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P23599 (1A11_CUCMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 31, 2011. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-aminocyclopropane-1-carboxylate synthase CMW33

Short name=ACC synthase
EC=4.4.1.14
Alternative name(s):
S-adenosyl-L-methionine methylthioadenosine-lyase
Gene names
Name:ACS1
Synonyms:ACCW
OrganismCucurbita maxima (Pumpkin) (Winter squash)
Taxonomic identifier3661 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsfabidsCucurbitalesCucurbitaceaeCucurbiteaeCucurbita

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of 1-aminocyclopropane-1-carboxylate, a direct precursor of ethylene in higher plants.

Catalytic activity

S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.

Cofactor

Pyridoxal phosphate.

Pathway

Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 1/2.

Subunit structure

Homodimer.

Induction

By tissue wounding.

Sequence similarities

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4934931-aminocyclopropane-1-carboxylate synthase CMW33
PRO_0000123907

Amino acid modifications

Modified residue2791N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P23599 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: F39234AC99CBEF6B

FASTA49355,896
        10         20         30         40         50         60 
MEFHQIDERN QALLSKIAVD DGHGENSPYF DGWKAYDNDP FHPEDNPLGV IQMGLAENQL 

        70         80         90        100        110        120 
SFDMIVDWIR KHPEASICTP KGLERFKSIA NFQDYHGLPE FRNGIASFMG KVRGGRVQFD 

       130        140        150        160        170        180 
PSRIVMGGGA TGASETVIFC LADPGDAFLV PSPYYAAFDR DLKWRTRAQI IRVHCNSSNN 

       190        200        210        220        230        240 
FQVTKAALEI AYKKAQEANI KVKGVIITNP SNPLGTTYDR DTLKTLVTFV NQHDIHLICD 

       250        260        270        280        290        300 
EIYSATVFKA PTFISIAQIV EEMEHCKKEL IHILYSLSKD MGLPGFRVGI IYSYNDVVVR 

       310        320        330        340        350        360 
RARQMSSFGL VSSQTQHLLA AMLSDEDFVD KFLAENSKRL AERHARFTKE LDKMGITCLN 

       370        380        390        400        410        420 
SNAGVFVWMD LRRLLKDQTF KAEMELWRVI INEVKLNVSP GSSFHVTEPG WFRVCFANMD 

       430        440        450        460        470        480 
DNTVDVALNR IHSFVENIDK KEDNTVAMPS KTRRRENKLR LSFSFSGRRY DEGNVLNSPH 

       490 
TMSPHSPLVI AKN 

« Hide

References

[1]"Molecular cloning and sequence of a complementary DNA encoding 1-aminocyclopropane-1-carboxylate synthase induced by tissue wounding."
Nakajima N., Mori H., Yamazaki K., Imaseki H.
Plant Cell Physiol. 31:1021-1029(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D01032 mRNA. Translation: BAA00838.1.
PIRJQ0926.

3D structure databases

ProteinModelPortalP23599.
SMRP23599. Positions 13-435.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001176. ACC_synthase.
IPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSPR00753. ACCSYNTHASE.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name1A11_CUCMA
AccessionPrimary (citable) accession number: P23599
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 31, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families