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Protein

C-type natriuretic peptide

Gene

NPPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • hormone receptor binding Source: UniProtKB
  • peptide hormone receptor binding Source: Ensembl
  • protein homodimerization activity Source: Ensembl
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive
Biological processOsteogenesis

Enzyme and pathway databases

ReactomeiR-HSA-5578768 Physiological factors

Protein family/group databases

TCDBi1.C.46.1.1 the c-type natriuretic peptide (cnp) family

Names & Taxonomyi

Protein namesi
Recommended name:
C-type natriuretic peptide
Cleaved into the following 3 chains:
Gene namesi
Name:NPPC
Synonyms:CNP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163273.3
HGNCiHGNC:7941 NPPC
MIMi600296 gene
neXtProtiNX_P23582

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4880
OpenTargetsiENSG00000163273
PharmGKBiPA31735

Polymorphism and mutation databases

BioMutaiNPPC
DMDMi113850

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000155324 – 73Add BLAST50
PeptideiPRO_000000155474 – 126CNP-53Add BLAST53
PeptideiPRO_000000155598 – 126CNP-29Add BLAST29
PeptideiPRO_0000001556105 – 126CNP-22Add BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 1261 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP23582
PeptideAtlasiP23582
PRIDEiP23582

PTM databases

iPTMnetiP23582
PhosphoSitePlusiP23582

Miscellaneous databases

PMAP-CutDBP23582

Expressioni

Gene expression databases

BgeeiENSG00000163273
CleanExiHS_NPPC
GenevisibleiP23582 HS

Organism-specific databases

HPAiHPA035362

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • hormone receptor binding Source: UniProtKB
  • peptide hormone receptor binding Source: Ensembl
  • protein homodimerization activity Source: Ensembl
  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110940, 8 interactors
STRINGi9606.ENSP00000295440

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JDPX-ray2.00H105-126[»]
ProteinModelPortaliP23582
SMRiP23582
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23582

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZBQ Eukaryota
ENOG410YUR4 LUCA
GeneTreeiENSGT00390000015492
HOGENOMiHOG000010304
HOVERGENiHBG004229
InParanoidiP23582
KOiK12336
OMAiGMWARLL
OrthoDBiEOG091G14FZ
PhylomeDBiP23582
TreeFamiTF106305

Family and domain databases

InterProiView protein in InterPro
IPR002406 C_natriurtcpep
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00713 CNATPEPTIDE
PR00710 NATPEPTIDES
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPAEEL AEPQAAGGGQ
60 70 80 90 100
KKGDKAPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG
110 120
ANKKGLSKGC FGLKLDRIGS MSGLGC
Length:126
Mass (Da):13,246
Last modified:November 1, 1991 - v1
Checksum:i58F6E657868F9A2D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01458382R → Q. Corresponds to variant dbSNP:rs5267Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64710 Genomic DNA Translation: AAA35703.1
D90337 Genomic DNA Translation: BAA14351.1
AC013435 Genomic DNA Translation: AAX88912.1
BC069120 mRNA Translation: AAH69120.1
BC105065 mRNA Translation: AAI05066.1
BC105067 mRNA Translation: AAI05068.1
CCDSiCCDS2489.1
PIRiJT0567 AWHUC
RefSeqiNP_077720.1, NM_024409.3
XP_011509547.1, XM_011511245.2
UniGeneiHs.247916
Hs.627236

Genome annotation databases

EnsembliENST00000295440; ENSP00000295440; ENSG00000163273
ENST00000409852; ENSP00000387159; ENSG00000163273
GeneIDi4880
KEGGihsa:4880
UCSCiuc002vsl.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANFC_HUMAN
AccessioniPrimary (citable) accession number: P23582
Secondary accession number(s): Q4ZG41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health