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Protein

Sugar transport protein 1

Gene

STP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major hexose transporter. Mediates an active uptake of hexoses, by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings.5 Publications

Kineticsi

  1. KM=20 µM for glucose (at pH 6.0 and 32 degrees Celsius)1 Publication
  2. KM=100 µM for 3-O-methylglucose (at pH 6.0 and 32 degrees Celsius)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • glucose import Source: GO_Central
    • hexose transmembrane transport Source: GO_Central
    • monosaccharide transport Source: TAIR
    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.60. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transport protein 1
    Alternative name(s):
    Glucose transporter
    Hexose transporter 1
    Gene namesi
    Name:STP1
    Ordered Locus Names:At1g11260
    ORF Names:T28P6.9
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 1

    Organism-specific databases

    TAIRiAT1G11260.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
    Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini44 – 79ExtracellularSequence analysisAdd BLAST36
    Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini101 – 117CytoplasmicSequence analysisAdd BLAST17
    Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini139 – 140ExtracellularSequence analysis2
    Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini162 – 171CytoplasmicSequence analysis10
    Transmembranei172 – 192Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini193 – 202ExtracellularSequence analysis10
    Transmembranei203 – 223Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini224 – 289CytoplasmicSequence analysisAdd BLAST66
    Transmembranei290 – 310Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini311 – 321ExtracellularSequence analysisAdd BLAST11
    Transmembranei322 – 342Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini343 – 348CytoplasmicSequence analysis6
    Transmembranei349 – 369Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini370 – 384ExtracellularSequence analysisAdd BLAST15
    Transmembranei385 – 405Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini406 – 427CytoplasmicSequence analysisAdd BLAST22
    Transmembranei428 – 448Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini449 – 452ExtracellularSequence analysis4
    Transmembranei453 – 473Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini474 – 522CytoplasmicSequence analysisAdd BLAST49

    GO - Cellular componenti

    • integral component of plasma membrane Source: GO_Central
    • nucleus Source: TAIR
    • plasma membrane Source: TAIR
    • plasmodesma Source: TAIR
    • vacuole Source: TAIR
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000504311 – 522Sugar transport protein 1Add BLAST522

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei252PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP23586.
    PRIDEiP23586.

    PTM databases

    iPTMnetiP23586.

    Expressioni

    Tissue specificityi

    Mostly expressed in young leaves, especially in guard cells (at protein level). Also present in roots.3 Publications

    Inductioni

    Strong increase at the onset of the dark period followed by a progressive decrease. Transient increase at midday.1 Publication

    Gene expression databases

    GenevisibleiP23586. AT.

    Interactioni

    Protein-protein interaction databases

    BioGridi22907. 4 interactors.
    STRINGi3702.AT1G11260.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP23586.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiP23586.
    OMAiFNTIGFT.
    OrthoDBiEOG093608DR.
    PhylomeDBiP23586.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23586-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MPAGGFVVGD GQKAYPGKLT PFVLFTCVVA AMGGLIFGYD IGISGGVTSM
    60 70 80 90 100
    PSFLKRFFPS VYRKQQEDAS TNQYCQYDSP TLTMFTSSLY LAALISSLVA
    110 120 130 140 150
    STVTRKFGRR LSMLFGGILF CAGALINGFA KHVWMLIVGR ILLGFGIGFA
    160 170 180 190 200
    NQAVPLYLSE MAPYKYRGAL NIGFQLSITI GILVAEVLNY FFAKIKGGWG
    210 220 230 240 250
    WRLSLGGAVV PALIITIGSL VLPDTPNSMI ERGQHEEAKT KLRRIRGVDD
    260 270 280 290 300
    VSQEFDDLVA ASKESQSIEH PWRNLLRRKY RPHLTMAVMI PFFQQLTGIN
    310 320 330 340 350
    VIMFYAPVLF NTIGFTTDAS LMSAVVTGSV NVAATLVSIY GVDRWGRRFL
    360 370 380 390 400
    FLEGGTQMLI CQAVVAACIG AKFGVDGTPG ELPKWYAIVV VTFICIYVAG
    410 420 430 440 450
    FAWSWGPLGW LVPSEIFPLE IRSAAQSITV SVNMIFTFII AQIFLTMLCH
    460 470 480 490 500
    LKFGLFLVFA FFVVVMSIFV YIFLPETKGI PIEEMGQVWR SHWYWSRFVE
    510 520
    DGEYGNALEM GKNSNQAGTK HV
    Length:522
    Mass (Da):57,611
    Last modified:June 20, 2002 - v2
    Checksum:i813AFC8AFA7AA583
    GO

