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Protein

Protein-glutamine gamma-glutamyltransferase K

Gene

Tgm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity).By similarity

Catalytic activityi

A protein-L-glutamine + a protein-L-lysine = a protein with an N6-(gamma-glutamyl)-L-lysine cross-link + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei385PROSITE-ProRule annotation1
Active sitei444PROSITE-ProRule annotation1
Active sitei467PROSITE-ProRule annotation1
Metal bindingi507CalciumBy similarity1
Metal bindingi509CalciumBy similarity1
Metal bindingi556CalciumBy similarity1
Metal bindingi561CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processKeratinization
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name:
TG(K)
Short name:
TGK
Short name:
TGase K
Transglutaminase-1
Short name:
TGase-1
Gene namesi
Name:Tgm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi61838 Tgm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137041 – 824Protein-glutamine gamma-glutamyltransferase KAdd BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphothreonineBy similarity1
Modified residuei22PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei92PhosphoserineBy similarity1
Modified residuei100PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP23606
PRIDEiP23606

PTM databases

iPTMnetiP23606
PhosphoSitePlusiP23606

Expressioni

Gene expression databases

BgeeiENSRNOG00000020136
GenevisibleiP23606 RN

Interactioni

Protein-protein interaction databases

BioGridi248784, 2 interactors
STRINGi10116.ENSRNOP00000027315

Structurei

3D structure databases

ProteinModelPortaliP23606
SMRiP23606
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
GeneTreeiENSGT00760000119108
HOGENOMiHOG000231695
HOVERGENiHBG004342
InParanoidiP23606
KOiK05619
OMAiNMREDIT
OrthoDBiEOG091G030K
PhylomeDBiP23606
TreeFamiTF324278

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequencei

Sequence statusi: Complete.

P23606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPRSDVGR WGRSPWQPTT PSPEPEPEPE PDRSSRSRRG GGRSFWARCC
60 70 80 90 100
GCCSCGNRAD DDWGPEPSGS RSRGTSSRGG GSRGGDSRGR DSRGGRRPES
110 120 130 140 150
RGSGVNAAGD GTIREGMLVV NGVDLLCSRS DQNRREHHTD EFEYDELILR
160 170 180 190 200
RGQPFHIILF LNREYESSDR IALELLIGNN PEVGKGTHVI IPVGKGGSGG
210 220 230 240 250
WKAQVTKTNG HNLTLRVHTS PNAIIGKFQF TVRTRSEAGE FQLPFDPRNE
260 270 280 290 300
IYILFNPWCP EDIVYVDHED WRQEYVLNES GRIYYGTEAQ IGERTWNYGQ
310 320 330 340 350
FDHGVLDACL YILDRRGMPY GGRGDPVSVS RVVSAMVNSL DDNGVLIGNW
360 370 380 390 400
TGDYSRGTNP SAWVGSVEIL LSYLRTGYSV PYGQCWVFAG VTTTVLRCLG
410 420 430 440 450
LATRTVTNFN SAHDTDTSLT MDIYFDENMK PLEHLNHDSV WNFHVWNDCW
460 470 480 490 500
MKRPDLPSGF DGWQVVDATP QETSSGIFCC GPCSVESIKN GLVYMKYDTP
510 520 530 540 550
FIFAEVNSDK VYWQRQDDGS FKIVYVEEKA IGTLIVTKAI NSNMREDITH
560 570 580 590 600
IYKHPEGSEA ERKAVEKAAA HGSKPNVYAT RDSAEDVAMQ VEAQDAVMGQ
610 620 630 640 650
DLTVSVVLTN RGSSRRTVKL HLYLCVTYYT GVSGPTFKET KKEVVLAPGA
660 670 680 690 700
SDTVAMPVAY KEYKPHLVDQ GAMLLNVSGH VKESGQVLAK QHTFRLRTPD
710 720 730 740 750
LSLTLLGAAV VGQECEVQIV FKNPLPITLT NVVFRLEGSG LQRPKVLNVG
760 770 780 790 800
DIGGNETVTL RQTFVPVRPG PRQLIASLDS PQLSQVHGVI QVDVAPSSGG
810 820
RGFSEAVGDS RSGENIPMAF RGGA
Length:824
Mass (Da):90,770
Last modified:November 1, 1991 - v1
Checksum:iA7D81C148CEFD938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57263 mRNA Translation: AAA63495.1
BC097305 mRNA Translation: AAH97305.1
PIRiB38423
RefSeqiNP_113847.1, NM_031659.1
XP_006252076.1, XM_006252014.3
XP_008768913.1, XM_008770691.2
UniGeneiRn.10039

Genome annotation databases

EnsembliENSRNOT00000027315; ENSRNOP00000027315; ENSRNOG00000020136
GeneIDi60335
KEGGirno:60335
UCSCiRGD:61838 rat

Similar proteinsi

Entry informationi

Entry nameiTGM1_RAT
AccessioniPrimary (citable) accession number: P23606
Secondary accession number(s): Q4QRA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health