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P23606

- TGM1_RAT

UniProt

P23606 - TGM1_RAT

Protein

Protein-glutamine gamma-glutamyltransferase K

Gene

Tgm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei385 – 3851PROSITE-ProRule annotation
    Active sitei444 – 4441PROSITE-ProRule annotation
    Active sitei467 – 4671PROSITE-ProRule annotation
    Metal bindingi507 – 5071CalciumBy similarity
    Metal bindingi509 – 5091CalciumBy similarity
    Metal bindingi556 – 5561CalciumBy similarity
    Metal bindingi561 – 5611CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: RGD

    GO - Biological processi

    1. keratinization Source: UniProtKB-KW
    2. organ morphogenesis Source: Ensembl
    3. peptide cross-linking Source: RGD

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Keratinization

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
    Alternative name(s):
    Epidermal TGase
    Transglutaminase K
    Short name:
    TG(K)
    Short name:
    TGK
    Short name:
    TGase K
    Transglutaminase-1
    Short name:
    TGase-1
    Gene namesi
    Name:Tgm1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi61838. Tgm1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell adherens junction Source: Ensembl
    2. intrinsic component of membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Protein-glutamine gamma-glutamyltransferase KPRO_0000213704Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei92 – 921PhosphoserineBy similarity
    Modified residuei100 – 1001PhosphoserineBy similarity
    Modified residuei103 – 1031PhosphoserineBy similarity
    Modified residuei812 – 8121PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP23606.
    PRIDEiP23606.

    PTM databases

    PhosphoSiteiP23606.

    Expressioni

    Gene expression databases

    GenevestigatoriP23606.

    Interactioni

    Protein-protein interaction databases

    BioGridi248784. 1 interaction.
    STRINGi10116.ENSRNOP00000027315.

    Structurei

    3D structure databases

    ProteinModelPortaliP23606.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG80379.
    GeneTreeiENSGT00740000115156.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    InParanoidiP23606.
    KOiK05619.
    OMAiGRWGGNP.
    OrthoDBiEOG7WT40M.
    PhylomeDBiP23606.
    TreeFamiTF324278.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23606-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGPRSDVGR WGRSPWQPTT PSPEPEPEPE PDRSSRSRRG GGRSFWARCC    50
    GCCSCGNRAD DDWGPEPSGS RSRGTSSRGG GSRGGDSRGR DSRGGRRPES 100
    RGSGVNAAGD GTIREGMLVV NGVDLLCSRS DQNRREHHTD EFEYDELILR 150
    RGQPFHIILF LNREYESSDR IALELLIGNN PEVGKGTHVI IPVGKGGSGG 200
    WKAQVTKTNG HNLTLRVHTS PNAIIGKFQF TVRTRSEAGE FQLPFDPRNE 250
    IYILFNPWCP EDIVYVDHED WRQEYVLNES GRIYYGTEAQ IGERTWNYGQ 300
    FDHGVLDACL YILDRRGMPY GGRGDPVSVS RVVSAMVNSL DDNGVLIGNW 350
    TGDYSRGTNP SAWVGSVEIL LSYLRTGYSV PYGQCWVFAG VTTTVLRCLG 400
    LATRTVTNFN SAHDTDTSLT MDIYFDENMK PLEHLNHDSV WNFHVWNDCW 450
    MKRPDLPSGF DGWQVVDATP QETSSGIFCC GPCSVESIKN GLVYMKYDTP 500
    FIFAEVNSDK VYWQRQDDGS FKIVYVEEKA IGTLIVTKAI NSNMREDITH 550
    IYKHPEGSEA ERKAVEKAAA HGSKPNVYAT RDSAEDVAMQ VEAQDAVMGQ 600
    DLTVSVVLTN RGSSRRTVKL HLYLCVTYYT GVSGPTFKET KKEVVLAPGA 650
    SDTVAMPVAY KEYKPHLVDQ GAMLLNVSGH VKESGQVLAK QHTFRLRTPD 700
    LSLTLLGAAV VGQECEVQIV FKNPLPITLT NVVFRLEGSG LQRPKVLNVG 750
    DIGGNETVTL RQTFVPVRPG PRQLIASLDS PQLSQVHGVI QVDVAPSSGG 800
    RGFSEAVGDS RSGENIPMAF RGGA 824
    Length:824
    Mass (Da):90,770
    Last modified:November 1, 1991 - v1
    Checksum:iA7D81C148CEFD938
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57263 mRNA. Translation: AAA63495.1.
    BC097305 mRNA. Translation: AAH97305.1.
    PIRiB38423.
    RefSeqiNP_113847.1. NM_031659.1.
    XP_006252076.1. XM_006252014.1.
    UniGeneiRn.10039.

    Genome annotation databases

    EnsembliENSRNOT00000027315; ENSRNOP00000027315; ENSRNOG00000020136.
    GeneIDi60335.
    KEGGirno:60335.
    UCSCiRGD:61838. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57263 mRNA. Translation: AAA63495.1 .
    BC097305 mRNA. Translation: AAH97305.1 .
    PIRi B38423.
    RefSeqi NP_113847.1. NM_031659.1.
    XP_006252076.1. XM_006252014.1.
    UniGenei Rn.10039.

    3D structure databases

    ProteinModelPortali P23606.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248784. 1 interaction.
    STRINGi 10116.ENSRNOP00000027315.

    PTM databases

    PhosphoSitei P23606.

    Proteomic databases

    PaxDbi P23606.
    PRIDEi P23606.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027315 ; ENSRNOP00000027315 ; ENSRNOG00000020136 .
    GeneIDi 60335.
    KEGGi rno:60335.
    UCSCi RGD:61838. rat.

    Organism-specific databases

    CTDi 7051.
    RGDi 61838. Tgm1.

    Phylogenomic databases

    eggNOGi NOG80379.
    GeneTreei ENSGT00740000115156.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    InParanoidi P23606.
    KOi K05619.
    OMAi GRWGGNP.
    OrthoDBi EOG7WT40M.
    PhylomeDBi P23606.
    TreeFami TF324278.

    Miscellaneous databases

    NextBioi 611983.
    PROi P23606.

    Gene expression databases

    Genevestigatori P23606.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiTGM1_RAT
    AccessioniPrimary (citable) accession number: P23606
    Secondary accession number(s): Q4QRA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3