    Sequence cautioni

    The sequence BAD95185 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti333A → G in CAA39037 (PubMed:2209537).Curated1
    Sequence conflicti431S → F (Ref. 7) Curated1
    Sequence conflicti470V → E in AAM67326 (Ref. 5) Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X55350 mRNA. Translation: CAA39037.1.
    AC007259 Genomic DNA. Translation: AAD49995.1.
    CP002684 Genomic DNA. Translation: AEE28705.1.
    AY059781 mRNA. Translation: AAL24129.1.
    AY054249 mRNA. Translation: AAL06908.1.
    AY133845 mRNA. Translation: AAM91779.1.
    AY087292 mRNA. Translation: AAM67326.1.
    AF083803 mRNA. Translation: AAN60361.1.
    AK221157 mRNA. Translation: BAD95185.1. Different initiation.
    PIRiE86246.
    S12042.
    RefSeqiNP_172592.1. NM_100998.4.
    UniGeneiAt.24793.
    At.67772.
    At.74867.

    Genome annotation databases

    EnsemblPlantsiAT1G11260.1; AT1G11260.1; AT1G11260.
    GeneIDi837667.
    GrameneiAT1G11260.1; AT1G11260.1; AT1G11260.
    KEGGiath:AT1G11260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X55350 mRNA. Translation: CAA39037.1.
    AC007259 Genomic DNA. Translation: AAD49995.1.
    CP002684 Genomic DNA. Translation: AEE28705.1.
    AY059781 mRNA. Translation: AAL24129.1.
    AY054249 mRNA. Translation: AAL06908.1.
    AY133845 mRNA. Translation: AAM91779.1.
    AY087292 mRNA. Translation: AAM67326.1.
    AF083803 mRNA. Translation: AAN60361.1.
    AK221157 mRNA. Translation: BAD95185.1. Different initiation.
    PIRiE86246.
    S12042.
    RefSeqiNP_172592.1. NM_100998.4.
    UniGeneiAt.24793.
    At.67772.
    At.74867.

    3D structure databases

    ProteinModelPortaliP23586.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi22907. 4 interactors.
    STRINGi3702.AT1G11260.1.

    Protein family/group databases

    TCDBi2.A.1.1.60. the major facilitator superfamily (mfs).

    PTM databases

    iPTMnetiP23586.

    Proteomic databases

    PaxDbiP23586.
    PRIDEiP23586.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblPlantsiAT1G11260.1; AT1G11260.1; AT1G11260.
    GeneIDi837667.
    GrameneiAT1G11260.1; AT1G11260.1; AT1G11260.
    KEGGiath:AT1G11260.

    Organism-specific databases

    TAIRiAT1G11260.

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiP23586.
    OMAiFNTIGFT.
    OrthoDBiEOG093608DR.
    PhylomeDBiP23586.

    Miscellaneous databases

    PROiP23586.

    Gene expression databases

    GenevisibleiP23586. AT.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSTP1_ARATH
    AccessioniPrimary (citable) accession number: P23586
    Secondary accession number(s): Q56Z12
    , Q8H775, Q8LBC8, Q9SXB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: June 20, 2002
    Last modified: November 30, 2016
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.