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P23582

- ANFC_HUMAN

UniProt

P23582 - ANFC_HUMAN

Protein

C-type natriuretic peptide

Gene

NPPC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 By similarity.By similarity

    GO - Molecular functioni

    1. receptor binding Source: UniProtKB

    GO - Biological processi

    1. cGMP biosynthetic process Source: UniProtKB
    2. growth plate cartilage chondrocyte differentiation Source: UniProtKB
    3. growth plate cartilage chondrocyte proliferation Source: UniProtKB
    4. negative regulation of cell proliferation Source: Ensembl
    5. negative regulation of DNA metabolic process Source: Ensembl
    6. negative regulation of meiotic cell cycle Source: MGI
    7. negative regulation of oocyte maturation Source: MGI
    8. ossification Source: UniProtKB-KW
    9. positive regulation of cGMP biosynthetic process Source: Ensembl
    10. positive regulation of osteoblast differentiation Source: Ensembl
    11. positive regulation of vasodilation Source: Ensembl
    12. post-embryonic development Source: Ensembl
    13. receptor guanylyl cyclase signaling pathway Source: UniProtKB
    14. regulation of blood vessel size Source: UniProtKB-KW
    15. regulation of cAMP metabolic process Source: MGI
    16. regulation of cGMP metabolic process Source: MGI
    17. regulation of multicellular organism growth Source: Ensembl
    18. regulation of smooth muscle cell proliferation Source: Ensembl
    19. response to drug Source: Ensembl
    20. response to ethanol Source: Ensembl
    21. response to hypoxia Source: Ensembl

    Keywords - Molecular functioni

    Hormone, Vasoactive

    Keywords - Biological processi

    Osteogenesis

    Protein family/group databases

    TCDBi1.C.46.1.1. the c-type natriuretic peptide (cnp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type natriuretic peptide
    Cleaved into the following 3 chains:
    Gene namesi
    Name:NPPC
    Synonyms:CNP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:7941. NPPC.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31735.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 7350PRO_0000001553Add
    BLAST
    Peptidei74 – 12653CNP-53PRO_0000001554Add
    BLAST
    Peptidei98 – 12629CNP-29PRO_0000001555Add
    BLAST
    Peptidei105 – 12622CNP-22PRO_0000001556Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi110 ↔ 1261 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiP23582.
    PRIDEiP23582.

    Miscellaneous databases

    PMAP-CutDBP23582.

    Expressioni

    Gene expression databases

    ArrayExpressiP23582.
    BgeeiP23582.
    CleanExiHS_NPPC.
    GenevestigatoriP23582.

    Organism-specific databases

    HPAiHPA035362.

    Interactioni

    Protein-protein interaction databases

    BioGridi110940. 3 interactions.
    STRINGi9606.ENSP00000295440.

    Structurei

    Secondary structure

    1
    126
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni116 – 1172

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JDPX-ray2.00H105-126[»]
    ProteinModelPortaliP23582.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP23582.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the natriuretic peptide family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43160.
    HOGENOMiHOG000010304.
    HOVERGENiHBG004229.
    InParanoidiP23582.
    KOiK12336.
    OMAiHKMDRIG.
    OrthoDBiEOG79CZ1S.
    PhylomeDBiP23582.
    TreeFamiTF106305.

    Family and domain databases

    InterProiIPR002406. C_natriurtcpep.
    IPR000663. Natr_peptide.
    [Graphical view]
    PfamiPF00212. ANP. 1 hit.
    [Graphical view]
    PRINTSiPR00713. CNATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTiSM00183. NAT_PEP. 1 hit.
    [Graphical view]
    PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23582-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPAEEL AEPQAAGGGQ    50
    KKGDKAPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG 100
    ANKKGLSKGC FGLKLDRIGS MSGLGC 126
    Length:126
    Mass (Da):13,246
    Last modified:November 1, 1991 - v1
    Checksum:i58F6E657868F9A2D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821R → Q.
    Corresponds to variant rs5267 [ dbSNP | Ensembl ].
    VAR_014583

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64710 Genomic DNA. Translation: AAA35703.1.
    D90337 Genomic DNA. Translation: BAA14351.1.
    AC013435 Genomic DNA. Translation: AAX88912.1.
    BC069120 mRNA. Translation: AAH69120.1.
    BC105065 mRNA. Translation: AAI05066.1.
    BC105067 mRNA. Translation: AAI05068.1.
    CCDSiCCDS2489.1.
    PIRiJT0567. AWHUC.
    RefSeqiNP_077720.1. NM_024409.2.
    UniGeneiHs.247916.
    Hs.627236.

