBy similarity1
Metal bindingi556CalciumBy similarity1
Metal bindingi561CalciumBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein-glutamine gamma-glutamyltransferase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Keratinization

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name:
TG(K)
Short name:
TGK
Short name:
TGase K
Transglutaminase-1
Short name:
TGase-1
Gene namesi
Name:Tgm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi61838. Tgm1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137041 – 824Protein-glutamine gamma-glutamyltransferase KAdd BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphothreonineBy similarity1
Modified residuei22PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei92PhosphoserineBy similarity1
Modified residuei100PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP23606.
PRIDEiP23606.

PTM databases

iPTMnetiP23606.
PhosphoSitePlusiP23606.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020136.
GenevisibleiP23606. RN.

Interactioni

Protein-protein interaction databases

BioGridi248784. 2 interactors.
STRINGi10116.ENSRNOP00000027315.

Structurei

3D structure databases

ProteinModelPortaliP23606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP23606.
KOiK05619.
OMAiCGCCSCR.
OrthoDBiEOG091G030K.
PhylomeDBiP23606.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPRSDVGR WGRSPWQPTT PSPEPEPEPE PDRSSRSRRG GGRSFWARCC
60 70 80 90 100
GCCSCGNRAD DDWGPEPSGS RSRGTSSRGG GSRGGDSRGR DSRGGRRPES
110 120 130 140 150
RGSGVNAAGD GTIREGMLVV NGVDLLCSRS DQNRREHHTD EFEYDELILR
160 170 180 190 200
RGQPFHIILF LNREYESSDR IALELLIGNN PEVGKGTHVI IPVGKGGSGG
210 220 230 240 250
WKAQVTKTNG HNLTLRVHTS PNAIIGKFQF TVRTRSEAGE FQLPFDPRNE
260 270 280 290 300
IYILFNPWCP EDIVYVDHED WRQEYVLNES GRIYYGTEAQ IGERTWNYGQ
310 320 330 340 350
FDHGVLDACL YILDRRGMPY GGRGDPVSVS RVVSAMVNSL DDNGVLIGNW
360 370 380 390 400
TGDYSRGTNP SAWVGSVEIL LSYLRTGYSV PYGQCWVFAG VTTTVLRCLG
410 420 430 440 450
LATRTVTNFN SAHDTDTSLT MDIYFDENMK PLEHLNHDSV WNFHVWNDCW
460 470 480 490 500
MKRPDLPSGF DGWQVVDATP QETSSGIFCC GPCSVESIKN GLVYMKYDTP
510 520 530 540 550
FIFAEVNSDK VYWQRQDDGS FKIVYVEEKA IGTLIVTKAI NSNMREDITH
560 570 580 590 600
IYKHPEGSEA ERKAVEKAAA HGSKPNVYAT RDSAEDVAMQ VEAQDAVMGQ
610 620 630 640 650
DLTVSVVLTN RGSSRRTVKL HLYLCVTYYT GVSGPTFKET KKEVVLAPGA
660 670 680 690 700
SDTVAMPVAY KEYKPHLVDQ GAMLLNVSGH VKESGQVLAK QHTFRLRTPD
710 720 730 740 750
LSLTLLGAAV VGQECEVQIV FKNPLPITLT NVVFRLEGSG LQRPKVLNVG
760 770 780 790 800
DIGGNETVTL RQTFVPVRPG PRQLIASLDS PQLSQVHGVI QVDVAPSSGG
810 820
RGFSEAVGDS RSGENIPMAF RGGA
Length:824
Mass (Da):90,770
Last modified:November 1, 1991 - v1
Checksum:iA7D81C148CEFD938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57263 mRNA. Translation: AAA63495.1.
BC097305 mRNA. Translation: AAH97305.1.
PIRiB38423.
RefSeqiNP_113847.1. NM_031659.1.
XP_006252076.1. XM_006252014.3.
XP_008768913.1. XM_008770691.2.
UniGeneiRn.10039.

Genome annotation databases

EnsembliENSRNOT00000027315; ENSRNOP00000027315; ENSRNOG00000020136.
GeneIDi60335.
KEGGirno:60335.
UCSCiRGD:61838. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57263 mRNA. Translation: AAA63495.1.
BC097305 mRNA. Translation: AAH97305.1.
PIRiB38423.
RefSeqiNP_113847.1. NM_031659.1.
XP_006252076.1. XM_006252014.3.
XP_008768913.1. XM_008770691.2.
UniGeneiRn.10039.

3D structure databases

ProteinModelPortaliP23606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248784. 2 interactors.
STRINGi10116.ENSRNOP00000027315.

PTM databases

iPTMnetiP23606.
PhosphoSitePlusiP23606.

Proteomic databases

PaxDbiP23606.
PRIDEiP23606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027315; ENSRNOP00000027315; ENSRNOG00000020136.
GeneIDi60335.
KEGGirno:60335.
UCSCiRGD:61838. rat.

Organism-specific databases

CTDi7051.
RGDi61838. Tgm1.

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP23606.
KOiK05619.
OMAiCGCCSCR.
OrthoDBiEOG091G030K.
PhylomeDBiP23606.
TreeFamiTF324278.

Enzyme and pathway databases

ReactomeiR-RNO-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiP23606.

Gene expression databases

BgeeiENSRNOG00000020136.
GenevisibleiP23606. RN.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGM1_RAT
AccessioniPrimary (citable) accession number: P23606
Secondary accession number(s): Q4QRA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.