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Protein

Protein-glutamine gamma-glutamyltransferase K

Gene

Tgm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei385 – 3851PROSITE-ProRule annotation
Active sitei444 – 4441PROSITE-ProRule annotation
Active sitei467 – 4671PROSITE-ProRule annotation
Metal bindingi507 – 5071CalciumBy similarity
Metal bindingi509 – 5091CalciumBy similarity
Metal bindingi556 – 5561CalciumBy similarity
Metal bindingi561 – 5611CalciumBy similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein-glutamine gamma-glutamyltransferase activity Source: RGD

GO - Biological processi

  • keratinization Source: UniProtKB-KW
  • organ morphogenesis Source: Ensembl
  • peptide cross-linking Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Keratinization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name:
TG(K)
Short name:
TGK
Short name:
TGase K
Transglutaminase-1
Short name:
TGase-1
Gene namesi
Name:Tgm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi61838. Tgm1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Protein-glutamine gamma-glutamyltransferase KPRO_0000213704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei92 – 921PhosphoserineBy similarity
Modified residuei100 – 1001PhosphoserineBy similarity
Modified residuei103 – 1031PhosphoserineBy similarity
Modified residuei812 – 8121PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP23606.
PRIDEiP23606.

PTM databases

PhosphoSiteiP23606.

Expressioni

Gene expression databases

GenevestigatoriP23606.

Interactioni

Protein-protein interaction databases

BioGridi248784. 1 interaction.
STRINGi10116.ENSRNOP00000027315.

Structurei

3D structure databases

ProteinModelPortaliP23606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP23606.
KOiK05619.
OMAiGRWGGNP.
OrthoDBiEOG7WT40M.
PhylomeDBiP23606.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPRSDVGR WGRSPWQPTT PSPEPEPEPE PDRSSRSRRG GGRSFWARCC
60 70 80 90 100
GCCSCGNRAD DDWGPEPSGS RSRGTSSRGG GSRGGDSRGR DSRGGRRPES
110 120 130 140 150
RGSGVNAAGD GTIREGMLVV NGVDLLCSRS DQNRREHHTD EFEYDELILR
160 170 180 190 200
RGQPFHIILF LNREYESSDR IALELLIGNN PEVGKGTHVI IPVGKGGSGG
210 220 230 240 250
WKAQVTKTNG HNLTLRVHTS PNAIIGKFQF TVRTRSEAGE FQLPFDPRNE
260 270 280 290 300
IYILFNPWCP EDIVYVDHED WRQEYVLNES GRIYYGTEAQ IGERTWNYGQ
310 320 330 340 350
FDHGVLDACL YILDRRGMPY GGRGDPVSVS RVVSAMVNSL DDNGVLIGNW
360 370 380 390 400
TGDYSRGTNP SAWVGSVEIL LSYLRTGYSV PYGQCWVFAG VTTTVLRCLG
410 420 430 440 450
LATRTVTNFN SAHDTDTSLT MDIYFDENMK PLEHLNHDSV WNFHVWNDCW
460 470 480 490 500
MKRPDLPSGF DGWQVVDATP QETSSGIFCC GPCSVESIKN GLVYMKYDTP
510 520 530 540 550
FIFAEVNSDK VYWQRQDDGS FKIVYVEEKA IGTLIVTKAI NSNMREDITH
560 570 580 590 600
IYKHPEGSEA ERKAVEKAAA HGSKPNVYAT RDSAEDVAMQ VEAQDAVMGQ
610 620 630 640 650
DLTVSVVLTN RGSSRRTVKL HLYLCVTYYT GVSGPTFKET KKEVVLAPGA
660 670 680 690 700
SDTVAMPVAY KEYKPHLVDQ GAMLLNVSGH VKESGQVLAK QHTFRLRTPD
710 720 730 740 750
LSLTLLGAAV VGQECEVQIV FKNPLPITLT NVVFRLEGSG LQRPKVLNVG
760 770 780 790 800
DIGGNETVTL RQTFVPVRPG PRQLIASLDS PQLSQVHGVI QVDVAPSSGG
810 820
RGFSEAVGDS RSGENIPMAF RGGA
Length:824
Mass (Da):90,770
Last modified:November 1, 1991 - v1
Checksum:iA7D81C148CEFD938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57263 mRNA. Translation: AAA63495.1.
BC097305 mRNA. Translation: AAH97305.1.
PIRiB38423.
RefSeqiNP_113847.1. NM_031659.1.
XP_006252076.1. XM_006252014.2.
XP_008768913.1. XM_008770691.1.
UniGeneiRn.10039.

Genome annotation databases

EnsembliENSRNOT00000027315; ENSRNOP00000027315; ENSRNOG00000020136.
GeneIDi60335.
KEGGirno:60335.
UCSCiRGD:61838. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57263 mRNA. Translation: AAA63495.1.
BC097305 mRNA. Translation: AAH97305.1.
PIRiB38423.
RefSeqiNP_113847.1. NM_031659.1.
XP_006252076.1. XM_006252014.2.
XP_008768913.1. XM_008770691.1.
UniGeneiRn.10039.

3D structure databases

ProteinModelPortaliP23606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248784. 1 interaction.
STRINGi10116.ENSRNOP00000027315.

PTM databases

PhosphoSiteiP23606.

Proteomic databases

PaxDbiP23606.
PRIDEiP23606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027315; ENSRNOP00000027315; ENSRNOG00000020136.
GeneIDi60335.
KEGGirno:60335.
UCSCiRGD:61838. rat.

Organism-specific databases

CTDi7051.
RGDi61838. Tgm1.

Phylogenomic databases

eggNOGiNOG80379.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP23606.
KOiK05619.
OMAiGRWGGNP.
OrthoDBiEOG7WT40M.
PhylomeDBiP23606.
TreeFamiTF324278.

Miscellaneous databases

NextBioi611983.
PROiP23606.

Gene expression databases

GenevestigatoriP23606.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTGM1_RAT
AccessioniPrimary (citable) accession number: P23606
Secondary accession number(s): Q4QRA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 27, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.