    Genome annotation databases

    EnsembliENST00000295440; ENSP00000295440; ENSG00000163273.
    ENST00000409852; ENSP00000387159; ENSG00000163273.
    GeneIDi4880.
    KEGGihsa:4880.
    UCSCiuc002vsl.2. human.

    Polymorphism databases

    DMDMi113850.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64710 Genomic DNA. Translation: AAA35703.1 .
    D90337 Genomic DNA. Translation: BAA14351.1 .
    AC013435 Genomic DNA. Translation: AAX88912.1 .
    BC069120 mRNA. Translation: AAH69120.1 .
    BC105065 mRNA. Translation: AAI05066.1 .
    BC105067 mRNA. Translation: AAI05068.1 .
    CCDSi CCDS2489.1.
    PIRi JT0567. AWHUC.
    RefSeqi NP_077720.1. NM_024409.2.
    UniGenei Hs.247916.
    Hs.627236.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JDP X-ray 2.00 H 105-126 [» ]
    ProteinModelPortali P23582.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110940. 3 interactions.
    STRINGi 9606.ENSP00000295440.

    Protein family/group databases

    TCDBi 1.C.46.1.1. the c-type natriuretic peptide (cnp) family.

    Polymorphism databases

    DMDMi 113850.

    Proteomic databases

    PaxDbi P23582.
    PRIDEi P23582.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295440 ; ENSP00000295440 ; ENSG00000163273 .
    ENST00000409852 ; ENSP00000387159 ; ENSG00000163273 .
    GeneIDi 4880.
    KEGGi hsa:4880.
    UCSCi uc002vsl.2. human.

    Organism-specific databases

    CTDi 4880.
    GeneCardsi GC02M232786.
    HGNCi HGNC:7941. NPPC.
    HPAi HPA035362.
    MIMi 600296. gene.
    neXtProti NX_P23582.
    PharmGKBi PA31735.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43160.
    HOGENOMi HOG000010304.
    HOVERGENi HBG004229.
    InParanoidi P23582.
    KOi K12336.
    OMAi HKMDRIG.
    OrthoDBi EOG79CZ1S.
    PhylomeDBi P23582.
    TreeFami TF106305.

    Miscellaneous databases

    EvolutionaryTracei P23582.
    GenomeRNAii 4880.
    NextBioi 18784.
    PMAP-CutDB P23582.
    PROi P23582.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23582.
    Bgeei P23582.
    CleanExi HS_NPPC.
    Genevestigatori P23582.

    Family and domain databases

    InterProi IPR002406. C_natriurtcpep.
    IPR000663. Natr_peptide.
    [Graphical view ]
    Pfami PF00212. ANP. 1 hit.
    [Graphical view ]
    PRINTSi PR00713. CNATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTi SM00183. NAT_PEP. 1 hit.
    [Graphical view ]
    PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human C-type natriuretic peptide. Characterization of the gene and peptide."
      Ogawa Y., Nakao K., Nakagawa O., Komatsu Y., Hosoda K., Suga S., Arai H., Nagata K., Yoshida N., Imura H.
      Hypertension 19:809-813(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1."
      Ishizaka Y., Kangawa K., Minamino N., Ishii K., Takano S., Eto T., Matsuo H.
      Biochem. Biophys. Res. Commun. 189:697-704(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 98-126.
    6. "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
      Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K., Matsuo H., Goeddel D.V.
      Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone."
      He X.-L., Chow D.-C., Martick M.M., Garcia K.C.
      Science 293:1657-1662(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 105-126 IN COMPLEX WITH NPR3, DISULFIDE BOND.

    Entry informationi

    Entry nameiANFC_HUMAN
    AccessioniPrimary (citable) accession number: P23582
    Secondary accession number(s): Q4ZG41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3