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Protein

Sugar transport protein 1

Gene

STP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major hexose transporter. Mediates an active uptake of hexoses, by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings.5 Publications

Kineticsi

  1. KM=20 µM for glucose (at pH 6.0 and 32 degrees Celsius)1 Publication
  2. KM=100 µM for 3-O-methylglucose (at pH 6.0 and 32 degrees Celsius)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • glucose import Source: GO_Central
    • monosaccharide transmembrane transport Source: TAIR

    Keywordsi

    Biological processSugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.60 the major facilitator superfamily (mfs)

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transport protein 1
    Alternative name(s):
    Glucose transporter
    Hexose transporter 1
    Gene namesi
    Name:STP1
    Ordered Locus Names:At1g11260
    ORF Names:T28P6.9
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 1

    Organism-specific databases

    AraportiAT1G11260
    TAIRilocus:2202044 AT1G11260

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
    Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini44 – 79ExtracellularSequence analysisAdd BLAST36
    Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini101 – 117CytoplasmicSequence analysisAdd BLAST17
    Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini139 – 140ExtracellularSequence analysis2
    Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini162 – 171CytoplasmicSequence analysis10
    Transmembranei172 – 192Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini193 – 202ExtracellularSequence analysis10
    Transmembranei203 – 223Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini224 – 289CytoplasmicSequence analysisAdd BLAST66
    Transmembranei290 – 310Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini311 – 321ExtracellularSequence analysisAdd BLAST11
    Transmembranei322 – 342Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini343 – 348CytoplasmicSequence analysis6
    Transmembranei349 – 369Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini370 – 384ExtracellularSequence analysisAdd BLAST15
    Transmembranei385 – 405Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini406 – 427CytoplasmicSequence analysisAdd BLAST22
    Transmembranei428 – 448Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini449 – 452ExtracellularSequence analysis4
    Transmembranei453 – 473Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini474 – 522CytoplasmicSequence analysisAdd BLAST49

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000504311 – 522Sugar transport protein 1Add BLAST522

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei252PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP23586
    PRIDEiP23586

    PTM databases

    iPTMnetiP23586

    Expressioni

    Tissue specificityi

    Mostly expressed in young leaves, especially in guard cells (at protein level). Also present in roots.3 Publications

    Inductioni

    Strong increase at the onset of the dark period followed by a progressive decrease. Transient increase at midday.1 Publication

    Gene expression databases

    ExpressionAtlasiP23586 baseline and differential
    GenevisibleiP23586 AT

    Interactioni

    Protein-protein interaction databases

    BioGridi22907, 4 interactors
    STRINGi3702.AT1G11260.1

    Structurei

    3D structure databases

    ProteinModelPortaliP23586
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254 Eukaryota
    ENOG410XNQK LUCA
    HOGENOMiHOG000202867
    InParanoidiP23586
    OMAiISTGSFC
    OrthoDBiEOG093608DR
    PhylomeDBiP23586

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083 Sugar_tr, 1 hit
    PRINTSiPR00171 SUGRTRNSPORT
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00879 SP, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 1 hit
    PS00217 SUGAR_TRANSPORT_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P23586-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MPAGGFVVGD GQKAYPGKLT PFVLFTCVVA AMGGLIFGYD IGISGGVTSM
    60 70 80 90 100
    PSFLKRFFPS VYRKQQEDAS TNQYCQYDSP TLTMFTSSLY LAALISSLVA
    110 120 130 140 150
    STVTRKFGRR LSMLFGGILF CAGALINGFA KHVWMLIVGR ILLGFGIGFA
    160 170 180 190 200
    NQAVPLYLSE MAPYKYRGAL NIGFQLSITI GILVAEVLNY FFAKIKGGWG
    210 220 230 240 250
    WRLSLGGAVV PALIITIGSL VLPDTPNSMI ERGQHEEAKT KLRRIRGVDD
    260 270 280 290 300
    VSQEFDDLVA ASKESQSIEH PWRNLLRRKY RPHLTMAVMI PFFQQLTGIN
    310 320 330 340 350
    VIMFYAPVLF NTIGFTTDAS LMSAVVTGSV NVAATLVSIY GVDRWGRRFL
    360 370 380 390 400
    FLEGGTQMLI CQAVVAACIG AKFGVDGTPG ELPKWYAIVV VTFICIYVAG
    410 420 430 440 450
    FAWSWGPLGW LVPSEIFPLE IRSAAQSITV SVNMIFTFII AQIFLTMLCH
    460 470 480 490 500
    LKFGLFLVFA FFVVVMSIFV YIFLPETKGI PIEEMGQVWR SHWYWSRFVE
    510 520
    DGEYGNALEM GKNSNQAGTK HV
    Length:522
    Mass (Da):57,611
    Last modified:June 20, 2002 - v2
    Checksum:i813AFC8AFA7AA583
    GO

    Sequence cautioni

    The sequence BAD95185 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti333A → G in CAA39037 (PubMed:2209537).Curated1
    Sequence conflicti431S → F (Ref. 7) Curated1
    Sequence conflicti470V → E in AAM67326 (Ref. 5) Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X55350 mRNA Translation: CAA39037.1
    AC007259 Genomic DNA Translation: AAD49995.1
    CP002684 Genomic DNA Translation: AEE28705.1
    AY059781 mRNA Translation: AAL24129.1
    AY054249 mRNA Translation: AAL06908.1
    AY133845 mRNA Translation: AAM91779.1
    AY087292 mRNA Translation: AAM67326.1
    AF083803 mRNA Translation: AAN60361.1
    AK221157 mRNA Translation: BAD95185.1 Different initiation.
    PIRiE86246
    S12042
    RefSeqiNP_172592.1, NM_100998.4
    UniGeneiAt.24793
    At.67772
    At.74867

    Genome annotation databases

    EnsemblPlantsiAT1G11260.1; AT1G11260.1; AT1G11260
    GeneIDi837667
    GrameneiAT1G11260.1; AT1G11260.1; AT1G11260
    KEGGiath:AT1G11260

    Similar proteinsi

    Entry informationi

    Entry nameiSTP1_ARATH
    AccessioniPrimary (citable) accession number: P23586
    Secondary accession number(s): Q56Z12
    , Q8H775, Q8LBC8, Q9SXB1
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: June 20, 2002
    Last modified: April 25, 2018
    This is version 150 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health