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Protein

Apolipoprotein D

Gene

Apod

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein D
Short name:
Apo-D
Short name:
ApoD
Gene namesi
Name:Apod
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2137. Apod.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosolic ribosome Source: RGD
  • dendrite Source: RGD
  • endoplasmic reticulum Source: RGD
  • extracellular space Source: UniProtKB
  • neuronal cell body Source: RGD
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001787621 – 189Apolipoprotein DAdd BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi28 ↔ 134By similarity
Disulfide bondi61 ↔ 185By similarity
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP23593.
PRIDEiP23593.

Expressioni

Tissue specificityi

Expressed in liver, kidney, bladder, adrenal, cerebrum, duodenum, testis, lung, spleen, pancreas, heart and skin.1 Publication

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi247279. 1 interactor.
STRINGi10116.ENSRNOP00000064368.

Structurei

3D structure databases

ProteinModelPortaliP23593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4824. Eukaryota.
COG3040. LUCA.
HOVERGENiHBG018734.
InParanoidiP23593.
KOiK03098.
PhylomeDBiP23593.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR026222. ApoD_vertbrte.
IPR002969. ApolipopD.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF08212. Lipocalin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSiPR02058. APODVERTBRTE.
PR01219. APOLIPOPROTD.
PR00179. LIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMLLLLAT LAGLFTTTEG QSFHLGKCPS PPVQENFDVK KYLGRWYEIE
60 70 80 90 100
KIPVSFEKGN CIQANYSLME NGNIKVLNKE LRPDGTLNQV EGEAKQSNMS
110 120 130 140 150
EPAKLEVQFF SLMPPAPYWI LATDYESYAL VYSCTTFFWF FHVDYVWILG
160 170 180
RNPYLPPETI TYLKYILTSN DIDIAKITTK DQANCPDFL
Length:189
Mass (Da):21,635
Last modified:November 1, 1991 - v1
Checksum:i1E4823A45E38B4C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180K → T AA sequence (PubMed:2090718).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55572 mRNA. Translation: CAA39158.1.
PIRiS12556. A60958.
RefSeqiNP_036909.1. NM_012777.1.
UniGeneiRn.11339.

Genome annotation databases

GeneIDi25239.
KEGGirno:25239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55572 mRNA. Translation: CAA39158.1.
PIRiS12556. A60958.
RefSeqiNP_036909.1. NM_012777.1.
UniGeneiRn.11339.

3D structure databases

ProteinModelPortaliP23593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247279. 1 interactor.
STRINGi10116.ENSRNOP00000064368.

Proteomic databases

PaxDbiP23593.
PRIDEiP23593.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25239.
KEGGirno:25239.

Organism-specific databases

CTDi347.
RGDi2137. Apod.

Phylogenomic databases

eggNOGiKOG4824. Eukaryota.
COG3040. LUCA.
HOVERGENiHBG018734.
InParanoidiP23593.
KOiK03098.
PhylomeDBiP23593.

Miscellaneous databases

PROiP23593.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR026222. ApoD_vertbrte.
IPR002969. ApolipopD.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF08212. Lipocalin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSiPR02058. APODVERTBRTE.
PR01219. APOLIPOPROTD.
PR00179. LIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOD_RAT
AccessioniPrimary (citable) accession number: P23593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.