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Protein

Apolipoprotein D

Gene

Apod

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein D
Short name:
Apo-D
Short name:
ApoD
Gene namesi
Name:Apod
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2137 Apod

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001787621 – 189Apolipoprotein DAdd BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi28 ↔ 134By similarity
Disulfide bondi61 ↔ 185By similarity
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP23593
PRIDEiP23593

Expressioni

Tissue specificityi

Expressed in liver, kidney, bladder, adrenal, cerebrum, duodenum, testis, lung, spleen, pancreas, heart and skin.1 Publication

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi247279, 1 interactor
STRINGi10116.ENSRNOP00000064368

Structurei

3D structure databases

ProteinModelPortaliP23593
SMRiP23593
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4824 Eukaryota
COG3040 LUCA
HOVERGENiHBG018734
InParanoidiP23593
KOiK03098
PhylomeDBiP23593

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR026222 ApoD_vertbrte
IPR002969 ApolipopD
IPR012674 Calycin
IPR022271 Lipocalin_ApoD
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PfamiView protein in Pfam
PF08212 Lipocalin_2, 1 hit
PIRSFiPIRSF036893 Lipocalin_ApoD, 1 hit
PRINTSiPR02058 APODVERTBRTE
PR01219 APOLIPOPROTD
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMLLLLAT LAGLFTTTEG QSFHLGKCPS PPVQENFDVK KYLGRWYEIE
60 70 80 90 100
KIPVSFEKGN CIQANYSLME NGNIKVLNKE LRPDGTLNQV EGEAKQSNMS
110 120 130 140 150
EPAKLEVQFF SLMPPAPYWI LATDYESYAL VYSCTTFFWF FHVDYVWILG
160 170 180
RNPYLPPETI TYLKYILTSN DIDIAKITTK DQANCPDFL
Length:189
Mass (Da):21,635
Last modified:November 1, 1991 - v1
Checksum:i1E4823A45E38B4C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180K → T AA sequence (PubMed:2090718).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55572 mRNA Translation: CAA39158.1
PIRiS12556 A60958
RefSeqiNP_036909.1, NM_012777.1
UniGeneiRn.11339

Genome annotation databases

GeneIDi25239
KEGGirno:25239

Similar proteinsi

Entry informationi

Entry nameiAPOD_RAT
AccessioniPrimary (citable) accession number: P23593
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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