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Protein

High-affinity glucose transporter HXT2

Gene

HXT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • pentose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • glucose transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32719-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.111. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity glucose transporter HXT2
Gene namesi
Name:HXT2
Ordered Locus Names:YMR011W
ORF Names:YM8270.15
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR011W.
SGDiS000004613. HXT2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 49CytoplasmicSequence analysisAdd BLAST48
Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini71 – 107ExtracellularSequence analysisAdd BLAST37
Transmembranei108 – 128Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini129 – 134CytoplasmicSequence analysis6
Transmembranei135 – 155Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini156 – 162ExtracellularSequence analysis7
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 192CytoplasmicSequence analysis9
Transmembranei193 – 213Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini214 – 227ExtracellularSequence analysisAdd BLAST14
Transmembranei228 – 248Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini249 – 327CytoplasmicSequence analysisAdd BLAST79
Transmembranei328 – 347Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini348 – 350ExtracellularSequence analysis3
Transmembranei351 – 371Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini372 – 379CytoplasmicSequence analysis8
Transmembranei380 – 400Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini401 – 418ExtracellularSequence analysisAdd BLAST18
Transmembranei419 – 439Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini440 – 456CytoplasmicSequence analysisAdd BLAST17
Transmembranei457 – 477Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini478 – 484ExtracellularSequence analysis7
Transmembranei485 – 505Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini506 – 541CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000503922 – 541High-affinity glucose transporter HXT2Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei29PhosphothreonineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Modified residuei266Phosphoserine; by PKASequence analysis1
Modified residuei539Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP23585.
PRIDEiP23585.
TopDownProteomicsiP23585.

PTM databases

iPTMnetiP23585.

Expressioni

Inductioni

Repressed at high glucose concentrations.

Interactioni

Protein-protein interaction databases

BioGridi35180. 96 interactors.
DIPiDIP-7912N.
IntActiP23585. 6 interactors.
MINTiMINT-4497394.

Structurei

3D structure databases

ProteinModelPortaliP23585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP23585.
KOiK08139.
OMAiCAFGGLT.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEFATSRVE SGSQQTSIHS TPIVQKLETD ESPIQTKSEY TNAELPAKPI
60 70 80 90 100
AAYWTVICLC LMIAFGGFVF GWDTGTISGF VNQTDFKRRF GQMKSDGTYY
110 120 130 140 150
LSDVRTGLIV GIFNIGCAFG GLTLGRLGDM YGRRIGLMCV VLVYIVGIVI
160 170 180 190 200
QIASSDKWYQ YFIGRIISGM GVGGIAVLSP TLISETAPKH IRGTCVSFYQ
210 220 230 240 250
LMITLGIFLG YCTNYGTKDY SNSVQWRVPL GLNFAFAIFM IAGMLMVPES
260 270 280 290 300
PRFLVEKGRY EDAKRSLAKS NKVTIEDPSI VAEMDTIMAN VETERLAGNA
310 320 330 340 350
SWGELFSNKG AILPRVIMGI MIQSLQQLTG NNYFFYYGTT IFNAVGMKDS
360 370 380 390 400
FQTSIVLGIV NFASTFVALY TVDKFGRRKC LLGGSASMAI CFVIFSTVGV
410 420 430 440 450
TSLYPNGKDQ PSSKAAGNVM IVFTCLFIFF FAISWAPIAY VIVAESYPLR
460 470 480 490 500
VKNRAMAIAV GANWIWGFLI GFFTPFITSA IGFSYGYVFM GCLVFSFFYV
510 520 530 540
FFFVCETKGL TLEEVNEMYV EGVKPWKSGS WISKEKRVSE E
Length:541
Mass (Da):59,841
Last modified:November 1, 1991 - v1
Checksum:i6AEFEC0A87391CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33270 Genomic DNA. Translation: AAA34701.1.
Z48613 Genomic DNA. Translation: CAA88528.1.
BK006946 Genomic DNA. Translation: DAA09909.1.
PIRiA36380. MMBYH2.
RefSeqiNP_013724.1. NM_001182507.1.

Genome annotation databases

EnsemblFungiiYMR011W; YMR011W; YMR011W.
GeneIDi855023.
KEGGisce:YMR011W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33270 Genomic DNA. Translation: AAA34701.1.
Z48613 Genomic DNA. Translation: CAA88528.1.
BK006946 Genomic DNA. Translation: DAA09909.1.
PIRiA36380. MMBYH2.
RefSeqiNP_013724.1. NM_001182507.1.

3D structure databases

ProteinModelPortaliP23585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35180. 96 interactors.
DIPiDIP-7912N.
IntActiP23585. 6 interactors.
MINTiMINT-4497394.

Protein family/group databases

TCDBi2.A.1.1.111. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP23585.

Proteomic databases

MaxQBiP23585.
PRIDEiP23585.
TopDownProteomicsiP23585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR011W; YMR011W; YMR011W.
GeneIDi855023.
KEGGisce:YMR011W.

Organism-specific databases

EuPathDBiFungiDB:YMR011W.
SGDiS000004613. HXT2.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP23585.
KOiK08139.
OMAiCAFGGLT.
OrthoDBiEOG092C1Q5W.

Enzyme and pathway databases

BioCyciYEAST:G3O-32719-MONOMER.

Miscellaneous databases

PROiP23585.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXT2_YEAST
AccessioniPrimary (citable) accession number: P23585
Secondary accession number(s): D6VZI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.