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P23606 (TGM1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-glutamine gamma-glutamyltransferase K

EC=2.3.2.13
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name=TG(K)
Short name=TGK
Short name=TGase K
Transglutaminase-1
Short name=TGase-1
Gene names
Name:Tgm1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length824 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.

Catalytic activity

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 824824Protein-glutamine gamma-glutamyltransferase K
PRO_0000213704

Sites

Active site3851 By similarity
Active site4441 By similarity
Active site4671 By similarity
Metal binding5071Calcium By similarity
Metal binding5091Calcium By similarity
Metal binding5561Calcium By similarity
Metal binding5611Calcium By similarity

Amino acid modifications

Modified residue221Phosphoserine By similarity
Modified residue921Phosphoserine By similarity
Modified residue1001Phosphoserine By similarity
Modified residue1031Phosphoserine By similarity
Modified residue8121Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P23606 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: A7D81C148CEFD938

FASTA82490,770
        10         20         30         40         50         60 
MEGPRSDVGR WGRSPWQPTT PSPEPEPEPE PDRSSRSRRG GGRSFWARCC GCCSCGNRAD 

        70         80         90        100        110        120 
DDWGPEPSGS RSRGTSSRGG GSRGGDSRGR DSRGGRRPES RGSGVNAAGD GTIREGMLVV 

       130        140        150        160        170        180 
NGVDLLCSRS DQNRREHHTD EFEYDELILR RGQPFHIILF LNREYESSDR IALELLIGNN 

       190        200        210        220        230        240 
PEVGKGTHVI IPVGKGGSGG WKAQVTKTNG HNLTLRVHTS PNAIIGKFQF TVRTRSEAGE 

       250        260        270        280        290        300 
FQLPFDPRNE IYILFNPWCP EDIVYVDHED WRQEYVLNES GRIYYGTEAQ IGERTWNYGQ 

       310        320        330        340        350        360 
FDHGVLDACL YILDRRGMPY GGRGDPVSVS RVVSAMVNSL DDNGVLIGNW TGDYSRGTNP 

       370        380        390        400        410        420 
SAWVGSVEIL LSYLRTGYSV PYGQCWVFAG VTTTVLRCLG LATRTVTNFN SAHDTDTSLT 

       430        440        450        460        470        480 
MDIYFDENMK PLEHLNHDSV WNFHVWNDCW MKRPDLPSGF DGWQVVDATP QETSSGIFCC 

       490        500        510        520        530        540 
GPCSVESIKN GLVYMKYDTP FIFAEVNSDK VYWQRQDDGS FKIVYVEEKA IGTLIVTKAI 

       550        560        570        580        590        600 
NSNMREDITH IYKHPEGSEA ERKAVEKAAA HGSKPNVYAT RDSAEDVAMQ VEAQDAVMGQ 

       610        620        630        640        650        660 
DLTVSVVLTN RGSSRRTVKL HLYLCVTYYT GVSGPTFKET KKEVVLAPGA SDTVAMPVAY 

       670        680        690        700        710        720 
KEYKPHLVDQ GAMLLNVSGH VKESGQVLAK QHTFRLRTPD LSLTLLGAAV VGQECEVQIV 

       730        740        750        760        770        780 
FKNPLPITLT NVVFRLEGSG LQRPKVLNVG DIGGNETVTL RQTFVPVRPG PRQLIASLDS 

       790        800        810        820 
PQLSQVHGVI QVDVAPSSGG RGFSEAVGDS RSGENIPMAF RGGA 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure of keratinocyte transglutaminase."
Phillips M.A., Stewart B.E., Qin Q., Chakravarty R., Floyd E.E., Jetten A.M., Rice R.H.
Proc. Natl. Acad. Sci. U.S.A. 87:9333-9337(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57263 mRNA. Translation: AAA63495.1.
BC097305 mRNA. Translation: AAH97305.1.
PIRB38423.
RefSeqNP_113847.1. NM_031659.1.
XP_006252076.1. XM_006252014.1.
UniGeneRn.10039.

3D structure databases

ProteinModelPortalP23606.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248784. 1 interaction.
STRING10116.ENSRNOP00000027315.

PTM databases

PhosphoSiteP23606.

Proteomic databases

PaxDbP23606.
PRIDEP23606.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000027315; ENSRNOP00000027315; ENSRNOG00000020136.
GeneID60335.
KEGGrno:60335.
UCSCRGD:61838. rat.

Organism-specific databases

CTD7051.
RGD61838. Tgm1.

Phylogenomic databases

eggNOGNOG80379.
GeneTreeENSGT00740000115156.
HOGENOMHOG000231695.
HOVERGENHBG004342.
InParanoidP23606.
KOK05619.
OMAGRWGGNP.
OrthoDBEOG7WT40M.
PhylomeDBP23606.
TreeFamTF324278.

Gene expression databases

GenevestigatorP23606.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERPTHR11590. PTHR11590. 1 hit.
PfamPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFPIRSF000459. TGM_EBP42. 1 hit.
SMARTSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio611983.
PROP23606.

Entry information

Entry nameTGM1_RAT
AccessionPrimary (citable) accession number: P23606
Secondary accession number(s): Q4QRA6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families